ライフサイエンスコーパス: carrot

1 r a 1; hazelnut), and Dau c 1.0104 (Dau c 1; carrot).

2 ich in both types of carotenoids (atomic red carrots).

3 on the same batches of broccoli, tomato and carrot.

4 taining good results except for eggplant and carrot.

5 s of nitrogen decreased the quality of fresh carrot.

6 ating anthocyanin biosynthesis in the orange carrot.

7 f combined biofortification with I and Se in carrot.

8 the carotenoid-rich vegetables, except with carrot.

9 ocyanin bioaccessibility in masticated black carrot.

10 llowed the order: sanguinello>apricot>tomato>carrot.

11 re observed between conventional and organic carrots.

12 etween conventionally- and organically-grown carrots.

13 il, 200 g carrots + 19 g olive oil, or 200 g carrots.

14 arge proportion of the observed variation in carrots.

15 containing a frame-shift insertion in orange carrots.

16 ts, red carrots, red tomatoes and atomic red carrots.

17 r determinants of nutritional quality of the carrots.

18 a higher vitamin C content and stability in carrots.

19 respectively, after 4 days compared to whole carrots.

20 e slightly more retained in parsnips than in carrots.

21 ter, to remove difenoconazole and linuron in carrots.

22 ollowed by papaya (5.3%), tomato (3.1%), and carrot (0.5%).

23 ys: 200 g carrots + 6.53 g tributyrin, 200 g carrots + 13.15 g C8-dietary oil, 200 g carrots + 19 g o

24 00 g carrots + 13.15 g C8-dietary oil, 200 g carrots + 19 g olive oil, or 200 g carrots.

25 following 4 meals on 4 different days: 200 g carrots + 6.53 g tributyrin, 200 g carrots + 13.15 g C8-

26 ted for the first time for classification of carrots according to their processing.

27 ese cellular insights confirm that the major carrot allergen has a special status among Bet v 1-relat

28 er Bet v 1-related food allergens, the major carrot allergen, Dau c 1, has been suggested to induce f

29 Serum IgE to carrot extract, recombinant carrot allergens (rDau c 1.0104; rDau c 1.0201; rDau c 4

30 ive of this study was to evaluate a panel of carrot allergens for diagnosis of carrot allergy in Spai

31 f sensitization to carrot components between carrot allergic and carrot-tolerant but pollen sensitize

32 Sensitization to rDau c Cyc occurred in one carrot allergic patient and one nonatopic control.

33 Forty-nine carrot allergic patients, 71 pollen allergic but carrot-

34 ms were major allergens for Swiss and Danish carrot allergic patients, the profilin rDau c 4 for the

35 c IFR 2 were recognized by 6% and 20% of the carrot allergics, but did not contribute to a further in

36 a panel of carrot allergens for diagnosis of carrot allergy in Spain, Switzerland and Denmark.

37 PBMC of birch pollen-allergic patients with carrot allergy were analyzed for reactivity to Bet v 1,

38 Tributyrin and carrots alone resulted in no increase in any of the meas

39 detected in several weed plants surrounding carrot and parsnip fields.

40 related to Lso haplotype H recently found in carrot and parsnip.

41 Carrot and parsnips were prepared in four different form

42 growing in the UK and raises concern for the carrot and potato growing industry regarding the potenti

43 ied apples, prunes, figs, raisins, apricots, carrot and sweet potato, stevia leaves and liquorice roo

44 or the extraction of carotenoids from orange carrot and the extraction parameters were optimized.

45 While carrot and tomato contained large carotenoid crystals cl

46 eters) in order to assess the quality of the carrots and address the question whether organic also me

47 Tubers of carrots and beets contain the highest levels of Put.

48 tional vegetables (broccoli, collard greens, carrots and beets), both raw and cooked.

49 Raw carrots and carrots blanched in water and in 4% trehalos

50 Carrots and parsnips are often consumed as minimally pro

51 , especially the preparations that contained carrots and potatoes: five samples were in a concentrati

52 and 1,619 mug Trolox/mg phenolics for whole carrots and shreds, respectively, for Choctaw cultivar).

53 Wounding was applied by shredding carrots and storing the tissue (48 h, 15 degrees C).

54 by treated wastewater-irrigated root crops (carrots and sweet potatoes) grown in lysimeters and to e

55 tion system on the metabolite composition of carrots and to build statistical models for prediction p

56 sters) were isolated from different types of carrots and tomatoes.

