ライフサイエンスコーパス: catalytic domain

1 PUA or DUF3427 domain and HNH or PD-(D/E)XK catalytic domain.

2 stimulates PNKP by interacting with the PNKP catalytic domain.

3 acent homology (BAH) domain, which flank the catalytic domain.

4 und c(8) ring and the delta-subunit from the catalytic domain.

5 ances the cyclase activity of the C-terminal catalytic domain.

6 the structure of a shorter form lacking the catalytic domain.

7 ine resides, and their interactions with the catalytic domain.

8 er interface, and GTP-binding regions of the catalytic domain.

9 ansmitting the hormone binding signal to the catalytic domain.

10 the available crystal structure of the GtfC catalytic domain.

11 the EF domain and the conserved core of the catalytic domain.

12 h is predisposed to interact with its parent catalytic domain.

13 ET1ALT lacks the CXXC domain but retains the catalytic domain.

14 al domain did not result in unmasking of the catalytic domain.

15 ite near Arg-106, which is distinct from the catalytic domain.

16 sts that this residue interacts with the MKK catalytic domain.

17 s at the junction of the propeptide with the catalytic domain.

18 ctivates partnering JAKs, independent of its catalytic domain.

19 giotensin converting enzyme 2, but without a catalytic domain.

20 ivity by directly binding to its ATP-binding catalytic domain.

21 l region and a carboxy-terminal caspase-like catalytic domain.

22 ce a detailed topological model of the CesA8 catalytic domain.

23 bstrate and by an acidic patch in the kinase catalytic domain.

24 complexes that form over a large part of the catalytic domain.

25 encoded regions within the Drosophila myosin catalytic domain.

26 ain and the remaining C-Lip forms a HAD-like catalytic domain.

27 , thereby facilitating movement of the SLC13 catalytic domain.

28 ally expressing/generating a free PKCepsilon catalytic domain.

29 the adenosine binding site of the tankyrase catalytic domain.

30 h one of two major binding sites outside the catalytic domain.

31 4 plant genomes and a widely conserved GLCAT catalytic domain.

32 wo Ca(2+)-binding motifs inserted within the catalytic domain.

33 espite the presence of a putative PD-(D/E)XK catalytic domain.

34 ng proteins or in the C-terminal RING finger catalytic domain.

35 ovalently interacting with the PDE6 GAFa and catalytic domains.

36 ACE is composed of two independent catalytic domains.

37 on spatially separating independently active catalytic domains.

38 catalytic site characteristic of minimal PLP catalytic domains.

39 approximately 80% sequence identity in their catalytic domains.

40 ry or the net homo-FRET between Venus-tagged catalytic domains.

41 vocally assigned to the second of the tandem catalytic domains.

42 induce an active dimeric conformation of the catalytic domains.

43 ted proteins, four of which were modified in catalytic domains.

44 air in vivo by inactivating each of the four catalytic domains.

45 regions that connect the protease-resistant catalytic domains.

46 in the N-terminal regulatory and C-terminal catalytic domains.

47 prevents dimerization and activation of the catalytic domains.

48 o oligomerization interfaces mediated by non-catalytic domains.

49 discovered interaction between Src's SH4 and catalytic domains.

50 tional units of CaMKII holoenzyme are paired catalytic-domains.

51 re, we present high-resolution structures of catalytic domain 2 from Danio rerio HDAC6 (henceforth si

52 f the potent azaphenothiazine inhibitor with catalytic domain 2 from Danio rerio HDAC6.

53 of four of these loops in TrCel7B makes its catalytic domain a more open cleft.

54 Despite conservation of the catalytic domain, a recent study identified differences

55 as been proposed to bind, in addition to the catalytic domain, a site at the PAH N-terminal regulator

56 delivery of its N-terminal adenylate cyclase catalytic domain (AC domain) into the cytosol, generates

57 alysis revealed conservation of the helicase catalytic domain across the order Nidovirales (families

58 We also observed that the DddY catalytic domain adopts a typical beta-barrel fold and c

59 In the complex structure, the catalytic domain adopts an open conformation, with the K

60 ease and virulence, and glycosylation at the catalytic domain affects its thermostability; however, g

61 se enzymes contain two functional domains: a catalytic domain and a C-terminal ricin-like lectin doma

62 es, we found that native HjLPMO9A contains a catalytic domain and a family-1 carbohydrate-binding mod

63 or domains: a cytochrome P450 (heme-binding) catalytic domain and a NADPH-cytochrome P450 reductase (

