ライフサイエンスコーパス: casein kinase 2

1 he pleiotropic protein kinase, CK2 (formerly casein kinase 2).

2 mulation by phosphorylation by CK2 (formerly casein kinase 2).

3 s identified as protein kinase CK2 (formerly casein kinase 2).

4 modulated CSNK2B (the regulatory subunit of casein kinase 2).

5 n synthase kinase-3beta, whereas stimulating casein kinase 2.

6 ing that this phosphorylation is mediated by casein kinase 2.

7 ved sites (Ser712/713) are phosphorylated by casein kinase 2.

8 iated vimentin kinases and identified one as casein kinase 2.

9 ites in the acidic domain of WRN targeted by Casein Kinase 2.

10 t we identified as substrates for Erk1/2 and casein kinase 2.

11 I, whereas Ca(V)1.1-T1579 is a substrate for casein kinase 2.

12 c but not the cardiac CCRK with cyclin H and casein kinase 2.

13 iated by the alpha prime (alpha') subunit of casein kinase 2.

14 es with thapsigargin (10 mum), inhibition of casein kinase 2 (4,5,6,7-tetrabromobenzotriazole; 10 mum

15 overed that murine Arl13b is a substrate for casein kinase 2, a contaminant in our preparation from h

16 Protein kinase CK2 (CK2) (formerly casein kinase 2, a protein Ser/Thr kinase signal that is

17 complex of protein machinery that sequesters casein kinase 2-a Wnt pathway activator.

18 ine 424 by protein kinase CK2 (also known as casein kinase 2) activated the HDAC3 in vitro.

19 of either Galpha(q) or Galpha(o) stimulates casein kinase 2 activation and Lef/Tcf-sensitive gene ex

20 ha(q) or Galpha(o) blocks Wnt stimulation of casein kinase 2 activation, as does suppression of the p

21 ied extracellular regulated kinase 2 blocked casein kinase 2 activity and increased protein serine/th

22 Herein we show to the contrary that casein kinase 2 activity is rapidly and transiently incr

23 minal kinase; (ii) inhibition of calpain and casein kinase 2 activity; and (iii) induction of fibrobl

24 Casein kinase 2 alpha phosphorylates PDCD5 at Ser-119 to

25 lation sites and two putative GRIP1 kinases, casein kinase 2 and cyclin-dependent kinase 9.

26 transport in beta-cells that is mediated by casein kinase 2 and PP2B.

27 of which contains a large number of putative casein kinase 2 and protein kinase C phosphorylation sit

28 lation through a dynamic interaction between casein kinase 2 and protein serine/threonine phosphatase

29 We show that Casein Kinase 2 and the C-terminal domain Nuclear Envelo

30 molecular events of this modulation involved casein kinase 2 and the synaptic vesicle rapid endocytos

31 s NMDA receptor activity by interacting with casein kinase-2 and protein phosphatases in the hypothal

32 As in the case of Nopp140, casein kinase 2 appears to be responsible for the unusua

33 has been shown recently to potently inhibit casein kinase 2 as well as PI3K, we hypothesize that cas

34 The amount of Inh2 kinase attributed to casein kinase 2, based on inhibition by heparin, increas

35 ; allograft inflammatory factor 1 (AIF1) and casein kinase 2, beta polypeptide (CSNK2B), all found in

36 levels of [Ca2+]i KHC was phosphorylated by casein kinase 2, but KHC was rapidly dephosphorylated by

37 rf1 mutation led to the discovery of a novel casein Kinase 2 catalytic subunit (CK2alpha").

38 posttranslationally regulated by TNF-induced casein kinase 2 catalytic subunit (CK2alpha') phosphoryl

39 Casein kinase 2 catalyzed protein serine/threonine phosp

40 anine nucleotide exchange factor (eIF-2B) by casein kinase 2 (CK-2) was previously shown to stimulate

41 ific inhibitors of casein kinase 1 (CK1) and casein kinase 2 (CK2) (10 muM D4476, 100 muM CK2-inhibit

42 rapeutic potential against TNBC by targeting Casein Kinase 2 (CK2) (PDB ID: 3H30) and ULK2 (Unc-51-li

43 effects of mutant M1 spastins on FAT involve casein kinase 2 (CK2) activation.