57 iscriminate organic and conventional potato, carrot, and cabbage from rigidly controlled long-term fi

58 h as tomato, potato, cucumber, sweet pepper, carrot, and grapevine.

59 ited for prediction of carotenoids in orange carrots, and especially for ranking them according to th

60 ides on raw agricultural produce like pears, carrots, and melons etc.

61 etween conventionally- and organically-grown carrots, and no potential harm arising from heavy metal

62 of compliance, which was facilitated via a "carrot-and-stick" approach that publicly rewarded good b

63 th different anthocyanin extracts from black carrot (Anthocarrot), grape fruit skins (Enocolor), elde

64 The purple carrot anthocyanin (0.025%) in model beverages (citric a

65 The degradation of purple carrot anthocyanin in model beverage systems (pH 3.0) co

66 in prolonging the color stability of purple carrot anthocyanins (0.025%) in model beverages (0.05% l

67 for a child at a daily consumption of half a carrot ( approximately 60 g).

68 Based on our data, carrots are an excellent source of potassium.

69 ther carotenoid accumulating systems, orange carrots are characterized by unusually high levels of al

70 volatile terpenes and plays a major role in carrot aroma and flavor.

71 and lemon flesh as citrus fruit fibres, and carrot as vegetable fibre.

72 tion of organically and conventionally grown carrots, as well as for the geographical origin differen

73 Conventionally-, organically- and self-grown carrots available across the Czech market were character

74 effects of co-digestion of red cabbage with carrot, baby spinach and/or cherry tomato on the bioacce

75 Four landrace carrots ("Becaria", "CRS", "Gonzalez" and "Rodriguez") a

76 Over time, mothers liked the tastes of carrot, beet, and celery juices more, but no changes in

77 lsion and pure olive oil phase enriched with carrot beta-carotene was investigated.

78 nd purple grape, purple sweet potato, purple carrot, black and purple bean, black lentil (BL), black

79 of vitamin C in the range 37.5-85%, whereas carrots blanched conventionally at 60 degrees C and by U

80 Raw carrots and carrots blanched in water and in 4% trehalose and maltos

81 ility of phytoene and phytofluene in tomato, carrot, blood orange (sanguinello cultivar), and apricot

82 ed sensitivity and specificity comparable to carrot broth- and LIM broth-enhanced real-time PCRs.

83 Carrot broth-enhanced subculture to GBS Detect (Hardy Di

84 to enhance the antioxidant capacity (AC) of carrots by increasing the synthesis of phenolic compound

85 CAR) concentrations and bioaccessibility in carrots by manipulating post-harvest factors.

86 dy clearly shows that PEF could add value to carrots by maximising bioprotective effects.

87 e removal of difenoconazole and linuron from carrots by ozone.

88 Thus, proVA CAR concentrations in stored carrots can be increased significantly through storage t

89 Wounded carrots can be promoted as an inexpensive rich source of

90 e commercial fresh-cut carrot products (baby carrots, carrot stixx, shredded carrots, crinkle cut coi

91 san was investigated after their uptake into carrot cell cultures.

92 ffect was attributed to strengthening of the carrot cell walls under high pressure, thereby hindering

93 For carrots, cell walls and chromoplast substructure were im

94 ssions of distaste initially when eating the carrot cereal.

95 as significantly higher (p < 0.05) than from carrot, cherry tomato or baby spinach digested alone.

96 stion of a carotenoid-rich vegetable such as carrot, cherry tomato or baby spinach with an anthocyani

97 ed alpha-carotene levels in leaves of orange carrots compared with white-rooted cultivars.

98 ns and in the prevalence of sensitization to carrot components between carrot allergic and carrot-tol

99 In this work we show that in carrots, contrary to that reported for aerial organs of

100 of 2-furoylmethyl-amino acids were found in carrots conventionally blanched with water at 95 degrees

101 ted in artichokes, green beans, broccoli and carrots cooked under different conditions.

