ライフサイエンスコーパス: caveolin-1

1 , is essential for normal oligomerization of caveolin 1.

2 pid raft-associated proteins VE-cadherin and caveolin-1.

3 detergent-resistant membranes (rafts) and to caveolin-1.

4 surface augmented degradation like wild-type caveolin-1.

5 colocalized with clathrin far more than with caveolin-1.

6 D1) cofactor during endolysosomal sorting of caveolin-1.

7 ins rich in the membrane raft marker protein caveolin-1.

8 ediated stabilization of endothelial surface caveolin-1.

9 r the lipid raft markers ganglioside GM1 and Caveolin-1.

10 accompanied by increased LD localization of caveolin-1.

11 se to the Ca(2+) signal, was also reduced by caveolin-1.

12 uired a functional scaffolding domain within caveolin-1.

13 ature senescence induced by the depletion of caveolin-1.

14 re positive for type I markers, T1alpha, and caveolin-1.

15 harmacologic inhibition of ERKs or silencing caveolin-1.

16 nic fibroblasts (MEFs), which do not express caveolin-1.

17 n impaired the antiproliferative function of caveolin-1.

18 impaired the anti-proliferative function of caveolin-1.

19 T domain mutant displayed reduced binding to Caveolin-1.

20 NA interference (RNAi)-mediated depletion of caveolin 1/2 or flotillin had no effect on ATP7A localiz

21 Notably, caveolin-1, a lipid raft protein, is exclusively detecte

22 We found that caveolin-1, a structural protein component of caveolar m

23 ncrease in Ca(2+) release in the presence of caveolin-1 activated protein kinase C, which accelerated

24 Caveolin-1 acts as a scaffolding protein to functionally

25 Functional studies demonstrate that caveolin-1 acts as an endogenous inhibitor of Nrf2, as s

26 tor light responses, indicating that lack of caveolin-1 affects photoreceptor function in a non-cell-

27 by the binding of the scaffolding domain of caveolin-1 (amino acids 82-101) to the caveolin-binding

28 by the binding of the scaffolding domain of caveolin-1 (amino acids 82-101) to the caveolin-binding

29 svascular pumping required the expression of caveolin 1 and annexin A1.

30 The CAV1/CAV2 (caveolin 1 and caveolin 2) genomic region previously was

31 ive endocytosis with increased expression of caveolin 1 and caveolin 2.

32 On the contrary, eNOS, Caveolin-1 and -2 expression were significantly increase

33 ith c-Abl, increased phosphorylation of both caveolin-1 and c-Abl and abolished the inhibitory effect

34 ative stress-induced phosphorylation of both caveolin-1 and c-Abl, which is the major kinase of caveo

35 R on oxidant-induced phosphorylation of both caveolin-1 and c-Abl.

36 ctures formed from a complex of the proteins caveolin-1 and caveolin-2.

37 xpression of claudin 2, increased binding of caveolin-1 and claudin 2, and increased trafficking of c

38 aveolae, modulates the oncogenic function of caveolin-1 and cooperates with caveolin-1 to enhance pan

39 ial cells resulted in an increased amount of CAVEOLIN-1 and decreased cell proliferation.

40 this study, we show that KSR1 interacts with caveolin-1 and is responsible for MEK and ERK redistribu

41 In cell culture studies, membranous caveolin-1 and nuclear p53 expression was greater in rep

42 Caveolin-1 and p53 expression was decreased in bone in S

43 rat serum significantly down-regulated both caveolin-1 and p53 in senescent and nonsenescent cells.

44 sion molecule-1 and the transcytosis protein Caveolin-1 and promoting endothelial transcytosis.

45 ke is dependent on host cell cholesterol and caveolin-1 and that internalization proceeds via clathri

46 further demonstrate that ShcA interacts with Caveolin-1 and the costameric protein plasma membrane Ca

47 aled the physical interaction of cavin-1 and caveolin-1 and their colocalization in pancreatic cancer

48 Correspondingly, significant increases of caveolin-1 and vascular endothelial growth factor (VEGF)

49 .g., matrix metalloproteinases, IL-8, PDGFs, caveolin 1, and lysyl oxidase), several of which were as

50 nto polarized trophoblasts that is clathrin, caveolin-1, and dynamin II independent but requires inta

51 in-1 and c-Abl, which is the major kinase of caveolin-1, and endocytosis of albumin in human umbilica

52 ment of cavin-1 on the prognostic potency of caveolin-1, and showed that combination of cavin-1 with

53 t is homologous to the Src-binding domain of caveolin-1, and this region is required for SSeCKS-Src i

54 of the Na(+),K(+)-ATPase with ankyrin B and caveolin-1 are expected to result in changes in plasma m

55 hat we find compartmentalizes exclusively to caveolin-1-associated detergent-resistant membrane (DRM)

56 Caveolin-1 associates with the endo/lysosomal machinery

57 ound in caveolae and directly phosphorylated caveolin-1 at Tyr14 in vitro and in vivo This modificati

58 vin-1/-2/-3/-4 and caveolin-1) in the cavins/caveolin-1 axis were screened by immunohistochemistry in

59 ely through inactivation of the NAD(+)-SIRT1-caveolin-1 axis, which limits an important fuel source f

60 re and driver-gene mutations, and the cavins/caveolin-1 axis.

