ライフサイエンスコーパス: catalytic RNA

1 etal binding site observed in the hammerhead catalytic RNA.

2 f pre-tRNA processing in vitro, i.e. it is a catalytic RNA.

3 its components, and the organization of its catalytic RNA.

4 understanding the structure and function of catalytic RNA.

5 up II introns are mobile elements as well as catalytic RNAs.

6 neral mechanism for the evolution of complex catalytic RNAs.

7 property has been shown in only a handful of catalytic RNAs.

8 utionary roots in the chemical repertoire of catalytic RNAs.

9 de insights on the structure and function of catalytic RNAs.

10 terogeneous cleavage kinetics common to many catalytic RNAs.

11 directly as structural, regulatory, or even catalytic RNAs [1, 2].

12 l RNase P holoenzyme is composed of a large, catalytic RNA and a small protein.

13 Nase P is a ribonucleoprotein made up of one catalytic RNA and five protein cofactors including L7Ae,

14 (RNP) form of archaeal RNase P comprises one catalytic RNA and five protein cofactors.

15 the RNase P holoenzyme consists of one large catalytic RNA and one small protein subunit, in archaea

16 Several types of catalytic RNAs and many classes of ligand-sensing RNA sw

17 n bacterial and organellar genomes, are both catalytic RNAs and retrotransposable elements.

18 ntegral subunits of RNase MRP, stabilize its catalytic RNA, and are required for rRNA maturation and

19 ncorporating ligand-responsive self-cleaving catalytic RNAs (aptazymes) into guide RNAs, we developed

20 New ligand-binding and catalytic RNAs are being created at a rapid pace.

21 Small catalytic RNAs are commonly produced either by transcrip

22 of protein, but several distinct classes of catalytic RNAs are known to promote chemical transformat

23 nomics" annotated proteins and catalytic/non-catalytic RNAs are studied in this context.

24 The catalytic, RNA-binding and oligomerization domains of th

25 tructed an empirical fitness landscape for a catalytic RNA by combining next-generation sequencing, c

26 approach to identify the general base within catalytic RNAs by chemogenetic suppression.

27 n the tertiary folding of a variety of large catalytic RNAs by providing a specific binding site for

28 sequence) complementary to a target RNA, the catalytic RNA can be converted into a sequence-specific

29 ailed understanding of the biochemistry of a catalytic RNA can facilitate the design of customized ri

30 caged RNA molecules: the light-regulation of catalytic RNA cleavage by RISC and the light-regulation

31 Typical RNase P consists of a catalytic RNA component and a protein moiety.

32 prokaryotic RNaseP holoenzyme consists of a catalytic RNA component and a protein subunit (RNaseP pr

33 A deletion mutant of the catalytic RNA component of Escherichia coli RNase P miss

34 Although the structure of the catalytic RNA component of ribonuclease P has been well

35 ssential for the folding and function of the catalytic RNA component of the tRNA processing enzyme ri

36 es were a ribonucleoprotein with a conserved catalytic RNA component.

37 he mutations create local distortions of the catalytic RNA component.When combined with a variety of

38 The hairpin ribozyme is a small catalytic RNA composed of two helical domains containing

39 The hairpin ribozyme is a small catalytic RNA comprised of two internal loops carried on

40 Group II introns are structurally complex catalytic RNAs considered evolutionarily related to the

41 The hairpin ribozyme is a small catalytic RNA consisting of two domains, A and B, which

42 The hairpin ribozyme, a small catalytic RNA consisting of two helix-loop-helix motifs,

43 Like protein enzymes, catalytic RNAs contain conserved structure motifs import

44 f-splicing group I introns, like other large catalytic RNAs, contain structural domains.

45 ) complex, consistent with the idea that the catalytic RNA core forms stepwise during the B to B(act)

46 the processing of mir-376a2 independently of catalytic RNA editing activity.