44 rt inhibition as a consequence of endogenous casein kinase 2 (CK2) activation.

45 urther, inhibition of claudin-2 by targeting casein kinase 2 (CK2) also ameliorated colitis.

46 ZEBRA, Ser167 and Ser173, are substrates for casein kinase 2 (CK2) and are constitutively phosphoryla

47 We focus on casein kinase 2 (CK2) and demonstrate that the regulator

48 to directly associate with and modulate both casein kinase 2 (CK2) and protein kinase A (PKA), which

49 glycerolipid biosynthesis, is stimulated by casein kinase 2 (CK2) and that a phosphorylated protein

50 This kinase complex contains casein kinase 2 (CK2) and the chromatin transcriptional

51 ified the regulatory (beta) subunit of human casein kinase 2 (CK2) as a CDC34-interacting protein and

52 In this study, we identified casein kinase 2 (CK2) as a critical modulator of NADPH o

53 We identify casein kinase 2 (CK2) as a key regulator of temperature

54 We also identify casein kinase 2 (CK2) as a kinase activity in embryonic

55 Previous work has implicated casein kinase 2 (CK2) as the kinase responsible for this

56 ave identified polo-like kinase 1 (Plk1) and casein kinase 2 (CK2) as two kinases of CLIP-170 and map

57 lear condensate; and that phosphorylation by casein kinase 2 (CK2) at ~80 serines targets Nopp140 to

58 Casein kinase 2 (CK2) binds to the NHE3 C-terminus and c

59 This protein kinase was identified as casein kinase 2 (CK2) by immunoblot and mass spectrometr

60 e that phosphorylated CD45 was identified as casein kinase 2 (CK2) by use of an in-gel kinase assay i

61 sing Ciona eggs and found that inhibition of casein kinase 2 (CK2) caused a shift from meiotic to mit

62 ormally long circadian periods, we show that casein kinase 2 (CK2) has a role in determining period l

63 Casein kinase 2 (CK2) has emerged as a promising therape

64 d for robust in vitro phosphorylation by the casein kinase 2 (CK2) holoenzyme, a cytoplasmic kinase s

65 Residue S583 of SUZ12 is phosphorylated by casein kinase 2 (CK2) in cells.

66 Our previous results highlighted a role for casein kinase 2 (CK2) in the modulation of dopamine D1 r

67 We demonstrate a role for protein kinase casein kinase 2 (CK2) in the phosphorylation and regulat

68 iated stimulation, PTEN is phosphorylated by casein kinase 2 (CK2) in the Ser380-Thr382-Thr383 cluste

69 tified serine 358 as a specific site used by casein kinase 2 (CK2) in vitro and in vivo.

70 A, S167 and S173, that are phosphorylated by casein kinase 2 (CK2) in vitro are also phosphorylated i

71 7 -: tetrabromobenzotriazole (TBB), a potent casein kinase 2 (CK2) inhibitor, as a strong suppressor

72 enhanced by LXR ligands and reduced both by casein kinase 2 (CK2) inhibitors and by activation of it

73 rylation by either protein kinase C (PKC) or casein kinase 2 (CK2) inhibits the assembly of myosin-II

74 beta subunit of the serine/threonine kinase casein kinase 2 (CK2) interacts specifically with the cy

75 Casein kinase 2 (CK2) is a multifunctional second messen

76 The protein kinase casein kinase 2 (CK2) is a pleiotropic and constitutivel

77 Casein kinase 2 (CK2) is a typical serine/threonine kina

78 kin (IL)-1 receptor-associated kinase 4, and casein kinase 2 (CK2) is formed.

79 Casein kinase 2 (CK2) is known to regulate cell growth a

80 Casein kinase 2 (CK2) is oncogenic and frequently upregu

81 Although protein kinase casein kinase 2 (CK2) is readily detected in MKs and pla

82 Phosphorylation of CBX3 at serine-95 by casein kinase 2 (CK2) kinase augments cadherin 1 (CDH1)-

83 Previous research suggests that casein kinase 2 (CK2) may be a promising therapeutic tar

84 Previous in vitro studies indicated that casein kinase 2 (CK2) mediated the phosphorylation of NS

85 We have previously shown that casein kinase 2 (CK2) negatively regulates dopamine D1 a

86 We demonstrated that increased activity of casein kinase 2 (CK2) observed in HPC and in MDSC could

87 w that murine caspase-9 is phosphorylated by casein kinase 2 (CK2) on a serine near the site of caspa

88 at shock and antioxidants induced Hsp90, and casein kinase 2 (CK2) phosphorylated INrf2Thr55.

