ライフサイエンスコーパス: catalytic mechanism

1 otation progresses underpin the ATP synthase catalytic mechanism.

2 ling studies are used to provide a tentative catalytic mechanism.

3 fords insight into substrate binding and the catalytic mechanism.

4 aches have revealed critical features of its catalytic mechanism.

5 help to understand the initial steps of the catalytic mechanism.

6 f TRAF6 to cytosolic p62 aggregates by a non-catalytic mechanism.

7 , TC, with direct implications for the eIF2B catalytic mechanism.

8 ural basis for its substrate selectivity and catalytic mechanism.

9 oli, and identify key features of the likely catalytic mechanism.

10 ating that they are likely to share a common catalytic mechanism.

11 ment of transient species important to their catalytic mechanism.

12 me and the structural basis of its inverting catalytic mechanism.

13 es an isomerization process within its known catalytic mechanism.

14 uggested roles for Glu-48 and His-164 in the catalytic mechanism.

15 ide chains to improve activity and probe the catalytic mechanism.

16 utamate residue is not relevant for the PatZ catalytic mechanism.

17 tep in this strictly ordered ternary complex catalytic mechanism.

18 sferases in folds, and share a two-metal-ion catalytic mechanism.

19 to TsdA and can be inferred to use a related catalytic mechanism.

20 in coding segments uncover the two-metal-ion catalytic mechanism.

21 t complexes supports the proposed PPP-family catalytic mechanism.

22 atures of the Fl(N5[O]) species and the EncM catalytic mechanism.

23 hii, strongly supports an active role in the catalytic mechanism.

24 mol for the slowest step in the iron(IV)-oxo catalytic mechanism.

25 binding affinity, catalytic efficiency, and catalytic mechanism.

26 ction to provide structural insight into its catalytic mechanism.

27 and implicate the cofactor oxo group in the catalytic mechanism.

28 tural and spectroscopic investigation of its catalytic mechanism.

29 enzymes, showing convergent evolution of the catalytic mechanism.

30 s and PDE6 that supports an alternating-site catalytic mechanism.

31 sis and structural data provide clues to the catalytic mechanism.

32 nor supports a direct displacement inverting catalytic mechanism.

33 a foundation for understanding the enzyme's catalytic mechanism.

34 lectivity and provide insights into a common catalytic mechanism.

35 ly little experimental information about its catalytic mechanism.

36 hat PL36 alginate lyases may adopt a similar catalytic mechanism.

37 on transfer are both associated with the CCD catalytic mechanism.

38 s as an essential prerequisite for proposing catalytic mechanisms.

39 esis analyses, provide explanations of their catalytic mechanisms.

40 nt control and a deeper understanding of the catalytic mechanisms.

41 secutive reactions by using hitherto unknown catalytic mechanisms.

42 n, and have been shown to exhibit a range of catalytic mechanisms.

43 binding sites, substrate binding sites, and catalytic mechanisms.

44 or the RNA-based RNase P, suggesting similar catalytic mechanisms.

45 scopic and computational characterization of catalytic mechanisms.

46 hibiting divergent substrate preferences and catalytic mechanisms.

47 e a structural basis for understanding their catalytic mechanisms.

48 romises to expand our understanding of their catalytic mechanisms.

49 will enable profound insights into nanoscale catalytic mechanisms.

50 as a key role in the deacylation step of the catalytic mechanism, allowing the acyl-enzyme adduct to

51 sites, details directly supporting a rotary catalytic mechanism analogous to that of the heterohexam

52 ning the reaction thermodynamics and thereby catalytic mechanism and activity.

53 ctenophore photoprotein family, the detailed catalytic mechanism and arrangement of amino acid residu

54 fundamental understanding of the formation, catalytic mechanism and degradation of active sites.

55 rk both for investigations of the class I FH catalytic mechanism and for drug design aimed at fightin

56 a Pseudomonas MDC and give insights into its catalytic mechanism and function.