47 The non-catalytic RNA Editing Substrate Binding Complex (RESC) c

48 Integrator is endowed with a core catalytic RNA endonuclease activity, which is required f

49 RNA-alkylating ribozymes are catalytic RNAs for post-transcriptional RNA modification

50 e ancestors of nuclear pre-mRNA introns, are catalytic RNAs found in bacteria, archaea, and eukaryote

51 a point mutation at nucleotide 86 of RNase P catalytic RNA from Escherichia coli (A(86)-->C(86)) incr

52 tation at nucleotides 224 and 225 of RNase P catalytic RNA from Escherichia coli (G(224)G(225) --> AA

53 a point mutation at nucleotide 95 of RNase P catalytic RNA from Escherichia coli (G(95) --> U(95)) in

54 utation at nucleotide position 80 of RNase P catalytic RNA from Escherichia coli (U80--> C80) increas

55 us to expand by 60% the total number of this catalytic RNA from prokaryotes.

56 iments revealed that we have selected a dual-catalytic RNA from random sequences: the RNA promotes bo

57 This catalytic RNA functions as a riboswitch, with activator-

58 icated in the activities of three classes of catalytic RNA: group I introns, group II introns, and 23

59 nd hybridoma technology and the discovery of catalytic RNA have led to new and very promising alterna

60 The smallest catalytic RNA identified to date is a manganese-dependen

61 It was one of the first catalytic RNAs identified and the first that acts as a m

62 rve as efficient templates for generation of catalytic RNAs in vitro.

63 ted in functionally critical motifs in large catalytic RNAs, in riboswitches, and in regulatory eleme

64 ent structures have been determined for this catalytic RNA, including two NMR structures of the isola

65 synthetic target-binding aptamers as well as catalytic RNAs, including the hammerhead ribozyme.

66 onent of ribonucleoprotein RNase P and other catalytic RNAs, indicating convergence on a common solut

67 Catalytic RNA is a special topic in the study of fitness

68 The emergence of catalytic RNA is believed to have been a key event durin

69 y to understanding the structural biology of catalytic RNA is determining the underlying networks of

70 The evolution of catalytic RNA is of special interest because RNA is beli

71 A Ca2+-requiring catalytic RNA is shown to create 5' phosphate-phosphate

72 the hepatitis delta virus (HDV) is the only catalytic RNA known to be required for the viability of

73 The glmS ribozyme is the only natural catalytic RNA known to require a small-molecule activato

74 Nase MRP is a ribonucleoprotein with a large catalytic RNA moiety that is closely related to the RNA

75 The hammerhead ribozyme is a small catalytic RNA molecule.

76 intersection of the genotype networks of two catalytic RNA molecules (ribozymes).

77 particularly as required cofactors for many catalytic RNA molecules (ribozymes).

78 Catalytic RNA molecules can achieve rate acceleration by

79 A population of catalytic RNA molecules has been engineered to operate a

80 It was one of the first catalytic RNA molecules identified and consists of a sin

81 Catalytic RNA molecules possess simultaneously a genotyp

82 A population of catalytic RNA molecules shows significantly different be

83 Ribozymes are catalytic RNA molecules that can be designed to cleave s

84 Hammerhead ribozymes are small catalytic RNA molecules that can be designed to specific

85 Ribozymes are small, catalytic RNA molecules that can be engineered to down-r

86 Ribozymes are small catalytic RNA molecules that can be engineered to enzyma

87 Ribozymes, catalytic RNA molecules that cleave a complementary mRNA

88 Group II introns are large catalytic RNA molecules that fold into compact structure

89 Ribozymes are catalytic RNA molecules that recognize their target RNA

90 also provided the platform to develop those catalytic RNA molecules, called ribozymes, as trans -act

91 Catalytic RNA molecules, or ribozymes, have generated si

92 To determine if this catalytic RNA motif has a wider distribution, we decided

93 ary antigenome contain the same cis-cleaving catalytic RNA motif that plays a crucial role in virus r

