ライフサイエンスコーパス: catalytic activity

1 e/threonine kinase, completely abrogated its catalytic activity.

2 evaluation of the effect of the order on ORR catalytic activity.

3 omains with the kinase core, thus preventing catalytic activity.

4 ellar framework contribute to the ultra-high catalytic activity.

5 the substituent in the ylide-backbone on the catalytic activity.

6 reas the dimerization appeared to compromise catalytic activity.

7 e a general acid-base role, minimally affect catalytic activity.

8 s dependent on angiotensin-converting enzyme catalytic activity.

9 s and partly plays their role independent of catalytic activity.

10 he surface of Pd nanocubes to maximize their catalytic activity.

11 light irradiation, which is responsible for catalytic activity.

12 nal switch that allosterically modulates the catalytic activity.

13 hat nucleosome binding potently inhibits its catalytic activity.

14 onic stem cells that completely removes PRC1 catalytic activity.

15 gests that Ca(2+) binding is relevant to the catalytic activity.

16 lease through a mechanism that requires Hrq1 catalytic activity.

17 out any appreciable loss in particle size or catalytic activity.

18 ecific loop amino acid residues in mediating catalytic activity.

19 l of crossover numbers without requiring its catalytic activity.

20 ible for the changes in the external surface catalytic activity.

21 ctive effect is strictly dependent on Set1's catalytic activity.

22 autoinhibitory state, which has low "basal" catalytic activity.

23 arrangements of the DNA correlating with low catalytic activity.

24 (-1) , as well as good stability and durable catalytic activity.

25 ules, some of which possess (perhaps slight) catalytic activity.

26 ndent protein kinase A (PKA) pathway and PKA catalytic activity.

27 ting that the TM is not essential for enzyme catalytic activity.

28 ss of these substrates that have interesting catalytic activity.

29 sites are essential for FePc to achieve high catalytic activity.

30 in to DNA, which in turn is required for the catalytic activity.

31 many of these same residues are required for catalytic activity.

32 ite surface for assembly, which silences its catalytic activity.

33 d SAUR binding but had no apparent effect on catalytic activity.

34 tidine residues that play a critical role in catalytic activity.

35 roperties of different components to promote catalytic activity.

36 ycomb-mediated gene repression requires PRC1 catalytic activity.

37 mechanism of action and factors controlling catalytic activity.

38 's oncogenic potential is independent of its catalytic activity.

39 es is key for tuning product selectivity and catalytic activity.

40 r, calculations show a significantly reduced catalytic activity.

41 ing a nonallosteric enzyme that retains full catalytic activity.

42 oordinated Ca(2+) but exhibited little or no catalytic activity.

43 s further correlated Omega-loop opening with catalytic activity.

44 dependent of its cytoplasmic tail and of its catalytic activity.

45 display hypomorphic function in an assay of catalytic activity.

46 istinct structural elements influence enzyme catalytic activity.

47 cent to a (His)(3) metal binding site alters catalytic activity.

48 active site plays an important role for the catalytic activity.

49 in the triple mutant and investigated their catalytic activities.

50 Cu(I), making them interesting for redox and catalytic activities.

51 em on individual columns, separating the two catalytic activities.

52 TET inhibitor that specifically blocks their catalytic activities.

53 1 and 2 (NCoR1/2) is required to engage its catalytic activity(1-3).

54 previously been identified as essential for catalytic activity(8).

55 rinckii (CbHydA1) was reported to regain its catalytic activity after exposure to oxygen.

56 The PTPRU-D1 displays no detectable catalytic activity against a range of phosphorylated sub

57 Phe-316 and Tyr-766 variants retained catalytic activity, albeit with altered kinetics and coo

58 sociated 'reaction chambers', with augmented catalytic activity along gene bodies.

59 nzyme variants) that may hide yet unexplored catalytic activities and selectivity.

