ライフサイエンスコーパス: cardioprotective

1 te as to whether light-to-moderate intake is cardioprotective.

2 ) and/or endurance exercise training (EX) is cardioprotective.

3 ported by a perception that modest intake is cardioprotective.

4 s were not restricted to the kidney but were cardioprotective.

5 tion of O-GlcNAcylation has been shown to be cardioprotective.

6 r, evidence suggests that sirolimus might be cardioprotective.

7 s similar suggests that sirolimus is in fact cardioprotective.

8 y (ACM), given that some of these agents are cardioprotective.

9 Inclusion of CsA during cold storage is cardioprotective.

10 This cardioprotective action of HSPA12B was mediated, at leas

11 However, SF-PreCon exerts cardioprotective action via AMPK-independent activation

12 Oakley et al. provide new insight into their cardioprotective actions and highlight the importance of

13 we demonstrated that canagliflozin produces cardioprotective actions by promoting multiple antioxida

14 GLP-1R agonists and DPP-4 inhibitors exhibit cardioprotective actions in animal models of myocardial

15 schaemic insults in vitro, but its long-term cardioprotective actions in vivo are largely unknown.

16 Mechanisms mediating the cardioprotective actions of glucagon-like peptide 1 (GLP

17 rats and healthy volunteers, evaluate their cardioprotective actions, and identify the molecular mec

18 ectin, an adipocyte-derived cytokine, exerts cardioprotective actions, and its deficiency is implicat

19 , anti- inflammatory, anti-proliferative and cardioprotective activities.

20 t containing olive pomace (OP), that exhibit cardioprotective activities.

21 f both pharmacophores results in synergistic cardioprotective activity through the combination of bot

22 an target of rapamycin inhibitors may confer cardioprotective advantages, but clinical data are limit

23 mproves neonatal cardiac regeneration and is cardioprotective after myocardial infarction.

24 PC of the arm identified plasma nitrite as a cardioprotective agent in isolated Langendorff mouse hea

25 NN is a cardioprotective agent that promotes cardiomyocyte survi

26 chemotherapy, development and application of cardioprotective agents for prevention of cardiotoxicity

27 a gap in the ability to efficiently deliver cardioprotective agents in a cell specific manner while

28 iotoxicity should receive closer monitoring, cardioprotective agents, dose adjustment or alternative

29 HDL exhibits cardioprotective and anti-inflammatory properties though

30 ediated arrhythmias in T2DM via its putative cardioprotective and antidiabetic property.

31 Dexrazoxane was cardioprotective and did not compromise antitumor effica

32 des a novel mechanism by which HN exerts its cardioprotective and neuroprotective effects.

33 Furthermore, the observed cardioprotective and other health effects of ALA have be

34 has been suggested that autophagy may elicit cardioprotective and pro-survival modulating functions,

35 n of ketogenesis and erythrocytosis with the cardioprotective and renoprotective benefits of these dr

36 glycolytic intermediates are channeled into cardioprotective and repair pathways, such as the pentos

37 ndicate that a moderate increase in PDE4B is cardioprotective and suggest that cardiac gene therapy w

38 ypoxic stress is essential to maximize their cardioprotective and therapeutic potential.

39 NO3(-)) and nitrite (NO2(-)) are known to be cardioprotective and to alter energy metabolism in vivo

40 sociated peptide that offers cytoprotective, cardioprotective, and neuroprotective effects in vivo an

41 The recognition that cell therapy may be cardioprotective, and not just regenerative, merits furt

42 s, graft procurement and storage conditions, cardioprotective approaches, and graft evaluation strate

43 (NEP-generated) metabolite of GLP-1, was as cardioprotective as GLP-1 and was abolished by scramblin

44 While innately cardioprotective at high doses, unmodified CDC-exosomes

45 for the use of statins to confer additional cardioprotective benefits in older adults.

46 uch speculation with regard to the potential cardioprotective benefits of equol, a microbial-derived

47 ition, they have long been debated to confer cardioprotective benefits.

48 New antidiabetic agents show unexpected cardioprotective benefits.

49 eta-catenin pathway), and that they activate cardioprotective bone-morphogenetic-protein signalling i

50 might limit mitochondrial Ca(2+) load and be cardioprotective, but direct evidence for tPTP in cells

51 nd C24:1 ceramides and increased potentially cardioprotective C20- and C22-ceramides post-TAC.

