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1 glutamate to the opening of a transmembrane cation channel.
2 des the two-pore channel 2 (TPC2) protein, a cation channel.
3 ember 6 (TRPC6) gene encoding a nonselective cation channel.
4 th accessory subunit surrounding the central cation channel.
5 LGC-55 anion channel to an excitatory LGC-55 cation channel.
6 rm 4 (TRPV4), a polymodal swelling-sensitive cation channel.
7 ted genetically using a hyperactive vacuolar cation channel.
8 tor that forms a nonselective homotetrameric cation channel.
9 ient receptor potential melastatin 1 (TRPM1) cation channel.
10 t Receptor Potential Melanostatine 2 (TRPM2) cation channel.
11 muli in muscle, we examined the role of this cation channel.
12 the transient receptor potential A1 (TRPA1) cation channel.
13 ed to transient receptor potential canonical cation channels.
14 sensitive transient receptor potential (TRP) cation channels.
15 nges in pH, and three are putative ACh-gated cation channels.
16 -dependent excitation involving non-specific cation channels.
17 Two-pore channels (TPCs) are endolysosomal cation channels.
18 2X7R) belongs to the P2X family of ATP-gated cation channels.
19 ls (CNGCs) are nonspecific, Ca(2+)-permeable cation channels.
20 -dependent excitation involving non-specific cation channels.
21 sed in both animals and plants as organellar cation channels.
22 ctivated cyclic-nucleotide-gated nonspecific-cation channels.
23 cyclic-nucleotide-gated (CNG), nonselective cation channels.
24 Na K-ATPase, and hyperpolarization-activated cation channels.
25 tential (TRP) channel family of nonselective cation channels.
26 1) proteins are heat-activated nonselective cation channels.
27 or blockade of transient receptor potential cation channels.
28 Channelrhodopsins (ChRs) are light-gated cation channels.
29 tivity within this superfamily of tetrameric cation channels.
30 function and expression of Ca(2+)-permeable cation channels.
31 uding voltage, stretch, and ligand-activated cation channels.
32 ay have broad applications for voltage-gated cation channels.
33 ich are mechanically-activated non-selective cation channels.
34 pharmacological modulators for nonselective cation channels.
35 hibition of the transient receptor potential cation channel 6 (TRPC6) reduced platelet activation and
36 ntry though the transient receptor potential cation channel 6 (TRPC6), causing hyperactivation and co
41 (TRPM3) is a Ca(2+) permeable non-selective cation channel activated by heat and chemical agonists s
42 P2X receptors are trimeric, non-selective cation channels activated by ATP that have important rol
45 tial Canonical 4 (TRPC4) forms non-selective cation channels activated downstream from receptors that
46 um ion binding (P = 3.55 x 10(-)(1)(5)), and cation channel activity (P = 2.77 x 10(-)(1)(4)) were si
47 colon cancer cells to noninvasively monitor cation channel activity in real time by the appearance o
48 HD), is targeted to Golgi membranes, and has cation channel activity in vitro The E protein from avia
50 locus-encoded beta-subunit of rod cGMP-gated cation channel and associated glutamic acid rich protein
51 l recordings show that it is a non-selective cation channel and that its activity depends on Ca(2+) c
52 (h)KCNE beta subunits each regulate various cation channels and are linked to inherited cardiac arrh
55 X purinergic receptor family of ligand-gated cation channels and has recently been shown to regulate
57 among the most highly efficient light-gated cation channels and the most blue-shifted channelrhodops
58 (transient receptor potential, "canonical") cation channels, and powerful regulation of lipid metabo
59 ent and transient receptor channel potential cation channel ankyrin subtype 1 (TRPA1)-deficient mice
60 n mutations in mechanically activated Piezo1 cation channels are associated with the dehydrating RBC
62 (transient receptor potential, "canonical") cation channels are coupled to neuronal discharge proper
65 ansient receptor potential melastatin (TRPM) cation channels are polymodal sensors that are involved
66 hat sensory cilia and polycystin-2 (Pkd2), a cation channel, are required for sensing ciliary motilit
67 encodes TRPM4, a Ca(2+)-activated monovalent cation channel, as a cause of an autosomal dominant form
69 ) melastatin 4 (TRPM4) is a widely expressed cation channel associated with a variety of cardiovascul
71 was inhibited by tetrodotoxin as well as the cation channel blockers, 9-phenanthrol and clotrimazole.
