ライフサイエンスコーパス: cathepsin

1 tivity, including its processing by cysteine cathepsins.

2 Furthermore, expression of cathepsin 6 and monocyte to macrophage differentiation a

3 Cathepsin A (CatA) inhibitors attenuated L-ala,SP prodru

4 In the heart, the serine carboxypeptidase cathepsin A (CatA) is distributed between lysosomes and

5 the molecular chaperone, protective protein cathepsin A (PPCA).

6 h levels of ET-1 in the SVZ of patients with Cathepsin A-related arteriopathy with strokes and leukoe

7 st cytoplasm is sufficient to trigger active cathepsin accumulation in the host nucleus and cathepsin

8 We did not observe changes in individual cathepsin activities, suggesting that the increased leve

9 intensity of redness, but reduced muscle pH, cathepsin activity and fillet lightness.

10 ssion, thus revealing an unexpected role for cathepsin activity in non-canonical inflammasome regulat

11 We demonstrate that cathepsin activity is required for pyroptotic cell death

12 Modulation of cathepsin activity may prevent injury of organs exposed

13 rrowed down based on their ability to rescue cathepsin activity, a critical biochemical readout of ly

14 bolome, intracellular calcium, extracellular cathepsin activity, and cell migration and invasion anal

15 es over concurrent incubation, and of either cathepsin alone.

16 Cysteine cathepsins are proteases capable of cathepsin cannibalis

17 n aspartic protease in Alzheimer's disease), cathepsin B (a cysteine protease in cancer), and Alp2 (a

18 icles that deliver antimicrobial peptide and cathepsin B (AMP-CatB) mRNA.

19 Cathepsin B (CatB) proteolytically degrades Abeta into n

20 HIV-infected macrophages secrete cathepsin B (CATB), and serum amyloid p component (SAPC)

21 Cathepsin B (CtsB) contributes to atherosclerosis and ca

22 e intracellular activation of trypsinogen by cathepsin B (CTSB), which can be induced directly via G

23 gen activation) or by the lysosomal protease cathepsin B (CTSB).

24 posed to active recombinant histidine-tagged cathepsin B (His-CATB).

25 Cathepsin B activates trypsinogen in these colocalized o

26 as not altered in the cathepsin B mutant and cathepsin B activation was independent of vacuolar proce

27 lysosomal dysfunction, lysosomal rupture and cathepsin B activation.

28 suring conditions, the limit of detection of cathepsin B activity and concentration can reach 2.49 x

29 Trypsinogen activation, increased cathepsin B activity and inflammation around the pancrea

30 Trypsin activity, cathepsin B activity and myeloperoxidase activity on the

31 e-dependent increase in pH and a decrease in cathepsin B activity associated with bacterial survival.

32 rode array for rapid, multiplex detection of cathepsin B activity based on a simple electrochemical m

33 reactive oxygen species (ROS) production and cathepsin B activity, accompanied by an up-regulation of

34 on pathways was evaluated by studying pH and cathepsin B activity.

35 Annexin A3 colocalized with cathepsin B and C, claudin-1, phosphorylated ERK1/2, and

36 Co-expression of cathepsin B and cathepsin B-resistant mutant LFABP in Mc

37 phagic vacuoles and was blocked by lysosomal cathepsin B and L inhibition.

38 ERSID is regulated positively by cathepsin B and negatively by PBA1, revealing a complex

39 ion were used to investigate the function of cathepsin B and PBA1 in ER-stress-induced PCD (ERSID).

40 lant proteases with caspase-3-like activity, cathepsin B and proteasome subunit PBA1, remains to be e

41 cretion as compared with cells co-expressing cathepsin B and wildtype LFABP.

42 Data indicate cathepsin B as a key molecule mediating neurodegeneratio

43 Mice lacking cathepsin B display aberrant follicular architecture, a

44 derived neurons were shown to have decreased cathepsin B expression compared to controls.