60 However, the origin of the outstanding catalytic activities and structural changes of the mater

61 , and show that this function depends on its catalytic activity and ability to interact with Mhf1-Mhf

62 id metals render this possible as they offer catalytic activity and an ultrasmooth templating interfa

63 n mode in Pd/COF-DB endows it with excellent catalytic activity and cyclic stability as a heterogeneo

64 ogeneity of active-site loops in controlling catalytic activity and directing evolutionary trajectori

65 n in chloroplast biogenesis unrelated to its catalytic activity and driven by a moonlighting function

66 Increasing catalytic activity and durability of atomically disperse

67 classes in S. cerevisiae, we perturb Pol II catalytic activity and GTF function and analyze their ef

68 activated BTK, even in the absence of BTK's catalytic activity and independently of enhanced PLCgamm

69 n experiments demonstrated that both FANCJ's catalytic activity and interaction with BRCA1 are import

70 strong acidity of nanoboxes, provided superb catalytic activity and longevity in hydrocarbon cracking

71 to create orthogonal MTs possessing improved catalytic activity and selectivity for cxSAM, with subse

72 N(4) active sites have exhibited exceptional catalytic activity and selectivity for the electrochemic

73 tal-support interactions and correlations to catalytic activity and selectivity.

74 ) RR) and to extract correlations with their catalytic activity and selectivity.

75 tions, little is known with regards to their catalytic activity and stability during aqueous ROMP.

76 The clear enhancement of catalytic activity and stability of the material as comp

77 o interact with specific AHL, increase their catalytic activity and stability, or enhance their biote

78 A trade-off between catalytic activity and structural stability generally ex

79 effect of disulfide formation on PKARIalpha catalytic activity and subcellular localization, live-ce

80 ch as robust stability, lower cost, stronger catalytic activity and substrate affinity.

81 hat the examined domain supports Pol epsilon catalytic activity and symmetric movement of replication

82 pha(o) over Galpha(i) as a substrate for its catalytic activity and that M(2)R signals preferentially

83 idues involved in metal ion binding impaired catalytic activity and the formation of active hexamers.

84 In this model, Pol II catalytic activity and the rate and processivity of Pol

85 O-GlcNAcylation inhibits PKM2 catalytic activity and thereby promotes aerobic glycolys

86 tages may include significant enhancement in catalytic activity and/or selectivity and substantial re

87 during stress, which adversely affect their catalytic activities, and that PIMT repairs the isoAsp r

88 protein phosphorylation, (iv) regulation of catalytic activity, and (v) cytoskeletal regulation.

89 gh chiroptical activity, enantioselectivity, catalytic activity, and biocompatibility.

90 oid-inducible kinase 1 (SGK1) transcription, catalytic activity, and phosphorylation are upregulated

91 which typically use ssDNA binding to enhance catalytic activity, and suggests that the C-terminal reg

92 Magnesium is a cofactor for SpxB catalytic activity, and supplementation increases the pr

93 ling properties of these molecules and their catalytic activity as ligands in copper-catalyzed azide

94 als with 16 isoforms that differ in terms of catalytic activity as well as cellular and tissue distri

95 imal to the sgRNA do in fact inactivate Cas9 catalytic activity at the specified target site.

96 2) The doping of CeO(2) with Ni improves the catalytic activity because the NiO participates in the c

97 5, and phosphomimetic mutations enhance Set5 catalytic activity but diminish its ability to interact

98 ontaining PKARIalpha was not found to impact catalytic activity, but instead led to enhanced AKAP (A-

99 erminal lysine doublet which likely augments catalytic activity by increasing the positive electrosta

100 Dynamic regulation of MPS1 catalytic activity by kinetochore-localized PP2A-B56 is

101 er numerous degrees of freedom for enhancing catalytic activity by tailoring their physicochemical pr

102 aryl and alkyl amines, but notably enhanced catalytic activity can be realized with challenging N-al

103 mimetic nanostructures possessing intrinsic catalytic activity circumvent various limitations of nat

104 flat oxide surfaces such as CeO(2)(111) have catalytic activities comparable to those of molecular co

105 2 protein expression and sulfamethazine NAT2 catalytic activity correlated highly across the cryopres

106 The catalytic activity descriptor TON(1h) correlates predomi

107 Although inhibition of PDE3A catalytic activity did not account for DNMDP sensitivity

108 , the effect of transition metal alloying on catalytic activity differs from reaction to reaction.