74 s, we show that transient receptor potential cation channel C3 (TRPC3) controls the simple spike acti
76 oendocrine bag cell neurons triggers various cation channels, causing an ~30 min afterdischarge of ac
77 the plasma membrane and formed pH-sensitive cation channels, causing collapse of cellular Na(+) and
78 esumptive transient receptor potential (TRP) cation channel, CED-11, that acts in the dying cell to p
81 Canonical (TRPC) proteins form nonselective cation channels commonly known to be activated downstrea
82 PC6 and function as diacylglycerol-activated cation channels coordinately, the role of TRPC6 in heart
83 Hence, the mechanism by which voltage-gated cation channels couple conformational changes within the
85 rpolarization-activated and nucleotide-gated cation channels decreasing the firing rate of MNCs and t
89 We found the expression of the chemosensory cation channel dTRPA1 in these cells to be necessary and
90 as largely eliminated during the blockade of cation channels due to the internal dialysis of Cs(+) ,
92 nt stimulator of Ca(2+) influx through TRPA1 cation channels (EC50 ca. 200 nM), thereby explaining it
93 3 (TRPC3), a calcium-permeable, nonselective cation channel endowed with high constitutive function,
94 l Melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channel essential for immunocyte activation, insu
95 de-gated (CNG) ion channels are nonselective cation channels, essential for visual and olfactory sens
96 rformed on mice expressing a light sensitive cation channel exclusively on cholinergic neurons (ChAT-
97 ntial melastatin 8 (TRPM8) is a nonselective cation channel expressed in a subpopulation of sensory n
98 l melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channel expressed in immune cells of phagocytic l
99 vanilloid type 1 (TRPV1) is a non-selective cation channel expressed in sensory neurons of the dorsa
101 -permeant Transient Receptor Potential (TRP) cation channel expressed primarily on the endoplasmic re
102 ffect was caused by acid activation of these cation channels expressed in airway sensory nerves.
105 s caused by mutations in MCOLN1, a lysosomal cation channel from the transient receptor potential (TR
108 at DmPiezo, a Ca(2+)-permeable non-selective cation channel, functions as an intrinsic inhibitor for
109 omeostasis, AQP1 also acts as a nonselective cation channel gated by cGMP, a property shown previousl
114 ecies variant of the human apoptosis-related cation channel hTRPM2, is gated by ADP-ribose (ADPR) ind
115 Receptor Potential Melastatin 2 (TRPM2) is a cation channel important for the immune response, insuli
118 f a plant ion channel and identify the first cation channel in plant mitochondria from a molecular po
120 (TRPV4), a Ca(2+)-permeable mechanosensitive cation channel in the transient receptor potential vanil
121 e presence of apically located voltage-gated cation channels in a population of electrosensory hair c
122 function as Ca(2+) conducting, non-selective cation channels in endothelial, smooth muscle, and neuro
124 DP- and PI(3,5)P2-sensitive Ca(2+)-permeable cation channels in the endolysosomal system of cells, as
126 alanced translocation disruption of TRPC6, a cation channel, in a non-syndromic autistic individual.