52 activated kinase that has been shown to have cardioprotective capabilities against myocardial ischemi

53 some of the newest agents that seem to have cardioprotective capabilities.

54 heart failure by potentially activating this cardioprotective channel.

55 Moderate alcohol consumption is known to be cardioprotective compared with either heavy drinking or

56 To address the cardioprotective contribution of PGI2, we generated mice

57 n provides ultrafast and potently neuro- and cardioprotective cooling after shockable cardiac arrest

58 e endpoints, and in some cases initiation of cardioprotective drug therapy in asymptomatic women.

59 nate), which is an approved, clinically used cardioprotective drug, is a relatively poor BBOX inhibit

60 nsiderable efforts have been made to exploit cardioprotective drugs and gene delivery systems for myo

61 record to date of animal models for creating cardioprotective drugs, human pluripotent stem cell-deri

62 comprehensive prescription of evidence-based cardioprotective drugs.

63 d anesthetic sevoflurane (SF-PreCon) remains cardioprotective during DM, and identified the involved

64 s of the beta1AR transduction cascade and is cardioprotective during heart failure.

65 s, although short-term Akt activation may be cardioprotective during ischemia by reducing mitochondri

66 Hence, modulation of this axis may be cardioprotective during ischemia.

67 release of humoral factors and/or the direct cardioprotective effect at the myocardium is inhibited b

68 ac function in control animals, leptin had a cardioprotective effect following TAC, normalizing cardi

69 us on cardiac function in sham, leptin had a cardioprotective effect following TAC.

70 This study sought to determine how this cardioprotective effect is influenced by the timing of m

71 cardiac-specific GRK2 knockdown restored the cardioprotective effect of adiponectin.

72 Here, we investigated whether part of the cardioprotective effect of BNP in infarcted hearts relat

73 A cardioprotective effect of cGMP/cGKI has been reported i

74 In addition, whether the cardioprotective effect of exenatide, a glucose-lowering

75 ay significantly contributes to the observed cardioprotective effect of FTY720.

76 The cardioprotective effect of HDL is thought to be largely

77 ective of this study was to determine if the cardioprotective effect of PAI-1 is mediated through its

78 The cardioprotective effect of SCFAs were mediated via the c

79 most likely contribute only partially to the cardioprotective effect of SGLT2 inhibition.

80 amelioration of pathological remodeling, the cardioprotective effect of this drug was not significant

81 The cardioprotective effect of ultrasound targeted hs-MB des

82 This was predominantly because of a cardioprotective effect on ischemic segments (strain rat

83 Mechanistically, TAK1 exerts its cardioprotective effect through activation of NFAT/NFkap

84 This cardioprotective effect was associated with alleviation

85 nes, particularly estrogen exerts a profound cardioprotective effect which may be associated with fav

86 tration of DNase I and rhADAMTS13 revealed a cardioprotective effect, resulting in subsequent improve

87 adult mice after myocardial infarction by a cardioprotective effect.

88 thus, RAS activation, ultimately exerting a cardioprotective effect.

89 se-derived stem cells (ADSCs) enhances their cardioprotective effects after transplantation into infa

90 se results strongly indicate that Myr exerts cardioprotective effects against DCM through the blockag

91 peroxide-mediated toxicity in H9c2 cells and cardioprotective effects against myocardial ischemic/rep

92 ced alphaCGRP has blood pressure-independent cardioprotective effects and is crucial for maintaining

93 The remarkable cardioprotective effects ascribed to heme oxygenase-1 ar

94 or, beyond its antiplatelet efficacy, exerts cardioprotective effects by reducing necrotic injury and

95 oglia at the level of the spinal cord elicit cardioprotective effects during seizure.

96 nutrient deprivation sensors exert striking cardioprotective effects in a broad range of experimenta

97 e, a representative prodrug exhibited potent cardioprotective effects in a murine model of myocardial

98 Apo M exerts anti-inflammatory and cardioprotective effects in animal models.

99 ced alphaCGRP has blood pressure-independent cardioprotective effects in chronic hypertension.

