ライフサイエンスコーパス: catenin

1 ion increased in the presence of active beta-catenin.

2 ed FRG mouse livers demonstrated active beta-catenin.

3 eleton, and enhances the acetylation of beta-catenin.

4 erin (E-cad) and consequent activity of p120-catenin.

5 ing short polyQ tract AR and stabilized beta-catenin.

6 while NCC defects could be rescued with beta-catenin.

7 ss damage through anabolic pathways and beta-catenin.

8 umoroids harboring a mutation at S45 of beta-catenin.

9 ence of a proteasome degradable form of beta-catenin.

10 termates that expressed only stabilized beta-catenin.

11 BBR after pharmacological inhibition of beta-catenin.

12 erspective for therapeutic targeting of beta-catenin.

13 o achieve high efficient degradation of beta-catenin.

14 are reduced by inhibiting Akt-activated beta-catenin.

15 asma membrane through alpha-, beta- and p120 catenins.

16 y (IHC) for CTNNB1 (beta-Catenin; clone beta-Catenin-1) was performed on the constructed TMAs.

17 1) maintains composition and binding to beta-catenin, (2) moves toward the plasma membrane, and (3) r

18 Here, we uncovered a pathway in which delta-catenin, a component of the cadherin-catenin cell adhesi

19 rs that promote differentiation towards beta-catenin, a driver of proliferation and colorectal tumori

20 chemical environment for non-enzymatic beta-catenin acetylation downstream of WNT signalling.

21 its phosphorylation by Src, leading to beta-catenin activation and disseminating phenotypes in early

22 mental mechanism for post-translational beta-catenin activation and is required to complete EGA.

23 nnections, Yap/Taz accumulated upon Myc/beta-catenin activation and were required not only for the en

24 ver, there was also less DNA damage and beta-catenin activation in H. pylori-infected Smox(-/-) mice

25 Prostate tumors with beta-catenin activation relied on the noncanonical WNT ligand

26 iscover that, while elevated, sustained beta-catenin activation sequentially promotes proliferation a

27 Thus, OTULIN-mediated Wnt/beta-catenin activation upon genotoxic treatments promotes dr

28 The link between SMOX and beta-catenin activation was confirmed in human gastric organo

29 beta-Catenin activation, independent of the cell of origin, c

30 is essential for the DNA damage-induced beta-catenin activation.

31 Addition of the Wnt/beta-catenin activator CHIR99021 reduced wound closure in the

32 l rotation to generate a dorsal pole of beta-catenin activity [4-8], and the release of Nodal signals

33 C expression levels strongly influenced beta-catenin activity, indicating that inter-tumor heterogene

34 ive liver tumors marked by elevated Myc/beta-catenin activity.

35 showed high level expression of active beta-catenin, alpha-fetoprotein, and SOX9, suggesting that DC

36 assembles a protein complex comprising alpha-catenin and a group of Hippo PY motif-containing compone

37 identified ubiquitin ligase of nuclear beta-catenin and a suppressor of colorectal cancer (CRC) grow

38 lyses revealed increased recruitment of beta-catenin and AR on the c-Myc gene regulatory locus in the

39 Overall, WNT/beta-catenin and AR signaling are reciprocally inhibited.

40 n (IDR) of APC, which contains multiple beta-catenin and Axin interacting sites, undergoes liquid-liq

41 s, such as APC mutations that stabilize beta-catenin and cause intestinal tumors in mice and humans.

42 levels were sensitive to inhibition of beta-catenin and cholesterol pathways.

43 aling including nuclear localization of beta-catenin and E-cadherin.

44 on, and unphosphorylated Hsp27 binds to beta-catenin and enhances its phosphorylation by Src, leading

45 n of AnxA8 led to an increase in active beta-catenin and GSK-3beta phosphorylation.

46 ithelial cells results in activation of beta-catenin and increased expression of lymphoid enhancer-bi

47 7 may act through the activation of Wnt/beta-catenin and Jagged1 expression to control EC proliferati

48 results in pathologic stabilization of beta-catenin and oncogenesis.