57 roviding insight into the serine recombinase catalytic mechanism and how resolvase interacts with the

58 However, despite extensive study, the catalytic mechanism and molecular basis of substrate rec

59 tes for an atomic-level understanding of the catalytic mechanism and rational design of high-performa

60 Little is known about the catalytic mechanism and regulation of alarmone synthesis

61 The catalytic mechanism and substrate specificity of a major

62 The catalytic mechanism and substrate specificity of cinnamo

63 ta, challenge previous proposals of the ACLY catalytic mechanism and suggest additional therapeutic p

64 The catalytic mechanism and the active-site fold, however, a

65 wo HO isoforms, HO1 and HO2, exhibit similar catalytic mechanisms and efficiencies.

66 udy on VvAHGD sheds light on the diversified catalytic mechanisms and evolution of NAD(P)(+)-dependen

67 The results provide insights into the enzyme catalytic mechanisms and reveal structural snapshots of

68 ve been determined, although the structures, catalytic mechanisms, and substrate specificities of GH6

69 ghts into the structure of the active sites, catalytic mechanisms, and the long-term cycling stabilit

70 Details of the catalytic mechanism are unknown, and it has been suggest

71 a protein superfamily, and its structure and catalytic mechanism are unknown.

72 luble methyltransferases, and aspects of its catalytic mechanism are unknown.

73 Conventionally, computational studies on catalytic mechanisms are heavily dependent on the chemic

74 ps are well established, key features of the catalytic mechanisms are poorly characterized, including

75 itude suggests the involvement of additional catalytic mechanisms as well.

76 We conclude that the most likely catalytic mechanism begins with abstraction of a hydroge

77 nts at a potential role for adenine-6 in the catalytic mechanism besides the previously identified in

78 metalloenzymes have a crucial impact on the catalytic mechanism beyond their primary chemical proper

79 milar active site structure and an analogous catalytic mechanism, but they exhibit a variety of disti

80 e synthase structure, enabled probing of the catalytic mechanism by mutagenesis, demonstrating the es

81 he fundamental understanding of their unique catalytic mechanisms call for serious advances in this f

82 nge has mostly proved ineffective because of catalytic mechanism constraints and required chaperone c

83 However, the understanding of its catalytic mechanism, despite the recently determined cry

84 ng artificial enzymes with high activity and catalytic mechanism different from naturally occurring e

85 contains a dimetal active site involved in a catalytic mechanism distinct from that of the housekeepi

86 an evolutionarily conserved fold and related catalytic mechanism, each catalytic subunit uses unique

87 e-directed mutagenesis reveal aspects of its catalytic mechanism, especially retinyl moiety isomeriza

88 hen cleaving xylan, suggesting that distinct catalytic mechanisms exist for xylan and glucan cleavage

89 er, no study has unequivocally established a catalytic mechanism for (p)ppGpp synthesis.

90 We propose a catalytic mechanism for alpha-N-terminal methylation.

91 reported kinetics data, we propose a refined catalytic mechanism for Chd-mediated TPN dehalogenation.

92 for convergent evolution toward a conserved catalytic mechanism for citrate production.

93 We propose a catalytic mechanism for Cu(II)-enhanced NfoR activity in

94 On the basis of (77)Se-NMR experiments, a catalytic mechanism for diselenide 6 was proposed involv

95 CglI and NgoAVII enzymes may employ a unique catalytic mechanism for DNA cleavage.

96 e, arguing that OLD proteins use a conserved catalytic mechanism for DNA cleavage.

97 n the catalytic pathway and suggest a common catalytic mechanism for Nudix hydrolases.

98 The catalytic mechanism for oxidizing alcohols to carboxylat

99 ient to hydrolyze PGP, indicating a specific catalytic mechanism for PgpB in PG biosynthesis.

100 llow us to propose a pitcher-catcher type of catalytic mechanism for the isomerization.

101 ions of an unprecedented dynamic single-atom catalytic mechanism for the oxidation of carbon monoxide

102 The catalytic mechanism for the production of H2 and CO2 fro

103 lations were used to identify a preferential catalytic mechanism for the transformation of acetylene,

104 A catalytic mechanism for this unique enzyme is proposed.

105 results presented support bioorganometallic catalytic mechanisms for IspG and IspH, and open up new

106 '-triphosphates (NTPs) could help define the catalytic mechanisms for nucleotidyl transfer during RNA

107 AP/UBE3A suggest convergent evolution of the catalytic mechanisms for prokaryotic and eukaryotic liga

108 for environmental remediation, but detailed catalytic mechanisms for these enzymes are not yet known

109 ling high-resolution snapshots of the entire catalytic mechanism from the initial to final reaction s

110 Its catalytic mechanism has been explored in great detail by

111 Still, its exact catalytic mechanism has remained unclear.

112 Several different catalytic mechanisms have been proposed for the [FeFe] e

113 residues suggests that IcaB uses an altered catalytic mechanism in comparison to other characterized

114 ble implications for elucidating the elusive catalytic mechanism in LTs and expansins.