45 myelin build-up induces lysosomal damage and cathepsin B extracellular release by lysosomal exocytosi

46 uggest that activity-dependent exocytosis of Cathepsin B from lysosomes regulates the long-term struc

47 nterruption of either CCL2-CCR2 signaling or cathepsin B function significantly impaired PNI in vivo

48 ediated knock-down of genes belonging to the cathepsin B gene family.

49 Knock-down of cathepsin B genes reduced aphid fitness, but only on the

50 Now, a chemiluminescent probe for cathepsin B has been developed that provides a 16,000-fo

51 Leukocytes were the source of cathepsin B in drain fluid.

52 ified the activity of the lysosomal protease cathepsin B in macrophages as a rate-limiting factor in

53 siRNA-mediated knockdown of cathepsin B in McA-RH7777 cells resulted in a 39% increa

54 containing antimicrobial peptides linked to cathepsin B in the lysosomes (MACs) can be applied for t

55 ion of CTSB, as well as stronger staining of cathepsin B in the stratum granulosum of affected indivi

56 Cathepsin B increased the activity of matrix metalloprot

57 of these organelles resulting in leakage of cathepsin B into the cytosol leading to acinar cell deat

58 Accurate activity of cathepsin B is derived with an improved fitting algorith

59 The cathepsin B knockdown and 24-h treatment with OA resulte

60 Cathepsin B knockdown was accompanied by a 74% increase

61 Our results showed that digestion with cathepsin B led to nanoparticle size reduction.

62 Cathepsin B may execute its function after tonoplast rup

63 Tonoplast rupture was not altered in the cathepsin B mutant and cathepsin B activation was indepe

64 Simultaneous detection of the proteolysis of cathepsin B on the microelectrode array functionalized w

65 enhanced excretion of peptides derived from cathepsin B or C.

66 ategies for these ADCs involve cleavage with cathepsin B or papain to release and measure the antibod

67 Inhibition of cathepsin B prevents neuronal death and behavioural anom

68 dition that was also associated with greater cathepsin B production.

69 Together, these data indicate that cathepsin B regulates VLDL secretion and free fatty acid

70 ccumulation of non-functional autophagosome, cathepsin B release and pineoblastoma cell death.

71 tion of either lysosomal Ca(2+) signaling or Cathepsin B release prevented the maintenance of dendrit

72 Overexpression of cathepsin B resulted in decreased OA uptake and VLDL sec

73 Knock down of Beclin1, ATG16L1, Rubicon or cathepsin B significantly lowered the ability of neratin

74 CXCL13 solubilization requires the protease cathepsin B that cleaves CXCL13 into a stable product.

75 Co-localization of LFABP and cathepsin B was observed in a distinct Golgi apparatus-l

76 biquitin, p62/sequestosome1, cathepsin D and cathepsin B were detected with co-localizations of ubiqu

77 Transcript level and activity labelling of cathepsin B were used to assess activation.

78 In addition, inhibition of cathepsin B with different drugs or microglia from CatB-

79 n close proximity to SNCA and CTSB (encoding cathepsin B) are the most significant contributors.

80 e VC(S) linker was designed to be cleaved by cathepsin B, a lysosomal cysteine protease.

81 sponse of the formulation to the presence of cathepsin B, a proteolytic enzyme that is overexpressed

82 actions among three cancer-related proteases cathepsin B, ADAM10, and ADAM17.

83 ike receptor protein 3 (NLRP3) inflammasome, cathepsin B, and caspase-1 and may play a role in the pa

84 ysteine protease CPR-4, a homologue of human cathepsin B, as the first RIBE factor in nematodes, to o

85 IHC showed that glomerular tuft staining for cathepsin B, cathepsin C, and annexin A3 in cFSGS was si

86 The lysosomal proteases cathepsin B, D, and L have been identified as regulators

87 tivator of various lysosomal enzymes such as cathepsin B, D, and L.

88 vealed an inflammatory infiltrate expressing cathepsin B, independent of the presence of pancreatic f

89 on correlates with loss of the expression of cathepsin B, known to be essential for EBOV entry.