49 utophagy mechanism may be leveraged by delta-catenin and other effectors to sculpt the developing den

50 ous junctions stabilized by N-cadherin, beta-catenin and p120-catenin, which undergo kinetic turnover

51 The Wnt-beta-catenin and PI3K-Akt pathways cooperate to promote tumor

52 axin, reducing targeted destruction of beta-catenin and promoting beta-catenin-mediated transcriptio

53 the tumor tissues expressing stabilized beta-catenin and shorter polyQ tract AR.

54 ntestinal epithelial cells with nuclear beta-catenin and SRY-box transcription factor 9 in APC(+/+) c

55 of the key regulators of Wnt signaling, beta-catenin, and E-cadherin, to the nucleus.

56 ressed phosphorylation of Smad3, STAT3, beta-catenin, and expression of Snail after ureteral obstruct

57 single-cell live imaging of endogenous beta-catenin, and subsequent target gene transcription.

58 nt also caused decreases in E-cadherin, beta-catenin, and YAP in the striola, and stimulated robust p

59 on Wnt target genes transcription in a beta-catenin- and TCF/LEF-dependent manner.

60 oth murine Met transgene and stabilized beta-catenin are conditionally co-expressed in prostatic epit

61 Wilms tumor 1 (WT1) and beta-catenin are two master regulators that play opposing rol

62 cumulation and nuclear translocation of beta-catenin, as measured by single-cell live imaging of endo

63 tent and activity of the ROS/AMPK/EP300/beta-catenin axis are opposite in healthy versus tumor sectio

64 merase reverse transcriptase (TERT) (58.1%), catenin beta 1 (CTNNB1) (30.7%), tumor protein 53 (TP53;

65 Deletion of the beta-catenin-binding domain of LEF1 in HNF-1beta-deficient ce

66 g (Shh), wingless-integrated site (Wnt)/beta-catenin, bone morphogenetic protein (Bmp), and fibroblas

67 essential cell-cell adhesion protein alphaE-catenin but not its homolog vinculin.

68 cing destruction complex-phosphorylated beta-catenin, but high-molecular-weight beta-catenin is unexp

69 ed dissociation between VE-cadherin and beta-catenin, but increased association between N-WASP and VE

70 Through direct binding to beta-catenin, C2 renders the target inactive that eventually

71 We report the discovery of beta-catenin(+) cancer cells that coexpress E-cadherin and vi

72 e implicated mechanisms, which involve alpha-catenin capture at the nuclear envelope by nesprin upon

73 aberrant activation of HGF/MET and Wnt/beta-catenin cascades in prostate tumorigenesis by using a ne

74 h delta-catenin, a component of the cadherin-catenin cell adhesion complex, promotes coordination of

75 Immunohistochemistry (IHC) for CTNNB1 (beta-Catenin; clone beta-Catenin-1) was performed on the cons

76 elevated levels of LRP5/6 and FZD10 and beta-catenin co-localization with enhancer of zeste 2 polycom

77 Sox17 and beta-catenin co-occupy hundreds of key enhancers.

78 nin signaling increased binding of Tcf4/beta-catenin complex and upregulated its enhancer function.

79 that Pp1 promotes proper levels of cadherin-catenin complex proteins at cell-cell junctions within t

80 Activation of the WNT/beta-catenin (CTNNB1) signaling pathway plays a critical role

81 beta-catenin deficiency in these cells indeed causes insuffic

82 lecular mechanism by which APC promotes beta-catenin degradation is unclear.

83 ells promotes Axin puncta formation and beta-catenin degradation.

84 , eventually leading to inactivation of beta-catenin degradation.

85 ex organization and BRB properties in a beta-catenin-dependent manner.

86 In addition to microbes, beta-catenin-dependent pattern formation is also affected by

87 context-dependent component of the Wnt/beta-catenin-dependent transcriptional complex.