94 It utilizes a self-cleaving catalytic RNA motif to process multimeric intermediates

95 is delta virus (HDV) harbors a self-cleaving catalytic RNA motif, the genomic HDV ribozyme, whose cry

96 a virus (HDV) employs a unique self-cleaving catalytic RNA motif, the HDV ribozyme, during double-rol

97 ary antigenome contain a common cis-cleaving catalytic RNA motif, the HDV ribozyme, which plays a cru

98 among the smallest and simplest of the known catalytic RNA motifs and has a unique metal ion specific

99 Together, these results imply that similar catalytic RNA motifs can arise under fairly simple condi

100 nd glmS ribozymes comprise a family of small catalytic RNA motifs that catalyze the same reversible p

101 This novel approach to the synthesis of catalytic RNAs offers a number of differences and potent

102 cted mutations within Ll.ltrB, either in the catalytic RNA or in the intron-encoded protein gene ltrA

103 cription can be extended to the synthesis of catalytic RNAs outside the hammerhead ribozyme motif; (i

104 The 154 kDa complex consists of a large catalytic RNA (P RNA), a small protein cofactor and a ma

105 T7 DNA primase is composed of a catalytic RNA polymerase domain (RPD) and a zinc-binding

106 nition of a specific template sequence and a catalytic RNA polymerase domain.

107 Systems of catalytic RNAs presumably gave rise to important evoluti

108 n all domains of life and comprises a single catalytic RNA (ribozyme) and a variable number of protei

109 We show the development of a catalytic RNA (ribozyme) that generates the nucleoside t

110 mplexity and activity in a comparison of two catalytic RNAs (ribozyme ligases), raising the possibili

111 Inhibition of gene expression by catalytic RNA (ribozymes) requires that ribozymes effici

112 reactions involving oligonucleotides such as catalytic RNA (ribozymes).

113 Diverse small molecules interact with catalytic RNAs (ribozymes) as substrates and cofactors,

114 The early evolution of life relied on catalytic RNAs (ribozymes) for central functions.

115 The effectiveness of catalytic RNAs (ribozymes) should be increased when they

116 tions are the only known methods to generate catalytic RNAs (ribozymes) that do not exist in nature.

117 assembly factor, Puf6, binds to the nascent catalytic RNA-rich subunit interface within the 60S pre-

118 Ribozymes are small catalytic RNA sequences capable of nucleotide-specific s

119 le for Mg(2+) adds to the diversity of known catalytic RNA strategies and unifies functional features

120 interactions drive the stepwise assembly of catalytic RNA structures.

121 This enzyme from Escherichia coli contains a catalytic RNA subunit (M1 ribozyme) and a protein subuni

122 s a tRNA-processing enzyme and consists of a catalytic RNA subunit (M1 RNA) and a protein component (

123 Bacterial RNase P is comprised of a catalytic RNA subunit and a lone protein cofactor which

124 e involved in tRNA maturation, consists of a catalytic RNA subunit and a protein cofactor.

125 RNase P in eubacteria has a large, catalytic RNA subunit and a small protein subunit that a

126 e 5'-end of mature tRNA and is composed of a catalytic RNA subunit and a small protein subunit.

127 In bacteria, RNase P is composed of a catalytic RNA subunit and an associated protein subunit

128 d the biological function of RNase P and its catalytic RNA subunit and to employ it as a tool to down

129 dent reconstitutions of Pfu RNase P with its catalytic RNA subunit and two interacting protein cofact

130 cleaving the cognate RNA ligand, M1 RNA, the catalytic RNA subunit of E. coli RNase P, in the presenc

131 By linking a guide sequence to the catalytic RNA subunit of RNase P (M1 RNA), we constructe

132 pecific ribozyme (M1GS RNA) derived from the catalytic RNA subunit of RNase P from Escherichia coli w

133 pecific ribozyme (M1GS RNA) derived from the catalytic RNA subunit of RNase P from Escherichia coli w

134 pecific ribozyme (M1GS RNA) derived from the catalytic RNA subunit of RNase P from Escherichia coli w

135 M1 RNA, the catalytic RNA subunit of RNase P from Escherichia coli,

136 ate from or covalently linked to M1 RNA, the catalytic RNA subunit of RNase P.

