ライフサイエンスコーパス: cause of disease

1 mutations in sarcomere protein genes as the cause of disease.

2 tation-induced loss of stability is a common cause of disease.

3 ed to the establishment of autoimmunity as a cause of disease.

4 r, a prime candidate gene, was excluded as a cause of disease.

5 ction of sophisticated exotoxins is the main cause of disease.

6 limination of classical biotype strains as a cause of disease.

7 h as multiple sclerosis may be a clue to the cause of disease.

8 21ins2) is the predominant but not exclusive cause of disease.

9 iquitous in the environment and an important cause of disease.

10 iral immune response within the brain is the cause of disease.

11 occus, serotype V (GBS-V), was an infrequent cause of disease.

12 T) were helpful in suggesting the underlying cause of disease.

13 atory mechanism regardless of the initiating cause of disease.

14 Chronic inflammation is a major cause of disease.

15 treatments address the symptoms, but not the cause of disease.

16 e therapies are designed to address the root cause of disease.

17 Genetic testing may elucidate an underlying cause of disease.

18 to disease, and relationship of organism to cause of disease.

19 es encoding the sarcomere is the predominant cause of disease.

20 ars due to its potential to address the root cause of disease.

21 of familiality is consistent with a genetic cause of disease.

22 rapid elucidation of the underlying genetic cause of disease.

23 ndent on the ability to identify the genetic cause of disease.

24 quitoes are an increasingly important global cause of disease.

25 gation is increasingly being recognized as a cause of disease.

26 Smoking is a common addiction and a leading cause of disease.

27 Mycobacterium mucogenicum was the leading cause of disease.

28 (tubulin beta-4; Arg2Gly) gene as the likely cause of disease.

29 action between the genetic and environmental causes of disease.

30 smaller subfibrillar oligomers are the prime causes of disease.

31 igins, susceptibility to illness and genetic causes of disease.

32 aware of inherited genetic abnormalities as causes of disease.

33 nt susceptibility to two vaccine-preventable causes of disease.

34 ditions by targeting the fundamental genetic causes of disease.

35 research to further our understanding of the causes of disease.

36 rom normality include diagnostic markers and causes of disease.

37 rect link between filament formation and the causes of disease.

38 ve analysis of genomic variants as potential causes of disease.

39 rated with the goal of identifying molecular causes of disease.

40 laboratory evaluations to exclude secondary causes of disease.

41 studies are important tools for identifying causes of disease.

42 cerned with determining the distribution and causes of disease.

43 edicines require understanding the molecular causes of disease.

44 worry, and depression are significant direct causes of disease.

45 sed to predict new functions in proteins and causes of disease.

46 have so far been identified as the monogenic causes of disease(2-7).

47 ulation of Notch signaling is the underlying cause of diseases affecting the skeletal tissue, includi

48 Identification of precise genetic causes of disease aids diagnosis and advances our unders

49 Falciparum malaria is a major cause of disease and death in African children and pregn

50 r bacterium Rhodococcus equi is an important cause of disease and death in immunocompromised hosts, e

51 uman cytomegalovirus (HCMV) is a significant cause of disease and death in immunocompromised patients

52 s a ubiquitous herpesvirus and a significant cause of disease and death in the immunocompromised and

53 PIV is an established cause of disease and death in the pediatric and immunoco

54 Ageing is the single greatest cause of disease and death worldwide, and understanding

55 Seasonal influenza infection remains a major cause of disease and death, underscoring the need for im

56 inues to question whether tobacco is a major cause of disease and death.

57 r that reveals an underlying and preexisting cause of disease and death.

58 trials to establish the similarities in the cause of disease and in treatment response between child

59 Smoking is a leading global cause of disease and mortality.

60 f mitochondrial DNA (mtDNA) are an important cause of disease and play a role in the ageing process.

61 Nicotine addiction remains a major cause of disease and premature death worldwide.

62 virus type 1 (HIV-1) continues to be a major cause of disease and premature death.

63 Nematodes are a major cause of disease and the discovery of new pathways not f

64 lts because of uncertain similarities in the cause of disease and the treatment course between the 2

65 orical trial data suggests similarity in the cause of disease and the treatment response between neon

66 y demonstrated that ANCAs are a transferable cause of disease and this is supported by studies of the

67 g age may provide clues as to the underlying cause of disease and to guide treatment.

68 will permit us to investigate the underlying cause of diseases and help us to develop therapeutics.

69 rting to take into account the polymicrobial cause of diseases and the repercussions of treatment and

70 Better understanding of the mechanisms and causes of disease and an increasingly extensive and robu

71 ssociated bacterial pneumonia (VABP), common causes of disease and death in hospitalized patients.

