ライフサイエンスコーパス: catalytic site

1 he nucleotide monophosphate product from the catalytic site.

2 of two protein subunits, each containing one catalytic site.

3 trate-binding pocket providing access to the catalytic site.

4 te, resulting in an allosteric switch in the catalytic site.

5 s of lentil peptides and residues of the ACE catalytic site.

6 pn11, which controls ubiquitin access to its catalytic site.

7 mbrane tunnel that converge at the predicted catalytic site.

8 atin-like subdomain of PNPLA1 containing the catalytic site.

9 ation of adenosine triphosphate (ATP) to the catalytic site.

10 r phosphatase, despite containing a putative catalytic site.

11 idues Ser773 and Ser774 in the PI3Kalpha ATP catalytic site.

12 all fungal P450 inhibitors, that dock in the catalytic site.

13 tion of a radical with a metal cofactor of a catalytic site.

14 que C-terminal domain harboring the putative catalytic site.

15 xin inhibitors that do not interact with the catalytic site.

16 ATX but no interaction with zinc ions of the catalytic site.

17 tions of a collagen triple helix with an MMP catalytic site.

18 result of the steric environment around the catalytic site.

19 (SAM) or S-adenosylhomocysteine (SAH) in the catalytic site.

20 ting a new composite surface adjacent to the catalytic site.

21 -RhoGAP contains two arginine fingers at its catalytic site.

22 e binding of the two substrate waters to the catalytic site.

23 a position at the bottom of V1 near an open catalytic site.

24 ects of the inhibitors on the RNA polymerase catalytic site.

25 rate, orienting its targeted arginine to the catalytic site.

26 ergy, but the effect of Y208F extends to the catalytic site.

27 as only associated with proton uptake to the catalytic site.

28 the enzyme, and the oxidized NAD leaves the catalytic site.

29 ng sites to ensure full metal loading of the catalytic site.

30 ream kinase (RSK1) faces the enzyme's (ERK2) catalytic site.

31 ts in a decrease in enzyme reactivity at the catalytic site.

32 H)(2) domain and restricts access to the XPF catalytic site.

33 es capable of binding two metal atoms in the catalytic site.

34 isplacing the phosphate nucleophile from the catalytic site.

35 of more than 10,000 experimentally annotated catalytic sites.

36 se holoenzymes contain fast- and slow-acting catalytic sites.

37 s nSH2 to release its autoinhibition of p110 catalytic sites.

38 a route to custom design ligand-binding and catalytic sites.

39 eight small (RbcS) subunits containing eight catalytic sites.

40 tion sites are more densely populated at the catalytic sites.

41 from inhibitor release and rebinding to PNP catalytic sites.

42 a large density of exposed surface reactive/catalytic sites.

43 can have access to both the ATP-binding and catalytic sites.

44 , CN(-), and CO at three well-differentiated catalytic sites.

45 m (Pt) single atoms are exceptionally active catalytic sites.

46 bound reactants and five are remote from the catalytic sites.

47 affinity for ATP in both the allosteric and catalytic sites.

48 ng was hypothesized to prevent ATP access to catalytic sites.

49 AD+ in an allosteric location, away from the catalytic sites.

50 terlinking the inhibitor with regulatory and catalytic sites.

51 ponsible for the affinity differences of the catalytic sites.

52 (1) How do OH groups on MOF nodes act as catalytic sites?

53 y high concentration of atomically dispersed catalytic sites (9.7x10(20) sites g(-1) ) capable of cat

54 In contrast to catalytic-site ABL1 kinase inhibitors, ABL001 binds to t

55 y of the extended arrays of enantioselective catalytic sites achieve template-directed polymerization

56 highly conserved structural features of the catalytic sites across the class.

57 s, while a divalent cation is located at the catalytic site, acting as a cofactor.

58 o its roles in the elevation of PI3,5P2: its catalytic site, an N-terminal disease-related surface, a

59 nhibitory conformation, with a self-occluded catalytic site and a fully-closed cofactor pocket.

60 The presence of a structurally divergent catalytic site and a proline-rich C-terminal subdomain s

61 variants formed a distorted and inactivated catalytic site and confirmed that the pentamer interacti

62 S variants which affect the structure of the catalytic site and either decrease or increase the RNase

63 in an increase in the affinity of GTP at the catalytic site and full activation of sGC.

