ライフサイエンスコーパス: cathepsin V

1 intracellularly with the latter credited to cathepsin V.

2 ne proteases that would be selective against cathepsin V.

3 rated to identify elastin-binding domains in cathepsin V.

4 Cathepsin V, a thymus and testis-specific human cysteine

5 d in atherosclerotic plaques, an increase of cathepsins V and K activities may accelerate the destruc

6 ically inhibit the elastolytic activities of cathepsins V and K via the formation of specific catheps

7 In this study, a total of 11 chimeras of cathepsins V and L were generated to identify elastin-bi

8 1.6 A resolution crystal structure of human cathepsin V associated with an irreversible vinyl sulfon

9 Gene silencing of cathepsin V by siRNA in human SK-N-MC cells results in r

10 A class I antibodies significantly increased cathepsin-V (CTSV) expression and galectin-1 expression

11 to cathepsin L, but similar to cathepsin S, cathepsin V exhibited only a very weak collagenolytic ac

12 Whereas human cathepsin V exhibits a potent elastolytic activity, the

13 than 80%, illustrating the prominent role of cathepsin V for neuropeptide production.

14 ndings indicate the unique function of human cathepsin V for producing enkephalin and NPY neuropeptid

15 Findings here show that expression of cathepsin V in neuroendocrine PC12 cells and human neuro

16 t could be exploited in identifying specific cathepsin V inhibitors or in identifying inhibitors of o

17 Cathepsin V is a highly effective elastase and has been

18 Cathepsin V is a human-specific cysteine protease gene.

19 Cathepsin V is a lysosomal cysteine protease that is exp

20 yet described among human proteases and that cathepsin V is present in atherosclerotic plaque specime

21 Cathepsin V is present in human brain cortex and hippoca

22 can be attributed to cysteine proteases with cathepsins V, K, and S contributing equally.

23 Degradative enzymes examined were cathepsin V/L2 and matrix metalloproteinase (MMP)-1, -2,

24 In addition, decreased TIMP-1 and increased cathepsin V/L2 levels may play a role in the matrix degr

25 activity (P < 0.03); a 1.5-fold increase of cathepsin V/L2 mRNA (P < 0.03) and abnormal protein dist

26 ioxidant enzymes, matrix metalloproteinases, cathepsin V/L2, and tissue inhibitor of matrix metallopr

27 Keratoconus corneas have elevated levels of cathepsins V/L2, -B, and -G, which can stimulate hydroge

28 ly, the electrostatic potential of the human cathepsin V model structure resembled that of the model

29 In vitro processing of proenkephalin by cathepsin V occurs at dibasic residue sites to generate

30 udy demonstrates the novel function of human cathepsin V protease for producing the neuropeptides enk

31 A homology structure model of cathepsin V revealed completely different electrostatic

32 A comparison of cathepsin V's active site with the active sites of relat

33 k for understanding the structural basis for cathepsin V's activity and will aid in the design of inh

34 contributing to the elastolytic activity of cathepsin V that are distant from the active cleft of th

35 Furthermore, cathepsin V was determined to be significantly more stab

36 The S2P2 subsite specificity of cathepsin V was found to be intermediate between those o

37 Cathepsin V was mapped to the chromosomal region 9q22.2,

38 model-based electrostatic potential of human cathepsin V was neutral to weakly positive at and in the

39 press a third elastolytic cysteine protease, cathepsin V, which exhibits the most potent elastase act

40 Colocalization of cathepsin V with enkephalin and NPY in secretory vesicle

41 Furthermore, expression of cathepsin V with proNPY results in NPY production.