115 transport chain for the understanding of the catalytic mechanism in SCD1.

116 ing a well-defined platform for studying the catalytic mechanism in the solution phase.

117 The catalytic mechanism in the STAO is determined by a new s

118 structural and functional data to unveil the catalytic mechanism in unprecedented detail, including t

119 We propose a catalytic mechanism in which lysine-180 acts as a cataly

120 C proteins transfer palmitate via a two-step catalytic mechanism in which the enzyme first modifies i

121 This unusual arrangement suggests a catalytic mechanism in which the two copies of dIII alte

122 Although catalytic mechanisms in natural enzymes are well underst

123 f DMSP cleavage, enabling elucidation of the catalytic mechanism, in which the residue Tyr271 of DddY

124 The structures reveal the underlying catalytic mechanism, in which two zinc ions activate a w

125 lyses reveal critical details of the Cd-MsrB catalytic mechanism, including a major structural rearra

126 However, little is known about the catalytic mechanisms, including the parameters that dete

127 We propose a general acid base-promoted catalytic mechanism, invoking direct nucleophilic attack

128 The proposed catalytic mechanism involves consecutive alkyne-carbonyl

129 l group was produced, consistent with a RedG catalytic mechanism involving hydrogen abstraction from

130 Computational studies implicate a catalytic mechanism involving initial kinetic differenti

131 mutational, kinetic and modeling analyses, a catalytic mechanism involving leaving group stabilizatio

132 rium labeling studies, are consistent with a catalytic mechanism involving olefin-dione oxidative cou

133 PKA) and computational studies corroborate a catalytic mechanism involving rapid allene hydrometalati

134 afel slope of 150 mV/decade, indicative of a catalytic mechanism involving rate-limiting one-electron

135 itions, along with other data, corroborate a catalytic mechanism involving ruthenium(0)-mediated alle

136 On the basis of these results, we propose a catalytic mechanism involving substrate tautomerization,

137 w functionally characterized members share a catalytic mechanism involving the oxidation of an amine

138 the active site and analysis of kinetics, a catalytic mechanism involving two water molecules and re

139 amplitude and oxidation/reduction peaks, the catalytic mechanism is an electron-proton coupled proces

140 Sequence analysis suggests that the proposed catalytic mechanism is common for bacterial Tmms.

141 Sequence comparisons suggested that the catalytic mechanism is conserved among the bacterial hom

142 ding and catalysis and demonstrated that the catalytic mechanism is conserved between human and plant

143 hat, contrary to our initial hypotheses, the catalytic mechanism is monometallic and proceeds via dea

144 This finding suggests that the catalytic mechanism is more similar to the mechanism of

145 A catalytic mechanism is proposed.

146 y mutagenesis studies, and a structure-based catalytic mechanism is proposed.

147 Therefore, an in-depth understanding of the catalytic mechanism is required for advancing the design

148 A notable feature of its catalytic mechanism is that it forms a stable product-re

149 lativorans (ex. Mesorhizobium) sp. BNC1, its catalytic mechanism is unknown.

150 ymes use a single-metal ion, but the precise catalytic mechanism is unknown.

151 Although their catalytic mechanism is well characterized and the cataly

152 ytosine C5)-methyltransferases have a common catalytic mechanism, it is likely that other enzymes of

153 Furthermore, using a non-catalytic mechanism, MMP-9 promotes rounded-amoeboid 3D

154 PIEZOelectric semiconductors, their possible catalytic mechanisms, novel techniques to produce their

155 h a kinetics framework for understanding the catalytic mechanism of [FeFe] hydrogenases.