64 f a type II HE with a receptor analog in the catalytic site and identify the mutations underlying the

65 fferences in organization of the ferroxidase catalytic site and neighboring secondary metal-binding s

66 at the surface of domain A, distant from the catalytic site and not previously identified in other gl

67 ws them to shuttle protons in and out of the catalytic site and reduce activation barriers.

68 entarity enhance peptide affinity beyond the catalytic site and support a limited selectivity model f

69 ns, revealing that His-257 is located in the catalytic site and that the substitution does not produc

70 terms that reflect the proficiencies of the catalytic site and the electron transfer pathway in each

71 HO2 has three heme binding sites: one at its catalytic site and the others at its two heme regulatory

72 tudied, yet issues such as the nature of the catalytic site and the role of the reducible support rem

73 structures, acting as a mediator between the catalytic site and the sugar-binding pockets of domain V

74 n situ measurements enable identification of catalytic sites and reaction intermediates, which facili

75 tial binding of an ATP molecule to its three catalytic sites and the release of the products of hydro

76 in contrast, acts as a monomer with only one catalytic site, and cleaves the DNA strands sequentially

77 ail that appears to block access to the CpaA catalytic site, and functional experiments with truncate

78 ent progress on the structure of the natural catalytic site, and on inorganic catalyst function, dete

79 een them was lost upon mutation of the AtMC1 catalytic site, and that the AtMC1 prodomain was not req

80 Mo-cofactor, which provides the N(2)-binding catalytic site, and the other is an 8Fe-7S species desig

81 t restriction enzymes act as dimers with two catalytic sites, and cleave the two strands of duplex DN

82 istidine residue in position 265 of the CdtB catalytic site appeared to play a role in the regulation

83 th a pair of deep clefts each containing two catalytic sites appropriately positioned and oriented fo

84 he ceramide binding pocket and putative zinc catalytic site are exposed to the inner membrane leaflet

85 We propose the active catalytic sites are cationic interfacial Pt atoms bonded

86 We show that the Stealth domain harbors the catalytic site, as some mutations in these regions great

87 has led to extensive investigation of their catalytic sites at an atomic scale, and to an in-depth u

88 Engineering catalytic sites at the atomic level provides an opportun

89 8 enzymes, as annotated in the Mechanism and Catalytic Site Atlas (M-CSA), and compare our results wi

90 luate whether sequence identity, InterPro or Catalytic Site Atlas sequence signatures provide enough

91 de synthase and TRYPSIN-like enzyme sites in Catalytic Site Atlas, and showed good performance on cha

92 on of CO2 can be achieved on multifunctional catalytic sites available at the metal/oxide interface b

93 The uniform catalytic sites available in MOFs provide a unique oppor

94 nd the molecular level details regarding the catalytic sites before and during the MDA reaction.

95 not only in the proteolytic activity of the catalytic sites but also in the peptide transport.

96 tutions cluster in regions adjacent to ATL's catalytic site, but the consequences for the GTPase's mo

97 he affected subsites that were closer to the catalytic site, but without affecting their ability to s

98 e amphiphilic polymer and proximal to copper catalytic sites, but with unprecedented rates.

99 tion by these segments is transmitted to the catalytic sites by the DELSEED loop in the C-terminal do

100 trates that NSAH functions by binding at the catalytic site (C-site) where it makes both common and u

101 simple yet elegant model by which a protein catalytic site can confer catalytic bias.

102 ueprint for somatic mutations as well as the catalytic site can guide therapeutic targeting of PFK1 a

103 ght or ten hydrophobic layers are perturbed, catalytic sites can be introduced at other regions of th

104 the active site and the conformation of the catalytic site cavity at near-physiological temperature.

105 Structural modeling and comparisons, catalytic-site changes and an interspecies chimera indic

106 dicts that this protease adopts a fold and a catalytic site characteristic of minimal PLP catalytic d

107 alent metal ion(s) (Mg(2+) or Mn(2+)) in its catalytic site: chelation of these metal cofactors is an

108 probed for local or global contributions to catalytic site chemistry by generating [15N, 2H]His8-PNP

109 iction is experimentally supported by slowed catalytic site chemistry in isotopically labeled PNP (13

110 [15N, 2H]His8-PNP had reduced catalytic site chemistry larger than proportional to the

111 Catalytic site chemistry was slowed for both [2H]PNP and

112 of the larger protein architecture to alter catalytic site chemistry.