90 hepsin B, and IL-6 concentrations as well as cathepsin B, myeloperoxidase and trypsin activities were

91 rogrammed cell death through upregulation of cathepsin B, Tnf and Bid in a neutrophil-independent man

92 ppressed vesicle formation and knock down of cathepsin B-AIF significantly reduced neratinib lethalit

93 ) containing photosensitizer (Ce6) through a Cathepsin B-cleavable peptide.

94 studies in human specimens demonstrated that cathepsin B-producing macrophages were enriched in invad

95 Co-expression of cathepsin B and cathepsin B-resistant mutant LFABP in McA-RH7777 cells r

96 conjugated ex vivo to Cys34 of albumin via a cathepsin B-sensitive dipeptide linker to ensure that al

97 ed protein levels of the lysosomal protease, cathepsin B.

98 Gly-Ala-NH-CH(2)-Fc is the optimal probe for cathepsin B.

99 plasma membrane, resulting in the release of Cathepsin B.

100 ing the derepression of the lysomal protease cathepsin B.

101 cross-reactivity with the cysteine protease cathepsin B.

102 abel as the peptide molecules are cleaved by cathepsin B.

103 A cathepsin B/pH dual-sensitive block copolymer with a mol

104 Transcripts for cathepsins B and C were increased in FSGS glomeruli comp

105 y increasing cathepsin D activity, levels of cathepsins B and D and two proteins known to interact wi

106 om lysosomal permeabilization and release of cathepsins B and L in autophagy-deficient cells.

107 ncreases the activity of cathepsin D but not cathepsins B or L.

108 ated that it was a potent inhibitor of human cathepsins B, K, and L ( Ki = 6.87, 0.49, and 0.34 nM, r

109 derate to excellent selectivity versus human cathepsins B, L, and S and showed no apparent toxicity t

110 current study found that a cysteine protease Cathepsin B3 (CathB3), and the associated gene CathB3, w

111 By contrast, cathepsin B3 protein and activity were upregulated by ER

112 Cathepsin C (CatC) is a cysteine dipeptidyl aminopeptida

113 at glomerular tuft staining for cathepsin B, cathepsin C, and annexin A3 in cFSGS was significantly g

114 ayload release suggested that other cysteine cathepsins can cleave the VC(S) linker.

115 Cysteine cathepsins are proteases capable of cathepsin cannibalism, where one cathepsin hydrolyzes an

116 ble inhibitors (E-64 derivative) of cysteine cathepsins (CCs) as trapping agents to increase the tumo

117 s with self-immolative hydrolytic linkers or cathepsin-cleavable valine-citrulline peptide linkers.

118 bitors may achieve selectivity for different cathepsins, cruzain, rhodesain, and falcipain-2.

119 lysosomal activity attributable to cysteine cathepsins (Cts).

120 ojection neurons contain lysosomal hydrolase cathepsin D (CatD), a marker of neurons vulnerable to NF

121 Human cathepsin D (CatD), a pepsin-family aspartic protease, p

122 e have previously demonstrated the effect of cathepsin D (CD) on the mechanical disruption of retinal

123 B regulation by another lysosomal hydrolase, cathepsin D (CTSD), using mice with a complete (CTSD(-/-

124 uniting three major lysosomal proteins: (i) cathepsin D (CTSD), which plays a major role in alpha-sy

125 aturation of the lysosomal aspartyl protease cathepsin D (CTSD).

126 In particular, the level of mature cathepsin D (CTSDmat) dramatically changed depending upo

127 associated degradation (ERAD) of nascent pro-cathepsin D (pCatD) and consequent suppression of lysoso

128 lysosomal proteolytic activity by increasing cathepsin D activity, levels of cathepsins B and D and t

129 e product of PGRN, is sufficient to increase cathepsin D activity.

130 proteins LC3B, ubiquitin, p62/sequestosome1, cathepsin D and cathepsin B were detected with co-locali

131 ically interacts with the lysosomal protease cathepsin D and is required to maintain proper cathepsin

132 proteases, including multiple forms of MMPs, cathepsin D and K, kallikrein 4 and proprotein convertas

133 creased lysosomal proteins including LAMP-2, cathepsin D and LC3.