109 tionally, while Mn2+ accelerates the overall catalytic activity, dsDNA length-dependent dimerization

110 metals and their related materials show poor catalytic activity due to a broadened single resonance d

111 all fraction of the assembled ligases retain catalytic activity due to the presence of disabling muta

112 l electrocatalysts because of their superior catalytic activities during the oxygen-reduction and -ev

113 as the enzyme's structure determined and its catalytic activity elucidated.

114 , yielded a panel of optoPLDs whose range of catalytic activities enables mimicry of endogenous, phys

115 The catalytic activities for 1,1,1-TCA and TCE reductions re

116 hat the Mo(2)N nanobelt cathodes had similar catalytic activities for H(2) evolution compared to that

117 -index facets is favorable for improving the catalytic activity for all three classes of reactions st

118 s containing six branches showed significant catalytic activity for copper sulfate mediated cycloaddi

119 Surprisingly, the catalytic activity for methane production increased sign

120 d the 3D alloy electrocatalyst exhibits high catalytic activity for NH(3) production with a yield rat

121 However, this material shows no catalytic activity for ODH of propane to propene.

122 t show an order of magnitude higher apparent catalytic activity for OER in acidic solution.

123 ng a rationale for targeting EZH2 beyond its catalytic activity for overcoming cisplatin resistance i

124 ed by successive infiltration to have higher catalytic activity for soot combustion than the Ni-impre

125 CeO(2) on the physicochemical properties and catalytic activity for soot combustion was studied.

126 nstrated nearly an order of magnitude higher catalytic activity for the breakdown of a chemical warfa

127 es with a size range of 79-200 nm and showed catalytic activity for the degradation (in high yields)

128 fective elements dramatically gave excellent catalytic activity for the oxygen evolution reaction in

129 The HEO has ultra-high catalytic activity for the solvent-free aerobic oxidatio

130 ysis shed light on the origins of the varied catalytic activities found in metazoan CCDs, opening the

131 the conductivity (from polypyrrole -PPy) and catalytic activities (from manganese dioxide -MnO(2)) we

132 alian development, and the inhibition of its catalytic activity has been extensively studied for canc

133 one of the core particle (CP) subunits with catalytic activity, has been shown to be incorporated in

134 hat the active site metal ions essential for catalytic activity have a secondary structural role medi

135 l nanocrystals with integrated plasmonic and catalytic activities hold great promise for analyzing ch

136 al understanding of all processes leading to catalytic activity, i.e., light absorption, charge separ

137 erated immobilized pectinase showed enhanced catalytic activity, improved operational stability, and

138 on the NP surface also lead to an increased catalytic activity, improving the sensitivity of the NP

139 We evaluated their catalytic activity in ascorbate oxidation based on redox

140 s where the variants still retain sufficient catalytic activity in both directions: An inflection app

141 Such a combination showed enhanced catalytic activity in catalyzing the cross-coupling hydr

142 The catalytic activity in DPA hydrogenation follows the orde

143 matically examined the role of DOT1L and its catalytic activity in embryonic stem cells (ESCs).

144 contention that role of Fe(3+) in enhancing catalytic activity in Ni oxide catalysts arises from its

145 ly-ubiquitin chains of >= Ub3 stimulate TDP2 catalytic activity in nuclear extracts and enhance TDP2

146 e, we directly test the requirement for PRC1 catalytic activity in Polycomb system function.

147 likely accounts for the significant loss of catalytic activity in the AbCntA-E205A mutant.

148 found vital for imparting high stability and catalytic activity in the dry reforming of methane.

149 near nakedness of the cation results in high catalytic activity in the hydrosilylation of 1-hexene an

150 P-1 binds to snoRNAs, which stimulate PARP-1 catalytic activity in the nucleolus independent of DNA d

151 n family members bind PPP5C increasing PPP5C catalytic activity in vitro.

152 ediate, was able to effectively inhibit AasS catalytic activity in vitro.

153 nd 3'-nucleotide overhangs negate Cas9/sgRNA catalytic activity in vivo.