102 oducts (baby carrots, carrot stixx, shredded carrots, crinkle cut coins, and oblong chips) were evalu

103 The nutritional value of carrot crops (with an acceptable physical quality) can b

104 under a constitutive promoter in the orange carrot cultivar 'Danvers 126' lead to consistent upregul

105 om forest analysis of volatiles from colored carrot cultivars identified nine terpenes that were clea

106 the estimated activation energy of the three carrot cultivars situated between 114.33 and 191.45 kJ/m

107 AAO activity in all carrot cultivars was stable up to 50 degrees C and inact

108 crease in carotenoid levels of the different carrot cultivars when parasitized by P. aegyptiaca.

109 In all carrot cultivars, two dominant discriminative quality-re

110 osynthesis of phenolic antioxidants in three carrots cultivars (Navajo, Legend and Choctaw) were stud

111 In 2008-2010 the field study with carrot cv. 'Kazan F1' was conducted.

112 ike proteins rDau c IFR 1, rDau c IFR 2; the carrot cyclophilin rDau c Cyc) were analyzed by ImmunoCA

113 Carrot (Daucus carota L.) is an important root vegetable

114 hromosome-scale assembly and analysis of the carrot (Daucus carota) genome, the first sequenced genom

115 roccoli (Brassica oleracea L. var. italica), carrot (Daucus carota), corn (Zea mays), and tomato (Sol

116 Carrots (Daucus carota L.) were used to investigate the

117 ascorbic acid oxidase (AAO) on vitamin C in carrots (Daucus carota subsp. sativus), namely Nantes, E

118 use using 660 seeds originating from 33 wild carrots (Daucus carota) collected near the Chernobyl nuc

119 oid accumulation in cultivated orange-rooted carrots (Daucus carota) is determined by a high protein

120 ntrast, the co-digestion of red cabbage with carrot decreased bioaccessibility of total carotenoids b

121 rent from the profile in the reference black carrot 'Deep Purple'.

122 HPHT) processing on the volatile fraction of carrots, differently coloured cultivars exhibiting orang

123 d several fractures on both raw and blanched carrots due to ice crystals formation and re-crystallisa

124 cids as indicators of the damage suffered by carrots during their blanching and subsequent drying.

125 ativus), namely Nantes, Egmont Gold and baby carrots during thermal treatment.

126 l ingestion (variety of vegetables including carrot) during lactation.

127 ols and phenolic acids) in tomato, broccoli, carrot, eggplant and grape has been carried out by ultra

128 beta-carotene isomerisation in an olive oil/carrot emulsion and pure olive oil phase enriched with c

129 In the oil/carrot emulsion, less beta-carotene isomerisation was ob

130 et during lactation (alcohol, anise/caraway, carrot, eucalyptus, garlic, mint) transmit to and flavor

131 Dried carrot exhibited the highest (0.988 g/g) and liquorice t

132 y, pectin in tissue particles of LTB and HTB carrots exhibited low degree of methylesterification (DM

133 ong pollen allergic controls, 34% had IgE to carrot extract, 18% to each of rDau c 1.0104, rDau c 1.0

134 Serum IgE to carrot extract, recombinant carrot allergens (rDau c 1.0

135 The sensitivity of the carrot extract-based test was 82%.

136 ons for encapsulating anthocyanin-rich black carrot extract.

137 The carrot extracts have no antimicrobial effects, while the

138 th direct correlations to major compounds of carrot flavor and aroma including germacrene D (DcTPS7/1

139 admap for future breeding efforts to enhance carrot flavor and aroma.

140 g of exposure affected the acceptance of the carrot flavor that did not generalize to the novel brocc

141 7.9 mo of age, infants' acceptance of plain, carrot-flavor (exposed flavor), and broccoli-flavor (non

142 e, which resulted in a faster rate of eating carrot-flavored cereal than that in infants who were exp

143 ronomic rules for iodine biofortification of carrot for: (a) consumption and/or processing directly a

144 In order to speed up the breeding of orange carrots for high carotenoid content it is imperative to

145 f the necessary biosynthetic genes in orange carrots for production of anthocyanins and demonstrates

146 ents, both occurring after the divergence of carrot from members of the Asterales order, clarifying t

147 or verifying regional geographical origin of carrots from specific production regions in Austria ("Ge

148 ence indicates that flavors (alcohol, anise, carrot, garlic) originating from the maternal diet durin

149 19 terpene synthase (TPS) genes in an orange carrot (genotype DH1) and compared tissue-specific expre

150 ndophytic mycobiome in the taproots of three carrot genotypes that vary in resistance to two pathogen

151 ene profiles from DH1 and four other colored carrot genotypes.

