ライフサイエンスコーパス: cargo receptor

1 ins (zymogens) with Muclin, a putative Golgi cargo receptor.

2 mpartments is critical for its function as a cargo receptor.

3 which we demonstrate here to be a bona fide cargo receptor.

4 secreted proteins with the help of specific cargo receptors.

5 how that exit must occur by association with cargo receptors.

6 at the trans-Golgi network by transmembrane cargo receptors.

7 tures with mammalian and yeast transmembrane cargo receptors.

8 hat aid cargo recruitment are referred to as cargo receptors.

9 lysosomes were ubiquitin-binding autophagic cargo receptors.

10 ficient to induce EVP secretion of autophagy cargo receptors.

11 ne in complex with ER-derived chaperones and cargo receptors.

12 -enriched proteins in human cells, including cargo receptors.

13 tion of the distinct sequence signals on the cargo receptors.

14 involved in protein trafficking and serve as cargo receptors.

15 1p, and Bch2p), which are believed to act as cargo receptors.

16 n of retrograde trafficking of transmembrane cargo receptors.

17 th enhanced protein levels of the respective cargo receptors.

18 y autophagy utilizes a specialized cytosolic cargo receptor and a dedicated SNARE system.

19 d signaling by NSF through direct binding to cargo receptor and its ATPase activity and uncovered an

20 with the idea that APP serves as a kinesin-1 cargo receptor and that PS and BACE1 are associated with

21 for the entrapment of misfolded proteins by cargo receptors and a strategy for their release and ant

22 relies on hierarchical binding of autophagy cargo receptors and adaptors to ATG8/LC3 protein family

23 lacked members of the p24 family of putative cargo receptors and contained enzymes instead of anterog

24 embranes and a number of proteins, including cargo receptors and core autophagy components.

25 Cargo triggers the assembly of a web of cargo receptors and core machinery.

26 e' signals, the specific roles of individual cargo receptors and how disrupting cargo receptor functi

27 es PI(4,5)P(2) clustering at the boundary of cargo receptors and that this accumulation enhances clat

28 is recruited to specific cargo material via cargo receptors and the Atg11/FIP200 scaffold protein.

29 hagy relies on the core autophagy machinery, cargo receptors, and "eat-me" signals such as galectin-8

30 tinylation proteomics of autophagy adaptors, cargo receptors, and galectins in response to acute lyso

31 as regulators of autophagy and as autophagic cargo receptors, and reveals a basis for selective autop

32 It has become evident that cargo receptors are acting as Swiss army knives in selec

33 rgeted autophagy and suggests that autophagy cargo receptors are attractive entry points for the deve

34 Members of the p24 family of putative cargo receptors are proposed to contain retrograde and a

35 We identify BNIP3 (a mitochondrial cargo receptor) as an HCC suppressor that mitigates agai

36 VTI1a colocalizes with the putative vacuolar cargo receptor AtELP on the trans-Golgi network and the

37 We examined the ability of the vacuolar cargo receptor AtELP to interact with the sorting signal

38 TGN), where it colocalizes with the vacuolar cargo receptor AtELP.

39 Recruitment of autophagy cargo receptors, ATG8-like proteins, or the kinases ULK1

40 upon starvation, but with the acquisition of cargo receptors, autophagy has become an important cellu

41 lass I molecules associate with the putative cargo receptor BAP31.

42 e proteins have been proposed to function as cargo receptors, but the identity of putative cargos in

43 we demonstrate that the human transmembrane cargo receptors can initiate autophagosome biogenesis no

44 t to trigger mitophagy, while only autophagy cargo receptors capable of self-oligomerization degrade

45 results suggest that LMAN1 and MCFD2 form a cargo receptor complex and that the primary sorting sign

46 r deficiency protein 2), which encode the ER cargo receptor complex LMAN1-MCFD2.

47 ple coagulation factor deficiency protein 2) cargo receptor complex transports coagulation factors V

48 cking at the nuclear pore complex (NPC), the cargo-receptor complex moves through the aqueous pore ch

49 uclear pore complex is vulnerable to unusual cargo receptor complexes and sheds light on the importan

50 4 and PEX13 are peroxins involved in docking cargo-receptor complexes at the peroxisomal membrane, th

51 d associated with ATG8 proteins that recruit cargo-receptor complexes into autophagosomes.

52 and movement across the nuclear envelope of cargo-receptor complexes that interact with the small GT

53 rce for further dissection of autophagosomal cargo-receptor connectivity.