100 n-like peptide 1 (GLP-1) agonists have shown cardioprotective effects in early clinical studies of pa

101 ors of the renin-angiotensin system exerting cardioprotective effects in models of heart failure.

102 ew evaluates the current evidence behind the cardioprotective effects of a Mediterranean dietary patt

103 the mobilization of CXCR4(+) cells, and the cardioprotective effects of AMD3100 were retained in eNO

104 Test whether Gq coupling is required for the cardioprotective effects of an alpha-1A-AR (adrenergic r

105 Similarly, cardioprotective effects of AnxA1 were obtained in pigs

106 The cardioprotective effects of autophagy deficiency were re

107 -secreted exosomes (CDCexo) recapitulate the cardioprotective effects of CDC therapy known as cellula

108 PKCdelta transcript levels and underlies the cardioprotective effects of CDCs administered after repe

109 otein kinase G (PKG) might contribute to the cardioprotective effects of cholinergic stimulation.

110 at epicatechin may in part contribute to the cardioprotective effects of cocoa and tea by improving i

111 Cardioprotective effects of FTY720 were abolished follow

112 Cardioprotective effects of FTY720 were confirmed in pol

113 This novel mechanism might contribute to the cardioprotective effects of ghrelin in HF.

114 s largely in ventricles and is vital for the cardioprotective effects of Hsp20.

115 of the technique was tested by investigating cardioprotective effects of hydrogen sulphide (H(2) S) a

116 The aim of this study was to confirm the cardioprotective effects of hypothermia using a combinat

117 summarize the data to date on the potential cardioprotective effects of influenza vaccines, and desc

118 r outcomes trials to determine the potential cardioprotective effects of influenza vaccines.

119 This study compared the cardioprotective effects of intravenous statin administr

120 Previous studies have indicated that the cardioprotective effects of long-chain (LC) n-3 (omega-3

121 Although studies have demonstrated the cardioprotective effects of matrix metalloproteinase inh

122 upplementation was conducted to evaluate the cardioprotective effects of microbiota on the mice after

123 Furthermore, the cardioprotective effects of NaHS were enhanced by inhibi

124 Cardioprotective effects of propionate were abrogated in

125 The promising cardioprotective effects of recombinant human erythropoi

126 indings provide new insights into the remote cardioprotective effects of RF-RDN acting directly on ca

127 The cardioprotective effects of SAHA during ischemia/reperfu

128 The cardioprotective effects of SGLT2 (sodium-glucose cotran

129 uding HF, the mechanisms responsible for the cardioprotective effects of SGLT2 inhibitors remain inco

130 inhibition may partially explain the robust cardioprotective effects of statins are warranted.

131 hat quercetin plays an important role in the cardioprotective effects of tea.

132 ular targeting of Pim1 bolsters the distinct cardioprotective effects of this kinase in hCPCs to incr

133 yl)theophylline administration abolished the cardioprotective effects of ticagrelor over clopidogrel.

134 The cardioprotective effects of TNF-alpha are a consequence

135 Na2S induces cardioprotective effects through miR-21-dependent attenu

136 ke peptide-1, an incretin hormone with known cardioprotective effects, alongside MSC endogenous parac

137 MPCs exert extensive cardioprotective effects, and are considered to be immun

138 I restored myeloid cell proportions, yielded cardioprotective effects, and shifted the balance of SCF

139 s), which have known hypotriglyceridemic and cardioprotective effects, can also impact WAT and BAT fu

140 naling by SGLT2 inhibitors may explain their cardioprotective effects, even though SGLT2 is not expre

141 ncluding positive fluid balance), along with cardioprotective effects, modulation of circulatory infl

142 dine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy a

143 Because of its documented cardioprotective effects, we sought to determine the imp

144 c hypertrophy, and blunts metformin-mediated cardioprotective effects.

145 known free radical scavengers and have shown cardioprotective effects.

146 g was followed by significant angiogenic and cardioprotective effects.

147 sential autophagy proteins, abolished SAHA's cardioprotective effects.

148 roviding a novel potential mechanism for its cardioprotective effects.

149 canagliflozin is reported to possess several cardioprotective effects.

150 in is widely used for relief of pain and for cardioprotective effects.

151 ntribute to ACE inhibitors' (ACEi) reno- and cardioprotective effects.