88 Senescent beta-catenin-depleted hepatocytes in aged mice create an infl

89 us, we screened new potent targets from beta-catenin destruction complex associated with GC progressi

90 We have proposed that sequestration of beta-catenin destruction complex components in multivesicular

91 In response, the endogenous beta-catenin destruction complex reoriented toward the local

92 actions between APC and Axin drives the beta-catenin destruction complex to form biomolecular condens

93 sembles Wnt signalosomes to inhibit the beta-catenin destruction complex via recruitment of Axin.

94 ng that PTPRF functions upstream of the beta-catenin destruction complex.

95 aling such that in response to Wnt, the beta-catenin destruction complex: (1) maintains composition a

96 -Dlx5;Lck-MyrAkt mice demonstrated that beta-catenin directly regulates genes involved in sterol regu

97 these studies have identified a pool of beta-catenin effectively shielded from regulation by Wnt.

98 vated protein kinase (AMPK), can reduce beta-catenin expression and downstream signaling in HCC cells

99 Finally, suppressing beta-catenin expression is able to rescue deficits of Nae1 mu

100 DCLK1 downregulation inhibited 48-kDa beta-catenin expression.

101 Arm/[Formula: see text]-catenin family proteins contain a conserved domain of 12

102 ytoplasmic protein complex that targets beta-catenin for destruction.

103 t scaffolds GSK3beta and CK1 to earmark beta-catenin for proteosomal degradation.

104 notype, suggesting caution in targeting beta-catenin globally for all cholestatic conditions.

105 Further, we find that beta-catenin has a cell autonomous role in the development of

106 Therefore, intratumor delta-catenin heterogeneity originated from genetic remodeling

107 e model of CAC, we show that the LRP5/6-beta-catenin-IL-10 signaling axis in intestinal CD11c(+) APCs

108 bs, BCL9 proteins sustain the action of beta-catenin in a largely PYGO-independent manner.

109 Genetic activation of beta-catenin in beta-cells restores the diabetes-like phenoty

110 g pharmaceutical agents that can target beta-catenin in cancer cells, we observed that the plant comp

111 ition is likely due to stabilization of beta-catenin in cohesin-mutant cells, and that Wnt-responsive

112 n a better insight into the role of Wnt/beta-catenin in dentinogenesis, we used dental pulp cells fro

113 set of phenotypes that can be linked to p120-catenin in epithelial integrity and turnover, and additi

114 Loss of beta-catenin in fetal mouse mesoderm causes loss of Tbx4(+) t

115 chanistic link between DOCK6, Rac1, and beta-catenin in GCCSC for the first time, supporting the util

116 Short-term induction of MYC and beta-catenin in hepatocytes, followed by RNA-sequencing profi

117 alize these observations, we suppressed beta-catenin in Mdr2 knockout (KO) mice, which develop sclero

118 CRC were associated with activation of beta-catenin in physically fit, overweight and obese patients

119 g different polyQ tracts and stabilized beta-catenin in prostate tumorigenesis using newly generated

120 We interrogated the dual functions of beta-catenin in relation to CK5.

121 ikely to increase the levels of nuclear beta-catenin in the intestinal crypt, augmenting CRC tumorige

122 established HCC oncogene (either MYC or beta-catenin) in combination with an additional alteration in

123 Here we have identified a beta-catenin-independent function of BCL9 in a poor-prognosis

124 y, inhibition of miR-466o-3p alleviated beta-catenin-induced podocyte dysfunction.

125 feration and differentiation, transient beta-catenin induces apoptosis.

126 Since Akt can activate beta-catenin, inhibiting this interaction might target therap

127 tor bortezomib did not block the 48-kDa beta-catenin, instead, caused a threefold accumulation, sugge

128 ubicin (DXR) as an inhibitor of the Akt-beta-catenin interaction at low doses.