154 ing lead to a unique temperature dependence: catalytic activity increases as temperature decreases in

155 These results disclose a catalytic activity-independent growth-promoting role of

156 atalyzes cellulose synthesis and whether its catalytic activity influences efficient CSC transport at

157 f N-MYLK domain (amino acids 1-919 devoid of catalytic activity) into Mylk-L(-/-) EC rescued SOCE to

158 Understanding the catalytic activity is a fundamental goal in elucidating

159 The results suggest that the catalytic activity is confined to the zone physically cl

160 compromise the stability of the protein, the catalytic activity is decreased, or a combination of bot

161 associated with Sts-1 and indicate that this catalytic activity is linked to specific cell-signaling

162 structural basis for the regulation of their catalytic activity is not fully understood, and RPTPs ar

163 Increased ATP is due to ACE C-domain catalytic activity; it is reversed by an ACE inhibitor b

164 We combine catalytic activity measurements with quantum chemical ca

165 the possibility that the inhibition of their catalytic activities might not be sufficient per se to b

166 Biochemical analysis has now identified the catalytic activities of all enzymes encoded by the 34 TP

167 Tight regulation of the cellular levels and catalytic activities of HO1 and HO2 is important for mai

168 groups on ice, putatively linked to the high catalytic activities of ice surfaces.

169 The catalytic activities of single-atom alloys in a few repr

170 owever, nonhistone substrates and additional catalytic activities of SIRT6, including long-chain deac

171 We discuss the catalytic and non-catalytic activities of TETs, and their roles as epigene

172 ailor both the electronic structures and the catalytic activities of the nanohybrid structures.

173 However, whether the catalytic activities of these enzymes are important for

174 w an adaptor can simultaneously modulate the catalytic activity of a AAA+ enzyme, efficiently promote

175 We found that the catalytic activity of a conserved family of fructosamine

176 ortant in determining a tradeoff between the catalytic activity of a MOF and its resistance to unzipp

177 of Galpha regulation by RGS, we examine the catalytic activity of all canonical human RGS proteins a

178 entered at -140 mV Vs Ag/AgCl confirming the catalytic activity of anammox bacteria towards the elect

179 he regulation of ubiquitin signals, and both catalytic activity of and target recruitment by DUBs nee

180 The catalytic activity of artificial iron biocatalysts is al

181 electron density of pyridines modulates the catalytic activity of Au(III) complexes in propargyl est

182 We monitored the catalytic activity of AuNCs in the collected urine of a

183 s to propose a mechanism explaining the high catalytic activity of bismuth to reduce these families o

184 While effective at blocking the catalytic activity of BTK, consequences of drug binding

185 , are expected to locally tune the intrinsic catalytic activity of carbon materials.

186 due near the active site participates in the catalytic activity of Cd-SrtB and also SrtB from Staphyl

187 e cell imaging, we found that inhibiting the catalytic activity of CESA6 by ES20 treatment reduced th

188 The catalytic activity of CTK-1 is required for such a respo

189 These results suggest that the catalytic activity of DIMT1 is involved in protein trans

190 eposition of methylation marks relies on the catalytic activity of DNA methyltransferases (DNMTs), an

191 te how the binding of arrestin-1 affects the catalytic activity of enolase-1.

192 Owing to the unique electronic structure and catalytic activity of Fe-N-C SACs, large amounts of ROS

193 genetic or pharmacological abolition of the catalytic activity of HDAC3.

194 Being a putative ribosyltransferase, the catalytic activity of HopO1-1 is required for regulation

195 The catalytic activity of human AURORA-A kinase (AURKA) regu

196 We observed the changes in the catalytic activity of immobilized SOD1 as well as its re

197 Moreover, we demonstrate that the catalytic activity of Integrator cleaves nascent capped

198 The high catalytic activity of ion pair catalysts appears to be d

199 The present report is focused on the catalytic activity of iron catalysts in promoting alkene

200 The catalytic activity of KDM4A is essential for normal epig

201 HD11 associates with the OGDHc and maintains catalytic activity of lipoyl domain by preventing the fo

202 nature of active sites, nanostructures, and catalytic activity of M-N-C catalysts at the atomic scal

203 in the extracellular matrix is regulated by catalytic activity of matrix metalloproteinases MMP-2,9.

204 ns up a new avenue to dramatically enhancing catalytic activity of metal oxides for other application

205 tructures that can be used for improving the catalytic activity of metal surfaces.