156 is study reveals the molecular structure and catalytic mechanism of a PL36 alginate lyase, broadening

157 op new strategies to probe the structure and catalytic mechanism of a ribozyme.

158 Our experiments support a catalytic mechanism of acetylation where residues D567 a

159 talytic acid, which represents a new kind of catalytic mechanism of alginate lyases.

160 Here we have studied the catalytic mechanism of alkaline phosphatase (AP), which

161 The hypothesized catalytic mechanism of alpha-terpineol-to-1,8-cineole co

162 The results reveals a conserved catalytic mechanism of AlucJHEH toward JH.

163 d on structural and mutational analyses, the catalytic mechanism of Aly36B for alginate degradation w

164 To probe the catalytic mechanism of Aly36B, the structures of wild-ty

165 , providing further support for the proposed catalytic mechanism of AmiA.

166 er, the role of fast dynamics in the overall catalytic mechanism of an enzyme has not been addressed.

167 We report the crystal structure and the catalytic mechanism of Asp f3, a two-cysteine type perox

168 To elucidate the catalytic mechanism of ATP hydrolysis by YchF, we have t

169 These findings provide insight into the catalytic mechanism of ATP-grasp enzymes.

170 our findings provide fresh insight into the catalytic mechanism of AURKA, and identify a key structu

171 The catalytic mechanism of BACE-1 requires water-mediated pr

172 While the iterative catalytic mechanism of bacterial NRPSs is known, it rema

173 These findings unveil a one-base catalytic mechanism of C2 deprotonation/reprotonation vi

174 ly, these data give a new perspective on the catalytic mechanism of CCoAOMTs and provide a basis for

175 However, the detailed catalytic mechanism of CE is unclear due to the lack of

176 and galacturonate provide insights into the catalytic mechanism of CE15.

177 The catalytic mechanism of class A beta-lactamases is often

178 ction of the conserved residue Lys 73 in the catalytic mechanism of class A type beta-lactamase enzym

179 e structural framework and insights into the catalytic mechanism of CpsUbiX.

180 EPR-based strategies for investigating the catalytic mechanism of decarboxylation are complicated b

181 irical valence bond simulations to probe the catalytic mechanism of DFPase as well as temperature, pH

182 active strategy to understand the underlying catalytic mechanism of different edge sites and improve

183 s and provide insights for understanding the catalytic mechanism of dithiol oxidases involved in natu

184 ovide insights into the atomic structure and catalytic mechanism of DNase II.

185 The proposed catalytic mechanism of DNMT1 involves nucleophilic attac

186 Here, we investigated the catalytic mechanism of DNMT3A for cytosine N3 methylatio

187 at T775 has an essential dynamic role in the catalytic mechanism of DNMT3B.

188 irected mutagenesis allowed us to derive the catalytic mechanism of DrrA from the FTIR difference spe

189 view the knowledge about the structure-based catalytic mechanism of each enzyme of hydrogenotrophic m

190 This work reveals the catalytic mechanism of EBP-mediated isomerization in cho

191 d acyl chains, and provides insight into the catalytic mechanism of enzymes within the MBOAT family(8

192 Protein mass-modulated effects in the catalytic mechanism of Escherichia coli dihydrofolate re

193 nds of introns and provides insight into the catalytic mechanism of exon ligation.

194 active site, consistent with studies of the catalytic mechanism of GlpG that suggest that TM5 serves

195 The structure and catalytic mechanism of group II introns have recently be

196 is finding radically changes the view on the catalytic mechanism of H2O2 production by Cu-Abeta, and

197 ogether, our results suggested the potential catalytic mechanism of hydroxylation by YfcM.

198 The catalytic mechanism of iron oxidation in the ferritin fa

199 This study provides insight into the catalytic mechanism of JIP60.

200 The possible catalytic mechanism of LM nanozymes was also proposed.

201 s with co-substrate NADPH and PEG, suggest a catalytic mechanism of MtmW.

202 ich may provide new avenues for studying the catalytic mechanism of nitrogenase.

203 tive of the key intermediate-in our proposed catalytic mechanism of NosN.

204 Many questions remain about the catalytic mechanism of OxDC although it has been propose

205 stability of plausible intermediates in the catalytic mechanism of OxDC, and suggests that removal o

206 us closer to understanding the structure and catalytic mechanism of P450 BM3.