152 different matrices such as tomato, broccoli, carrot, grape and eggplant, observing that chlorogenic a

153 resh and fresh-cut samples including tomato, carrot, grape, eggplant and broccoli.

154 al species of precooked vegetables (cabbage, carrots, green beans and bell peppers).

155 d distribution among fields across the major carrot growing areas of Scotland were assessed using rea

156 his is the first report of Lso in cultivated carrot growing in the UK and raises concern for the carr

157 t analysis to characterise and differentiate carrots grown in five regions in Austria.

158 erent chemical species of Se in broccoli and carrots grown in soils amended with ground shoots of the

159 Carrots grown with no supplement of B in the nutrient so

160 On average, the carrots had a total vitamin C content amounting from 368

161 24 to 379.87 mug/g dry matter and the Nantes carrots had the highest vitamin C content.

162 Nantes carrots had the lowest AAO activity.

163 ostructure changes) of convective dehydrated carrots has been assessed.

164 vitamin A in humans after consumption of raw carrots.Healthy adults (n = 12) consumed a meal containi

165 ochromanols was observed in raw broccoli and carrot homogenates.

166 Postharvest wounding stress in carrots induces the accumulation of phenolics, whereas e

167 Carrot is a frequent cause of food allergy in Europe.

168 Black carrot is an important source for anthocyanins; however,

169 Black carrot is indicated to play an important role in nutriti

170 Since the top of the carrot is intact, it may still be used for growing.

171 lack of anthocyanin production in the orange carrot is unknown.

172 so), associated with vegetative disorders in carrots, is transmitted by the carrot psyllid Bactericer

173 oxidant capacity and phenolic acids in black carrot jams and marmalades after processing, storage and

174 conclusion, current study highlighted black carrot jams and marmalades as good sources of polyphenol

175 fication and pasteurisation on ACNs of black carrot juice (BCJ).

176 (P = 0.004) but not of the control solutions carrot juice (P = 0.26), NaCl (P = 0.68), caffeine (P =

177 re employed in the formulation of functional carrot juice and functional juices were treated using th

178 ch focuses on the study of polyacetylenes in carrot juice and their response to pH, storage and therm

179 (FaDOAc) and falcarinol (FaOH) were in fresh carrot juice at concentrations of 73 and 233 mug/L, resp

180 ing technology for preserving the quality of carrot juice by minimising the physicochemical changes d

181 prepared from natural green precursors i.e. carrot juice by the one-step hydrothermal process.

182 ween phenolic acids (PA) derived from purple carrot juice concentrate (PCJC) and PCW components.

183 Reducing the pH of the raw carrot juice from its natural pH 6.13 to pH 3.5 resulted

184 Finally, carrot juice provided the greatest amount of bioaccessib

185 ication of the method to a BoNT-contaminated carrot juice sample resulted in the identification of 98

186 Carrot juice was thermo-sonicated (24 kHz, 120 mum ampli

187 vels was applied for the optimization of the carrot juice with peel (CJPL) and pulp (CJPP) extracts.

188 s after repeated maternal ingestion (garlic, carrot juice), and within 1-4 mo postpartum after repeat

189 digestion of carotenoids and retinoids from carrot juice, raw and cooked spinach, micronutrient-fort

190 tase activity, colour, and browning index of carrot juice.

191 ructural properties of microcapsules of pure carrot juice.

192 roduced by lactic acid fermentation of black carrot juice.

193 microbial and enzymatic stability of cloudy carrot juice.

194 nt improvements in the quality of functional carrot juice.

195 g mothers drank vegetable, beet, celery, and carrot juices for 1 mo beginning at 0.5, 1.5, or 2.5 mo

196 cal qualities of kefirs fortified with black carrot (KBCJ), black mulberry (KBMJ), pomegranate (KPJ),

197 All detected pesticides in apricot, carrot, kiwifruit and leek were below the MRLs.

198 n activate the anthocyanin pathway in orange carrots, leading to the synthesis and accumulation of an

199 n represents a critical quality attribute of carrots, little is known about the biosynthesis of terpe

200 (BA) of carotenoids from edible portions of carrot, mango, papaya, and tomato was compared using an

201 L: 0.2 ppm), bell peppers (MRL: 0.1 ppm) and carrots (MRL: 5 ppm).

202 In the case of carrots, no effect of thermal treatments on carotenoid b

203 of the agricultural system of the harvested carrots on the basis of features determined by liquid ch

204 gy and associated food allergy to hazelnuts, carrots, or both were analyzed for IgE cross-reactivity,

205 Oil-in-water emulsions were prepared with carrot- or tomato-enriched olive oil (5%w/v) and stabili

206 Higher consumption of carrots (P = .061) and spinach (P = .094) also showed so

207 interactions were observed for pectin of LTB carrot particles.