72 The root causes of disease and death in the unhappy few remained

73 Obesity is among the leading causes of disease and death.

74 ility-adjusted life-years (DALYs) due to 359 causes of disease and injury burden from 2022 to 2050 fo

75 nts about health losses associated with many causes of disease and injury were elicited from the gene

76 ised approach is not tackling the underlying causes of disease and is not addressing inequalities in

77 this genome are now recognized as important causes of disease and may take the form of point mutatio

78 Neglected diseases remain one of the largest causes of disease and mortality.

79 within 24 h of inclusion for main treatable causes of disease and second-line testing was done there

80 at facilitates elucidation of the underlying causes of disease and the best ways to target them.

81 r and sensitive biomarkers both to track the causes of disease and to develop and evolve therapies du

82 g whole chromosomes, have been identified as causes of diseases and developmental abnormalities and a

83 rigorous and unbiased conclusions about the causes of diseases and their population-wide impact will

84 ate diagnosis, recognition of the modifiable causes of disease, assessment of symptoms and complicati

85 D1 may generate new insights into underlying causes of diseases associated with infertility or develo

86 Major depressive disorder (MDD) is a leading cause of disease-associated disability, with much of the

87 r age at diagnosis, sex, race and ethnicity, cause of disease, Barcelona Clinic Liver Cancer (BCLC) s

88 or injecting drug use (IDU) is a substantial cause of disease burden and a contributor to blood-borne

89 st cancer remains the leading cancer-related cause of disease burden for women, affecting one in 20 g

90 Alcohol-related harm, a major cause of disease burden globally, affects people along a

91 Cancer is a leading cause of disease burden globally, with more than 19.3 mi

92 Dementia is the second leading cause of disease burden in Australia.

93 pwards of two billion people and are a major cause of disease burden in children and pregnant women.

94 HIV/AIDS is a leading cause of disease burden in sub-Saharan Africa.

95 Cardiovascular diseases remain the leading cause of disease burden in the world.

96 arette smoking remains the leading avoidable cause of disease burden worldwide, and observational stu

97 y 2030, major depression will be the leading cause of disease burden worldwide.

98 Major depressive disorder (MDD) is a leading cause of disease burden worldwide.

99 late matter pollution (PM2.5) is one leading cause of disease burden, but no study has quantified the

100 Depression is a leading cause of disease burden, yet current therapies fully tre

101 and other developing regions is an important cause of disease burden.

102 heterogeneity exists in rankings of leading causes of disease burden among regions.

103 aimed to quantify differences in the leading causes of disease burden between females and males acros

104 tes for females and males for the 20 leading causes of disease burden for individuals older than 10 y

105 ilable resources effectively to reduce major causes of disease burden globally and to decrease health

106 Stress disorders are leading causes of disease burden in the U.S. and worldwide, yet

107 od pressure, and high cholesterol were major causes of disease burden.

108 nd nutritional disorders remain the dominant causes of disease burden.

109 e therapeutics rarely address the underlying cause of disease but rather focus on managing or modifyi

110 ead in mammalian genomes and is an important cause of disease, but just how abundant and important st

111 chanisms integrate genetic and environmental causes of disease, but comprehensive genome-wide analyse

112 mples but could be distinguished as possible causes of disease by parsing for outlier organisms.

113 e proven to be helpful for finding genotypic causes of diseases, classifying disease subtypes, and id

114 r of lung fibrosis and remains a significant cause of disease despite strict regulations to limit exp

115 ined the human genome (G) mainly to discover causes of disease, despite evidence that G explains rela

116 ention of mutant transcripts, are probably a cause of disease development.

117 dysfunction, arguing for a tissue autonomous cause of disease development.

118 bacco use remains the number-one preventable cause of disease, disability, and death in the United St

119 Tobacco use is the leading preventable cause of disease, disability, and death in the US.

120 Smoking is the leading preventable cause of disease, disability, and premature death.

121 (immune-mediated pathology) is a ubiquitous cause of disease during infection, but how will parasite

122 kely that B. miyamotoi is an underrecognized cause of disease, especially in sites where Lyme disease

123 types that were disproportionately common as causes of disease, even taking into account their relati

124 ed loss of lung function compared with other causes of disease exacerbation.

