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5 ne amide derivative 1 was initially found to catalyze a model aldol reaction between cyclohexanone an
11 tatively our data to experiments on membrane-catalyzed amyloid aggregation of alpha-synuclein, a prot
12 ronsted basic guanidinylated peptides, which catalyze an efficient atroposelective chlorination, is r
13 A protein predicted to have a WD40-like fold catalyzes an unprecedented benzilic acid rearrangement i
18 st clades of P-loop NTPase fold enzymes that catalyze ATP-hydrolysis and utilize its free energy for
21 s and bromophenols, proceeds via a palladium-catalyzed Barluenga-Valdes cross-coupling, followed by a
26 intramolecular allylic substitution reaction catalyzed by a combination of palladium and a chiral pho
28 ating mechanism for the forward reaction and catalyzed by a single charge-transfer process for the re
29 reaction that generates N-phenylaziridines, catalyzed by a supramolecular host, that provides the st
31 this segment also inhibits seeding of Abeta catalyzed by Abeta fibrils extracted from the brain of a
33 The two major types of reactions that are catalyzed by AOXs are the hydroxylation of heterocycles
34 ot the result of thermal fluctuations but is catalyzed by Bicoid and Zelda, possibly through histone
35 le involves chemically challenging reactions catalyzed by complex enzyme machineries with unique meta
36 on of protochlorophyllide to chlorophyllide, catalyzed by dark-operative protochlorophyllide oxidored
38 fatty acid synthesis, one in the cytoplasm (catalyzed by fatty acid synthase, FASN) and one in the m
40 ed increase in flux from pyruvate to lactate catalyzed by lactate dehydrogenase using hyperpolarized
41 ommitted step in menaquinone biosynthesis is catalyzed by MenD, a thiamine diphosphate-dependent enzy
42 ansformations that are essential to life are catalyzed by metalloenzymes that feature Earth-abundant
44 at the hydrolysis of NO(2) in clouds must be catalyzed by organic or inorganic species adsorbed on th
45 from those previously proposed for processes catalyzed by related metals, particularly those of the s
48 merization of epoxides into allylic alcohols catalyzed by supported Au nanoparticles proceeds via an
50 he mechanism of the aza-Diels-Alder reaction catalyzed by tetraalkylammonium or trialkylsulfonium sal
53 rrangements of beta-substituted styrenes are catalyzed by the C(2)-symmetric aryl iodide 1 to provide
54 ture under visible light irradiation and are catalyzed by the combination of an iridium(III) photocat
55 In tryptophan biosynthesis, the reaction catalyzed by the enzyme indole-3-glycerol phosphate synt
56 tion, the most abundant RNA modification, is catalyzed by the H/ACA small ribonucleoprotein (snoRNP)
57 the kinetics and fidelity of DNA replication catalyzed by the labeled enzyme are largely unaffected b
58 e transfer of WTA from lipid carriers to PG, catalyzed by the LytR-CpsA-Psr (LCP) enzyme family, offe
59 CofB product, with the former reaction being catalyzed by the NADPH-dependent dehydrogenase CofA.
60 , we present a detailed study on epoxidation catalyzed by the nonheme iron(II)- and 2-oxoglutarate-de
62 entioned enzymes highlights their ability to catalyze C-H bond activation and functionalization, in m
64 tly invoked in the proposed mechanisms of Pd-catalyzed C(sp(3))-H functionalization reactions, though
66 including base-mediated ring-opening, metal-catalyzed C-C insertions and eliminations, oxidative fra
67 a completely diastereoselective rhodium(II)-catalyzed C-H amination reaction to set the configuratio
68 t-mediated dual transition-metal/photo-redox-catalyzed C-H arylation and intermolecular atom-transfer
69 C(sp)-C(sp3) bond-forming step in the copper-catalyzed C-H functionalization of benzylic substrates R
72 cylation, S(N)Ar, silylation, solvolysis, Pd catalyzed C-S cross-coupling and cycloadditions) is demo
73 otentially general paradigm in photoredox Ni-catalyzed carbon-heteroatom cross-coupling reactions thr
74 onyl-alpha'-amide sulfoxonium ylides by Pd/C-catalyzed carbonylative transformation of azides with al