61 The caveolin-1 bound fatty acids were immunoprecipitated by

62 investigated the fatty acids in caveolae and caveolin-1 bound fatty acids.

63 nsive element (ARE) after down-regulation of caveolin-1 by small interfering RNA or overexpression of

64 A heterozygous caveolin-1 c.474delA mutation has been identified in a f

65 A heterozygous Caveolin-1 c.474delA mutation has been identified in a f

66 in the pathogenesis of PAH in patients with caveolin-1 c.474delA mutation.

67 in the pathogenesis of PAH in patients with caveolin-1 c.474delA mutation.

68 Caveolin 1 (Cav-1) is a plasma membrane-associated prote

69 1 enzyme, together with the scaffold protein caveolin 1 (CAV-1), also acts as a negative regulator of

70 howed that overexpression of synapsin-driven caveolin-1 (Cav-1) (SynCav1) increases MLR localization

71 d overexpression of an MLR scaffold protein, caveolin-1 (Cav-1) (via a synapsin promoter, SynCav1), i

72 Caveolin-1 (Cav-1) ablation results in loss of caveolae

73 endocytosis of ALK-1, and it is mediated by caveolin-1 (CAV-1) and dynamin-2 (DNM2) but not clathrin

74 mily, is largely different from better known caveolin-1 (Cav-1) and thus might play distinct function

75 Occludin (ocln) and caveolin-1 (cav-1) are critical determinants of BBB inte

76 t the Na/K-ATPase alpha1 subunit, c-Src, and caveolin-1 (cav-1) are essential for the Na/K-ATPase sig

77 Plasma and tumor caveolin-1 (Cav-1) are linked with disease progression i

78 t levels of the endothelial-enriched protein caveolin-1 (Cav-1) are reduced in the brains of T2DM pat

79 Caveolin-1 (Cav-1) gene inactivation interferes with cav

80 Hence, this study evaluated the role of caveolin-1 (Cav-1) in modulating P2Y2R subcellular distr

81 cells to assess the role of cholesterol and caveolin-1 (CAV-1) in the diffusion, expression, and fun

82 Caveolin-1 (Cav-1) interacts with and mediates protein t

83 es this gap in knowledge by identifying that caveolin-1 (Cav-1) is a candidate mechanism-based biomar

84 Caveolin-1 (Cav-1) is a key organizer of membrane specia

85 Caveolin-1 (cav-1) is an important player in cell signal

86 We report that caveolin-1 (cav-1) is essential for sorting of selected

87 Here we show that the expression of caveolin-1 (Cav-1) is reduced in the brain in Type 2 dia

88 We hypothesized that caveolin-1 (Cav-1) participates in IOP maintenance via m

89 ions in the caveolar structural protein gene Caveolin-1 (CAV-1) were identified in two patients with

90 Evidence suggests that Caveolin-1 (Cav-1), a major component of caveolae which

91 Caveolin-1 (Cav-1), a major component of caveolae, is a

92 Caveolin-1 (CAV-1), a structural protein of the cell mem

93 to-oncogene tyrosine-protein kinase Src, and caveolin-1 (Cav-1), among others.

94 One LD coat protein is caveolin-1 (Cav-1), an essential component for caveola a

95 lasma membrane in DM, which colocalized with caveolin-1 (Cav-1), the key structural protein of caveol

96 yrosine kinase constitutively interacts with caveolin-1 (Cav-1), the key structural protein of caveol

97 titioning into caveolae and association with caveolin-1 (Cav-1).

98 g tissue, we identified the membrane protein caveolin -1 (Cav1) as a direct interaction partner of th

99 ssue, which is triggered by a dysfunction of caveolin 1 (CAV1) and subsequent uncoupling of feedback

100 Caveolin 1 (Cav1) is a required structural component of

101 e-like polygonal structures [7, 8] formed by caveolin 1 (Cav1) or Cav3 and one of the cavin proteins

102 roliferation, and invasion by downregulating caveolin 1 (CAV1) that plays a pivotal and versatile rol

103 We hypothesized that caveolin 1 (CAV1), a well-known eNOS interactor, regulat

104 ding protein and main component of caveolae, caveolin 1 (cav1), which was present in each epicardial

105 d indirectly through another miR-204 target, Caveolin 1 (CAV1).