129 While the regulatory effect of RUNX3 in beta-catenin is already known, our results suggest the possib

130 Interestingly, Sox9 binding to beta-catenin is enhanced in Med23(fx/fx);Wnt1-Cre mutant embr

131 We show that beta-catenin is neddylated; and inhibiting beta-catenin neddy

132 ipitation experiments demonstrated that beta-catenin is part of a protein complex that binds the NF-k

133 naling, the transcriptional coactivator beta-catenin is regulated by its phosphorylation in a complex

134 beta-catenin, but high-molecular-weight beta-catenin is unexpectedly increased by Wnt signaling.

135 SW480+APC cells revealed an increase in p120-catenin isoform 3A; similarly, depletion of APC altered

136 iptional regulatory programs leading to p120-catenin isoform switching and associated changes in cell

137 fl-APC) on cell-cell adhesion genes and p120-catenin isoform switching in SW480 colon cancer cells: f

138 rm a multiprotein complex that includes beta-catenin, it remained unclear how this would contribute t

139 enic process in the hepatic conditional beta-catenin knockout mouse model.

140 tly attenuated BBR-induced reduction of beta-catenin levels and expression of its downstream target g

141 (ADP-ribosyl) polymerase that regulates beta-catenin levels, undergoes programmed translation during

142 e homozygous missense M466V mutation in beta-catenin-like protein 1 (CTNNBL1).

143 Thus, beta-catenin likely represents another player through which B

144 alpha-Catenin links cell-cell adhesion complexes to the actin

145 ind that shape change is regulated by a beta-catenin-mediated decrease in RhoA activity and subsequen

146 e results indicate a role of HGF/MET in beta-catenin-mediated prostate cancer cell growth and progres

147 also required to sustain cell-intrinsic beta-catenin-mediated signaling to promote cellular adhesion/

148 struction of beta-catenin and promoting beta-catenin-mediated transcription of target genes, includin

149 les, implicating a novel role of MET in beta-catenin-mediated transcription.

150 its histone-binding capability promotes beta-catenin-mediated Wnt signaling and transcriptional contr

151 beta-catenin mRNA expression showed a strong positive correla

152 Localization specific delta-catenin mutants influenced p120(ctn)-dependent Rho GTPas

153 a-catenin is neddylated; and inhibiting beta-catenin neddylation increases its nuclear accumulation a

154 rns of seven candidate genes, including beta-catenin, Notch1, GATA6, CDX2, miR-34a, miR-181a, and miR

155 complex formation, while not affecting beta-catenin nuclear localization.

156 helial-mesenchymal transition (EMT) and beta-catenin nuclear translocation to promote cell migration

157 hylation repressive marks and increases beta-catenin occupancy at a site 4 kb upstream to Lef1.

158 revealed that BBR-induced reduction of beta-catenin occurs independently of AMPK activation and does

159 lains how mechanical force applied to alphaE-catenin or its homolog vinculin favors the strongly boun

160 ction approaches, we tested the role of p120-catenin (p120) and VE-cadherin (VE-cad) endocytosis in v

161 and tumor suppressors such as Ras, Myc, beta-catenin, p53, and APC.

162 findings indicate that BBR antagonizes beta-catenin pathway by inhibiting beta-catenin translation a

163 C1q inhibitors blocked the beta-catenin pathway in both the expanding HPCs and the liver

164 he unorthodox signal that activated the beta-catenin pathway in periportal HPCs and was responsible f

165 strate that C1q- mediated activation of beta-catenin pathway in periportal HPCs is a previously unrec

166 IC influences the expression of the Smp/beta-catenin pathway in the lateral skeletal precursor cells,

167 transcriptional co-activator of the Wnt/beta-catenin pathway, which plays critical roles in CRC patho

168 odel system, we show that depletion of alpha-catenin perturbs adherens junctions, enhances cell proli

169 a mechanism for efficient inhibition of beta-catenin phosphorylation upon Axin recruitment to the Wnt

170 ral protein E4orf1 sufficient to induce beta-catenin phosphorylation.

171 phosphorylation and increased level of beta-catenin phosphorylation.

172 otein complexes comprising relatives of beta-catenin (plakoglobin) and p120 catenin (plakophilins).

173 tives of beta-catenin (plakoglobin) and p120 catenin (plakophilins).

