ライフサイエンスコーパス: cathepsin L

1 rs, including the receptor ACE2 and protease Cathepsin L.

2 POMC consistent with proteolysis of POMC by cathepsin L.

3 expression of nuclear target genes RyR1 and cathepsin L.

4 n L because of its inhibitory action against cathepsin L.

5 three cathepsin Cs, one cathepsin B, and one cathepsin L.

6 ibility to proteolysis by endocytic protease cathepsin L.

7 a previously unreported biological role for cathepsin L.

8 nhibition with selectivity for inhibition of cathepsin L.

9 itors of the pH-sensitive endosomal protease cathepsin L.

10 0, RIG-G, and EMAPII and decreased MEF2D and cathepsin L.

11 he 20S proteasome and its 19S regulator, and cathepsin L.

12 lla spp. is a competitive inhibitor of human cathepsin L.

13 e acid-dependent lysosomal cysteine protease cathepsin L.

14 recombinant protein on the cysteine protease cathepsin L.

15 d 100-fold selective for cruzain relative to cathepsin L.

16 64), an inhibitor of thiol proteases such as cathepsin L.

17 ail cleavage events mediated by the protease Cathepsin L.

18 t the small molecule is a mixed inhibitor of cathepsin L.

19 n and did not inhibit the cysteine protease, cathepsin L.

20 ed a non-elastase variant similar to that of cathepsin L.

21 ble inhibitor of the human cysteine protease cathepsin L.

22 potent gallinamide analog yet tested against cathepsin L (10, K(i) = 0.0937 +/- 0.01 nM and k(inact)/

23 antiviral action likely is the inhibition of cathepsin L, a cellular enzyme that is essential for the

24 inant CTLA-2beta helped us to determine that cathepsin L, a cysteine protease, is one of its targets

25 tified, including hydrolytic enzymes such as cathepsin L, a cysteine proteinase involved in lysis of

26 ideneamino]thiourea} acts later, by blocking cathepsin L, a host protease required for processing of

27 rict reovirus uncoating still express mature cathepsin L, a lysosomal protease required for virion di

28 , we assessed the effects of this microbe on cathepsin L, a protease that cleaves CDP into a form wit

29 Cells and mice lacking cathepsin L accumulate full-length Ctr1 and hyper-accumu

30 agocytophilum infection resulted in elevated cathepsin L activity and the proteolysis of CDP.

31 The intracellular localization of cathepsin L activity and topo I in necrotic cells was ex

32 ate that testican-1 is capable of modulating cathepsin L activity both in intracellular vesicles and

33 However, removal of both cathepsin B and cathepsin L activity completely abrogates disassembly an

34 For the ice stored fillets, the cathepsin L activity decreased significantly from 6 to 2

35 During necrosis, cathepsin L activity diffused from lysosomes into the cy

36 in macrophages, TLR9-GFP cleavage depends on cathepsin L activity in B cells.

37 There was also a significantly lower cathepsin L activity in the super-chilled fillets at 0h

38 These data demonstrate that increasing cathepsin L activity is a strategy used by A. phagocytop

39 ide evidence that NPC1(+) LE/Lys have higher cathepsin L activity than LE, with no detectable activit

40 Cathepsin L activity was 100-fold greater in Vero cells

41 ed in crowded and chilled salmon whereas the cathepsin L activity was found to be significantly affec

42 Furthermore, while cathepsin L activity was seen to be marginally important

43 ty in vitro and partially inhibits lysosomal cathepsin L activity within live APCs.

44 only endosomal requirement for SARS entry is cathepsin L activity, we tested and provide evidence tha

45 locking antibody increased the expression of cathepsin L activity.

46 PDK4 protein expression, and proteasome and cathepsin-L activity, and reduced muscle PDC activity.

47 p between the expression of cystatin E/M and cathepsin L and a direct relationship between the loss o

48 ry event involving a novel interplay between cathepsin L and alpha(3) integrin.

49 ated interplay between the cysteine protease cathepsin L and alpha(3) integrin.