54 MUC1-fs is trapped in TMED9 cargo receptor-containing vesicles of the early secretor

55 the Apg/Cvt vesicle component Aut7, the Cvt cargo receptor Cvt19, and the Apg conjugation machinery,

56 Thus, PGRMC1 acts as a size-selective cargo receptor during RTN3-dependent ER-phagy, and is a

57 ecognize specific internalization signals on cargo receptors, either recruiting cargos into clathrin-

58 loid precursor protein (APP)-like, a kinesin cargo receptor, enhanced the severity of a Dab1 overexpr

59 ted a conditional knockout allele of the Wnt cargo receptor Evi/Gpr177/Wntless and studied mice that

60 2 form a protein complex that functions as a cargo receptor ferrying FV and FVIII from the endoplasmi

61 receptor coactivator 4 (NCOA4) is a critical cargo receptor for autophagic breakdown of ferritin and

62 This work identifies NCOA4 as a selective cargo receptor for autophagic turnover of ferritin (ferr

63 normal functions of APP may be as a membrane cargo receptor for kinesin-I and that KLC is important f

64 No cargo receptor for proinsulin has been identified.

65 NCOA4 is a selective cargo receptor for the autophagic turnover of ferritin,

66 nsport, with CNIH2 functioning as a specific cargo receptor for the auxin efflux carrier PINA, with t

67 hat the MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected

68 serves two functions in insulin action: as a cargo receptor for the Myo1c motor, and as a signal for

69 -2/PICALM complex functions as an autophagic cargo receptor for the recognition and shipment of APP-C

70 er with the cargo molecules directly or with cargo receptors for anterograde trafficking.

71 or LMAN1 and FV/FVIII that are essential for cargo receptor formation and cargo loading in the ER.

72 Subcellular retrograde transport of cargo receptors from endosomes to the trans-Golgi networ

73 nding of the molecular mechanisms underlying cargo receptor function are described.

74 II (FVIII; F5F8D), suggesting an ER-to-Golgi cargo receptor function for the LMAN1-MCFD2 complex.

75 ndividual cargo receptors and how disrupting cargo receptor function may be important for bacterial e

76 ligomerization of LMAN1 is necessary for its cargo receptor function.

77 n this process, a suite of ubiquitin-binding cargo receptors function to initiate autophagosome assem

78 ong evidence that the cellular turnover of a cargo receptor, i.e., LRP, is regulated by the proteasom

79 LMAN1 is a cargo receptor in the early secretory pathway that is re

80 current knowledge regarding two prototypical cargo receptors in mammals, LMAN1 and SURF4, and their r

81 misfolded proteins, and discuss the role of cargo receptors in protein trafficking and lipid homeost

82 nt insights into the mechanisms of action of cargo receptors in selective autophagy by focusing on th

83 y focusing on the roles of sequestosome-like cargo receptors in the degradation of misfolded, ubiquit

84 ns are believed to be bound by transmembrane cargo receptors in the trans-Golgi network (TGN) that re

85 ediates EVP-associated release of autophagic cargo receptors, including p62/SQSTM1.

86 d clathrin, activated upon ligand binding to cargo receptors, inhibited by inhibitors of dynamin, Rac

87 erning how organelle-localized transmembrane cargo receptors initiate selective autophagy remain poor

88 tg34 and the human p62, Optineurin and NDP52 cargo receptors interact with the E3-like enzyme Atg12~A

89 Together, our results argue that specific cargo-receptor interactions give rise to distinct transp

90 depends on the Ran-GTPase system to regulate cargo-receptor interactions.

91 ess (Wls, also known as Evi or Srt), the key cargo receptor involved in Wg secretion.

92 Here we describe prediction of protein cargo receptors involved in vesicle formation and protei

93 PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interfe

94 a its C-terminal domain to impair docking of cargo-receptor (karyopherin/importin) complex and disrup

95 und that inducing internalization of a SNX17 cargo receptor, low-density lipoprotein receptor-related

96 Here, we discovered that the COPII cargo receptor MoErv29 functions as a target of MoHac1,

97 We show that the autophagy cargo receptor NBR1 suppresses viral accumulation by tar

98 endent mechanism that involves the autophagy cargo receptor NBR1.

99 is through the accumulation of the autophagy cargo receptor NBR1.