208 ck currant (BC), red cabbage (RC) and purple carrot (PC) in the presence of ferric ions.

209 Purple carrot (PC) is a potential dietary constituent, which re

210 subtilis from rhizospheric soil and roots of carrot plant.

211 found in a small percentage of asymptomatic carrot plants (9.34%, n = 139) from a field in Milnathor

212 res were also detected in extracts of intact carrot plants cultivated on triclosan contaminated soils

213 e different anthocyanin compounds from black carrot pomace with cyanidin-3-xyloside-galactoside-gluco

214 compounds would be maximized from the black carrot pomace.

215 traction of anthocyanin colorants from black carrot pomace.

216 xtraction of anthocyanin pigments from black carrot pomace.

217 Association mapping analysis using a large carrot population revealed a significant association of

218 erence material for selected pesticides in a carrot/potato matrix was investigated.

219 A commercially available baby food (carrot/potato-based mash) was spiked with 11 pesticides

220 Carrot powder (CP) in citrate-buffer (pH 5.20) was submi

221 Carrot powders with GA used as a carrier material result

222 properties have been evaluated in air-dried carrots previously subjected to different ultrasound (US

223 Dried carrots previously subjected to ultrasound blanching pre

224 nica (dicot, Apiaceae), also known as deadly carrot, produces the highly toxic compound thapsigargin.

225 (PAL) activity of five commercial fresh-cut carrot products (baby carrots, carrot stixx, shredded ca

226 Total carotenoids of the carrot products were unchanged by UV-B exposure.

227 es in PAL activity were also observed in all carrot products, except crinkle cut coins.

228 eight ratio (exposure area) of the fresh-cut carrot products.

229 arly JA-responsive genes in a Daucus carota (carrot) protoplast expression system.

230 n = 12) consumed a meal containing 300 g raw carrot (providing 27.3 mg beta-carotene and 18.7 mg alph

231 disorders in carrots, is transmitted by the carrot psyllid Bactericera trigonica.

232 tion describing the elemental composition of carrots published previously, recommended daily intakes,

233 omanian agro-industrial wastes (apple peels, carrot pulp, white- and red-grape peels and red-beet pee

234 of endogenous ascorbic acid oxidase (AAO) in carrot puree (Daucus carota cv. Nantes) after being trea

235 the same order of magnitude as the untreated carrot puree after being exposed to pulsed electrical en

236 rrot puree could be related to the resulting carrot puree composition, alteration in intracellular en

237 nzyme kinetics and thermostability of AAO in carrot puree could be related to the resulting carrot pu

238 f k value (Ea value) for AAO inactivation in carrot puree decreased, indicating that the changes in k

239 processing on the bioprotective capacity of carrot puree for White Belgian, Yellow Solar, Nantes, Nu

240 apolation of data for these model systems to carrot puree suggests that nutritionally-significant amo

241 As a case study, a thermally sterilised carrot puree was selected.

242 apple puree serum was compared with that in carrot puree.

243 pressure high temperature (HPHT) sterilised carrot purees using a 'fingerprinting kinetics' approach

244 chemical composition of broccoli, tomato and carrot purees were investigated by using a range of comp

245 s (with I and N application) with respect to carrot quality when compared to results obtained after t

246 The matrices studied were orange carrots, red carrots, red tomatoes and atomic red carrot

247 he matrices studied were orange carrots, red carrots, red tomatoes and atomic red carrots.

248 Carrot residues were upgraded as pectin-enriched fractio

249 In fact, overexpression of CYP97A3 in orange carrots restored leaf carotenoid patterns almost to thos

250 three orders of magnitude, while the dynamic carrot root (DCR) portion overpredicted by a single orde

251 analysis (PCA) revealed metabolic variety of carrot root composition depending on root color and bota

252 egyptiaca tubercles parasitizing the various carrot root cultivars and show that they accumulate diff

253 l regulation for carotenoid synthesis during carrot root development.