50 blockade of other cysteine proteases such as cathepsin L and calpain, aminopeptidases, elastase, or m

51 s of cathepsin L in neuronal media, and both cathepsin L and cathepsin B were demonstrated to be impo

52 ons, and increased activity of extracellular cathepsin L and D.

53 Interactions of endopin 2C with cathepsin L and elastase were indicated by protease clea

54 Mechanistically, both glomerular cathepsin L and heparanase expression were reduced.

55 by analysis of I-A(b) mice deficient in both cathepsin L and invariant chain.

56 y that histone proteolysis, brought about by Cathepsin L and potentially other family members, plays

57 Markers of tumor invasion, cathepsin L and TGFbeta1, were overexpressed; calcium-de

58 vel substituents for the apolar S2 pocket of cathepsin L and was conducted entirely in a prospective

59 t, small GTPases, and the cysteine proteases cathepsin-L and -B.

60 The expressions of cathepsin-L and the muscle-specific E3 ligases MuRF-1 an

61 ceptor binding, and ability to be cleaved by cathepsins L and B.

62 by inhibits acid-dependent proteases such as cathepsins L and B.

63 cleavage profile was reproduced in vitro by cathepsins L and H and was inhibited by the cathepsin L

64 teases but are potent inhibitors of parasite cathepsins L and host lysosomal cathepsin L, S and K cys

65 f F. hepatica, FhCL1 and FhCL2, and of human cathepsins L and K (Ki = 0.4-27 nm).

66 itors docked within the active sites of both cathepsins L and K have rationalized the observed select

67 s selectivity toward FhCL1, FhCL2, and human cathepsins L and K.

68 activity of other cysteine proteases such as cathepsins L and S at 37 degrees C.

69 In contrast to the joint requirement for cathepsins L and S for TLR9 cleavage in macrophages, TLR

70 to cleavage by the NOX2-controlled cysteine cathepsins L and S in a redox-dependent manner.

71 selective for cathepsin K when compared with cathepsins L and S, with the Ki values in the 10-30 nM r

72 extracts, and pure cathepsins, we identified cathepsins L and Z as the lysosomal cysteine proteases t

73 RNAi for cathepsins L and Z in different cell lines and adult mou

74 1-dependent haptotaxis, whereas induction of cathepsins-L and -B promotes matrix invasion.

75 is, increased expression of the tumor marker cathepsin L, and a high degree of invasiveness as tested

76 killing, regulation of the hydrolytic enzyme cathepsin L, and for coordination and trafficking of MHC

77 tion by three classes of proteases: plasmin, cathepsin L, and matrix metalloproteinases (MMP-2 and MM

78 e increased mRNA levels of atrogin-1, MuRF1, cathepsin L, and/or Bnip3 and inhibited muscle fiber atr

79 Nine genes, PDGF A, Cathepsin L, annexin A1, Mm.112139, Est2 repressor facto

80 Isolated podocytes from mice lacking cathepsin L are protected from cell puromycin aminonucle

81 finding suggests that factors in addition to cathepsin L are required for efficient intracellular pro

82 represent the basis for a novel function of cathepsin L as a cell survival molecule responsible for

83 These findings demonstrate cathepsin L as a distinct cysteine protease pathway for

84 We map the sites of H3 cleavage and identify Cathepsin L as a protease responsible for proteolyticall

85 Cathepsin L, B, and D cleavage sites in mouse Tg were pr

86 , NM23-H1, is degraded by lysosomal cysteine cathepsins (L,B), which directly cleave NM23-H1.