89 ay is a key regulator of RUNX2 stability, as Casein kinase 2 (CK2) phosphorylates RUNX2, recruiting t

90 Casein kinase 2 (CK2) phosphorylates the NR2B subunit wi

91 ith SUMOylated RNF111, which is regulated by casein kinase 2 (CK2) phosphorylation of ARKL1 at a seri

92 The MRE11-PIH1D1 interaction is dependent on casein kinase 2 (CK2) phosphorylation of two acidic sequ

93 The Foxc2 amino terminus has a consensus casein kinase 2 (CK2) phosphorylation site at serine 124

94 Molecular studies identified the unique casein kinase 2 (CK2) phosphorylation site within isofor

95 ariant of the formin FHOD3 that introduces a casein kinase 2 (CK2) phosphorylation site.

96 the C terminus, which was predicted to be a casein kinase 2 (CK2) phosphorylation site.

97 ) of MDC1, which contains multiple consensus casein kinase 2 (CK2) phosphorylation sites.

98 and overexpression experiments, we show that casein kinase 2 (CK2) promotes stress granule dynamics.

99 that phosphorylation of recombinant TFIIF by casein kinase 2 (CK2) reduces or eliminates some of the

100 As the casein kinase 2 (CK2) site at serine 392 is the C-termin

101 We also found that two putative casein kinase 2 (CK2) sites adjacent to IE2-SIM1 are pho

102 serine residues 16 and 18, which are within casein kinase 2 (CK2) sites, and serine residue 114, whi

103 inases with enriched substrates detects that casein kinase 2 (CK2) subunits negatively regulate lifes

104 ctivated through pharmacologic inhibition of casein kinase 2 (CK2) to eradicate disease in high-risk

105 sh1 is phosphorylated by the Cka2 subunit of casein kinase 2 (CK2) to promote its E3 activity for Cse

106 Casein kinase 2 (CK2) was one of the first protein kinas

107 Casein kinase 2 (CK2) was previously reported to be over

108 he major site of in vitro phosphorylation by casein kinase 2 (CK2) was the conserved Ser(232) in the

109 D025 potently inhibits catalytic subunits of casein kinase 2 (CK2), a constitutively active serine/th

110 ntly shown that the serine/threonine kinase, casein kinase 2 (CK2), a major regulator of cell growth

111 Casein Kinase 2 (CK2), a positive regulator of Wnt signa

112 CD5 activates casein kinase 2 (CK2), a serine/threonine kinase that co

113 ere, we report that Brg1 is also a target of casein kinase 2 (CK2), a serine/threonine kinase, in pro

114 wn previously to require the Cka2 subunit of casein kinase 2 (CK2), a ubiquitous enzyme with multiple

115 Casein kinase 2 (CK2), a ubiquitous kinase, regulates se

116 Inhibition of casein kinase 2 (CK2), an enzyme implicated in DNA damag

117 eral kinases among these proteins, including casein kinase 2 (CK2), and a new bud neck-associated pro

118 nsists of Daz interacting protein 1 (Dzip1), casein kinase 2 (CK2), and B56 containing protein phosph

119 dentify the heterotetrameric protein kinase, casein kinase 2 (CK2), as a new KSR1-binding partner.

120 recovered cDNA revealed a unique isoform of casein kinase 2 (CK2), CK2alpha".

121 on was dependent on XRCC1 phosphorylation by casein kinase 2 (CK2), enhancing XRCC1's interaction wit

122 on events catalyzed first by MEK and then by casein kinase 2 (CK2), followed by interaction with impo

123 s of ATR could be counteracted by inhibiting casein kinase 2 (CK2), the kinase responsible for phosph

124 e, and this phosphorylation was catalyzed by casein kinase 2 (CK2), the levels of which were dramatic

125 1 and Fhl1, Ifh1 forms a complex (CURI) with casein kinase 2 (CK2), Utp22, and Rrp7.