113 itively charged channel connected to the CTD catalytic site, consisting of NTD loop-1 and CTD loop-3.

114 The catalytic site contained bound Fe(2+) and N-oxalylglycin

115 e avenues, including direct targeting of the catalytic sites, controlling disease-associated protein-

116 y a flexible linker and is far away from the catalytic site, couples F-actin to the enhancement of re

117 on reduction of N2O occurs at a [Cu4(mu4-S)] catalytic site (CuZ*) embedded within the nitrous oxide

118 dentification of a putative C-terminal REase catalytic site D507-H508-N522.

119 inorganic form, aerogels can have ultrahigh catalytic site density, high surface area, and tunable p

120 for organizing high concentrations of single catalytic sites derived from metallic or oxo-metallic no

121 heme deficiency, loss of heme binding to the catalytic site destabilizes HO2.

122 ferent functional states captured in its six catalytic sites, details directly supporting a rotary ca

123 tionships Knockdown of GAPDH1 expression and catalytic site disruption validate the essentiality of G

124 ecular basis for the affinity changes of the catalytic sites during ATP synthase rotation.

125 of the recognition residues relative to the catalytic site enabling this enzyme to cleave the recogn

126 We show that mutation of the Fig4 catalytic site enhances the formation of the Fab1-Vac14-

127 a large water-filled membrane chamber whose catalytic site faces the chamber interior.

128 ssing when only His are heavy supports local catalytic site femtosecond perturbations coupled to tran

129 ening, and closes upon disengagement, of the catalytic site following ATP hydrolysis.

130 nown as UCR2, that opens and closes over the catalytic site for cAMP hydrolysis.

131 HRM-bound heme is readily transferred to the catalytic site for degradation to facilitate turnover bu

132 xidation in the BFR cavity, to the di-ferric catalytic site for safe reduction of O2.

133 entral cavity facilitate the exposure of the catalytic site for substrate cleavage.

134 (i) the identification of the most relevant catalytic site for the oxygen reduction reaction (ORR) a

135 anion control as a concept for the design of catalytic sites for C-H bond activation, thereby enablin

136 were required, and the defect alone acted as catalytic sites for carbon dioxide activation and hydrog

137 patite, are highly active and coke-resistant catalytic sites for DRM.

138 nanolayers, creating superactive nonmetallic catalytic sites for HER that are more active than those

139 A to form esters, (2) these OH groups act as catalytic sites for TBA dehydration to isobutylene, and

140 solid solutions possess more active iridium catalytic sites for the oxygen evolution reaction (OER)

141 er interactions are essential for productive catalytic site formation.

142 polar aminoacyl-tRNA substrate to access the catalytic site from opposite directions.

143 ron, which forces open a short tunnel to the catalytic site gated by the ValG8/IleE15 pair and LeuE11

144 nerates dimer and dNTP binding to the A2 and catalytic sites generates active tetramer.

145 ynamics of native and F159Y PNPs explore the catalytic-site geometry associated with these catalytic

146 ic uncoupling of femtosecond motions between catalytic site groups and reactants decreased transition

147 The [FeFe]-hydrogenase catalytic site H cluster is a complex iron sulfur cofact

148 golgin-97/245-binding, but not the putative catalytic site, impairs neuronal growth and brain develo

149 of dual inhibitor recognition involving the catalytic site in both enzymes.

150 ains a DFDxD sequence motif, which forms the catalytic site in cellular multisubunit RNA polymerases

151 , the B3 and B4 loops, located closer to the catalytic site in TrCel7A, were less important for these

152 ransport of both charge and substrate to the catalytic sites in an efficient manner.

153 providing a physical connection between the catalytic sites in F(1) and the proton translocation cha

154 ay extending from one end of the molecule to catalytic sites in its center.

155 Sequential engineering of multiple catalytic sites in MOFs thus presents a unique opportuni

156 al results show that the S-vacancies are new catalytic sites in the basal plane, where gap states aro

157 synthesis and hydrolysis, which occur at the catalytic sites in the beta subunits.