87 Here, we identify the cathepsin L/B endolysosomal proteases functioning in a d

88 ate that the combination of cisplatin with a cathepsin L/B inhibitor enhances cisplatin uptake and ce

89 The compound also displayed cathepsin L/B selectivity of >700-fold and was nontoxic

90 Optimization of cathepsin L binding by the combination of the P3 naphthy

91 Inhibitors of cathepsin L blocked infection by SARS-CoV and by a retro

92 RS-S with ACE2 or the enzymatic functions of cathepsin L but prevents fusion of the viral membrane wi

93 APOL1 silencing enhanced miR193a and Cathepsin L, but down-regulated dynamin expressions.

94 ontrary, DPDG1s/G2s displayed an increase in Cathepsin L, but down-regulation of dynamin expressions

95 Cathepsin L, but not cathepsin B, is an important contri

96 LECs express invariant chain and cathepsin L, but not H2-M, suggesting that they cannot l

97 than caspases have shown that inhibition of cathepsin L, but not proteasome or cathepsin B, was resp

98 cleavage by the endosomal/lysosomal protease cathepsin L, but the route of Hendra virus F following i

99 cysteine protease activity was identified as cathepsin L by affinity labeling with an activity-based

100 whereas thymic cortical epithelial cells use cathepsin L (Cat L) for invariant chain degradation and

101 the elastinolytic and collagenolytic enzyme cathepsin L (Cat L) in human atherosclerotic lesions sug

102 Cathepsin L (Cat L) is a cysteine protease that can prot

103 immune response, we generated mice that lack cathepsin L (Cat L) on the autoimmune diabetes-prone NOD

104 rther, processing of the lysosomal proteases cathepsin L (CatL) and CatB into their fully active, mat

105 h the cleavage of GP by proteases, including cathepsin L (CatL) and/or CatB, in the endosome or cell

106 Here we demonstrate a role for cathepsin L (CatL) cleavage of Ebola virus GP in the gen

107 how that mice lacking the endosomal protease cathepsin L (catL) have greatly reduced numbers of V(alp

108 e confirmed roles for cathepsin B (CatB) and cathepsin L (CatL) in Ebola virus glycoprotein (GP)-medi

109 cathepsin B (CatB) and an accessory role for cathepsin L (CatL) in EboV GP-dependent entry.

110 Cathepsin S (catS) and cathepsin L (catL) mediate late stages of invariant chai

111 ity complex (MHC), invariant chain (Ii), and cathepsin L (CatL) molecules involved in thymocyte-posit

112 by the collagenolytic cathepsin K (catK) and cathepsin L (catL), with a temporal component to their a

113 on factor to promote expression of cytosolic cathepsin L (CatL).

114 ivation of a lysosomal and nuclear protease, cathepsin L, causes a global redistribution of epigeneti

115 ings were achieved by coexpression of PE and cathepsin L cDNAs in PC12 cells with analyses of PE-deri

116 The cysteinal lysosomal proteases, cathepsin L (CL) and cathepsin S (CS), have been shown t

117 tive endosomal compartments, suggesting that cathepsin L cleavage occurs in early endosomes.

118 overed a small molecule that can inhibit the cathepsin L cleavage of all viral peptides with minimal

119 to identify small molecules that can prevent cathepsin L cleavage of viral glycoproteins derived from

120 age, and these amino acids included a likely cathepsin L cleavage site.

121 he aforementioned viruses, which contain the cathepsin L cleavage site.

122 ough dynamin self-assembly, are resistant to cathepsin L cleavage.

123 Structure-assisted modeling of the cathepsin L-cleaved ZEBOV-GP revealed that cleavage remo

124 2C that demonstrates selective inhibition of cathepsin L compared to papain or elastase.

125 Processing of cathepsin L (CPL) in these mutants was deficient only wh

126 (now Ctsl(nkt)) comprises a deletion in the cathepsin L (Ctsl) gene.

127 unprecedented role for the cysteine protease Cathepsin L (CTSL) in the degradation of 53BP1.

128 The cysteine protease cathepsin L (CTSL) is often thought to act as a tumor pr

129 We found that the T cell-expressed protease cathepsin L (CTSL) processed C3 into biologically active

130 activated by HDAC and an endogenous protease cathepsin L (CTSL) that remove the acetyl group first an

131 re, we demonstrate that BRCA1 loss activates cathepsin L (CTSL)-mediated degradation of 53BP1.