64 RgNanH comprises a GH33 catalytic domain and a sialic acid-binding carbohydrate-

65 RNase E consists of a highly conserved catalytic domain and a variable non-catalytic domain tha

66 raction between the POLD1 CysB motif and the catalytic domain and also between POLD1 and the Poldelta

67 The VPS34 catalytic domain and BECN1:ATG14 subcomplex do not touch

68 extending from near the top of the enzyme's catalytic domain and crossing the membrane domain of the

69 ical domain of B3GNTs that may stabilize the catalytic domain and distinguish among different accepto

70 silio-ME1 to simultaneously deliver the TET1-catalytic domain and GADD45A (Casilio-ME2) or NEIL2 (Cas

71 rate-binding domain immediately precedes the catalytic domain and has tight associations with it.

72 s stabilizes binding of the substrate to the catalytic domain and improves the catalytic efficiency o

73 ly available tankyrase inhibitors target the catalytic domain and inhibit tankyrase's poly(ADP-ribosy

74 including crystallographic structures of its catalytic domain and the J-domain of its stimulatory Hsp

75 sensitivity conferral protein (OSCP) to the catalytic domain and the membrane domain of subunit b to

76 ap, we explored the roles of residues of the catalytic domain and the regulatory subunit of human PI3

77 In particular, the catalytic domain and the RNA-binding domain can move aro

78 s tight mechanochemical coupling between the catalytic domain and the rotating central shaft, as well

79 ved by synergistic combination of E2-derived catalytic domain and tridomain.

80 interactions are entirely independent of the catalytic domains and are mediated by ionic interactions

81 Several sequences displayed multiple catalytic domains and few of these potential multi-activ

82 expressed, although some do not have active catalytic domains and their expression can be altered du

83 through association between the Rad50 ATPase catalytic domains and undergoes extensive conformational

84 te motifs, distal negative subsites from the catalytic domain, and a surface-associated aromatic clus

85 nesis mapped the interaction to the APOBEC3B catalytic domain, and biochemical studies demonstrated t

86 core protein or the adaptor proteins of the catalytic domain, and hence interfering with normal cell

87 near the junction between the prodomain and catalytic domain, and inhibits MMP9 by two mechanisms.

88 ts the dislodging and tethering of the VPS34 catalytic domain, and its regulation by VPS15, as a mast

89 ts canonical RVxF motif, which binds the PP1 catalytic domain, and its SH3 domain, which engages the

90 s; all but one such variant occur within the catalytic domain, and most display hypomorphic function

91 of a C-terminal part of HUWE1, including the catalytic domain, and reveal an asymmetric auto-inhibite

92 on analyses and identified S1777, in TRPM7's catalytic domain, and S1565, in TRPM7's exchange domain

93 proposed to mitigate toxicity, the targeted catalytic domains are highly conserved.

94 possible and highlight specific sites of its catalytic domain as potentially of high interest.

95 Cps1B consists of two catalytic domains, as well as a domain rich in tetratric

96 organization or eventually consisted of one catalytic domain associated with a non-catalytic accesso

97 a stalk composed of the SRCR domains and the catalytic domain at its tip.

98 obe the functions of individual PKS and NRPS catalytic domains at the cellular metabolic level.

99 We find that the LSD1 catalytic domain binds extranucleosomal DNA and is unexp

100 LOXs share a conserved C-terminal catalytic domain but differ in their N-terminal region,

101 THEMIS lacks defined catalytic domains but contains two tandem repeats of a d

102 istone deacetylase 1 (HDA-1), with an intact catalytic domain, but HDA-1 was not essential for de nov

103 catalytic domain (Mt2mask) indicate that the catalytic domain, but not its proteolytic activity, was

104 N-terminal domain binds and inhibits an MMP catalytic domain, but the role of the TIMP C-terminal do

105 erminal family 4 carbohydrate esterase (CE4) catalytic domain, but unlike other MurNAc deacetylases,

106 (TM) helix that is connected to the globular catalytic domain by a flexible linker sequence.

107 occlusion of anion-binding exosite 2 in the catalytic domain by the covalently retained propiece in

108 w that an N-terminal fragment comprising the catalytic domain can interact both with itself and with

109 t human RHOGAPs, from which 57 have a common catalytic domain capable of terminating RHO protein sign

110 eveloped an optogenetic toolbox fused to the catalytic domain (CD) of DNA-methyltransferase3A (DNMT3A

111 linker connected to an N- and O-glycosylated catalytic domain (CD)-a domain architecture common to ma

112 Its C-terminal catalytic domain (CD2) alone is capable of binding singl

113 an alternative strategy that utilizes multi-catalytic domain cellulases.