134 slowed LC3 turnover and the inactivation of cathepsin D and other lysosomal hydrolases known to be u

135 ng activity from human saliva, we identified cathepsin D as a protease that can activate VEGF-C as we

136 n D, and that PGRN increases the activity of cathepsin D but not cathepsins B or L.

137 uppression of proapoptotic lysosomal protein cathepsin D by promotion of the ER-associated degradatio

138 thepsin D and is required to maintain proper cathepsin D levels in oligodendrocytes.

139 matrix metalloproteinase [MMP]-8, MMP-9, and cathepsin D levels) evaluations were performed.

140 Mechanistically the availability of active cathepsin D mediates the effect of VPS35 on pathological

141 his functional relationship between PGRN and cathepsin D provides a possible explanation for overlapp

142 (matrix metalloproteinase 9, S100A8/S100A9, cathepsin D, and galectin-3-binding protein) improved ri

143 urthermore, we find that PGRN interacts with cathepsin D, and that PGRN increases the activity of cat

144 ation with incident diabetes and 3 proteins (Cathepsin D, Galectin-4, Paraoxonase type 3) with a nove

145 nd D and two proteins known to interact with cathepsin D, NPC1 and ABCA1.

146 mal membrane permeabilization and release of cathepsin D, which contributes to cell death.

147 mutations in PGRN or CTSD, the gene encoding cathepsin D.

148 decreased activity of the lysosomal enzyme, cathepsin D.

149 d decreased activity of the lysosomal enzyme cathepsin D.

150 Increased concentrations of caspase-3 and cathepsin-D proteases and components of the 26S proteaso

151 sion with siRNA or BACE1 inhibition reversed cathepsin deficits in both fibroblasts and neurons.

152 thepsin accumulation in the host nucleus and cathepsin-dependent cell death.

153 c Atg5 knockout were similarly sensitized to cathepsin-dependent hepatocellular injury and death from

154 within the intestinal epithelial cells in a cathepsin-dependent manner.

155 me through a reactive oxygen species- and/or cathepsin-dependent mechanism that was independent of ca

156 Genes encoding PD-1, CD62L, Bcl-2, cathepsin E, and Cxcr4 were within SJL genetic content i

157 utrophil proteases such as elastase (NE) and cathepsin G (CG) attach to NETs and contribute to the di

158 We hypothesized that the protease cathepsin G (CG) may participate in degrading lubricin i

159 mice lacking the neutrophil serine protease cathepsin G (CG)-induced hapten-reactive CD4 and CD8 T c

160 ted than in uninfected B cells, induction of cathepsin G activity by EBV led to total degradation of

161 We found that cathepsin G and matrix metallopeptidase 9 directly inhib

162 1 interferon-associated genes, but increased cathepsin G and matrix metallopeptidase 9 expression.

163 ypsin inhibitor-1 (SFTI-1) produced a potent cathepsin G inhibitor (Ki = 0.89 nM).

164 the most selective (>/=360-fold) engineered cathepsin G inhibitor reported to date.

165 a promising lead for further development of cathepsin G inhibitors targeting chronic inflammatory di

166 peptides MOG35-55 and MOG1-20 Inhibition of cathepsin G or citrullination of the arginine residue wi

167 The serine protease cathepsin G recapitulated the effects of MET-1 on DRG ne

168 Substituting preferred cathepsin G substrate sequences into sunflower trypsin i

169 vels of elastin degraded by proteinase 3 and cathepsin G were independently associated with mortality

170 Cathepsin G's P2' preference was determined by screening

171 rine protease activity in BALF (elastase and cathepsin G), plasma elastase footprint (Aalpha-Val(360)

172 ses polymorphonuclear (neutrophil) elastase, cathepsin G, and proteinase 3, but not neutrophil motili

173 ntified by mass spectroscopy, five proteins, cathepsin G, glutaredoxin-1, thioredoxin, GP1b, and fibr

174 ial proteins, elastase, myeloperoxidase, and cathepsin G, in response to these species was measured u

175 ducts generated by the enzymes proteinase 3, cathepsin G, neutrophil elastase, MMP7 or MMP9/12 were p

176 r the homologous neutrophil serine protease, cathepsin G.