132 but were again sex specific for three genes: cathepsin-L (CtsL), matrix metalloproteinase-14 (MMP-14)

133 was a potent inhibitor of the major secreted cathepsin L cysteine proteases of F. hepatica, FhCL1 and

134 Our data indicate the cathepsin L defect in CD4+ T cell selection is haplotype

135 lock in invariant chain cleavage we analyzed cathepsin L-deficient mice expressing the I-A(q) haploty

136 bitor Z-Phe-Tyr(t-Bu)-diazomethyl ketone and cathepsin L-deficient mouse embryo fibroblasts resulted

137 de-induced cell migration was slowed down in cathepsin L-deficient podocytes and by the preservation

138 ling acts, in part, through calcineurin- and cathepsin L-dependent cleavage of synaptopodin, a regula

139 13) report the discovery of an intracellular cathepsin-L-dependent C3 activation pathway.

140 vesicles, demonstrated by colocalization of cathepsin L-DsRed fusion protein with enkephalin and chr

141 3631927) was tested as an inhibitor of human cathepsin L (EC 3.4.22.15) and as an entry blocker of se

142 m SID 26681509), a potent inhibitor of human cathepsin L (EC 3.4.22.15) with an IC(50) of 56 nM, was

143 DPDG0s showed decreased Cathepsin L, enhanced dynamin expressions, and the intac

144 provide evidence that a lysosomal protease, cathepsin L, exists in a previously unsuspected isoform

145 Cathepsin L expression and activity were induced in podo

146 mycin aminonucleoside treatment up-regulates cathepsin L expression in podocytes in vivo as well as e

147 The functional significance of cathepsin L expression was underscored by the observatio

148 Virus infection induced cellular cathepsin L expression while reducing the levels of othe

149 cent phenotype and a marked up-regulation of cathepsin-L expression.

150 Cruzain is a member of the papain/cathepsin L family of cysteine proteases, and the major

151 newly defined secretory vesicle function of cathepsin L for biosynthesis of active enkephalin opioid

152 These viruses depend on cathepsin L for entry into their target cells.

153 region is consistent with the specificity of cathepsin L for hydrophobic residues in the P2 position

154 The importance of cathepsin L for infection of other cell types is unknown

155 novel cellular role of the cysteine protease cathepsin L for producing the (Met)enkephalin peptide ne

156 Key findings from this study show that cathepsin L functions as a major proteolytic enzyme for

157 We describe a mutant of pro-cathepsin L fused to YFP that no longer targets to the l

158 Finally, in cathepsin L gene knockout mice, [Met]enkephalin levels i

159 Although cathepsin L generated the requisite TLR9 cleavage produc

160 ndrial stress-induced expression of RyR1 and cathepsin L genes.

161 endosomal cysteine proteases cathepsin B and cathepsin L greatly reduce MHV-2 spike-mediated entry, w

162 virus entry requires the endosomal protease cathepsin L; however, it was also found that infection o

163 uvate kinase, Glut4), oncogenesis (TGFbeta1, cathepsin L, IGFR1, melanoma antigen) and apoptosis (Bcl

164 y of acoustic dispensing by delivering human cathepsin L in a drop-on-drop fashion into individual 50

165 The reduction in active cathepsin L in inhibitor-treated cells correlated well w

166 r hand, IL-1alpha treatment raised levels of cathepsin L in neuronal media, and both cathepsin L and

167 Expression of cathepsin L in pituitary AtT-20 cells resulted in increa

168 well as expression and enzymatic activity of cathepsin L in podocytes in vitro.

169 Thus, we propose a novel role for cathepsin L in regulating positive selection by generati

170 Similar localization of a related cathepsin L in the filarial nematode Onchocerca volvulus

171 erized biological role for secretory vesicle cathepsin L in the production of [Met]enkephalin, an end

172 se findings demonstrate a prominent role for cathepsin L in the production of ACTH, beta-endorphin, a

173 In vivo studies also showed that cathepsin L in vivo was colocalized with enkephalin.

174 e results implicate cathepsins, particularly cathepsin L, in the cleavage of topo I during necrosis.

175 or virus-specific differences in the role of cathepsin L, including cooperation with cathepsin B.