114 e report a strong linear correlation between catalytic domain complementation and cyclase activity up

115 APOBEC3B catalytic domain complexes also elicit the lowest freque

116 ased PKCdeltaI activation via release of its catalytic domain concurrent with increased expression of

117 of tandem GAF domains (GAFa and GAFb) and a catalytic domain, cone PDE6 is a homodimer whereas rod P

118 for the MetAP induces amino acid change in a catalytic domain conserved across many bacterial species

119 The crystal structure of LKA1gp49 catalytic domain consists of a beta-helix, an insertion

120 lex that suggests that both the PNKP FHA and catalytic domains contact the XRCC4 coiled-coil and LigI

121 R spectra show the N-terminal and C-terminal catalytic domains (Cre(NTD) and Cre(Cat)) to be structur

122 presented of the 220 phosphodiesterase (PDE) catalytic domain crystal structures present in the Prote

123 inant MMP12 peptide fragments, including its catalytic domain, CTD, and a 20 amino acid peptide withi

124 er, acquired resistance mutations within the catalytic domain decrease the efficacy of this strategy

125 g the crystal structure of the human nSMase2 catalytic domain determined at 1.85-A resolution.

126 We fused the catalytic domain (DHPH domain) of the RhoA activator ARH

127 rved GalNAc binding pocket in the GalNAc-T12 catalytic domain dictates its unique substrate selectivi

128 affected by two LytM factors with degenerate catalytic domains, DipM and LdpF, which may serve as reg

129 or approximately 54% of the conformers whose catalytic domain directly interacts with the bilayer.

130 The catalytic domain displayed a polypeptide fold similar ov

131 whereas mutation R360P in the N lobe of the catalytic domain disrupted an autoinhibitory mechanism,

132 residues in the flexible gating loop of the catalytic domain distinctively influence the peptide sub

133 r work highlights how regions outside of the catalytic domain enable a conceptually intriguing interp

134 i, which typically comprise multiple, single catalytic domain enzymes for biomass degradation, some b

135 oop and switch I at the effector lobe of the catalytic domain exhibit large conformational changes in

136 or the three N-terminal beta-strands of the catalytic domain face the membrane.

137 An analog that docked poorly in the GtfC catalytic domain failed to inhibit the activity of Gtfs

138 Five variants destabilized the catalytic domain-fold as assessed by lower transition te

139 carrier domain, is delivered to neighboring catalytic domains for bond formation and modification.

140 Individual CESA proteins contain conserved catalytic domains for catalyzing cellulose synthesis, ot

141 Residues Thr-123 and Phe-382 in the catalytic domain form a latch-like interaction with hydr

142 tain a structure of the entire PKG enzyme or catalytic domain from any species have failed.

143 dy to the cysteine-rich domain liberates the catalytic domain from autoinhibition, enhancing enzymati

144 y and biochemically characterise the RNase E catalytic domains from four pathogenic bacteria: Yersini

145 The catalytic domain has a metallophosphatase fold, and two

146 nt and implications of the variations in the catalytic domain have not been described, and it is uncl

147 rboring KR1 was engineered, whose individual catalytic domains have been crystallographically charact

148 ependent conformational dynamics of the Cas9 catalytic domains (HNH and RuvC), responsible for concer

149 Overexpression of human TET catalytic domains (hTETCDs) from the TET family members,

150 3 to Val (E183V) mutation in the CaMKIIalpha catalytic domain, identified in a proband diagnosed with

151 Here we report structures of the A3B catalytic domain in a new crystal form that show alterna

152 A non-catalytic domain in A3G binds strongly to RNA, an intera

153 ggesting a role for Set1A independent of its catalytic domain in ESC self-renewal.

154 Expression of the Tet1 catalytic domain in HSCs effectively restored the LT pop

155 Overexpression of the AtCCT1 catalytic domain in Nicotiana benthamiana leaves increas

156 y inositol phosphates, which also bridge the catalytic domain in protein-protein interactions with SA

157 Overexpression of the TET1 catalytic domain in TET1-deficient hESCs significantly i

158 y exposed protein surface extending from the catalytic domain in the C terminus of A3G to its N termi

159 this approach by constructing models for all catalytic domains in the human tyrosine kinase family, u

160 cGAS(CD)-DNA interface (labeled site-C; CD, catalytic domain) in the crystal structure of a human SR

161 2) appears to strengthen the pseudosubstrate-catalytic domain interaction in a nucleotide-dependent m

162 arily via the hybrid binding domain, however catalytic domain interactions also contribute to overall

163 We find the soluble catalytic domain interacts directly with the membrane-as

164 large conformational changes in the GRK5 RH/catalytic domain interface upon receptor binding.