174 ese results shift the paradigm from Wnt/beta-catenin primarily as an activator of transcription to a

175 As acetylated beta-catenin promotes mesodermal rather than neural fate(7),

176 ver a new pathogenic mechanism by which beta-catenin promotes podocyte injury and proteinuria in glom

177 ciated histone H3K9 by interacting with beta-catenin, promoting HP1gamma removal and transcriptional

178 similarly, depletion of APC altered the p120-catenin protein isoform profile.

179 beta-catenin rather participated to the regulation of NF-kapp

180 r cycloheximide antagonized BBR-induced beta-catenin reduction, suggesting that BBR affects beta-cate

181 We propose that delta-catenin regulates the dendritic arbor by coordinating th

182 bution of centrosomes to Wnt signaling, beta-catenin regulation, and posttranslational modifications.

183 nhancers of the IrxB locus that promote beta-catenin-responsive ovary expression.

184 d ability to promote phosphorylation of beta-catenin, resulting in enhanced Wnt signaling.

185 al transition (CDH1, SNAI2, TWIST1, and beta catenin); ruxolitinib blocked these effects.

186 e apoptosis mechanism is deregulated in beta-catenin S45F mutants, resulting in decreased induction o

187 he inhibition of apoptosis found in the beta-catenin S45F mutants.

188 Inhibiting OTULIN or Wnt/beta-catenin sensitizes triple-negative breast cancer xenogra

189 Myc and beta-catenin show a strong cooperative action in liver carcin

190 Wnt/beta-catenin signaling achieves this in part by increasing th

191 Wnt/beta-catenin signaling activates the transcription of target

192 Pharmacological stimulation of Wnt/beta-catenin signaling activity by small-molecule GSK-3 inhib

193 o define the mediators of activated Wnt/beta-catenin signaling after hyperoxia injury.Methods: Three

194 ics have been shown to activate the Wnt/beta-catenin signaling although the underlying mechanism rema

195 ds was facilitated through elevated Wnt/beta-catenin signaling and greater intestinal stem cell (ISC)

196 activators known to be activated by WNT/beta-catenin signaling and to cooperate with MYC in mitogenic

197 increased cell surface Frizzled and Wnt/beta-catenin signaling and were responsive to porcupine (PORC

198 Thus, canonical Wnt/beta-catenin signaling appears to be principally reliant on l

199 We identified Fzd7/beta-catenin signaling as new regulator of pathological retin

200 These findings identify the Wnt-KDM4C-beta-catenin signaling axis as a critical mechanism for gliom

201 hing picomolar IC(50) inhibition in WNT/beta-catenin signaling cellular reporter assay.

202 Inhibition of beta-catenin signaling compromised activation of the emergenc

203 lly, we demonstrated that Nodal and Wnt/beta-catenin signaling cooperate to promote the dorsal-specif

204 iption to a more nuanced view where Wnt/beta-catenin signaling drives both widespread gene repression

205 Wntless-dependent manner, activated Wnt/beta-catenin signaling in 2D and 3D cell culture experiments,

206 rated that RSPOs 2 and 3 potentiate WNT/beta-catenin signaling in cells lacking leucine-rich repeat-c

207 identified a mechanism to regulate Wnt/beta-catenin signaling in cortical development.

208 se phenotypes are not caused by reduced beta-catenin signaling in ECs, despite the close resemblance

209 Norrin inhibited cell growth via beta-catenin signaling in GSCs that had low expression levels

210 further identify a critical role of WNT/beta-catenin signaling in regulating human cortical neuron su

211 din1 (RSPO1) mediated activation of WNT/beta-catenin signaling in XX gonads.

212 Activating beta-catenin signaling increased binding of Tcf4/beta-catenin

213 rgets for tumors having deregulated Wnt/beta-catenin signaling induced by this mutation.