177 rmolecular interactions formed by EapH1 with cathepsin-G differed considerably from that with neutrop

178 ealed a protease-binding mode for EapH1 with cathepsin-G that was globally similar to that seen in th

179 We found that EapH1 inhibits cathepsin-G with a K(i) of 9.8 +/- 4.7 nm Although this

180 serine proteases (NSPs) neutrophil elastase, cathepsin-G, and proteinase-3.

181 the physical basis for EapH1's inhibition of cathepsin-G, we crystallized EapH1 bound to this proteas

182 ributions from the inhibitor backbone in the cathepsin-G-bound form.

183 e proteinases such as thrombin, trypsin, and cathepsin-G.

184 us by enzymes such as thrombin, trypsin, and cathepsin-G.

185 SPs, we studied here the effects of EapH1 on cathepsin-G.

186 oncogene homolog 1 (AKT1), and the protease cathepsin H (CTSH), for which we establish a role in fil

187 capable of cathepsin cannibalism, where one cathepsin hydrolyzes another with substrate present, and

188 EBOV, the GP1 domain is cleaved by cellular cathepsins in acidic endosomes, removing the glycan cap

189 ripts increases the translation of lysosomal cathepsins in dendritic cells, and inhibition of catheps

190 Pharmacological cathepsin inhibition and nuclear targeting of a cellular

191 Finally, cathepsin inhibition reduced gasdermin D expression, thu

192 ced macrophage cell death not rescued by pan-cathepsin inhibition, and 3) show that NSA inhibits infl

193 hibition and nuclear targeting of a cellular cathepsin inhibitor (stefin B) suppressed S. enterica Ty

194 rotease inhibitor was more protective than a cathepsin inhibitor in SARS-CoV-infected mice.

195 (DAM), which encodes an endosomal/lysosomal cathepsin inhibitor named Cystatin F.

196 even when its cleavage was prevented with a cathepsin inhibitor, indicating that it is endocytic F t

197 is, in part, mediated by the collagenolytic cathepsin K (catK) and cathepsin L (catL), with a tempor

198 ectrophile into small molecule inhibitors of cathepsin K (CatK).

199 n osteoclasts for bone resorption, including cathepsin K (Ctsk), and lactation elevates their express

200 id phosphatase 5, tartrate resistant (Acp5), cathepsin K (Ctsk), and TNF superfamily member 11 (Tnfsf

201 ver kinase b1 (Lkb1; also known as Stk11) in Cathepsin K (Ctsk)-Cre expressing cells.

202 In vitro, fibroblast extracellular cathepsin K activity was minimal at pH 7.5 but significa

203 oblast co-cultures, acidification paralleled cathepsin K activity, and both were reduced by sodium bi

204 sion of osteoclast specific markers, such as cathepsin K and integrin beta3 at mRNA and protein level

205 gy, glutathione levels and protein levels of cathepsin K and those associated with Ca(2+) handling, c

206 o that esterase activity will liberate 5 and cathepsin K cleavage of the Leu-Arg-PABA element will li

207 results in lower expression and activity of cathepsin K compared with resting unpolarized macrophage

208 dult-onset osteopetrotic phenotype caused by cathepsin K deficiency(23,24).

209 itively correlated with TNF-alpha, IL-6, and cathepsin K expression and negatively correlated with Ru

210 ear factor of activated T cells type c-1 and cathepsin K expression is defective in these macrophages

211 Cathepsin K gene expression and protein and protease act

212 e expression profiling in whole lung tissue, cathepsin K gene expression was 40-fold overexpressed in

213 In lung nodules, cathepsin K immunoreactivity predominantly co-localized

214 MIV-711 is a novel selective cathepsin K inhibitor with beneficial effects on bone an

215 Odanacatib, a cathepsin K inhibitor, reduces bone resorption while mai

216 Wild-type and cathepsin K knockout mice were rendered diabetic by stre

217 ocyte apoptosis, which were mitigated in the cathepsin K knockout mice.