165 via its coiled-coil domain, to reorient the catalytic domain into an active conformation.

166 into the Jumonji domain, which separates the catalytic domain into two fragments (JmjN and JmjC).

167 , which, in turn, use the motion to move the catalytic domains into an active conformation.

168 nomer form a tight hairpin, bringing the two catalytic domains into an active dimerized state.

169 he complex, including one in which the VPS34 catalytic domain is dislodged from the complex but remai

170 The catalytic domain is responsible for binding donor and ac

171 ture of the alpha(3)beta(3)-component of the catalytic domain is similar to those in active F(1)-ATPa

172 o propose that the hinge twisting within the catalytic domain is the key for both enhancement of cata

173 owever, how the NTD activates the C-terminal catalytic domain is unclear.

174 membrane region, which links the NTD and the catalytic domain, is necessary and sufficient for activa

175 are dichain toxins, comprising an N-terminal catalytic domain (LC) disulfide bond linked to a C-termi

176 rvative missense mutations distal to the OGT catalytic domain lead to X-linked intellectual disabilit

177 o 5 pc-9 molecules to the apoptosome and one catalytic domain may be parked on the hub, when an odd n

178 icated that enzymes containing more than one catalytic domain may be particularly powerful in the deg

179 sical interaction between the C-terminal and catalytic domains mediates ARTEMIS autoinhibition.

180 Here, we report an OGT catalytic domain missense mutation in monozygotic female

181 ains binds a single transposon end while the catalytic domain moves to accommodate the varying substr

182 2S762A) and the truncated Mt2 that lacks the catalytic domain (Mt2mask) indicate that the catalytic d

183 is a zinc metalloprotease consisting of two catalytic domains (N- and C-).

184 ntration-dependent manner and the N-terminal catalytic domain of ACT (AC domain) is necessary and suf

185 To mediate repair, we exploit the catalytic domain of Adenosine Deaminase Acting on RNA (A

186 To study this phenomenon, the catalytic domain of APOBEC3G (A3G-CTD), an ssDNA-specifi

187 fully human antibody (MAA868) that binds the catalytic domain of both FXI (zymogen) and activated FXI

188 through direct binding to the conserved HNH catalytic domain of Cas9.

189 poly-proline region found N-terminal to the catalytic domain of choline kinase.

190 strand machinery via an interaction with the catalytic domain of DNA Pol e.

191 Here we targeted the catalytic domain of E3 ligase, CHIP, to YFP-tagged KCNQ1

192 determinants of ubiquitin recognition by the catalytic domain of E6AP and assign them to particular s

193 se possibilities, we genetically deleted the catalytic domain of either EHMT2 or SETDB1 in growing oo

194 We observed no conformational changes in the catalytic domain of either isoform and no corresponding

195 These findings establish a role of the catalytic domain of HDAC5 in the control of cardiomyocyt

196 tructural studies showed that the C-terminal catalytic domain of human A3B has a tightly closed activ

197 e force, velocity and ATPase activity of the catalytic domain of human beta-cardiac myosin have not s

198 Here we report the structure of the catalytic domain of human MANEA and complexes with subst

199 They solved the crystal structure of the catalytic domain of human SQLE alone and in complex with

200 The crystal structure of the catalytic domain of KAT2A in complex with succinyl-CoA a

201 underlying the fine-tuned regulation of the catalytic domain of MORC3 by the epigenetic reader, CW.