127 encoding polycystin-L (PCL), a non-selective cation channel, increases neuronal excitability and the
128 It is postulated that mechanically activated cation channels initiate touch sensation, but the identi
129 el, subfamily M, member 2) is a nonselective cation channel involved in the response to oxidative str
131 (TRPC5), a calcium-permeable, non-selective cation channel is expressed in the periphery, but there
133 e-shift displayed by hyperpolarization-gated cation channels is likely caused by structural changes a
134 vation of transient receptor potential (TRP) cation channels is one of the most striking examples of
138 lipin 1) is a Ca(2+)-permeable, nonselective cation channel localized to the membranes of endosomes a
139 is a dual water and cyclic-nucleotide-gated cation channel located in lamellipodia and is essential
140 receptor potential mucolipin 1 (TRPML1) is a cation channel located within endosomal and lysosomal me
141 urea receptor-1-transient receptor potential cation channel M4 is upregulated only after brain injury
142 (TRPC6), a nonselective and Ca(2+)-permeable cation channel, mediates pathophysiological responses wi
143 2) expressed in endothelial cells (ECs) is a cation channel mediating Ca(2+) entry in response to int
145 sistent with either the ER stress or surface cation channel models of APOL1-mediated cytotoxicity.
149 nation of the Asp-96 homolog is required for cation channel opening and occurs >10-fold faster than r
150 channels in the ER/SR and the non-selective cation channels or putative 'Ca(2+) leak channels', incl
151 hR-2), a direct light-activated nonselective cation channel originally discovered in Chlamydomonas re
152 d forms a pore complex with the ligand-gated cation channel P2X7, allowing the release of excitatory
154 et al. show that the mechanically activated cation channel Piezo1 is a molecular sensor of physical
155 shown that the endothelial mechanosensitive cation channel PIEZO1 is required for flow-induced ATP r
156 at platelets and Meg-01 cells express the MS cation channel Piezo1, which may contribute to Ca(2+) en
157 that the mechanically activated nonselective cation channel Piezo2 was expressed in sensory endings o
159 vestigated if TRPV4, a temperature-sensitive cation channel, plays an important role in acute itch in
161 d at whether the P2X1 receptor, an ATP-gated cation channel present on platelets, neutrophils, and ma
162 ensing ion channel 1 (ASIC1), a proton-gated cation channel primarily expressed in the nervous system
164 euromediators and expression of chemosensory cation channels, protein gene product 9.5 (PGP 9.5), and
165 proteins form a superfamily Ca(2+)-permeable cation channels regulated by a range of chemical and phy
166 potential channel (TrpC) family, a family of cation channels regulated by activation of phospholipase
167 sential for proper localization of the TRPM1 cation channel required for ON BC light-evoked depolariz
170 PA-type glutamate receptors are ligand-gated cation channels responsible for a majority of the fast e
171 n the vacuole, cooperating with the vacuolar cation channel SlTPC1 and the two vacuolar H(+)-pumps, S
172 PGP9.5; TRPV1; transient receptor potential cation channel subfamily A, receptor 1 (TRPA1); TRPV4; t
175 Ca(2+) channel, transient receptor potential cation channel subfamily C member 6 (TRPC6), and the pro
177 onjunction with transient receptor potential cation channel subfamily M member 4 (TRPM4), and perhaps
179 EGFPf) from the transient receptor potential cation channel subfamily M member 8 (TRPM8(EGFPf/+)) loc
180 which acted on transient receptor potential cation channel subfamily M member 8 (TRPM8) channels to
181 n of Piezo2 and transient receptor potential cation channel subfamily M member 8 (TRPM8) transcripts
183 (TRPA1); TRPV4; transient receptor potential cation channel subfamily M, member 8 (TRPM8); and nerve
184 l activation of transient receptor potential cation channel subfamily V member 1 (TRPV1) and CB1Rs.