125 It is important to identify the cause of disease for a better disease prognosis and a po

126 sing mutations and may represent a molecular cause of disease for a number of inherited and somatic m

127 has been progress in defining the underlying cause of disease for some patients of muscular dystrophy

128 ts of this class are likely underreported as causes of disease for several reasons: Most clinical DNA

129 The immune system can be a cure or cause of disease, fulfilling a protective role in attack

130 B meningococcus (MenB) remains an important cause of disease globally, and additional vaccines again

131 pectancy and health outcomes for preventable causes of disease have continued to lag in many populati

132 To identify putative genetic causes of disease heterogeneity, we examined the distrib

133 whether distinct genes represent independent causes of disease (heterogeneity) or whether they intera

134 mising tool for investigating the underlying causes of disease; however, this potential currently rem

135 data to understand underlying environmental causes of disease, identify biomarkers of exposure and r

136 We sought to identify the cause of disease in 3 unrelated Finnish kindreds with va

137 natal meningitis and sepsis and an important cause of disease in adults.

138 an important neonatal pathogen and emerging cause of disease in adults.

139 ale germ cell-associated kinase (MAK) as the cause of disease in an isolated individual with RP.

140 la catarrhalis continues to be a significant cause of disease in both children and adults, the steps

141 m, trypanosomes, and Leishmania, are a major cause of disease in both humans and other animals, highl

142 Serogroup C was the main cause of disease in Brazil; the majority of disease seen

143 terial meningitis (PBM) remains an important cause of disease in children in Africa.

144 Diarrheal disease is the second leading cause of disease in children less than 5 y of age.

145 s, they are now increasingly recognized as a cause of disease in dogs in temperate climates and urban

146 =0.0001) CFH variants were identified as the cause of disease in each family: CFH c.1243del, p.(Ala41

147 infections in children as well as a serious cause of disease in elderly and immunosuppressed populat

148 netic and genomic approaches to identify the cause of disease in extensive pedigrees comprising over

149 ogen Pneumocystis jirovecii is a significant cause of disease in HIV-infected patients and others wit

150 Pseudomonas aeruginosa is an important cause of disease in hospitalized and immunocompromised p

151 s a commensal organism in poultry and as the cause of disease in humans.

152 VV) is a mosquito-borne virus that is a rare cause of disease in humans.

153 overburden the immune system and are a major cause of disease in humans.

154 Candida albicans is a significant cause of disease in immunocompromised humans.

155 s organism has recently been recognized as a cause of disease in immunocompromised patients, presenti

156 ratory syncytial virus (RSV) is an important cause of disease in older adults.

157 is to efficiently determine the presence and cause of disease in order to provide the most appropriat

158 strated that mutations in this gene were the cause of disease in other, unrelated families.

159 X-770) was designed to target the underlying cause of disease in patients with cystic fibrosis.

160 To identify the cause of disease in patients without JAG1 mutations, we

161 ions due to Cryptococcus neoformans, a major cause of disease in persons with AIDS and other disorder

162 lude Mycobacterium tuberculosis complex as a cause of disease in smear-positive respiratory specimens

163 e biogenesis defect and thus constitutes the cause of disease in the affected individuals.

164 genes were performed to identify the genetic cause of disease in the family with the Carney complex a

165 To determine the cause of disease in the remaining families, linkage test

166 Inquiring whether KCNV2 is the cause of disease in the remaining patients with cone-dom

167 human pathogen continues to be a significant cause of disease in this broad spectrum of patients beca

168 Mutations in ABCA4 were the most common cause of disease in this cohort (173 families), whereas

169 9V) within the linkage region as the genetic cause of disease in this family.

170 icularly high levels in the striatum, as the cause of disease in this family.

171 er gene family (gene symbol: SLC52A2) as the cause of disease in this family.

172 actin-filament crosslinking protein, as the cause of disease in three families with an autosomal dom

173 ed primarily by Aedes mosquitos and is major cause of disease in tropical and subtropical regions.

174 we investigated the genetic and mechanistic cause of disease in two independent consanguineous famil

175 Although they are recognized as a leading cause of disease in young children, the cellular factors

176 acteria - vibrios - are a globally important cause of diseases in humans and aquatic animals.

177 prevalence and overlap of other significant causes of disease in HIV endemic populations.

178 individuals can be summed to understand the causes of disease in populations, academic epidemiology

179 fection with a microbe, considered to be the cause of disease, in cells, tissues, or organisms seen a

180 c trials, focus on addressing the underlying cause of disease, insufficient production of full-length

181 tations; however, the translation of genetic causes of disease into pathobiological understanding rem

182 ynaptic function in disease once the primary cause of disease is abrogated.