137 is either a ribonucleoprotein complex with a catalytic RNA subunit or a protein-only RNase P (PRORP).

138 Bacterial ribonuclease P contains a catalytic RNA subunit that cleaves precursor sequences f

139 chia coli, this RNP complex is composed of a catalytic RNA subunit, M1 RNA, and a protein cofactor, C

140 tions in tRNA biosynthesis, is composed of a catalytic RNA subunit, M1 RNA, and a protein cofactor, C

141 The enzyme possesses a putatively catalytic RNA subunit, structurally related to that of R

142 ssential protein subunits in addition to the catalytic RNA subunit.

143 of varied coenzyme ribozymes using a single catalytic RNA subunit.

144 o multi-subunit ribonucleoprotein forms with catalytic RNA subunits to protein-only enzymes, the latt

145 The hairpin ribozyme is a small catalytic RNA that accelerates reversible cleavage of a

146 The hairpin ribozyme is a small catalytic RNA that achieves an active configuration by d

147 he hairpin ribozyme is an example of a small catalytic RNA that catalyses the endonucleolytic transes

148 Ribonuclease P (RNase P) contains a catalytic RNA that cleaves precursor tRNA (pre-tRNA) to

149 bozyme riboswitch is the first known natural catalytic RNA that employs a small-molecule cofactor.

150 examples of chemical modifications within a catalytic RNA that enhance the rate of the chemical step

151 se ribonuclease P (RNase P) is composed of a catalytic RNA that is assisted by protein subunits.

152 ein U1A was engineered into a segment of the catalytic RNA that is dispensable for catalysis.

153 mS ribozyme is the first naturally occurring catalytic RNA that relies on an exogenous, nonnucleotide

154 The hammerhead ribozyme is a catalytic RNA that requires divalent metal cations for a

155 The glmS ribozyme is a catalytic RNA that self-cleaves at its 5'-end in the pre

156 Group II introns are large catalytic RNAs that are ancestrally related to nuclear s

157 rpin ribozyme belongs to the family of small catalytic RNAs that cleave RNA substrates in a reversibl

158 Group I introns are catalytic RNAs that coordinate two consecutive transeste

159 Group II introns are catalytic RNAs that have been proposed to be the evoluti

160 located in different folding domains of the catalytic RNA, the first in the substrate binding domain

161 crystal structure has been reported of a new catalytic RNA, the TS ribozyme, that has been identified

162 are predicted for several nucleotides in two catalytic RNAs, the hairpin ribozyme and the hepatitis d

163 trans-cleavage substrate interacts with the catalytic RNA via tertiary interactions.

164 The turnover number of the catalytic RNA was found to depend on the binding of at l

165 across a wastewater microbiome, a synthetic catalytic RNA was used to barcode a highly conserved seg

166 on rate constant for every point mutant of a catalytic RNA, we demonstrated that abundance in seriall

167 ion conditions, crystals of a 247 nucleotide catalytic RNA were obtained.

168 s modified for nuclease stability can target catalytic RNAs when the elements of tertiary interaction

169 he hairpin ribozyme is an example of a small catalytic RNA which catalyses the endonucleolytic transe

170 This results in monomer-length catalytic RNAs which have self-complementary sequences t

171 ts and led to a highly active RNA-alkylating catalytic RNA, which we termed RACR.

172 ng-lived misfolded conformation of a group I catalytic RNA with efficiencies that depend on the stabi

173 The hairpin ribozyme is a small catalytic RNA with reversible phosphodiester cleavage ac

174 ribozyme is among the smallest of the known catalytic RNAs, with an active site consisting of a six-