126 -LDH associates with NDPK-A, AMPK alpha1 and casein kinase 2 (CK2), whereas H-LDH associates with loc

127 a striking resemblance to that of eukaryotic casein kinase 2 (CK2), which also exhibits dual nucleoti

128 perone complex and IKK through activation of casein kinase 2 (CK2), which in turn activates NF-kappaB

129 d51 phosphorylation at threonine 13 (T13) by casein kinase 2 (CK2), which in turn triggers direct bin

130 ed up-regulation of the SK channel modulator casein kinase 2 (CK2), which we corroborated by immunohi

131 ulator of Poll III (MAF1), via a synergistic casein kinase 2 (CK2)- and mammalian target of rapamycin

132 es astrocytic protein synthesis and, through casein kinase 2 (CK2)-dependent mechanisms, disrupts the

133 Wnt stimulation induces the casein kinase 2 (CK2)-dependent phosphorylation of LRP6

134 their spontaneous intrinsic pacemaking via a casein kinase 2 (CK2)-dependent signaling pathway, which

135 We have also noted that casein kinase 2 (CK2)-directed phosphorylation of Pax7 a

136 In this report, we show that a casein kinase 2 (CK2)-like protein kinase co-purifies wi

137 Additionally, p17 increases casein kinase 2 (CK2)-mediated phosphorylation, strength

138 We identified a casein kinase 2 (CK2)-PRMT6-regulator of chromatin conde

139 cal/functional relationship between CD45 and casein kinase 2 (CK2).

140 osphorylated at its N terminus with purified casein kinase 2 (CK2).

141 vity showed it to be identical to Drosophila Casein Kinase 2 (CK2).

142 extremely low concentration of tightly bound casein kinase 2 (CK2).

143 various kinases, including GPCR kinases and casein kinase 2 (CK2).

144 the unsuspected tyrosine kinase activity of casein kinase 2 (CK2).

145 ISA analyses and Western blotting to measure casein kinase 2 (CK2).

146 by the disease-relevant signalling protein, casein kinase 2 (CK2).

147 orylated on conserved serines 487 and 491 by casein kinase 2 (CK2).

148 t human cytomegalovirus pUL84 interacts with casein kinase 2 (CK2).

149 nts indicate that phosphorylation of TLE1 by casein kinase-2 (CK2) at Ser-239 and Ser-253 is necessar

150 Casein kinase-2 (CK2) promotes cell survival and is upre

151 Conversely, casein kinase-2 (CK2)-inhibitor increases Ikaros functio

152 hibition of one of the catalytic subunits of casein kinase 2, CK2A1, but not CK2A2, improved cell via

153 how that the catalytic subunit of Drosophila casein kinase 2 (CK2alpha) is expressed predominantly in

154 ynthase promoter activity were controlled by casein kinase 2 complexed with protein serine/threonine

155 to mutation to alanine or disruption of the casein kinase 2 consensus sequence directing phosphoryla

156 uired Rab11-dependent trafficking and FAM20C/casein kinase 2-dependent C-terminal phosphorylation of

157 required for insulin induction of Sort1 in a casein kinase 2-dependent manner and that inhibition of

158 B by markedly enhancing GTPCH-1 activity via casein kinase 2-dependent phosphorylation on serine 81.

159 M1-type muscarinic receptors and occur in a casein kinase-2-dependent manner.

160 How casein kinase 2 exerts an influence in Wnt signaling is

161 an influence in Wnt signaling is not clear; casein kinase 2 has been reported to be constitutively a

162 Casein kinase 2 has been shown to affect Wnt/beta-cateni

163 other kinases; only c-src (IC50, 15 microM), casein kinase 2 (IC50, 20 microM), erk 1 (IC50, 20 micro

164 The serine is phosphorylated by casein kinase 2 in in vitro assays.

165 These data support a role for casein kinase 2 in regulation of protein synthesis by do

166 These findings illustrate a new function of casein kinase 2 in the endothelium and provide insight i

167 inase 2 as well as PI3K, we hypothesize that casein kinase 2 inhibition is responsible for the enhanc