76 as developed through CuI/DBU/MS joint system-catalyzed carboxylative cyclization of arylacetylene, ar
79 the recent developments in transition-metal-catalyzed cleavage of C-C bonds in unstrained alcohols v
81 ,6-bis(di-tert-butylphosphinito)phenyl) that catalyzes CO(2) hydrogenation to formate with faster rat
83 ca and the high diversity of salamanders has catalyzed concern about Bsal in the U.S. Surveillance pr
84 ]-5,5'-diylbis(aryl)methanol under mild acid-catalyzed conditions in CH(2)Cl(2) followed by oxidation
87 contributed to the understanding of laccase-catalyzed conjugation reaction for the controlled synthe
92 ny ideas of tinnitus pathophysiology and may catalyze cooperative efforts to develop tinnitus therapi
93 ent, enantio- and diastereoselective, copper-catalyzed coupling of imines, 1,3-enynes, and diborons i
94 xiranes, as well as chemodivergent palladium catalyzed cross-coupling reactions using boronic acids a
95 nucleophilic coupling partners in palladium-catalyzed cross-coupling reactions with (hetero)aryl hal
100 entally intriguing observations in the Au(I)-catalyzed cyclization of cyclic and acyclic acetals of a
101 step mechanism of these lithium cation Li(+)-catalyzed DA reactions changes to a two-step one for the
102 active sites, Hf(12) -Ru-Co-OTf competently catalyzed dehydrogenative tandem transformations of indo
104 family utilizes a glycyl radical cofactor to catalyze difficult chemical reactions in a variety of an
106 talline steroid dimers were obtained by acid-catalyzed double acetalization of (20S)-5alpha-pregnan-3
107 raquinones and S-alkylated SAM analogues and catalyzes efficient installation of reactive alkyl handl
109 deposited on carbon support) is designed for catalyzing electrochemical allylic alkylation in water/i
112 Recent achievements in transition-metal catalyzed enantioselective functionalizations of carbon-
115 heses of a range of hongoquercins using gold-catalyzed enyne cyclization reactions and further deriva
116 toxicity of iron stems from its potential to catalyze formation of reactive oxygen species that, in a
118 arned, to facilitate pipeline validation and catalyze further pipeline improvement by the community,
120 port our full investigation into the calcium catalyzed generation and trapping of N-acyliminium ions
125 It is the key enzymatic protein complex that catalyzes histone H3 lysine 27 (H3K27) methylation to me
127 eed, TMG-SYNPHOS forms a copper complex that catalyzes hydroboration of 1,1-disubtituted alkenes with
128 aka Tsuji-Trost allylic substitution), metal-catalyzed hydrofunctionalization does not require the pr
133 derstanding is used to develop the magnesium-catalyzed hydrosilylation of the C-C sigma bonds of alky
134 ies were found to be complementary, together catalyzing important new science, partnerships, coordina
135 ite-specific recombinase Integrase (Int) can catalyze integrative site-specific recombination and rec
139 the starting substrate to undergo palladium-catalyzed intramolecular C-H/C-Br bond cross-coupling to
140 drocannabinol, is achieved through a proline-catalyzed inverse-electron-demand Diels-Alder reaction.
143 ysS uses Cbl, SAM, and a [4Fe-4S] cluster to catalyze iterative methylation reactions: a cyclopropylc
144 monoxide, and until now, none of them could catalyze its chemical transformation, a classical task f
145 NEMO during the late phase of infection and catalyzed K-48-linked ubiquitination of Lys326 on NEMO,
146 eracts with TRAF6 E3 ubiquitin ligase, which catalyzes K63 polyubiquitination for NF-kappaB activatio
147 ne to a tetrasubstituted double bond, enzyme-catalyzed malonate desymmetrization, and highly diastere
149 chromes P450 are heme-dependent enzymes that catalyze many vital reaction processes in the human body
151 mplex required for transport-III (ESCRT-III) catalyzes membrane fission from within membrane necks, a
153 be highly effective and thermally stable to catalyze methane combustion at low temperatures (<500 de
154 exane-1,4-dicarboxylate (+)-1, via palladium-catalyzed methoxycarbonylation of an enol triflate deriv