100 When autophagy is inhibited, the autophagy cargo receptors NBR1 and p62/SQSTM1 accumulate within bi

101 racterised by sequestration of the xenophagy cargo receptor Ndp52 and its paralogue Tax1bp1, which we

102 essential for anti-bacterial autophagy, the cargo receptor NDP52 forms a trimeric complex with FIP20

103 65, which serves as a recognition signal for cargo receptor NDP52-mediated selective autophagic degra

104 duced PINK1/Parkin mitophagy mediated by the cargo receptor NDP52.

105 cles (GUVs), GST-Ub(4) as a model cargo, the cargo receptors NDP52, TAX1BP1, and OPTN, and the autoph

106 hermore, we identify the selective autophagy cargo receptor neighbor of BRCA1 (NBR1) as a key mediato

107 bidopsis thaliana We show that the autophagy cargo receptor NEIGHBOR OF BRCA1 (NBR1) targets nonassem

108 pon preventing accumulation of the autophagy cargo receptor, Neighbor to BRCA1 (NBR1).

109 The plant selective autophagy cargo receptor neighbour of breast cancer 1 gene (NBR1)

110 tivates autophagy through recruitment of the cargo receptor nuclear dot protein 52 (NDP52).

111 n iron is mobilized by autophagy through the cargo receptor, nuclear co-activator 4.

112 Like known cargo receptors, nuclear receptor coactivator 4 (NCOA4)

113 brane protein, Cornichon-1 (CNIH), acts as a cargo receptor of proTGFalpha.

114 to the lysosomal compartment and 3 lysosomal cargo receptors, of which most exhibited a significant d

115 ULK1 phosphorylates the BNIP3 mitochondrial cargo receptor on a critical serine residue (S17) adjace

116 Sorting nexin 17 (SNX17) functions as cargo receptor on endosomal membranes that enables the r

117 Previously, we identified dynactin as a cargo receptor or adaptor for cytoplasmic dynein, mediat

118 of BISP and BPH14 to the selective autophagy cargo receptor OsNBR1, which delivers BISP to OsATG8 for

119 egulate the stability and trafficking of the cargo receptor p24 and the distribution of the vesicle t

120 hosphorylation/deactivation of the autophagy-cargo receptor p62 (SQSTM1), through its C-terminal regi

121 interaction between RIG-I and the autophagic cargo receptor p62 and to mediate RIG-I degradation via

122 The autophagy cargo receptor p62 facilitates the condensation of misfo

123 nhanced the interaction between p65/RelA and cargo receptor p62, thus facilitating the degradation of

124 dation through the activity of the autophagy cargo receptor p62.

125 anization and up-regulation of the autophagy cargo receptor p62.

126 sociated protein light chain 3 and autophagy cargo receptor p62/sequestosome 1 strongly increase upon

127 Here we show that the human cargo receptor p62/SQSTM-1 employs oligomerization to st

128 ntriguingly, overexpression of the autophagy cargo receptor p62/SQSTM1 in PI3K-H1047R cells is suffic

129 inhibiting self-interaction of the autophagy cargo receptor p62/SQSTM1, impeding p62 autophagy flux.

130 The autophagy cargo receptors p62, NDP52 and Optineurin detect incomin

131 l domain-containing 1 (FYCO1), and autophagy cargo receptors p62/sequestosome 1 (SQSTM1) and neighbor

132 A second autophagy cargo receptor, p62, then targeted seeded tau aggregates

133 While the cargo receptor PEX5 depends on its mono-ubiquitination f

134 We also show that the PTS2 cargo receptor, Pex7, is required for Pex20 polyubiquiti

135 All three cargo receptors potently stimulated LC3 lipidation on GU

136 The transmembrane emp24 domain 9 (TMED9) cargo receptor promotes a general mechanism of cytotoxic

137 Autophagy of these cargo receptors promotes non-canonical NF-kappaB signall

138 We present evidence that the putative cargo receptor protein Bap31 participates in the transpo

139 d conditional knockout mice where Wntless, a cargo receptor protein required for Wnt secretion, was s

140 It is known that cargo receptor proteins form part of the COPII complex a

141 Although the mechanisms by which soluble cargo receptors recruit the autophagy machinery are beco

142 osome membrane and are thought to facilitate cargo receptor recruitment, vesicle maturation, and lyso

143 This dataset harbors information on the cargo-receptor relationship of almost all vacuolar prote

144 ro-TRH in the trans-Golgi network, and not a cargo-receptor relationship, is important for the downst

145 ate compartment 53 kDa protein (ERGIC-53), a cargo receptor required for glycoprotein trafficking wit

146 derstood, including the role and identity of cargo receptors required for completion of lysophagy.