214 beta-catenin signaling is aberrantly activated in different g

215 show that genotoxic agent-activated Wnt/beta-catenin signaling is independent of the FZD/LRP heterodi

216 trated that the spatial activity of Wnt/beta-catenin signaling is located in presumptive dorsal cells

217 d provided functional evidence that Wnt/beta-catenin signaling is necessary for the specification of

218 th positive and negative effects of Wnt/beta-catenin signaling on dentinogenesis have been reported,

219 WNT/beta-Catenin signaling pathway has a potential to be used as

220 The Wnt/beta-catenin signaling pathway has a well-described role in l

221 Our results uncover a role for the beta-catenin signaling pathway in fine tuning the granulocyti

222 We also investigated the role of Wnt/beta-catenin signaling pathway in IL-1beta induced inflammati

223 The Wnt/beta-catenin signaling pathway is central to metazoan develop

224 Dysregulation of the Wnt/beta-catenin signaling pathway is critically involved in gast

225 enesis likely via the modulation of Wnt/beta-catenin signaling pathway, a key signaling pathway invol

226 nt of DOCK6-correlated genes in the WNT/beta-catenin signaling pathway.

227 receptor tyrosine kinase (MET) and Wnt/beta-catenin signaling pathways has been observed in advanced

228 ll as those associated with RAR and Wnt/beta-catenin signaling pathways.

229 These findings reveal that Wnt-KDM4C-beta-catenin signaling represents a novel mechanism for the t

230 Lastly, activation of Wnt/beta-catenin signaling skewed the profile of human and murine

231 Activation of WNT/beta-catenin signaling strongly accelerated MYC-driven carcin

232 results expand the current model of Wnt/beta-catenin signaling such that in response to Wnt, the beta

233 extracellular domain hyperactivate Wnt/beta-catenin signaling through formation of inactive dimers w

234 e results suggest that FL3 inhibits Wnt/beta-catenin signaling via PHB1-dependent activation of Axin1

235 with high affinity, and potentiate Wnt-beta-catenin signaling, presumably by the same mechanism: for

236 In Wnt/beta-catenin signaling, the transcriptional coactivator beta-

237 ereby nuclear MET promotes aberrant Wnt/beta-catenin signaling-mediated prostate tumorigenesis.

238 d the ability of AM-ADSC to inhibit Wnt/beta-catenin signaling.

239 mazepine can suppress FZD8-mediated Wnt/beta-catenin signaling.

240 hat caused by EC-specific reductions in beta-catenin signaling.

241 protein modification, in inhibiting Wnt/beta-catenin signaling.

242 reases its nuclear accumulation and Wnt/beta-catenin signaling.

243 , as well as a greatly reduced level of beta-catenin signaling.

244 ammation, DNA damage, and activation of beta-catenin signaling.

245 LRP6 phosphorylation and potentiate Wnt-beta-catenin signaling.

246 pc(Min/+) mouse model by inhibiting Wnt/beta-catenin signaling.

247 iency is associated with an increase in beta-catenin signaling.

248 ntracellular crowding and elevating Wnt/beta-catenin signaling.

249 tionally redundant manner to permit WNT/beta-catenin signalling and their genetic deletion leads to a

250 During kidney development, WNT/beta-catenin signalling has to be tightly controlled to ensur

251 Wnt/beta-catenin signalling thus has a dual role in promoting rep

252 n cancer progression and may induce Wnt-beta-catenin signals that expand cancer stem cells.

253 Finally, the Myc/beta-catenin signature was enriched in a subset of human hepa

254 g, allowed the identification of a "Myc/beta-catenin signature," composed of a discrete set of Myc-ac

255 A Wnt3a-beta-catenin-Sp5/8 pathway, which is active in the dorsal hin

256 of epithelial morphogenesis enriched in beta-catenin-stabilized adrenals.

257 fibroblast-specific genetic ablation of beta-catenin strongly decreased the number of cancer-associat

258 thus reveal a "phospho-switch" within delta-catenin, subject to a glutamate-mediated signaling pathw

259 In some cases, Sox17 and beta-catenin synergistically activate transcription apparentl

260 Disruption of the beta-catenin-TCF/LEF interaction resulted in the accumulation

261 or (dnTCF4) that specifically abrogates beta-catenin-TCF/LEF interaction.