218 Therefore, cathepsin K may represent a potential target in treating

219 disease and the lysosomal cysteine protease cathepsin K plays a critical role in cardiac pathophysio

220 , we tested the hypothesis that, knockout of cathepsin K protects against diabetes-associated cardiac

221 Immunohistochemistry confirmed cathepsin K protein was expressed in LAM but not control

222 Interestingly, AAV-sh-Ac45 impaired mature cathepsin K secretion more significantly than that by AA

223 ammation through impairing acidification and cathepsin K secretion.

224 d tartrate-resistant acid phosphatase (TRAP)/cathepsin K(+) OCs expressing phosphorylated Janus kinas

225 , FGF18 (fibroblast growth factor 18), CTSK (cathepsin K), and IL11 (interleukin 11), have therapeuti

226 ted T-cells cytoplasmic 1, NF-kappaB ligand, cathepsin K, and serum tartrate-resistant acid phosphata

227 levels of the osteoclast marker genes TRAP, Cathepsin K, dendritic cell-specific transmembrane prote

228 oclast-promoting genes, including Dickkopf1, Cathepsin K, Nf-kbeta,; and Calcr, suggesting a role for

229 9c2 myoblasts, pharmacological inhibition of cathepsin K, or treatment with calcineurin inhibitor res

230 ption volume and examined periodontal tissue cathepsin K, Runx2, TNF-alpha, and IL-6 expression.

231 ia-derived IFN-gamma exhibited low levels of Cathepsin K, TRAP, RANK, and tumor necrosis factor recep

232 uced the mRNAs encoding for RANKL, TRAP, and Cathepsin K.

233 ydrase type II, but relatively low levels of cathepsin K.

234 potent gallinamide analog yet tested against cathepsin L (10, K(i) = 0.0937 +/- 0.01 nM and k(inact)/

235 Cathepsin L (Cat L) is a cysteine protease that can prot

236 by the collagenolytic cathepsin K (catK) and cathepsin L (catL), with a temporal component to their a

237 ons, and increased activity of extracellular cathepsin L and D.

238 Mechanistically, both glomerular cathepsin L and heparanase expression were reduced.

239 vel substituents for the apolar S2 pocket of cathepsin L and was conducted entirely in a prospective

240 pe inhibitor family likely regulate parasite cathepsin L proteases and/or impairs host immune cell ac

241 of IL-10, whereas tumor necrosis factor and cathepsin L release was reduced, further confirming pola

242 rier function through influencing macrophage cathepsin L secretion, thus reducing activation of the g

243 tion by three classes of proteases: plasmin, cathepsin L, and matrix metalloproteinases (MMP-2 and MM

244 APOL1 silencing enhanced miR193a and Cathepsin L, but down-regulated dynamin expressions.

245 ontrary, DPDG1s/G2s displayed an increase in Cathepsin L, but down-regulation of dynamin expressions

246 DPDG0s showed decreased Cathepsin L, enhanced dynamin expressions, and the intac

247 of parasite cathepsins L and host lysosomal cathepsin L, S and K cysteine proteases (inhibition cons

248 pite close sequence homology to the protease cathepsin L, the silicateins seem to exhibit no signific

249 Regulation of parasite-secreted cathepsin L-like cysteine proteases associated with viru

250 ble inhibitor of the human cysteine protease cathepsin L.

251 rs, including the receptor ACE2 and protease Cathepsin L.

252 teases but are potent inhibitors of parasite cathepsins L and host lysosomal cathepsin L, S and K cys

253 as intracellular cysteine proteases, such as cathepsin-L, might be involved in the degradation of gas

254 ESM [endothelial cell-specific molecule]-1, cathepsin L1, osteopontin, and MCSF-1) was also identifi

255 ess involves crystal phagocytosis, lysosomal cathepsin leakage, and increased release of reactive oxy

256 type II cystatin gene cluster, mucin 5, and cathepsin loci, via enhancer regulation of cancer-associ

257 epsins in dendritic cells, and inhibition of cathepsins markedly enhances cross-presentation of wild-

258 These cells and their cathepsins may be therapeutic targets.

259 ntify cooperative and conflicting actions of cathepsin mediated collagen matrix degradation by consid

260 CD74, which inhibits viral entry by blocking cathepsin-mediated processing of the Ebola glycoprotein.

261 efflux and calcium influx but not lysosomal cathepsin or mitochondrial reactive oxygen species.