147 A/Gea1/Gea2, and totally with the retrograde cargo receptor Rer1, consistent with Uso1 dwelling in a

148 LMAN1 (ERGIC-53) is a key mammalian cargo receptor responsible for the export of a subset of

149 ecular rules for initiation by transmembrane cargo receptors, revealing remarkable flexibility in the

150 icating a potential selective autophagosomal cargo receptor role for P3IP.

151 Furthermore, cargo receptors sequester ubiquitinated proteins into la

152 ic cargo for retrograde transport by binding cargo receptors such as Rab GTP-binding (G) proteins.

153 coat proteins accumulates in the absence of cargo receptors, suggesting that disruption of hsc70 act

154 Here, we find that the cargo receptor, SURF4, recruits different SEC24 cargo ad

155 e rescued by overexpression of the conserved cargo receptor Tango1 and partially rescued by supplemen

156 Current models suggest that the conserved cargo receptor Tango1 mediates the packaging of collagen

157 interface with the outer COPII coat and the cargo receptor Tango1/cTAGE5.

158 leared via selective autophagy requiring the cargo receptor TAX1BP1.

159 conclude that Erv14 functions as a canonical cargo receptor that couples membrane proteins to the COP

160 i targeting of Rud3p also requires Erv14p, a cargo receptor that cycles between the endoplasmic retic

161 (ERGIC-53) and MCFD2 form a Ca(2+)-dependent cargo receptor that cycles between the endoplasmic retic

162 known physiological role, as a non-canonical cargo receptor that directly binds to core autophagy pro

163 Gpr177 (Evi/Wls) is a Wnt-specific cargo receptor that is required for the secretion of Wnt

164 nduced ferritinophagy by recruiting NCOA4, a cargo receptor that mediates ferritinophagy, a selective

165 Here we identify SHISA9 as an autophagy cargo receptor that mediates the autophagy-dependent deg

166 k demonstrates that SURF4 functions as an ER cargo receptor that mediates the efficient secretion of

167 rv41-Erv46 complex is a conserved retrograde cargo receptor that retrieves ER resident proteins from

168 transport carriers occurs via transmembrane cargo receptors that connect lumenal cargo to the cytoso

169 Selectivity is achieved by cargo receptors that detect substrate-associated "eat-me

170 ytosol against bacterial invasion, relies on cargo receptors that juxtapose bacteria and phagophore m

171 neral, selectivity is achieved by autophagic cargo receptors that link the cargo to autophagosomal me

172 Selective autophagy is mediated by cargo receptors that link the cargo to the isolation mem

173 tophagy and compare the "eat-me" signals and cargo receptors that mediate autophagy of bacteria and b

174 raditionally, they had been regarded as mere cargo receptors that promote the endocytosis and lysosom

175 Cargo specificity is conferred by autophagic cargo receptors that selectively link the cargo to the a

176 on a cargo trigger a cascade from autophagic cargo receptors through the core complexes ULK1 and clas

177 4 protein transport domain-containing (TMED) cargo receptors TMED2, TMED9, and TMED10 bind UMOD and r

178 of Muclin fulfils the requirement of a Golgi cargo receptor to bind to regulated secretory proteins u

179 r has evolved to antagonize a host autophagy cargo receptor to counteract host defenses.

180 ecognized by specialized secretory autophagy cargo receptor TRIM16 and that this receptor interacts w

181 These include the cargo receptor UNC-33/CRMP2, the cargo adaptor protein U

182 ked with ubiquitin and how ubiquitin-binding cargo receptors use conserved structural modules to recr

183 ins of members of the p24 family of putative cargo receptors were shown to bind to coatomer, the coat

184 the intracellular accumulation of autophagy cargo receptors when classical autophagic degradation is

185 that exits the ER with the aid of the Erv29 cargo receptor, which is homologous to mammalian Surf4.

186 ditional cargo diversity is achieved through cargo receptors, which include the Erv14/Cornichon famil

187 rine Wnt signaling, as deficiency of the Wnt cargo receptor Wls in HEC of Wls(HEC-KO) mice did not af

188 lipidation is common to multiple autophagic cargo receptors, yet the details of core complex engagem