207 To study the catalytic mechanism of phosphorylation catalyzed by cAMP

208 nsights into the product specificity and the catalytic mechanism of protein arginine methyltransferas

209 s and serve as a model for understanding the catalytic mechanism of related heterogeneous systems.

210 The catalytic mechanism of RlmH enzyme is unknown.

211 nd experimental approaches shed light on the catalytic mechanism of Salmonella FraB and of phosphosug

212 tions in the SA binding site, we propose the catalytic mechanism of SGE and SAG formation and that SA

213 rovides an excellent platform to examine the catalytic mechanism of sulfoxide synthases by comparativ

214 n atoms, and computation to characterize the catalytic mechanism of the enzyme.

215 rting point for research on the dynamics and catalytic mechanism of the HDV ribozyme and demonstrate

216 Although some aspects of the catalytic mechanism of the Msr enzymes have been reporte

217 H-bond and dispersion contact as part of the catalytic mechanism of the Na(+),K(+)-ATPase.

218 The catalytic mechanism of the organic oxidases has been elu

219 ystal structure of TPST2, which revealed the catalytic mechanism of the tyrosine sulfation reaction.

220 the stroma and consistent with the canonical catalytic mechanism of these enzymes.

221 of AaTPS and FgGS provide insights into the catalytic mechanism of this cryptic function.

222 The complex catalytic mechanism of this enzyme reaction has emerged

223 anges in structural dynamics with the unique catalytic mechanism of this enzyme.

224 and its role in substrate binding and in the catalytic mechanism of this family.

225 ich do not provide information regarding the catalytic mechanism of this important enzyme.

226 tification of intermediates, elucidating the catalytic mechanism of this multi-redox reaction on meta

227 ctural and kinetic evidence, we describe the catalytic mechanism of this unusual C-S bond-forming rea

228 However, the catalytic mechanism of this very unusual sulfur-sacrific

229 ine bacterial Tmm (RnTmm) and elucidated the catalytic mechanism of TMA oxidation by RnTmm.

230 derstanding of the substrate recognition and catalytic mechanism of Tps2 and provide a structural bas

231 n calorimetry experiments to investigate the catalytic mechanism of Trm10 in vitro.

232 ates in VAO, providing new insights into the catalytic mechanism of VAO and related enzymes that oxid

233 To explain the catalytic mechanism of VvAHGD, we solved the structures

234 Our results provide insights into the catalytic mechanism of Xer recombination and a model for

235 Identifying catalytic mechanisms of CO(2) reduction in (photo)electr

236 equence alignment suggests that the proposed catalytic mechanisms of DmdB and DmdC are likely widely

237 D have been proposed, little is known of the catalytic mechanisms of DmdB and DmdC, which are central

238 al and biochemical analyses to elucidate the catalytic mechanisms of DmdB and DmdC.

239 es common to natural heme-containing enzymes.Catalytic mechanisms of enzymes are well understood, but

240 icantly advanced in our understanding of the catalytic mechanisms of GHs and GTs, not only the molecu

241 ural studies have focused on elucidating the catalytic mechanisms of individual multidomain proteins

242 overview of recent progress in understanding catalytic mechanisms of perovskite and pyrochlore oxides

243 Till now, the structures or catalytic mechanisms of PL36 alginate lyases have yet to

244 informatic results, provide insight into the catalytic mechanisms of the Cy domain and implicate a pr

245 elis complexes, which illuminate distinctive catalytic mechanisms of the lysine adenylylation reactio

246 actor and substrate binding sites and on the catalytic mechanisms of these enzymes, comparing them wi

247 rase (DGAT) enzymes(2-4), the structures and catalytic mechanisms of which remain unknown.

248 mental studies have suggested that different catalytic mechanisms operate depending on the type of AT

249 n paid to improving our understanding of its catalytic mechanisms or substrate preferences.

250 RNA synthetase classes possess sophisticated catalytic mechanisms: pre-steady state bursts, significa

251 nding direct support to the 'ping-pong'-like catalytic mechanism proposed for YopJ effectors.