176 Deletion of CTSB reduced and deletion of cathepsin L increased intracellular trypsin activation.

177 In the cathepsin L inhibition assay, the oxocarbazate caused a

178 All together, these findings suggest that cathepsin L inhibition in drug-resistant cells facilitat

179 on of the underlying mechanism revealed that cathepsin L inhibition resulted in the alteration of int

180 nhibitors (FK506 and cyclosporine A) and the cathepsin L inhibitor E64 all inhibited protamine sulfat

181 cathepsins L and H and was inhibited by the cathepsin L inhibitor Z-FY-CHO.

182 nfection of both L929 cells treated with the cathepsin L inhibitor Z-Phe-Tyr(t-Bu)-diazomethyl ketone

183 When tested against cathepsin L, inhibitor I and all its polymer conjugates

184 The potent selective cathepsin L inhibitors (K(i) = 0.0099, 0.034, and 0.27 n

185 hibitors of the homologous cysteine protease cathepsin L is detailed.

186 Testican-1 inhibition of cathepsin L is independent of its chondroitin sulfate ch

187 The expressions of involucrin, loricrin, and cathepsin L is initially increased by day 19 but subsequ

188 demonstrate here that the cellular protease cathepsin L is involved in converting the Hendra virus p

189 SARS-CoV membrane fusion and indicates that cathepsin L is sufficient to activate membrane fusion by

190 ry into murine fibroblasts and indicate that cathepsin L is the primary mediator of reovirus disassem

191 We show here that secretory vesicle cathepsin L is the responsible cysteine protease of chro

192 and exhibited notable selectivity over human cathepsins L, K, and B.

193 Specifically, cathepsin L knock-out mice showed major decreases in ACT

194 In cathepsin L knockout cells, the levels of trimethylated

195 ggesting cortical thymic epithelial cells in cathepsin L knockout mice express an altered peptide rep

196 ric kidney disease, induction of cytoplasmic cathepsin L leads to cleavage of dynamin at an evolution

197 exosite 1 or 2 with analogous residues from cathepsin L led to a 75 and 43% loss in the elastolytic

198 Treatment of wt mice with an inhibitor of cathepsin L led to amelioration of reovirus infection.

199 Rhodesain, a cathepsin L-like cysteine protease of T. brucei rhodesie

200 ain (also brucipain, trypanopain), the major cathepsin L-like cysteine protease of T. brucei, genomic

201 Regulation of parasite-secreted cathepsin L-like cysteine proteases associated with viru

202 t T. b. gambiense displayed higher levels of cathepsin L-like cysteine proteases, we investigated whe

203 nzene (K11777), an irreversible inhibitor of cathepsin L-like cysteine proteases.

204 human malaria, there are four members of the cathepsin L-like family of cysteine proteases.

205 ease for proline and leucine residues into a cathepsin L-like preference for bulky aromatic residues.

206 phatase (TgVP1), a vacuolar proton ATPase, a cathepsin L-like protease (TgCPL), an aquaporin (TgAQP1)

207 the major parasite-secreted proteases and/or cathepsin L-like proteases of its host.

208 The cathepsin L-like S2 specificity of the mutant protein an

209 ed the S2 pocket of human cathepsin K into a cathepsin L-like subsite.

210 ffect interactions with the ACE2 receptor or cathepsin L-mediated activation of SARS-S-driven membran

211 oad-spectrum small molecule that could block cathepsin L-mediated cleavage and thus inhibit the entry

212 evels, 53BP1 loss is caused by activation of cathepsin L-mediated degradation of 53BP1 protein.

213 raction, in turn, protects synaptopodin from cathepsin L-mediated degradation.

214 ediated Akt/FOXO inhibition, and blunting of cathepsin-L-mediated lysosomal protein breakdown.

215 Cathepsin L mediates invariant chain processing in corti

216 Concordantly, cathepsin L mediates reovirus disassembly more efficient

217 as intracellular cysteine proteases, such as cathepsin-L, might be involved in the degradation of gas

218 , c-Jun, Sp1, Sin, and tomosyn and decreased cathepsin L, Mre11, and topoisomerase II alpha.