202 Mutations in the catalytic domain of Mps1 that give rise to inhibitor res

203 Here, we identify the complete catalytic domain of nSMase2, which was misannotated beca

204 e report a co-structure of HPF1 bound to the catalytic domain of PARP2 that, in combination with NMR

205 ce electrostatic potentials of AfGDH and the catalytic domain of PcCDH might be why their intramolecu

206 mpounds from this series in complex with the catalytic domain of PDE1B and PDE10A were determined, al

207 sensitivity, we found that expression of the catalytic domain of PDE3A in cancer cells lacking PDE3A

208 a homozygous R565Q missense mutation in the catalytic domain of PDE6C, a cone-specific phototransduc

209 um-specific lysine-rich insertion within the catalytic domain of PfCCT acts as a nuclear localization

210 ramide was revealed to interact with the PIK-catalytic domain of PI3KC2beta and affect its compartmen

211 T590 and T597 in the variable insert of the catalytic domain of PIP5K6, and this modification inhibi

212 ion (P-CR), one of two unique domains in the catalytic domain of plant CesAs, was solved to 2.4 A res

213 We have developed techniques to purify the catalytic domain of plasmin, micro-plasmin (uPlm), which

214 The catalytic domain of protein tyrosine kinases can interco

215 Since the catalytic domain of Raf is its kinase domain, we ask the

216 Here, we report the structure of the catalytic domain of recombinant human Artemis.

217 unit of DNA polymerase delta, Pol32, and the catalytic domain of Rev1, a translesion polymerase, act

218 y SPY in planta, while point mutation in the catalytic domain of SPY abolishes the O-fucosylation of

219 le not affecting the activity of a truncated catalytic domain of TDP1 lacking the N-terminal regulato

220 phic fragment screening campaign against the catalytic domain of TDP1 was conducted to identify new l

221 activator-like effector protein fused to the catalytic domain of TET1 (ICR2-TET1) would repress p57 e

222 We identify that a fusion of the catalytic domain of TET1 to dCas9 targeted to the CDKL5

223 Reciprocally, induced expression of the catalytic domain of TET2 led to an obvious increase in h

224 The crystal structure of the F(1)-catalytic domain of the adenosine triphosphate (ATP) syn

225 ATP synthase, upon its dissociation from the catalytic domain of the enzyme.

226 an activating mutation (p.Asp769Tyr) in the catalytic domain of the ERBB2 receptor tyrosine kinase i

227 r plants, utilizing a SunTag system with the catalytic domain of the Nicotiana tabacum DRM methyltran

228 ction between CNNM2 and PRL-1 occurs via the catalytic domain of the phosphatase.

229 d zinc-associated Cys-X-X-Cys motif near the catalytic domain of the protein, decreases SIRT6 deacety

230 re, these crystal structures only reveal the catalytic domain of the protein, residues 80-457.

231 op interaction between the substrate and the catalytic domain of the ribozyme, resulting in a rearran

232 nformation of the substrate, docked into the catalytic domain of the ribozyme.

233 old, the overall structure of the C-terminal catalytic domain of TSP3 is quite different when compare

234 igands that bind in the "palm" region of the catalytic domain of USP7 and inhibit its catalytic activ

235 cular dynamics simulations revealed that the catalytic domain of wild-type Cel7A and the FCA398 varia

236 tion, we report the crystal structure of the catalytic domain of XOAT1, which adopts a unique conform

237 Moreover, the crystal structure of the catalytic domain of zymogen matriptase was solved to 2.5

238 Each Gt(alpha) interacts with the catalytic domains of both catalytic subunits and induces

239 d, we generated fusion proteins in which the catalytic domains of different deubiquitinase (DUB) enzy

240 vestigated the structure and dynamics of the catalytic domains of GDP-bound (inactive) and GTP-bound

241 In addition, using IAV without the stalk and catalytic domains of NA as a live attenuated vaccine was

242 on surface of Pgamma with the regulatory and catalytic domains of Palphabeta in its nonactivated stat

243 strategies have been successfully applied to catalytic domains of protein kinases, Rho family GTPases

244 f unknown structure (J segment), bridges the catalytic domains of the CCTalpha dimer to the membrane-

245 This structure is similar to those of core catalytic domains of the foot-and-mouth disease virus le

246 We combined catalytic domains of Trk (tropomyosin receptor kinase) f

247 onstrates that the two motifs (TM region and catalytic domain) of NMCR-2 are functionally exchangeabl

248 e they have a transmembrane domain and their catalytic domain on the cell surface can function to rel

249 Lyn was nullified by point mutations of Lyn catalytic domain or Src homology 2 (SH2) or SH3 domains

250 A point mutation (A119W) in the catalytic domain or truncating the C-terminal domain of

251 e binding of the herbicide either at or near catalytic domains or in regions affecting access to them

252 to their bacterial counterparts, yet several catalytic domains originated via horizontal gene transfe

253 In addition to its catalytic domain, PHD2 contains an evolutionarily conser

254 ugar-binding pockets spatially closer to the catalytic domain play a major role in the control of pro

255 Dehydratase (DH) catalytic domains play an important role during polyketi

256 AtCCT1 phosphorylation directly affects the catalytic domain rather than interfering with phosphatid

257 membrane helix, and two tandem intracellular catalytic domains referred to as D1 and D2.