254 analysis of xyloglucan (tamarind) and whole carrot root.

255 n with iodine and nitrogen on the quality of carrot roots and its storage ability.

256 NES) analysis performed on broccoli florets, carrot roots and shoots, dried ground S. pinnata, and th

257 s, anthocyanins and carotenoids was noted in carrot roots directly after the harvest as well as at th

258 otenogenesis has been intensively studied in carrot roots, and transcriptional regulation is thought

259 arotenoids compared to those in non-infested carrot roots.

260 nificant variation in P. aegyptiaca infested carrot roots.

261 he best markers that could differentiate the carrot samples grown in Transylvania, Romania, from thos

262 logy with 97%) and correct classification of carrot samples.

263 able to differentiate the organically grown carrots samples in a percent of 83.3% (initial classific

264 Pectin present in the LTB carrot serum exhibited a lower DM, was more branched, an

265 d showed a higher molar mass compared to HTB carrot serum pectin.

266 Sciaenid swim bladders vary from simple carrot-shaped to two-chambered to possessing various div

267 in beta-carotene, such as natural (spinach, carrots, spirulina), hybrid (high-beta-carotene yellow m

268 ange, mango, apple, kiwi, lettuce, broccoli, carrot, squash, eggplant, radish, mushroom, cucumber, an

269 ial fresh-cut carrot products (baby carrots, carrot stixx, shredded carrots, crinkle cut coins, and o

270 Artichokes and carrots suffered pronounced losses of antioxidant activi

271 at conditions carotenoid accumulation (Y) in carrot taproot and is coexpressed with several isoprenoi

272 hanism regulating carotenoid accumulation in carrot taproot is not at the biosynthetic level.

273 ce production and post-harvest challenges in carrot, though the identity of these microbes as well as

274 arrot components between carrot allergic and carrot-tolerant but pollen sensitized patients.

275 ot allergic patients, 71 pollen allergic but carrot-tolerant patients and 63 nonatopic controls were

276 s a prototypical acetylenic lipid present in carrot, tomato, and celery that inhibits growth of fungi

277 The lowest storage ability was found for carrot treated with KI without N.

278 alose was able to limit the hardness loss of carrots undergone to B, C and D blanching pre-treatments

279 Regarding sensorial analysis of rehydrated carrots, US-pretreated samples presented acceptable qual

280 332 roots from 86 carrot varieties grown in 2014 at the experimental farm

281 enolics as well as on carotenoid profiles of carrots was evaluated.

282 on of total arsenic in potatoes, swedes, and carrots was lower in peeled produce compared to unpeeled

283 age of absorption of alpha-carotene from raw carrots was not significantly different from beta-carote

284 ssibility of beta-carotene in raw and pulped carrots was very low (<0.5%).

285 wash of iceberg lettuce, green cabbage, and carrots, we report the first in situ apparent reaction r

286 y related cyanidin-3-O-glycosides from black carrot were investigated in aqueous solutions (pH 3.6 an

287 The mechanical properties of carrots were affected by blanching which caused a hardne

288 Specifically, carrots were either blanched at low temperature (LTB) or

289 of phytochemicals was higher when fresh-cut carrots were stored at 4 degrees C regardless of the pre

290 In the current study, orange carrots were turned purple by simultaneous expression of

291 nces with respect to conventionally blanched carrots, were detected.

292 among samples A and B water-blanched and raw carrot while a thermo-protective effect due to the sugar

293 a soil amendment for enriching broccoli and carrots with healthful forms of organic-Se.

294 activation was found in 80 degrees C-treated carrots with high vitamin C retention predominantly in l

295 treatments at high temperature gave rise to carrots with retention of vitamin C in the range 37.5-85

296 ProVA CAR in carrots with the highest concentrations also proved to b

297 vels of total phenolic acids compared to the carrots with the supplement of B (e.g. -Ca treatment and

298 aternal ingestion (alcohol, garlic, vanilla, carrot), within days after repeated maternal ingestion (

299 old thus the intake of 100 g of biofortified carrot would substantially cover the RDA for I and Se.

300 In this issue of Cancer Cell, Carrot-Zhang et al., through a rigorous analytical frame