152 Beyond lipid-lowering, statins exert cardioprotective effects.

153 mines, small aliphatic amines with potential cardioprotective effects.

154 systemic metabolism and exerts also relevant cardioprotective effects; hence, it has been proposed fo

155 miR-181b alter Mvarphi phenotype and confer cardioprotective efficacy in a rat model of myocardial i

156 ytochrome-P450-derived anti-inflammatory and cardioprotective epoxy-PUFAs increased linearly with n-3

157 Surprisingly, A61603 activation of cardioprotective ERK (extracellular signal-regulated kin

158 Follistatin-like1 (FSTL1) is a cardioprotective factor against ischemic injury and is i

159 ectors (AAVs) encoding anti-inflammatory and cardioprotective factors appears to be a promising thera

160 pressive and prosurvival agents, delivery of cardioprotective factors packaged in exosomes rather tha

161 eptide with a short circulating-half life is cardioprotective following MI but its clinical use is li

162 Long-term HAART appears to be cardioprotective for HIV-infected children and adolescen

163 duced intermediate filament cytoskeleton has cardioprotective function in mice and potentially in hum

164 gest that the novel mechanism underlying the cardioprotective function of H2S is secondary to a combi

165 ciated proteins and, ultimately, improve the cardioprotective function of HDL.

166 phosphorylation of Ser96 is critical for the cardioprotective function of HRC.

167 Here we provide evidence for a cardioprotective function of TNF-alpha in a genetic hear

168 odel, whether the reported impairment of HDL cardioprotective function was associated with alteration

169 trin-1, is critical for mediating netrin-1's cardioprotective function.

170 tion of SIAH1/2 further augmented netrin-1's cardioprotective function.

171 Hydrogen sulfide (H2S), a cardioprotective gas, is endogenously produced from homo

172 in cardioGRMRdKO hearts reversed many of the cardioprotective gene changes and resulted in cardiac fa

173 calcineurin (CN) to potentiate induction of cardioprotective gene expression while suppressing expre

174 laborate a spatial- and chronologic model of cardioprotective gene networks to prevent left ventricul

175 ions of substantially greater use of drop-in cardioprotective glucose-lowering agents demonstrated bl

176 Cardioprotective GRK2 inhibition required an intact ERK

177 ferred into infarcted mice, which mediated a cardioprotective healing response.

178 prescribed antagonists that promote slower, cardioprotective heart rates during heightened vigilant

179 eostasis derailment, including exhaustion of cardioprotective heat shock proteins, disruption of cyto

180 NPR-C (natriuretic peptide receptor-C), are cardioprotective hormones that affect cardiac structure

181 est that B-type natriuretic peptide (BNP) is cardioprotective; however, in clinical studies, higher p

182 arious kinases, leading to activation of the cardioprotective HSP27.

183 dium by a pathway involving TLR4 and classic cardioprotective HSPs.

184 cellular regenerative products, interesting cardioprotective, immunoregulatory, and cardioregenerati

185 moking MR study to date, we failed to find a cardioprotective impact of genetically predicted alcohol

186 tigate whether gene transfer of Ang-(1-9) is cardioprotective in a murine model of myocardial infarct

187 The exosome-rich fraction was powerfully cardioprotective in all tested models of cardiac ischemi

188 tide), one of the strongest vasodilators, is cardioprotective in hypertension by reducing the elevate

189 sed for the treatment of type 2 diabetes are cardioprotective in preclinical studies; however, some c

190 Helium proved neuroprotective in rodents and cardioprotective in rabbits, and there were too few data

191 t effects, being neuroprotective in rodents, cardioprotective in rodents and pigs, and renoprotective

192 of enhanced catabolism or adipose tissue is cardioprotective in the context of HF.

193 inhibition initiated 1 week post-injury was cardioprotective in the I/R model of chronic HF, includi

194 (mRQ) when co-administered with ADR, will be cardioprotective in vitro and in vivo, while maintaining

195 eperfusion phase of myocardial infarction is cardioprotective in vivo in mice.

196 s deserves attention because Pim-1 kinase is cardioprotective, in part, by preservation of mitochondr

197 ation in neonatal hearts may present a novel cardioprotective intervention to limit post-ischemic con

198 Additive cardioprotective interventions are advocated.

199 onditioning procedures are the most powerful cardioprotective interventions in animal experiments.