183 in at least 5% of patients in whom a genetic cause of disease is identified, highlighting the fact th

184 The likely cause of disease is the missplicing of the PRPH2 message

185 candidate gene approach to identifying novel causes of disease is concept-limiting and in the new era

186 lop new approaches that directly address the cause of disease, leading to disease remission and ultim

187 cal information-demographic characteristics, cause of disease, liver-related blood tests, tumour char

188 le of multiple component, often interacting, causes of disease may be impossible with research tools

189 ility that both presynaptic and postsynaptic causes of disease might also exist in related disorders,

190 emoglobinuria (PNH) and constitutes the main cause of disease morbidity/mortality.

191 lays and arrhythmias, are the second leading cause of disease mortality.

192 Influenza remains a significant cause of disease mortality.

193 data indicate that subsequent to the genetic cause of disease, neuropathology is driven by pathogenic

194 Although they are a common cause of disease, no systematic cost-of-illness studies

195 ions in POLG are the most common single-gene cause of diseases of mitochondria and have been mapped o

196 tory microbiota of pigs that is also a major cause of disease on pig farms and an important zoonotic

197 ther directly address the underlying genetic cause of disease or induce fetal hemoglobin production b

198 scale, can generate valuable information on causes of disease outbreaks, reproductive losses and can

199 Staphylococcus aureus is a common cause of disease, particularly in colonized persons.

200 ernative approaches searched for preexisting causes of disease, particularly human genetic and immuno

201 stion might provide crucial insight into the cause of disease pathology at its earliest stages of dev

202 c response (CCR), implicating mutations as a cause of disease persistence.

203 pse suggesting that progressive LOH may be a cause of disease progression and/or drug resistance.

204 disease (CKD) since early stages during the cause of disease progression.

205 ditional chromosomal abnormalities are major causes of disease progression in chronic lymphocytic leu

206 es to revolutionize medicine by treating the causes of disease rather than the symptoms.

207 (P-gp) expression has been reported to be a cause of disease recurrence in osteosarcoma.

208 ignant cells is considered to be a prominent cause of disease relapse.

209 Although cancer remains the most common cause of disease-related death in adolescents and young

210 Brain tumors are the leading cause of disease-related death in children.

211 tate cancer, SCC is a clinically significant cause of disease-related morbidity and mortality.

212 Although cancer is the leading cause of disease-related mortality in children, the rela

213 Cancer is the leading cause of disease-related mortality in children.

214 gh early intervention against root molecular causes of disease remains largely unexplored.

215 orders directed at correcting the underlying cause of disease represents the most significant recent

216 Identifying the underlying causes of disease requires accurate interpretation of ge

217 n study (GWAS) with MEVs pinpoints potential causes of disease risk, including a LINE-1 insertion ass

218 tissue remodeling and scarring, the ultimate cause of disease sequelae.

219 ry response induced by SARS-CoV-2 is a major cause of disease severity and death in infected patients

220 ndrome coronavirus 2 (SARS-CoV-2) is a major cause of disease severity and death.

221 lammation triggered by SARS-CoV-2 is a major cause of disease severity, with activated macrophages im

222 altered RNA regulation by TDP-43 as a major cause of disease, specific changes within MNs that trigg

223 pe emm59 GAS, heretofore an exceedingly rare cause of disease, spread west to east across Canada over

224 actions can alter physiology and be the root cause of disease states.

225 with enteric pathogens are among the leading causes of disease, suffering, and death worldwide.

226 tis, the same genotype was implicated as the cause of disease, suggesting persistence of the organism

227 mily cytokines is recognized as an important cause of disease susceptibility, it is unclear whether a

228 en challenging because of the multifactorial causes of disease susceptibility and progression.

229 is considered both a defense mechanism and a cause of disease that leads to inflammation and psycholo

230 expression has been perceived as a potential cause of disease, there is mounting evidence that some E

231 Dystrophin deficiency is the underlying cause of disease; therefore, mutation-specific therapies

232 , insurance types, hospital characteristics, cause of disease, time to therapy, length of stay (LOS),

233 a second mutation, should not be taken as a cause of disease unless corroborated by family data and

234 le animal facility, designed to identify the causes of disease variability in the widely used dextran

235 The genetic cause of disease was identified in 6 patients.

236 ntific curiosity, but also to understand the causes of disease well enough to predict risks, make ear

237 tinues to evolve as it seeks to pinpoint new causes of disease with the hope of advancing personalize

238 (GAS) is a human-specific pathogen and major cause of disease worldwide.

239 ency is a common and potentially devastating cause of disease worldwide.

240 Entamoeba histolytica is a significant cause of disease worldwide.

241 ting nematodes are one of the most prevalent causes of disease worldwide.

242 Human noroviruses are a major global cause of disease, yet we know very little about their pa