155 The strategy involves graphene-oxide/I(2)-catalyzed nitrene insertion using PhINTs as a nitrene (N
156 ted syntheses of aminooxazoles based on gold-catalyzed nitrene transfers to ynamides to furnish 4-ami
160 on of a cytochrome P450 (CYP728B70) that can catalyze oxidation of a methyl to the acid moiety of deh
162 is work, mechanistic understanding of flavin-catalyzed oxidation reactions, in either the absence or
165 d atom-economy perspective, transition metal-catalyzed oxidative dehydrogenative C-H/X-H carbonylatio
166 ght on possible proton movements during heme-catalyzed oxygen activation, as well as on ascorbate oxi
167 sion introduced by d orbitals renders the Pd-catalyzed [pai2s + pai2s + sigma2s + sigma2s] reaction s
168 and methodological diversification of metal-catalyzed peptide macrocyclization as a special class of
169 ysteroid dehydrogenase-1 (3beta-HSD1), which catalyzes peripheral conversion from adrenal dehydroepia
170 f tumor promoting genes such as CHPT1, which catalyzes phosphatidylcholine (PtdCho) synthesis and reg
171 e activated by autophagy stimuli and that it catalyzes phosphorylation of IGPR-1 at Ser(220) The subs
172 and early endosome development, net VPS34CII-catalyzed PI3P production is greatly amplified by Rab5A,
173 c37/Hsp90, recruits the E3 ligase, NEDD4, to catalyze polyubiquitination of pro-IL-1beta, serving as
177 ilic early transition metal (groups 3 and 4)-catalyzed processes which have achieved remarkable succe
178 e-pot, multistep process entailing a gold(I)-catalyzed propargyl Claisen rearrangement/Nazarov cycliz
179 e but efficient one-pot or sequential copper-catalyzed protocol using 2-bromoaldehydes and active met
181 oss-coupling, followed by an aerobic, copper-catalyzed, radical cyclization to form Csp(2)-Csp(2) and
183 udies reveal the molecular mechanisms of the catalyzed reaction and of finasteride inhibition involvi
188 old but act on a wide range of substrates to catalyze reactions involved in bioluminescence, nonribos
190 so revealed distinct parallels to photoredox-catalyzed reactions, in which back-electron transfer and
194 ighly efficient asymmetric intermolecular Ni-catalyzed reductive dicarbofunctionalization of alkenes.
197 ndent halogenases (2ODHs) have been found to catalyze regioselective halogenation of unactivated C-H
200 iosynthetic pathway, revealing that (i) TnmH catalyzes regiospecific methylation at the C-7 hydroxyl
202 recognize precursor tRNAs (pre-tRNAs) as it catalyzes removal of the 5'-leader sequence from pre-tRN
204 istry, beta-keto radical chemistry, and acid-catalyzed ring-opening, as well as all other methods for
207 talytic interfaces in a single nanostructure catalyze sequential reactions, we describe its concept a
210 stabilized palladium nanoparticles (Pd-BNP) catalyzed single-step, stereoselective domino synthesis
211 SRPK1 initiates this life-beginning event by catalyzing site-specific phosphorylation of protamine, t
213 The flavin monooxygenase PhqK was found to catalyze spirocycle formation through two parallel pathw
214 ndings enrich the available arsenal of metal-catalyzed spirocyclization methods based on the use of c
215 of cyclic diazo compounds capable of Rh(II)-catalyzed spirocyclizations with tetrahydrofuran have be
217 ed in good to high yields by a cascade of Pd-catalyzed Suzuki-Miyaura cross-coupling and direct aryla
218 Protein arginine methyltransferase 5 (PRMT5) catalyzes symmetric dimethylation (SDM) of arginine, a p
219 nd simple NiBr(2)/1,10-phenanthroline system-catalyzed synthesis of a series of quinoxalines from bot
220 or advances and discoveries made in the gold-catalyzed synthesis of cyclopropanes, cyclopropenes, cyc
222 nt reaction outcomes are well-tuned by Rh/Ir-catalyzed system; in the Rh(III) catalysis, 3-alkenyl-1H
226 recent study suggests that caspase-2 (Casp2)-catalyzed tau cleavage at aspartate 314 mediates synapti
227 We cover a wide range of transition-metal-catalyzed, template-directed remote C-H activation react
230 phils during inflammation, has been shown to catalyze the biodegradation of carbon nanomaterials.