258 ious reports have demonstrated that the TET2 catalytic domain remains active independently of the N-t

259 repeats, rather than the C-terminal oxidase catalytic domain, represent the major deacetylase/deacet

260 ding A/PxxS consensus, but uniquely requires catalytic domain residues for intracellular interaction.

261 lytic subunits (Palpha and Pbeta) contains a catalytic domain responsible for cGMP hydrolysis and two

262 lication forks caused by the lack of Pol e's catalytic domains result in greater involvement of mutag

263 and that the separation of its two distinct catalytic domains results in a dramatic loss of both DAH

264 1, which contains an Alu exon peptide in its catalytic domain, RNA sequencing analyses of A-to-I edit

265 hat the linker forms an integral part of the catalytic domain structure, covering a hydrophobic patch

266 ne kinase family, using all available kinase catalytic domain structures from any organism as structu

267 roups that target the ATP-lid portion of the catalytic domain, such as a six-membered ring, confer se

268 e (Sec) residue, revealed a thioredoxin-fold catalytic domain supplemented with an unstructured Omega

269 and CoV-2 viruses are 100% identical in the catalytic domain that carries out protein cleavage.

270 l-1,6-deoxynojirimycin revealed a TIM barrel catalytic domain that contains a deep substrate-binding

271 member of the novel lyase family revealed a catalytic domain that displays an (alpha/alpha)6 barrel-

272 cture revealed an active conformation of the catalytic domain that formed canonical interactions with

273 onserved catalytic domain and a variable non-catalytic domain that functions as the structural scaffo

274 teins contain a bromodomain flanking the HAT catalytic domain that is important for the targeting of

275 tif near the C-terminal region of the PP2C.D catalytic domain that is required for SAUR binding in Ar

276 1 subunit N-terminal domain or in the CaMKII catalytic domain that largely prevent the in vitro inter

277 oth in the N- and C-terminal portions of the catalytic domain, that are important for the subsequent

278 thiolate subdomain away from the rest of the catalytic domain, thereby disrupting the NAD(+) and acet

279 of NRPS catalysis is based around sequential catalytic domains: these are organized into modules, whe

280 etalloproteases (MMPs) with highly conserved catalytic domains, this strategy failed to identify inhi

281 bility of F12 to reversibly bind to the (pro)catalytic domain through K2 with high affinity and highl

282 structures revealing the MCR-1 periplasmic, catalytic domain to be a zinc metalloprotein with an alk

283 s of CesA, accessory proteins, or other CesA catalytic domains to control substrate delivery.

284 here and a globular-structured SUMO-binding catalytic domain, to stabilize p53.

285 -terminal product of CLCA1, encompassing the catalytic domain together with its von Willebrand domain

286 PARP catalytic domains transfer the ADP-ribose moiety from NA

287 stigated DNA methylation by the human DNMT3B catalytic domain using substrate pools containing CpX ta

288 r-expression of two missense variants in the catalytic domain (V142M and P150A) generated aggregated

289 The M domain communicates with the catalytic domain via a conserved ~20-residue linker, ess

290 The X-ray crystal structure of the catalytic domain was determined at 2.1 A resolution and

291 signal the recognition of a DNA break to the catalytic domain, which licenses HPF1 binding and PARP2

292 leotide binding on the structure of myosin's catalytic domain while myosin is in complex with actin.

293 vealed that DddY contains a cap domain and a catalytic domain with a Zn(2+) bound at its active site.

294 hat distinct conformational ensembles of the catalytic domain with different dynamic properties exist

295 Thus, despite sharing the catalytic domain with ROCK2, ROCK1 appears to be the dom

296 carried a glycoside hydrolase family 9 (GH9) catalytic domain with sequence similarity to a gene from

297 -resolution crystal structures of human SQLE catalytic domain with small molecule inhibitors (2.3 ang

298 ger nucleases (ZFNs) that engineers the FokI catalytic domain with the aim of slowing cleavage, which

299 We find that a non-catalytic domain within Cas9, REC3, recognizes target co

300 etermined the crystal structure of human XPG catalytic domain (XPGcat), revealing XPG-specific featur