262 selectivity versus related cysteine protease cathepsins, other proteases, and receptors.

263 l role by stabilizing Bet v 1 and inhibiting cathepsin protease activity.

264 interface of the S1 and S1' subsites of the cathepsin protease, and (b) Arg(19) which forms cation-p

265 immune cell activation by blocking lysosomal cathepsin proteases involved in antigen processing and p

266 oteolytically cleaved, a process mediated by cathepsin proteases, liberating the N-terminal DID to fu

267 We verified that active cathepsins re-traffic to the nucleus and that these are

268 Pharmacological inhibition of cathepsin S (CatS) allows for a specific modulation of t

269 egradation by different proteases, including cathepsin S (CatS) and the intramembrane protease signal

270 Cathepsin S (CTSS) is highly increased in Sjogren's synd

271 MHC II, IFN-gamma, IL-1beta, TNF-alpha, and cathepsin S (Ctss) mRNA transcripts, and greater nitroty

272 1) repressed expression of the gene encoding cathepsin S (Ctss), a cysteine protease that cleaves inv

273 Activity of cathepsin S (CTSS), a cysteine protease, is significantl

274 Interestingly, cathepsin S activity was strongly up-regulated in sample

275 leavage sites of the endolysosomal proteases cathepsin S and legumain.

276 Cathepsin S is one of the most important cysteine protei

277 Inhibition of cathepsin S molecules, blockade of costimulation through

278 olecule inhibitors and siRNA gene silencing, cathepsin S was identified as the major IL-36gamma-activ

279 Rationale: CTSS (cathepsin S) is a cysteine protease that is observed at

280 thermostability while inhibiting cleavage by cathepsin S, an endosomal protease essential for antigen

281 teraction that responds to G-CSF by engaging Cathepsin S-CX3CR1-inducible NOS signaling.

282 mma-Ser18, identified as the main product of cathepsin S-dependent IL-36gamma cleavage, induced psori

283 Cathepsin S-digested allergenic lipocalins, but not dige

284 Effector genes namely Eng-1, Cathepsin S-like cysteine protease, cellulase, and two u

285 activation of IL-36gamma and highlight that cathepsin S-mediated activation of IL-36gamma may be imp

286 to Galpha(q), Galpha(s), and beta-arrestins, cathepsin-S (CS) and neutrophil elastase (NE) cleave PAR

287 impairs lysosomal calcium refilling, causes cathepsins translocation, inhibition of autophagic flux

288 These findings reveal a novel function for a cathepsin-type protease in aphid saliva that elicits eff

289 A class I antibodies significantly increased cathepsin-V (CTSV) expression and galectin-1 expression

290 rmal controls, and urinary excretion of both cathepsins was significantly greater in cFSGS compared w

291 The inhibition of cathepsins, widely implicated in particle-induced macrop

292 ificant causal effects of type 2 diabetes on cathepsin Z and rennin, both known to have roles in the

293 The results show for the first time that cathepsin Z could be a future diagnostic biomarker for o

294 ROC analysis showed that cathepsin Z mRNA has strong diagnostic value for osteopo

295 Cathepsin Z mRNA in human peripheral blood mononuclear c

296 Cathepsin Z mRNA level strongly correlated with low bone

297 his study was to investigate whether altered cathepsin Z mRNA levels are associated with osteoporosis

298 Importantly, cathepsin Z mRNA was significantly associated with fragi

299 The levels of cathepsin Z mRNA were not significantly higher in patien

300 ce these cell lineages produce the protease, cathepsin Z, the aim of this study was to investigate wh