219 ficantly reduce the LPS-mediated increase in cathepsin-L mRNA expression and enzyme activity by 43% (

220 uscle PDK4, muscle atrophy F-box (MAFbx) and cathepsin-L mRNA expression, increased PDK4 protein expr

221 Cathepsin-L mRNA was 2-fold higher (P < 0.01), whilst ca

222 ased muscle PDK4 mRNA and protein, MAFbx and cathepsin-L mRNA, increased activity of PDC and reduced

223 Production of [Met]enkephalin by cathepsin L occurred by proteolytic processing at dibasi

224 r cells and posttranslationally activated by cathepsin L of tubular origin, sustains continuous activ

225 These results demonstrate that either cathepsin L or cathepsin B is required for reovirus entr

226 SVPs) with either of the endocytic proteases cathepsin L or cathepsin D demonstrated that an isolated

227 ents of the NLRP3 inflammasome, cathepsin B, cathepsin L or IL-1 molecules.

228 ct in cell-mediated immunity in mice lacking cathepsin L or S.

229 carboxamide led to increased selectivity for cathepsin L over cathepsin K.

230 lso resulted in an increased selectivity for cathepsin L over cathepsin K.

231 i.e. MAFbx (P < 0.001), MuRF-1 (P < 0.001), cathepsin-L (P < 0.05), PDK2 (P < 0.05) and PDK4 (P < 0.

232 Endopin 2C formed SDS-stable complexes with cathepsin L, papain, and elastase that are typical of se

233 ent protein provide strong evidence that the cathepsin L phosphorylation signal is a simple structure

234 ides in vivo evidence that cysteine protease cathepsin L plays a critical role in hair follicle morph

235 signal sequence of endopin 2C, like that of cathepsin L, predicts their colocalization to subcellula

236 Additionally, we found that purified human cathepsin L processed immunopurified Hendra virus F(0) i

237 Cathepsin-L promotes injury through an antiapoptotic eff

238 Podocyte alkalinization reduces cytosolic cathepsin L protease activity and protects the podocyte

239 mbryonic lethality caused by the loss of the cathepsin L protease, indicating that the accumulation o

240 pe inhibitor family likely regulate parasite cathepsin L proteases and/or impairs host immune cell ac

241 es to cathepsin L which dramatically reduced cathepsin L protein expression and enzyme activity.

242 The requirement for cathepsin L proteolysis identifies a previously uncharac

243 tional changes in S glycoprotein followed by cathepsin L proteolysis within endosomes.

244 of IL-10, whereas tumor necrosis factor and cathepsin L release was reduced, further confirming pola

245 Expression of cathepsin L resulted in highly increased cellular levels

246 cells with CLIK-148, a specific inhibitor of cathepsin L, resulted in reduced production of ACTH and

247 -depleted cells stably expressing anti-sense cathepsin L RNA, TGFbeta1 RNA, or treated with specific

248 ivator in up-regulating the transcription of Cathepsin L, RyR1, and Glut-4, the target genes of stres

249 previously established stress response genes Cathepsin L, RyR1, and Glut4.

250 of parasite cathepsins L and host lysosomal cathepsin L, S and K cysteine proteases (inhibition cons

251 0 recognized by three major human proteases (cathepsins L, S, and D) important for antigen processing

252 r and plasminogen, the cysteine proteinases, cathepsins L, S, and K, and the matrix metalloproteinase

253 hly homologous cysteine proteases, including cathepsins L, S, and V.

254 llagenous barriers independently of plasmin, cathepsins L, S, or K, MMP-2, or MMP-9.

255 rier function through influencing macrophage cathepsin L secretion, thus reducing activation of the g

256 Cathepsin L shRNA-expressing Vero cells transfected with

257 it did not rely on nuclear factor kappaB or cathepsin L signaling.