206 w electrostatics can be employed to tune the catalytic activity of metalloenzymes and can thus contri

207 formation storage materials to understanding catalytic activity of metalloenzymes.

208 sites, fundamentally accounting for the high catalytic activity of MFe LDHs.

209 gs highlight an important, but unrecognized, catalytic activity of mineral nanoparticles produced by

210 e ability to use internal strain to increase catalytic activity of MOFs suggests that applying this s

211 daptors to regulate substrate choice and the catalytic activity of molecular machines.

212 cle, and both these functions require CW and catalytic activity of MORC4.

213 nce (HTRF)-based enzyme assay to measure the catalytic activity of N(6)-methyladenosine (m(6)A) methy

214 binding specifically increases the intrinsic catalytic activity of NAA80.

215 Computations support the catalytic activity of naked In(I)(+) ions, with an outer

216 have shown to have the ability to mimic the catalytic activity of natural enzymes (nanozymes).

217 It is thought that the catalytic activity of NOS promotes NADPH-dependent reduc

218 RECQL4 promotes catalytic activity of OGG1 and RECQL4 deficiency results

219 ly unknown regulatory mechanism by which the catalytic activity of OTUD3 is tightly controlled to ens

220 Notably, the catalytic activity of OTUD3 relies on acetylation of its

221 The mutation reduced the catalytic activity of PAICS in heterozygous carrier and

222 lation events that lead to activation of the catalytic activity of phosphoinositide 3-kinase (PI3K),

223 w that SULT4A1, by negatively regulating the catalytic activity of Pin1 toward PSD-95, facilitates NM

224 no acids that potentially participate in the catalytic activity of plant CESA6, in addition to previo

225 Moreover, the catalytic activity of Pop2 deadenylase is important for

226 The catalytic activity of RNase J is regulated by multiple m

227 fied as albumin, does not interfere with the catalytic activity of soluble receptor at saturating rec

228 phosphorylation and a consequent decrease in catalytic activity of sperm GSK3.

229 The catalytic activity of the cage was enhanced following it

230 response in the lung were dependent upon the catalytic activity of the enzyme, as a catalytically ina

231 In the material, the catalytic activity of the guest is retained, as evidence

232 -toxic chemical probe UNC0638 to inhibit the catalytic activity of the histone methyltransferases EHM

233 function theory calculations reveal that the catalytic activity of the main-group metals (Mg, Al and

234 The catalytic activity of the protease MALT1 is required for

235 systemic application of an inhibitor for the catalytic activity of the Rho GEF Vav2 at the organismal

236 In this study, we found that the catalytic activity of the Ser/Thr kinase Aurora A was in

237 ng receptor concentrations and amplifies the catalytic activity of the soluble receptor at a concentr

238 Here, we report that the catalytic activity of the terpene cyclases AaTPS and FgG

239 ng with our labeled inhibitors, we show that catalytic activity of these enzymes is not required for

240 5 nm L1(0)-CoMPt NPs, we could push the ORR catalytic activity of these NPs toward the optimum regio

241 obilized pectinase demonstrated the enhanced catalytic activity of this enzyme after immobilization.

242 culations provided a deeper insight into the catalytic activity of this new family of non-canonical,

243 dings highlight a potential link between the catalytic activity of topoisomerases and the fundamental

244 ins WDR-20 and WDR-48 bind and stimulate the catalytic activity of USP-46.

245 er-1003 after DNA damage, which enhances the catalytic activity of USP52.

246 Our results indicate that lowering the catalytic activity of Vav2 below specific thresholds is

247 es in our understanding of the structure and catalytic activity of viperin, together with studies inv

248 icrostructure and dimensions-and thereby the catalytic activity-of the nanofibres were controlled thr

249 ecently demonstrated that DspB has increased catalytic activity on de-N-acetylated PNAG oligosacchari

250 protein scaffold of DIMT1, regardless of the catalytic activity on m(2) (6,6)A in 18S rRNA, is essent

251 ntellectual disability and autism ablate its catalytic activity or ankyrin-G interaction.

252 in a polar fashion upon alteration in Pol II catalytic activity or GTF function.

253 cyclability of 1-OTf-Pd(NP) and its superior catalytic activity over the homogeneous counterparts.