158 A, carrying mutations at the predicted MTase catalytic sites in the L protein, were highly attenuated

159 ineating the structures and functions of the catalytic sites in two MMOs: soluble methane monooxygena

160 e pairs need to be stretched between the two catalytic sites, in order for a scissile phosphate to at

161 as for management of proton activity around catalytic sites, including those for water oxidation and

162 target-guided synthesis to design the first catalytic site inhibitor of IDE suitable for in vivo stu

163 n conformation that exposes the transamidase catalytic site involved in protein-protein crosslinking.

164 The low-pH proton configuration in the catalytic site is deemed critical for the catalytic acti

165 The catalytic site is defined by a fortuitous benzoic acid m

166 However, although the betaE-catalytic site is in the usual "open" conformation, it i

167 ospho-glucuronosyltransferases (UGTs), whose catalytic site is located within the smooth endoplasmic

168 site, which selectively binds iron when the catalytic site is occupied.

169 se (TIM)'s dimer interface, distant from its catalytic site, is a target site for certain benzothiazo

170 the homogeneous controls, likely a result of catalytic site isolation in the MOF which prevents bimol

171 event the placement of aminoacyl-tRNA in the catalytic site, it is commonly assumed that these drugs

172 weakly frustrated interactions surrounds the catalytic site itself.

173 ons revealed an elongated dimer with the two catalytic sites located on opposite sides.

174 However, their wide and polar catalytic sites make them a challenging target for ortho

175 Extent, timing, and role of non-catalytic-site movements are unknown.

176 Using catalytic site mutants to create Rad50 dimers with only

177 deglycination of glutathione conjugates, as catalytic-site mutants of PCS1 are still functional in i

178 Catalytic site mutations of D9 and D10, but not of eithe

179 is virus strain A59 (MHV-A59) with a mutated catalytic site (N1348A) replicated similarly to wild-typ

180 We observe that the catalytic site natively adopts a zwitterionic reactive f

181 with Ras.GTP binding as a substrate for the catalytic site of activated Sos more weakly than Ras.GDP

182 placed between nucleosides 10 and 12, at the catalytic site of Argonaute.

183 nd therefore from their interaction with the catalytic site of ArnT, an ent-beyerane scaffold is requ

184 transported by the ATP/ADP antiporter to the catalytic site of bound hexokinase or bound creatine kin

185 onstrate that Endosidin20 (ES20) targets the catalytic site of CESA6 in Arabidopsis (Arabidopsis thal

186 ound clinical drug darunavir, located in the catalytic site of enzyme HIV-1 protease.

187 cleoside reversible inhibitor binding at the catalytic site of hRRM1 provides a starting point for th

188 tion suggests that 1a prefers binding at the catalytic site of hTMPK, whereas the hTMPK inhibitors th

189 redicted femtosecond dynamic coupling at the catalytic site of human purine nucleoside phosphorylase

190 single amino acid substitution (K92E) in the catalytic site of its Nudix domain that renders it catal

191 n-like site is readily delivered to an empty catalytic site of metal-free HAO via an intermolecular t

192 Evidence that the catalytic site of MIF family cytokines has a structural

193 ron transfer (ET) from the Fe-protein to the catalytic site of MoFe-protein and how energy from ATP h

194 the formation of which is suppressed in the catalytic site of most DNA polymerases.

195 he behavior of 1 mimics aspects of the Cu(Z) catalytic site of nitrous oxide reductase: activity in t

196 tranded beta-helix fold that constitutes the catalytic site of PHD isoforms appeared responsible for

197 strate that KPT-6566 covalently binds to the catalytic site of PIN1.

198 elevated accessibility of ester bonds to the catalytic site of RoL due to increasing polyester chain

199 protein structure predictions, the putative catalytic site of SMase activity is in the alpha2 region

200 emonstrate that inactivating mutation of the catalytic site of SULF1 impairs the above actions of SUL

201 .Lys53Arg) that affects the structure of the catalytic site of the bifunctional enzyme phosphoribosyl

202 via targeted amino acid substitution in the catalytic site of the C-terminal nucleotide binding doma

203 mpared it to the conformation adopted in the catalytic site of the EAL phosphodiesterases (PDEs).

204 ed by a mutation in LDHD within the putative catalytic site of the encoded d-lactate dehydrogenase, r

205 onal changes in the enzyme, including in the catalytic site of the enzyme.