252 The DddY structure and proposed catalytic mechanism provide a better understanding of ho

253 on the structure-function relationships and catalytic mechanisms provide insights into biocatalytic

254 uitous Prx scaffold, and their structure and catalytic mechanism reconcile a plethora of partly confl

255 hese enzymes, including structural features, catalytic mechanisms, regulation, and many other aspects

256 A controversy has arisen regarding its catalytic mechanism related to the function of the activ

257 This Review critically examines the catalytic mechanisms relevant to each specific applicati

258 lusively by hydrogen bonds, and the proposed catalytic mechanism requires multiple proton-transfer ev

259 The reported dynamic single-atom catalytic mechanism results from the ability of the gold

260 Although these proteases use an unrelated catalytic mechanism, rotation of equivalent helices cont

261 However, the catalytic mechanism(s) of AHGDs is still unclear.

262 ded information relevant to describing their catalytic mechanism(s).

263 ar but distinct active-site architecture and catalytic mechanism shared between BcsG and the colistin

264 is a zinc-dependent metallopeptidase with a catalytic mechanism similar to that of glutamate carboxy

265 found that this enzyme follows an acid-base catalytic mechanism similar to the bacterial DHNAs, exce

266 elds of biosensors, fuel cells, solar cells, catalytic mechanism studies, and bioelectrosyntheses of

267 complex, yielding seminal insights into its catalytic mechanism, substrate specificity, allosteric r

268 that P. aerophilum EtfABCX provides a model catalytic mechanism that builds on and extends previous

269 re-guided mutagenesis, leads us to propose a catalytic mechanism that establishes LarE as a paradigm

270 Following a catalytic mechanism that is insufficiently understood, E

271 ncy, providing an unusual substrate-assisted catalytic mechanism that limits efficient ubiquitin tran

272 d by the genetic code restricts the range of catalytic mechanisms that are accessible in designed act

273 ting the redox balance, and they do so using catalytic mechanisms that are intrinsically vulnerable t

274 ubstrate binding and the two-cation-assisted catalytic mechanisms that are shared by eukaryotic C3POs

275 We cover the molecular architecture and catalytic mechanisms that distinguish SIRT6 from other N

276 Emphasis is placed on reaction types and catalytic mechanisms that showcase both the chemical div

277 ay structure of NadA will help us unveil its catalytic mechanism, the last step in the understanding

278 itive bacteria but little is known about the catalytic mechanisms they employ for succinate oxidation

279 More significantly, simplification of catalytic mechanisms through the incorporation of chemic

280 ing us with the most thorough picture of the catalytic mechanism to date.

281 t-driven model, this approach offers a novel catalytic mechanism to irreversibly inhibit protein func

282 We propose two catalytic mechanisms to account for our experimental res

283 FPase and PON1 also likely utilize identical catalytic mechanisms to hydrolyze their respective subst

284 The catalytic mechanisms underlying Escherichia coli alkalin

285 quantitative and detailed description of the catalytic mechanism utilized by DsbA that offers insight

286 esult, gaining atomic-level insight into the catalytic mechanism via electron paramagnetic resonance

287 A two-step catalytic mechanism was extrapolated: the catalyst trans

288 The catalytic mechanism was studied by performing deuterium-

289 the substrate-lsBSH complex and the putative catalytic mechanism were explored with molecular dynamic

290 Insights into the catalytic mechanism were gained by using variable concen

291 of the single-metal (Mg(II)) center, several catalytic mechanisms were carefully examined.

292 perature indicate that reaction occurs via a catalytic mechanism where changes to the positions of eq

293 ATP synthases operate by a rotary catalytic mechanism where proton translocation through t

294 of a 17-HOPC-CoA -docked model, we propose a catalytic mechanism where Tyr-294 acts as the general ba

295 omputational studies indicate a bifunctional catalytic mechanism whereby the thioimidate activates th

296 ed us to deduce a detailed and complete IspG catalytic mechanism, which describes all stages from ini

297 lysis implicated two ionizable groups in the catalytic mechanism, which we postulate to be Ser-491 an

298 ficity by retaining core closure as a common catalytic mechanism while optimizing substrate-binding i

299 strate selectivity and access to alternative catalytic mechanisms with only a few mutations.

300 core metabolic enzymes that share a fold and catalytic mechanism yet possess strict specificity for t