185 ated afferents [transient receptor potential cation channel subfamily V member 1 (TRPV1) expressing C
186 t activates the transient receptor potential cation channel subfamily V member 1 (TRPV1) on sensory n
188 smitted via the transient receptor potential cation channel subfamily V member 1 (TRPV1) population b
189 ively as either transient receptor potential cation channel subfamily V member 1 (TRPV1)-sensitive or
191 hibiting TRPV1 (transient receptor potential cation channel subfamily V member 1) immunoreactivity (p
194 higher baseline transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) expressio
195 ablation of the transient receptor potential cation channel subfamily V, receptor 1 (TRPV1)-substance
196 oid type-1, -3; transient receptor potential cation channel, subfamily A, member 1) have been implica
197 utations in the transient receptor potential cation channel, subfamily C, member 6 (TRPC6) gene encod
198 pression of the transient receptor potential cation channel, subfamily C, member 6 (TRPC6), consisten
201 )-dependent and transient receptor potential cation channel, subfamily M, member 7 (TRPM7)-dependent
202 ration, and the transient receptor potential cation channel, subfamily V, member 1 (TRPV1), in intest
205 l compartments is mediated via intracellular cation channels, such as two-pore channel (TPC) proteins
206 channels are members of the large tetrameric cation channels superfamily but are considered to be uni
207 te (PtdIns(4,5)P2) -modulated, non-selective cation channel that belongs to the family of melastatin-
208 (TRPC5) is a nonselective, Ca(2+)-permeable cation channel that belongs to the large family of trans
209 (CaChR1) is a low-efficiency light-activated cation channel that exhibits properties useful for optog
210 eceptor (P2X7R) is an ATP-gated nonselective cation channel that induces inflammatory responses in ce
211 ng ion channel-1A (ASIC1A) is a proton-gated cation channel that is activated by extracellular acidos
213 nonical type 5 (TRPC5) is a Ca(2+)-permeable cation channel that is highly expressed in the brain and
214 e envelope protein E, forms a homopentameric cation channel that is important for virus pathogenicity
215 ntial melastatin 3 (TRPM3) is a nonselective cation channel that is inhibited by Gbetagamma subunits
216 1) or vanilloid receptor 1 is a nonselective cation channel that is involved in the detection and tra
217 lipin 1) is a Ca(2+)-permeable, nonselective cation channel that is predominantly localized to the me
218 otential channel 1 (TRPC1) is a nonselective cation channel that is required for Ca(2+) homeostasis n
219 otide-gated (HCN) channel is a voltage-gated cation channel that mediates neuronal and cardiac pacema
220 l mucolipin 1 (TRPML1) is a Ca(2+)-releasing cation channel that mediates the calcium signalling and
221 s a TRP-type, Ca(2+)-permeable non-selective cation channel that plays an important role in Ca(2+) si
222 (TRPC6) is a nonselective receptor-operated cation channel that regulates reactive fibrosis and grow
223 TRP vanilloid 4 (TRPV4) is a non-selective cation channel that responds to mechanical, thermal, and
224 ily A member 1 (TRPA1) is a Ca(2+)-permeable cation channel that serves as one of the primary sensors
225 (TRPM8) is a calcium ion (Ca(2+))-permeable cation channel that serves as the primary cold and menth
226 ) channels are Ca(2+)-permeable nonselective cation channels that are activated by a wide variety of
227 Piezo1 and Piezo2 as mechanically activated cation channels that are expressed in many mechanosensit
228 onstitute an important class of ligand-gated cation channels that are involved in the majority of exc
229 s at acidic pH to form pH-gated nonselective cation channels that are opened upon pH neutralization.