206 ernative splicing of the region encoding the catalytic site of the enzyme.

207 sensing the effects of ligand-binding to the catalytic site of the H-cluster.

208 domain is essential for all three steps, the catalytic site of the intracellular RapGAP is engaged in

209 e PRNTase (capping) domain projects into the catalytic site of the RdRp, where it appears to have the

210 phospho-glucuronosyltransferases (UGTs), the catalytic site of which is located within the SER lumen.

211 nymous small nucleotide variations) near the catalytic sites of 17 enzymes frequently lost in cancer.

212 The catalytic sites of acidic zeolite are profoundly altered

213 In the presence of Mg(2+), the three catalytic sites of ATP synthase have vastly different af

214 The more enclosed catalytic sites of human MTAP require the inhibitors to

215 the development of functional models of the catalytic sites of MMOs is described.

216 ggests that several key residues outside the catalytic sites of PEDV nsp5 probably impact NEMO cleava

217 TP or nucleotide-free) at the allosteric and catalytic sites of Sos was comprehensively characterized

218 to-tail arrangement causes the RFK and FMNAT catalytic sites of the two neighboring protomers to appr

219 two regulatory phosphorylation sites and the catalytic site on human CaMKK2.

220 processes at highly active and well-defined catalytic sites on a light-harvesting electrode surface.

221 apable of providing hole escape from protein catalytic sites on biologically relevant timescales.

222 at during RCF tests the formation of nascent catalytic sites on the wear track can break down hydroca

223 radation (LID) region of hTMPK and block the catalytic site or ATP-binding site, thus attenuating the

224 orporation is useful, for example to confine catalytic sites or create electrically conducting pathwa

225 hat a number of ISG15 modifications occur at catalytic sites or dimerization interfaces of enzymes.

226 reported ASD substitutions are located near catalytic sites or within highly conserved regions of th

227 sting of a hydroxylase with a nonheme diiron catalytic site; pMMO is a membrane-bound metalloenzyme w

228 e of stacked tetramers oriented with exposed catalytic sites positioned along the edge of the polymer

229 a-sheet of 18 strands, extending between two catalytic sites positioned at its edges.

230 e that we have been successful in creating a catalytic site precisely mimicking that suggested for na

231 and the "PSGH" fingerprint peptide near the catalytic site, providing structural insight into PgpB s

232 specific substitutions in or near the enzyme catalytic site (R152W, A246T, and D293N, N2 numbering),

233 1 is auto-inhibited through occlusion of the catalytic site rather than by allostery.

234 metal presented preferentially binds to the catalytic site rather than the rubredoxin-like site, whi

235 ximity of RNase IIIa-S1344 to the RNase IIIb catalytic site, rationalizing why mutation of this site

236 Thus, the PNP catalytic site recapture of DADMe-ImmH is highly favored

237 ns revealed that the affinity changes of the catalytic sites required no specific interactions betwee

238 The catalytic site resides in a cleft at the interface betwe

239 Substitutions of the conserved catalytic site residues Lys-249, Arg-270, and His-271 re

240 tivity that was abrogated by mutation of the catalytic site residues.

241 3(h) revealed that the enzymes share similar catalytic site residues.

242 ence of ubiquitin, the neutral states of the catalytic-site residues in OTUB2 were more stable, resul

243 S6, or disruption of its furin processing or catalytic sites restores focal adhesions, implicating it

244 y binding of metal salts is reported for the catalytic site-selective hydro-heteroarylation of dienes

245 , information may be transmitted to a remote catalytic site, selectively directing the formation of e

246 ites in photocatalytic HERs, resulting in a "catalytic site self-optimization".

247 zyme WbbY possessing two glycosyltransferase catalytic sites solely responsible for O1 antigen polyme

248 tions formally demonstrate the importance of catalytic site specificity for directing protein kinase

249 s or in cells carrying a Caa1 variant with a catalytic site substitution, suggesting that the catalyt

250 f the defects in zeolite Beta, which include catalytic sites such as framework Lewis acidic Sn atoms

251 and dynamics of the apo-state of the hPHPT1 catalytic site, suggesting that if Met95 oxidation alter

252 sidue contacts between the GS domain and the catalytic site that controls the formation and disruptio

253 ral analysis, we identify regions around the catalytic site that play key roles in discriminating bet