258 hat lack the cathepsin L site, or render the cathepsin L site inaccessible through dynamin self-assem

259 Dynamin mutants that lack the cathepsin L site, or render the cathepsin L site inacces

260 At neutral pH, testican-1 also stabilizes cathepsin L, slowing pH-induced denaturation and allowin

261 cal approach, through cell transfection with cathepsin L small interfering RNA, also strongly reverse

262 Thus, our data show that cathepsin L stabilizes epigenetic heterochromatin marker

263 Expression of exogenous cathepsin L substantially enhanced infection mediated by

264 emonstrated that p21/WAF1 is a substrate for cathepsin L, suggesting that inhibition of this enzyme m

265 We evaluated E64 resistance and in vitro cathepsin L susceptibility of these viruses and found th

266 haracterized the T. gondii cysteine protease cathepsin L (TgCPL), one of five cathepsins found in the

267 ed 7- to 151-fold greater selectivity toward cathepsin L than papain and cathepsins B, K, V, and S wi

268 slow-binding, reversible inhibitor of human cathepsin L that blocked SARS-CoV and Ebola pseudotype v

269 ed nuclear enzymatic activity of a protease (cathepsin L) that has been shown to cleave full-length C

270 action of the inhibitors with intracellular cathepsin L, the activity-based probe biotin-Lys-C5 alky

271 pite close sequence homology to the protease cathepsin L, the silicateins seem to exhibit no signific

272 After a 4-h preincubation with cathepsin L, this compound became even more potent, demo

273 that the defect in positive selection in the cathepsin L-/- thymus is specific for CD4+ T cells that

274 including cysteine proteases cathepsin B and cathepsin L, tissue inhibitor of matrix metalloproteinas

275 redominantly expressed by melanoma cells and cathepsin L to be predominantly expressed by the tumor-a

276 s with increasing specificity, we identified cathepsin L to be the protease responsible for cleavage.

277 enzymatic activity of the cysteine protease cathepsin L to infect ACE2-expressing cells.

278 n, FhHDM-1 is rapidly processed by lysosomal cathepsin L to release a short C-terminal peptide (conta

279 Functional localization of cathepsin L to the regulated secretory pathway was demon

280 ng of the precursor forms of cathepsin D and cathepsin L to their mature, lysosomal forms, which coin

281 okinin (CCK) increased the activity of CTSB, cathepsin L, trypsin, chymotrypsin, and caspase 3 in viv

282 In contrast, cathepsin L, V, B, and S revealed no collagenase activit

283 CA, family C1) papain, bromelain, and human cathepsins L, V, K, S, F, B, and five proteases of paras

284 In addition, cathepsin L was able to cleave the G protein in Vero cel

285 Cathepsin L was detected in some bronchial epithelial, e

286 Consistent with this finding, expression of cathepsin L was detected in the giant trophoblast cells

287 In contrast, cathepsin L was only partially colocalized with the lyso

288 ispensable for establishment of viremia, but cathepsin L was required for maximal reovirus growth in

289 Cathepsin-L, water soluble and total protein components

290 Using this mutant pro-cathepsin L, we found that components of the mammalian E

291 of the 20S and 26S proteasomes, calpain and cathepsin L, were measured in the triceps surae muscles

292 We next designed shRNA oligonucleotides to cathepsin L which dramatically reduced cathepsin L prote

293 olytic activity, the structurally homologous cathepsin L, which shares a 78% amino acid sequence, has

294 ellular studies showed the colocalization of cathepsin L with [Met]enkephalin in secretory vesicles o

295 Blocking the action of cathepsin L with a chemical inhibitor or small interferi

296 elective, and competitive inhibitor of human cathepsin L with a K(i) = 0.43 nM.

297 nt endopin 2C showed effective inhibition of cathepsin L with a stoichiometry of inhibition (SI) of 1

298 rescence microscopy showed colocalization of cathepsin L with beta-endorphin and alpha-MSH in the int

299 Furthermore, expression of cathepsin L with PE resulted in increased amounts of nic

300 nhibitor of the lysosomal cysteine protease, cathepsin L, with a Ki of 0.7 nM, but it does not inhibi