200 The translation of cardioprotective interventions to clinical practice has

201 ss of CM YAP also impaired activation of the cardioprotective kinase Akt, which may underlie the YAP-

202 Our studies identify a cardioprotective lncRNA, define a new targeting mechanis

203 f cAMP from cardiac myocytes is an intrinsic cardioprotective mechanism in response to cardiac stress

204 Our findings uncover a new cardioprotective mechanism, which promotes a protective

205 antioxidative activity, representing two key cardioprotective mechanisms of HDL, were profoundly supp

206 We aimed to identify novel Nox4-driven cardioprotective mechanisms that promote adaptive cardia

207 Cardioprotective medication use at 2013 levels (29%-44%

208 At optimal cardioprotective medication use, the projected health ga

209 n with patients regarding their adherence to cardioprotective medication.

210 per was to examine disparities in the use of cardioprotective medications in the treatment of periphe

211 Effects of open-label drop-in cardioprotective medications need to be considered caref

212 tential gains from expanding indications for cardioprotective medications will not be realized.

213 Without the use of cardioprotective medications, for 60- to 69-year-old ind

214 ant with clinical guidelines in 2019) use of cardioprotective medications.

215 mass index and greater excursions in select cardioprotective metabolites in women despite less exerc

216 rs, whereas msR4M-L1 does not interfere with cardioprotective MIF/CD74 signaling.

217 ithin this cluster the cancer-associated and cardioprotective miR-22 was shown to repress fatty acid

218 The cardioprotective miRNA-133a (miR-133a) is downregulated,

219 nal nerves participate in the degradation of cardioprotective NP.

220 ide levels with the previously reported R19X cardioprotective null mutation (beta = -1.09,sigma = 0.1

221 cal studies suggest that these cells release cardioprotective paracrine factors that activate endogen

222 es to H-H, resulting in diminished levels of cardioprotective parasympathetic activity to the heart a

223 agon-like peptide-1 analog activates several cardioprotective pathways, prevents HFD-induced insulin

224 xercise have revealed novel pathological and cardioprotective pathways.

225 e for ACE2 and functions as an inotropic and cardioprotective peptide.

226 Increased expression of the EGR1-regulated cardioprotective peptides atrial natriuretic peptide (AN

227 This cardioprotective phenotype displayed improvements in all

228 ating macrophages can be primed to acquire a cardioprotective phenotype in ischemic heart and exert t

229 a inhibition revealed high glucose to show a cardioprotective phenotype in this setting.

230 t polarized macrophages toward a distinctive cardioprotective phenotype that was not M1 or M2.

231 n, the ischemia-injured heart elaborates the cardioprotective polypeptide, insulin-like growth factor

232 and, based on the findings, to evaluate the cardioprotective potency of metformin (Met).

233 In this investigation, we demonstrated a cardioprotective process involving FGF21 from the liver

234 y, little is known about how CDCs confer the cardioprotective process known as cellular postcondition

235 and that 30 minutes of unloading activates a cardioprotective program that limits reperfusion injury.

236 tenofovir alafenamide conferred potentially cardioprotective properties associated with ectonucleoti

237 t the remodeling of HDLs may impact on their cardioprotective properties is beginning to emerge.

238 the design, synthesis, and evaluation of the cardioprotective properties of a number of novel hybrid

239 Studies in healthy animals suggest cardioprotective properties of GLP-1 receptor agonists,

240 Cardioprotective properties of the blood plasma was inve

241 The in vitro cardioprotective properties of the polar lipid fractions

242 its reduced form may optimize its intrinsic cardioprotective properties.

243 n for polar lipid HPLC fractions with strong cardioprotective properties.

244 Exosomes can be proangiogenic and may have cardioprotective properties.

245 urface charge, as well as in their potential cardioprotective properties.

246 a-3 eicosapentaenoic acid (EPA) has multiple cardioprotective properties.

247 eMSCs enable sustained local delivery of cardioprotective proteins to the heart, thereby enhancin

248 sters, and proteomic changes, with losses in cardioprotective proteins.