254 Unlike PKM1, which has constitutively high catalytic activity, PKM2 is under complex regulation.

255 The reaction is limited by low catalytic activities, poor tolerance to a large excess o

256 chemical adsorption with active species and catalytic activity promotes conversion processes, suppre

257 elated to photosynthesis, metabolic process, catalytic activity, protein phosphorylation, kinase acti

258 require metabolic cofactors to support their catalytic activities, providing a direct path for fluctu

259 es occupy target sites independently of PRC1 catalytic activity, providing a putative mechanism for P

260 Despite their apparent lack of catalytic activity, pseudokinases are essential signalin

261 Importantly, despite the absence of catalytic activity, PTPRU binds substrates of related ph

262 nomaterials was chiefly responsible for this catalytic activity, rather than through the conventional

263 nding of how protein structure can influence catalytic activity remains elusive.

264 CA2a(WT)) and SERCA2a mutants with different catalytic activity revealed that an intact catalytic cyc

265 ses while on ibrutinib, which inhibits BTK's catalytic activity, revealed several mutations in BTK, m

266 The combination of catalytic activity, selectivity, efficiency, and durabil

267 tificial enzyme model (AEM) as it mimics the catalytic activity similar to enzyme alcohol dehydrogena

268 sure the DNA-binding specificity (Spec-seq), catalytic activity specificity (SEAM-seq) and cleavage e

269 ppress the peptidyl transferase center (PTC) catalytic activity stimulated by eukaryotic release fact

270 s at the single particle level showed higher catalytic activity, stronger adsorption strength, and hi

271 Here it is demonstrated that the inverse catalytic activity-structural stability relation can be

272 distribution (in micro- vs. mesopores), and catalytic activity suggest nearly invariant structure an

273 ynthesized and demonstrated 100-fold greater catalytic activity than 1.

274 phase olefin metathesis and exhibited higher catalytic activity than the corresponding catalysts synt

275 tric organo/photocatalyst has shown a better catalytic activity than those presenting a C(2) symmetry

276 nality can play a crucial role in tuning the catalytic activity that is observed and that advanced th

277 here is strong interest in stimulating SIRT1 catalytic activity, the homeostasis of SIRT1 at the prot

278 surface Bi is highly favorable for improving catalytic activity, there is little influence from trans

279 bility to bind penicillin, rather than their catalytic activity, these key targets are called penicil

280 with binding ability to specific targets and catalytic activities to gain signals are known to be ide

281 uclear NAD(+) synthase, which directs PARP-1 catalytic activity to Glu and Asp residues.

282 ons of SIRT6 with a focus on attributing its catalytic activity to its proposed biological functions.

283 ular probes that respond to disease-specific catalytic activity to produce a diagnostic readout, as w

284 howed that the Bi electrode exhibited a high catalytic activity to reduce alachlor, a chlorinated her

285 Through its catalytic activity to selectively process or degrade RNA

286 Sts-1 also had phosphodiesterase catalytic activity toward a 5-mer RNA oligonucleotide co

287 f the gamma-secretase complex as well as its catalytic activity toward its substrate Notch, a critica

288 rot fungus adsorption and its direct electro-catalytic activity toward oxygen reduction was investiga

289 Catalytic activity was demonstrated via the oxidative de

290 Moreover, sufficient catalytic activity was obtained for primary and secondar

291 mimics (named LM nanozymes) with a superior catalytic activity was successfully prepared by using gl

292 Rev1 protein, but not its catalytic activity, was required for efficient TLS.

293 inhibitor GTP binding and inhibition of GDH catalytic activity. We further show that the binding of

294 NO-CCSD(T)) calculations, both stability and catalytic activity were investigated for Rh single atoms

295 enzymes often show dramatic changes in their catalytic activity when subjected to chemically similar

296 PKM2, we used TEPP-46, which increases PKM2 catalytic activity while inhibiting any PKM2 signalling

297 eet morphology and regulate external surface catalytic activity while preserving micro- and mesoporos

298 cterial effectors frequently uncover diverse catalytic activities, while structure-informed similarit

299 ees C to enhance electronic conductivity and catalytic activity, while preserving its macrostructure.

300 ng the active site, we can rapidly switch on catalytic activity with light and monitor the ensuing dy