231 ensing ion channels (ASICs) are proton-gated cation channels that contribute to neurotransmission, as
232 rinatal development, 90-pS stretch-activated cation channels that could be blocked by Ca(2+) and by F
233 channels are highly homologous, nonselective cation channels that form many homo- and heterotetrameri
234 zo1 and Piezo2 encode mechanically activated cation channels that function as mechanotransducers invo
236 ceptors (nAChRs) are pentameric ligand-gated cation channels that include at least two alpha3 and two
237 spartate receptors (NMDARs) are ligand-gated cation channels that mediate excitatory synaptic transmi
238 AMPA receptors (AMPARs) are glutamate-gated cation channels that mediate fast excitatory neurotransm
239 acid receptors (AMPARs) are glutamate-gated cation channels that mediate fast excitatory synaptic tr
240 glutamate receptors (iGluRs) are tetrameric cation channels that mediate synaptic transmission and p
241 canonical (TRPC) proteins form nonselective cation channels that play physiological roles in a wide
242 Mammalian TRICs function as K(+)-permeable cation channels that provide counter ions for Ca(2+) han
243 MDA) receptors are heteromeric non-selective cation channels that require the binding of glycine and
246 f residues characteristic of the chlorophyte cation channels, these proteins are cation-conducting ch
247 excitatory synaptic transmission by forming cation channels through the membrane that open upon glut
249 e activation of transient receptor potential cation channels to attenuate cytosolic Ca2+ influx, impl
251 erfamily, which functions as glutamate-gated cation channels to mediate the majority of excitatory ne
253 esponding to moderate hypoxia via the sensor cation channel transient receptor potential (TRP) A1 but
256 d] activation of the intracellularly located cation channel transient receptor potential vanilloid 1
259 upled to hyperactivation of the nonselective cation channel, transient receptor potential canonical c
260 ular mechanism by which the mechanosensitive cation channel, transient receptor potential vanilloid 4
261 c oxide activates the nitric oxide-sensitive cation channel, transient receptor potential vanilloid f
262 ABSTRACT: The type A trimeric intracellular cation channel (TRIC-A) is a major component of the nucl
264 monstrated that transient receptor potential cation channel (TRP)-A1 was the ion channel downstream o
265 tivation of the transient receptor potential cation channels (TRP) TRPV1, TRPV4, and TRPA1 causes vis
269 lts reveal a previously unknown role for the cation channel Trpc5 in prolactin homeostasis of female
271 macological inhibition of the heat-activated cation channel TRPM3 alleviates inflammatory heat hypera
273 and function of the polymodal non-selective cation channel TRPV1 (transient receptor potential vanil
275 ensitive actuator, "Magneto," comprising the cation channel TRPV4 fused to the paramagnetic protein f
276 yses localized the putative mechanosensitive cation channel TRPV4 to the plasma membrane of primary a
278 olved transient receptor potential vanilloid cation channels (TRPVs) since TRPV1/TRPV4 antagonism blo
279 mily member 1 (WNT1), trimeric intracellular cation channel type b (TRIC-B), and old astrocyte specif
281 channelrhodopsin-2 (PsChR2), are light-gated cation channels used as optogenetic tools for photocontr
282 , including the transient receptor potential cation channel V1 expressed in the nociceptive neurons o
284 In contrast, transient receptor potential cation channel vanilloid subtype 1 channels were dispens
285 Furthermore, transient receptor potential cation channel vanilloid type 1 appears to counter the a
287 urrents is well documented for voltage-gated cation channels (VGCC), and it is considered a voltage-s
288 n activates a Na(+)-permeable, non-selective cation channel via depolarization-induced rise in [Ca(2+
289 trA, a RCK domain from the B. subtilis KtrAB cation channel, we have found that activation by nucleot
290 tial vanilloid type 4, TRPV4, is a polymodal cation channel which can be activated by diverse stimuli
291 tion-activated cyclic nucleotide-gated (HCN) cation channels, which are concentrated on dendritic spi
292 to ATP induces the opening of a nonselective cation channel; while repeated or prolonged exposure ind
293 resents a novel architecture of a tetrameric cation channel whose ion selectivity mechanism appears t
294 RPM7) is a ubiquitous, constitutively active cation channel with a cytosolic alpha-kinase domain that
295 curvature-sensitive, mechanically activated cation channel with a single channel conductance of ~28.
297 mucolipins) constitute a family of endosomal cation channels with homology to the transient receptor
298 1-3) of eukaryotic voltage- and ligand-gated cation channels with two non-equivalent tandem pore-form
299 Most viroporins are monovalent selective cation channels, with few showing the ability to conduct
300 rm of a tunable, high-conductance vertebrate cation channel, zTrpa1b, coupled with photo-activated ch