262 tly, genetic and chemical inhibition of beta-catenin-TCF/LEF signaling in human CD34+ cells reduced g

263 eas on other enhancers, Sox17 represses beta-catenin/Tcf-mediated transcription to spatially restrict

264 ytosis, followed by the activation of a beta-catenin/TCF4-dependent partial epithelial-to-mesenchymal

265 ciated with increased levels of nuclear beta-catenin, TCF7L2, JMJD6, and c-Myc in BETi-P/R sAML cells

266 ignificant associations pointing to wnt/beta-catenin, TGF-beta and sonic hedgehog pathways.

267 molecular-weight form of phosphorylated beta-catenin that is constitutively degraded in the absence o

268 her unspecific genetic manipulations of beta-catenin that yielded contradictory results.

269 e FRZB is a Wnt antagonist, we assessed beta-catenin, the canonical transducer of Wnt signaling, and

270 a14/+) c-Cbl(+/-) crypts showed nuclear beta-catenin throughout the length of the crypts and up-regul

271 D7 expression and dependent on the FZD7-beta-catenin-Tp63-GPX4 pathway for survival.

272 upon its relaxation, thereby regulating beta-catenin transcription.

273 on, Zic1 could physically interact with beta-catenin/transcription factor 4 (TCF4) and disrupt their

274 ed GJA1 mRNA transcripts dependent upon beta-catenin transcriptional activity during Ad5 infection, w

275 Knockout or knockdown of CK5 ablated beta-catenin transcriptional activity in response to progesti

276 alpha expression through suppression of beta-catenin transcriptional activity, and also through activ

277 candidate tissue-specific member of the beta-catenin transcriptional complex.

278 An inhibitor targeting beta-catenin transcriptional interactions hindered both NF-ka

279 izes beta-catenin pathway by inhibiting beta-catenin translation and mTOR activity and thereby reduce

280 reduction, suggesting that BBR affects beta-catenin translation.

281 ed cell morphology changes, and induced beta-catenin translocation and GSK-3beta phosphorylation in t

282 lear exclusion of FoxO1 and concomitant beta-catenin translocation to the nucleus, collectively leadi

283 characterized previously, in mediating beta-catenin-triggered WT1 inhibition.

284 RAD6B expression is induced by beta-catenin, triggering a positive feedback loop between the

285 Loss or knockdown of delta-catenin uncoupled this coordination, leading to retracti

286 ing HCCs that express mutated/activated beta-catenin variants that are currently undruggable.

287 beta-catenin was detected in all leukemic MCL samples and its

288 lso improved, and the expression of Wnt/beta-catenin was elevated.

289 When beta-catenin was knocked down (KD) in KO for 2 weeks, hepatic

290 Norrin signaling through beta-catenin was required for BRB restoration, but glycogen s

291 e 3, the integrins beta6 and beta8, and beta-catenin) were significantly different in epithelial cell

292 TULIN inhibits linear ubiquitination of beta-catenin, which attenuates its Lys48-linked ubiquitinatio

293 th and sequester a key pro-ovary factor beta-CATENIN, which may lead to up-regulation of testis-speci

294 bilized by N-cadherin, beta-catenin and p120-catenin, which undergo kinetic turnover, transmit interc

295 vealed an interaction between AnxA8 and beta-catenin, which was reduced in the presence of activated

296 inactivate Gsk3alpha/beta and stabilize beta-catenin while increasing the phosphatase activity of a P

297 s in GBM, indicating that targeting Wnt/beta-catenin-WISP1 signaling may effectively improve GBM trea

298 ed with an induction of a 48-kDa active beta-catenin with a preserved hypophosphorylated N-terminus t

299 Disruption of colocalization of nuclear beta-catenin with TBL1 and TCF7L2 by the small-molecule inhib

300 hways in MPNST cells, including the Wnt/beta-catenin, YAP/TAZ, RB/E2F, and BET pathways, which conver