254 ibits ATPase activity by stabilizing an open catalytic site that results in tight binding of inhibito

255 With Na(+) at the catalytic site, the mechanism is observed to be sequenti

256 (ED) substrate-docking site rather than the catalytic site, the sequence of which had only modest ho

257 At the catalytic site, the tetrahedral intermediate lies covale

258 The first domain contains the catalytic-site; the second contains residues for sequenc

259 In agreement with previous hypotheses, the catalytic sites themselves are often highly frustrated r

260 ves the electrostatic environment of the GLS catalytic site, thereby intrinsically inducing hyperacti

261 ed structure and highly charged and reactive catalytic site, they have been regarded as "undruggable.

262 inhibitors into the carbonic anhydrase (CA) catalytic site, thus highlighting the relevant role of n

263 occupancy by a second at the transpeptidase catalytic site, thus lowering the minimal-inhibitory con

264 omplexes, two related GEFs that use the same catalytic site to activate distinct Rabs, distinguish be

265 ticularly, a high charge capacity allows the catalytic site to carry more charges than required for t

266 confirming that ethionine also uses the same catalytic site to form the product SAE.

267 h osthole revealed that osthole bound to the catalytic site to prevent cAMP binding and hydrolysis.

268 well as its binding mode within the RNase H catalytic site to rationalize its selectivity.

269 are required to orient its acetyltransferase catalytic site to the methylated histone 3-bearing nucle

270 itution at position 471, proximal to the GAC catalytic site, to examine the conformational coupling b

271 is mechanism, the electrostatic field in the catalytic site turns the electric dipole associated with

272 Bifunctional coupling of two different catalytic site types has often been invoked to explain e

273 gstrom resolution, this structure revealed a catalytic site typical for papain-like cysteine protease

274 A catalytic site typically consists of one or more atoms o

275 Consistently, an HO2 catalytic site variant that is unable to bind heme exhib

276 g binding of trans-resveratrol to the CpLIP2 catalytic site via electrostatic and hydrophobic forces.

277 ductively recruit ASXH to the wild-type BAP1 catalytic site via the ULD, resulting in loss of BAP1 ub

278 scade reactions by linking multiple distinct catalytic sites via substrate channeling.

279 mutated heavy and light PNPs to increase the catalytic site vibrational freedom.

280 es predicted to influence the freedom of the catalytic site vibrational modes linked to heavy enzyme

281 In mutants where the C-terminal catalytic site was deleted but the WbdD-interaction site

282 ional HECT E3 ligase domain with a conserved catalytic site was identified in the C-terminal region o

283 inconspicuous Ala-to-Ser substitution in the catalytic site was key to the emergence of the type II H

284 y active form of OTUB1, whereas in OTUB2 the catalytic site was solvent-accessible, and a larger numb

285 Using variants of PrgA with mutations in the catalytic site we show that the surface exclusion effect

286 olecule inhibitor (SMI#9) targeting the RAD6 catalytic site, we demonstrate that SMI#9 potentiates th

287 mutants to assign the activities of the WbbY catalytic sites, we found that the C-terminal WbbY domai

288 binding domain (RBD) and neuraminidase (NA) catalytic site were identified.

289 indicating that ADP can remain bound to the catalytic site where product release occurs for the dura

290 est a rearrangement of loops surrounding the catalytic site, where they extend into the hydrocarbon c

291 ity and understanding performance at defined catalytic sites, whereas the semiconductor bridge ensure

292 id residue positioned at the entrance to the catalytic site: whereas group 1 dandelion PPOs possess a

293 e interactions of the iron-sulfur-containing catalytic site with the local protein environment are th

294 exosite I with segment Glu-35-Asp-47 and the catalytic site with the region Pro-49-Arg-56, which incl

295 chromesbact as electronic connectors for the catalytic sites with no fine tuning in DeltaEm_b require

296 n them provide opportunities for introducing catalytic sites with precisely defined structures.

297 The OTUB1 protein had a prearranged catalytic site, with strong electrostatic interactions b

298 zygous MYSM1 missense mutation affecting the catalytic site within the deubiquitinase JAB1/MPN/Mov34

299 ng a unique strategy to prepare dissymmetric catalytic sites within self-assembling de novo-designed

300 Identifying the RNA-binding and putative catalytic sites within the DWV virion structure enables