231 restingly, all the derivatives DA1-DA4 could catalyze the C-N bond formation reaction between activat
232 and noncoordinating anions such as BAr(F)(4) catalyze the cis haloalkynylation of the terminal alkyne
234 cently, however, viperin was demonstrated to catalyze the conversion of cytidine triphosphate (CTP) t
235 ting of visible light by TETPY assemblies to catalyze the coupling of o-phenylenediamine/substituted
236 t act against membrane proteins, which could catalyze the discovery of new candidates for antibody-ba
239 ation of acyl-activating enzymes (AAEs) that catalyze the formation of CoA esters of different organi
240 e C5-protons in poly(1,2,4-triazolium)s that catalyze the formation of imine bonds, and the simultane
242 Ten-eleven-translocation (TET) dioxygenases catalyze the oxidation of 5-methylcytosine (5mC), the ce
248 brid electrode containing Geobacter can also catalyze the reduction of soluble fumarate and heterogen
249 t-type 12-lipoxygenase (12-LOX) can directly catalyze the regioselective and stereospecific oxidation
251 caling, as well as biological catalysts that catalyze the same reactions as in electrochemical device
252 Beta zeolites containing framework Sn atoms catalyze the transfer hydrogenation reaction of cyclohex
254 family of 17 enzymes in humans, 16 of which catalyze the transfer of ADP-ribose from NAD(+) to macro
255 Mass-selected Ta(8)O(2)(+) cluster ions catalyze the transformation of methane in a gas-phase io
257 the mechanism of action of the first vaccine catalyzed the development of new strategies to control L
258 orrowing hydrogen conditions, NHC-iridium(I) catalyzed the direct or one-pot sequential synthesis of
259 metal-organic framework Bi-BTC successfully catalyzed the synthesis of para-xylene from bio-based 2,
260 (DGKepsilon) is a membrane-bound enzyme that catalyzes the ATP-dependent phosphorylation of diacylgly
261 7), which genomically clustered with SiTPS8, catalyzes the C19 hydroxylation of SiTPS8 products to ge
264 Nondenaturing sodium bisulfite treatment catalyzes the conversion of unpaired cytosines to uracil
265 Hyp) dehydratase (HypD), was discovered that catalyzes the dehydration of Hyp to (S)-Delta(1)-pyrroli
266 ces cerevisiae is a protein phosphatase that catalyzes the dephosphory-lation of Pah1 phosphatidate p
267 mine N-methyltransferase (PNMT, EC 2.1.1.28) catalyzes the final step in the biosynthesis of epinephr
268 distinct from its methyltransferase activity catalyzes the final two steps, NAD(+)-dependent dehydrog
269 gene encoding GDP-l-Gal phosphorylase, which catalyzes the first committed step in the biosynthesis o
272 OSPHO1) is a phosphocholine phosphatase that catalyzes the hydrolysis of phosphocholine (PC) to choli
275 The prokaryotic NAD synthetase enzyme NadE catalyzes the last step of NAD(+) biosynthesis, converti
276 sembly, and MRM2, the methyltransferase that catalyzes the modification of the 16S mt-rRNA A-loop U13
277 sferase (NMT) is an essential protein, which catalyzes the myristoylation of protein substrates, ofte
279 y player in the global nitrogen cycle, as it catalyzes the reduction of dinitrogen into ammonia.
281 al membrane enzyme in steroid metabolism and catalyzes the reduction of testosterone to dihydrotestos
282 minolevulinic acid dehydratase (ALAD), which catalyzes the second step of heme biosynthesis, is an Fe
283 Protein arginine methyltransferase 5 (PRMT5) catalyzes the symmetric di-methylation of arginine resid
284 The key enzyme CndF is PLP-dependent and catalyzes the synthesis of (S)-2-amino-6-oxoheptanoate 3
285 ana), TREHALOSE-6-PHOSPHATE SYNTHASE1 (TPS1) catalyzes the synthesis of the sucrose-signaling metabol
287 extracellular proteins plays a vital role in catalyzing the formation of cross-links in fibrillar ela
289 tructural framework comprising a core domain catalyzing the oxidation of amines with an auxiliary dom
291 his study describes a metal-free approach to catalyzing the reduction of O(2) into H(2)O(2), based on
292 e catalysts possess such multitask activity, catalyzing the transvinylation reaction of carboxylic ac
293 s review, we focus on how DNA topoisomerases catalyze their impressive range of DNA-conjuring tricks,
294 ed to hijack the host cellular machinery for catalyzing their replication, lead to profound disturban
295 sential for its functions, but the enzyme(s) catalyzing this post-translational modification is unkno
297 ade for conducting and reporting research to catalyze value creation: develop interventions systemati
299 il microbes and the ecosystem functions they catalyze, whether such heterogeneity can be maintained i
300 and molecular simulations to show that XOAT1 catalyzes xylan acetylation through formation of an acyl