168 in-1, and parkin, whereas treatment with the casein kinase 2 inhibitor 5,6-dichloro-1-beta-d-ribofura

169 on spontaneous release was reproduced by the casein kinase 2 inhibitor 5,6-dichlorobenzimidazole ribo

170 tric-oxide synthase transcription, we used a casein kinase 2 inhibitor coupled with immunoprecipitati

171 A clinical casein kinase 2 inhibitor, CX-4945 (silmitasertib), show

172 r localization of Atx3 was not affected by a casein kinase-2 inhibitor or by mutating a predicted nuc

173 he protein phosphatase 1/2A, calcineurin, or casein kinase-2 inhibitor.

174 osphoprotein Dishevelled, demonstrating that casein kinase 2 is downstream of heterotrimeric G protei

175 dues including two serines phosphorylated by casein kinase 2 is required for the localization of VMAT

176 Thus, casein kinase 2 is shown to be regulated by Wnt3a and es

177 Protein kinase CK2 (also known as Casein Kinase 2) is a serine/threonine kinase composed o

178 CK2 (formerly called casein kinase 2) is a ubiquitous messenger-independent s

179 esistance via ZFP91 rewiring, which involves casein kinase 2-mediated c-Jun inactivation.

180 Casein kinase 2-mediated phosphorylation at VHL N-termin

181 ERK promotes casein kinase 2-mediated phosphorylation of alpha-cateni

182 hin TMVs through a process that requires the casein kinase 2-mediated phosphorylation of RanGAP1.

183 Furthermore, inhibitors of casein kinase 2 mimicked the effect of phosphatase treat

184 Protein kinase CK2 (formerly casein kinase 2 or II) is a ubiquitous and highly conser

185 Chemical inhibition of casein kinase 2 or suppression of its expression blocks

186 We report here that casein kinase 2 phosphorylates a conserved threonine res

187 Upon hypertrophic stimuli, casein kinase 2 phosphorylates DPF3a at serine 348.

188 We also show that casein kinase 2 phosphorylates G3BP1 at serine 149 in vi

189 900 (Ser900) as a unique site of reversible casein kinase 2 phosphorylation in the cytoplasmic domai

190 This mutation introduces a putative casein kinase 2 phosphorylation site in C57BL/6J-A20 not

191 id repeat motifs which exhibit homology with casein kinase 2 phosphorylation sites.

192 Our experiments also disclosed that casein kinase 2 plays an integral role in Tpm phosphoryl

193 ylation of calmodulin by protein kinase CK2 (casein kinase 2) rapidly and reversibly modulated KCNQ2

194 a physical interaction between S6KII and the casein kinase 2 regulatory subunit (CK2beta), suggesting

195 We now show that TFIIF phosphorylated by casein kinase 2 remains competent to support PIC assembl

196 ation of ErbB2 or loss of the betasubunit of casein kinase 2, shifted the whole population toward a f

197 ly, in vitro phosphorylation assays with the casein kinase 2 show that the presence of the basic-leuc

198 sin-IIA heavy chain is phosphorylated on the casein kinase 2 site (S1943).

199 Secretion of DEK is modulated by casein kinase 2, stimulated by interleukin-8, and inhibi

200 Casein kinase 2 stimulates the biogenesis of Tom22 and T

201 an interacting protein, protein kinase C and casein kinase 2 substrate in neurons 1 (PACSIN1).

202 The PACSIN (protein kinase C and casein kinase 2 substrate in neurons) adapter proteins c

203 Further, AP-1 contained bound casein kinase-2 that phosphorylated GGA1 and GGA3, there

204 The MSY2 associated kinase is not casein kinase 2, the kinase believed to phosphorylate mR

205 We show that NS1 redirects casein kinase 2 to activate a phosphatase in the PP2C fa

206 This activity, and the ability of casein kinase 2 to use GTP as a phosphate donor, may be

207 ermore, GSH antagonism of the Ser/Thr kinase casein kinase 2 was by comparison weak (<25%).

208 Some interesting cross reactivity with casein kinase-2 was also identified, and structural feat

209 n FCP1 kinase from HeLa cells and identified casein kinase 2, which, surprisingly, displayed a negati