249 C3 provides robust evidence for a replicable cardioprotective rare variant aggregation (P = 3.2 x 10(

250 eriments, fingolimod treatment activated the cardioprotective reperfusion injury salvage kinase and s

251 Young euglycemic Dpp4(-/-) mice exhibited a cardioprotective response after TAC surgery or doxorubic

252 A cardioprotective response that alters ventricular contra

253 hese studies suggest that iPLA2gamma plays a cardioprotective role during the acute stage of Chagas'

254 Our data strongly support a cardioprotective role for sphingosine-1-phosphate recept

255 Our findings uncover an immune cardioprotective role for the pericardial tissue compart

256 PKA inhibition revealed a cardioprotective role of beta-adrenergic signaling via c

257 Our results suggest that the cardioprotective role of DeltaPDZ nNOS is likely through

258 This study establishes a cardioprotective role of eosinophils in post-MI hearts.

259 over-expression studies have established the cardioprotective role of neuronal nitric oxide synthase

260 peri-infarct zone, revealing a nonredundant, cardioprotective role of resident cardiac macrophages.

261 proteins (HDLs) contribute to explaining the cardioprotective role of the lipoprotein beyond quantita

262 ng the immunoproteasome inhibition-dependent cardioprotective role suggests the possibility of modula

263 beneficial effects, including its potential cardioprotective role.

264 w the utility of the technique for exploring cardioprotective roles of H(2) S in the chicken embryo h

265 Cardioprotective signal transduction appears as a highly

266 access a pharmacological profile stimulating cardioprotective signaling and inotropic effects through

267 ccessful, the pharmacological recruitment of cardioprotective signaling has been largely disappointin

268 Hydrogen sulfide is a cardioprotective signaling molecule but is toxic at elev

269 red using standard cold storage with a novel cardioprotective solution designed for room temperature

270 een beta1-adrenergic receptors (ARs) and the cardioprotective sphingosine-1-phosphate (S1P) receptor-

271 Many cardioprotective strategies act through common end-effec

272 Therefore, cardioprotective strategies aim to reduce infarct size.

273 RATIONALE: The impact of cardioprotective strategies and ischemia duration on pos

274 Cardioprotective strategies are urgently needed to impro

275 on of potential benefits associated with new cardioprotective strategies both in experimental and cli

276 g infarct size and MVO may help to translate cardioprotective strategies into improved clinical outco

277 at predicting cardiotoxicity and developing cardioprotective strategies may lead to changes in the a

278 sis of diabetic cardiomyopathy and potential cardioprotective strategies to prevent and treat the dis

279 ern in all 40-minute I/R pigs, regardless of cardioprotective strategy and the degree of intramyocard

280 ording to CMR timing, ischemia duration, and cardioprotective strategy.

281 of CAD and apoD may be part of an intrinsic cardioprotective system, possibly as a consequence of it

282 that FOXO1 inhibitors may have potential as cardioprotective therapeutic agents during cancer chemot

283 l ischemia, 2) evaluation and development of cardioprotective therapeutic strategies, and 3) decision

284 and offers a novel target for the design of cardioprotective therapeutics.

285 the Consortium for preclinicAl assESsment of cARdioprotective therapies (CAESAR), based on the princi

286 progress towards successful clinical use of cardioprotective therapies following AMI, focusing on th

287 However, translation of these cardioprotective therapies into the clinical setting of

288 Cardioprotective therapies, duration of index ischemia,

289 een used to assess myocardial salvage by new cardioprotective therapies.

290 rrogate cardiac biomarkers, and prophylactic cardioprotective therapy in asymptomatic women with limi

291 eeded to determine the effect of combination cardioprotective therapy on event-free survival in Duche

292 d mortality by allowing early instigation of cardioprotective therapy.

293 ho may benefit the most from early reno- and cardioprotective therapy.

294 hondrial function, which may present a novel cardioprotective treatment that inhibits the progress of

295 model indicates clear survival benefits with cardioprotective treatments in this population and scope

296 .8% of individuals are heterozygous for this cardioprotective variant, which was previously thought t

297 To determine if MICU2 expression was cardioprotective, we produced and characterized Micu2(-/

298 n of autophagy is generally considered to be cardioprotective, whereas excessive autophagy can lead t

299 hat a newly formulated, covalent NN would be cardioprotective with reduced proneoplastic effects in c

300 egulate fibrosis and induce transcription of cardioprotective wound healing genes, including COX-2.