106 s form a complex in membrane lipid raft with caveolin-1 (CAV1) and focal adhesion kinase (FAK) which

107 We show that caveolin-1 (Cav1) centrally regulates exosome biogenesis

108 idomic and gene array analyses revealed that caveolin-1 (CAV1) deficiency results in altered cellular

109 Caveolin-1 (Cav1) drives the formation of flask-shaped m

110 Caveolin-1 (CAV1) enhanced migration, invasion, and meta

111 ies have revealed significant association of caveolin-1 (Cav1) gene variants with increased risk of c

112 Owing to the important role of caveolin-1 (CAV1) in TGF-beta receptor internalization a

113 holesterol-binding integral membrane protein caveolin-1 (Cav1) into the membrane, however, the precis

114 erapeutic stress-resistant tumor clones, and caveolin-1 (CAV1) is a main regulator of numerous signal

115 Caveolin-1 (CAV1) is a multifunctional protein and a maj

116 Caveolin-1 (Cav1) is a scaffolding protein that serves t

117 Caveolin-1 (CAV1) is an essential component of caveolae

118 Caveolin-1 (Cav1) is an integral membrane, scaffolding p

119 The plasma membrane organizing protein caveolin-1 (Cav1) is increased in a variety of cancers,

120 Caveolin-1 (CAV1) is the defining constituent of caveola

121 Caveolin-1 (Cav1), a major Src kinase substrate phosphor

122 with hereditary hemorrhagic telangiectasia), caveolin-1 (CAV1), and a gene (KCNK3) encoding a two-por

123 show that the lipid raft-associated protein caveolin-1 (CAV1), in analogy with its previously descri

124 The absence of PTEN leads to caveolin-1 (CAV1)-dependent beta-catenin transcriptional

125 revious studies demonstrated that absence of caveolin-1 (Cav1)/caveolae in hyperlipidemic mice strong

126 use embryonic fibroblasts (pMEFs) expressing caveolin 1 (Cav1WT) demonstrated increased extracellular

127 These data support a role for caveolin 1, caveolin 2, or both in POAG and suggest that

128 Notably, caveolin-1, caveolin-2, and annexin A2, which are protei

129 ischemic penumbra of rat brains, and whether caveolin-1 changes correlated with reduced brain injury

130 odification regulated the generation of TIE2/caveolin-1 complexes and was essential for TIE2/caveolin

131 on and confocal microscopy demonstrated TIE2/caveolin-1 complexes in the nucleus, and using inhibitor

132 ucture analysis of a functional construct of caveolin-1, containing the intact C-terminal domain, was

133 e translocation of RIPK1, RIPK3, and MLKL to caveolin-1-containing DRM vesicles without fully blockin

134 The central portion of caveolin-1 contains two helices (H1 and H2) connected by

135 o characterize the structure and dynamics of caveolin-1 (D82-S136; Cav182-136) in a DMPC bilayer usin

136 signaling to RhoA is galectin-3 and phospho-caveolin-1 dependent and promotes the formation of trans

137 lmonary arteries via elastase inhibition and caveolin-1-dependent amplification of BMPR2 signaling.

138 In vitro, syndecan-2 promoted caveolin-1-dependent internalization of TGF-beta1 and Tb

139 de-in integrin signaling stimulating phospho-caveolin-1-dependent RhoA activation, actin reorganizati

140 n-2 exerts antifibrotic effects by promoting caveolin-1-dependent TGF-beta1 and TbetaRI internalizati

141 ERK as a KSR1 mutant unable to interact with caveolin-1 does not efficiently mediate growth factor-in

142 ycin signaling; reduced protein abundance of caveolin-1, dystrophin, epidermal growth factor receptor

143 in-depth functional experiments showed that caveolin-1-enhanced aggressiveness of pancreatic cancer

144 echanism that involves recruitment of KIT to caveolin-1-enriched microdomains.

145 ggests a bidirectional crosstalk between the caveolin-1/ERK and Wnt/beta-catenin pathways in mechanot

146 e show that there is interaction between the caveolin-1/ERK and Wnt/beta-catenin signaling pathways i

147 Caveolin-1 exhibits a stage-dependent, functional fluctu

148 We identified caveolin-1 expression as a crucial step in adipose cell

149 In contrast, manipulation of caveolin-1 expression did not affect the actions of E2 o

150 We demonstrate that a lack of caveolin-1 expression inhibits oncogenic K-Ras (K-Ras(G1

151 at the mRNA and protein levels, and that low caveolin-1 expression is associated with poor survival.

152 human sample analysis in which we show that caveolin-1 expression is dramatically down-regulated in

153 Cavin-1 stabilizes caveolin-1 expression or activity by inhibiting its inte

154 We found that depletion of caveolin-1 expression promotes primary cilia formation t

155 lial nitric oxide synthase (eNOS) and alters caveolin-1 expression to decrease nitric oxide bioavaila

156 mature senescence through down-regulation of caveolin-1 expression to progress from premalignant lesi

157 Soy protein isolate down-regulates caveolin-1 expression to suppress osteoblastic cell sene

158 cancer was found to be largely dependent on caveolin-1 expression, which highlights the critical rol

159 e expansion response correlated with initial caveolin-1 expression.

160 reduced enzyme activity and upregulation of caveolin-1 expression.

161 emodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis' (Goetz

162 emodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis' by Goet

163 po-osmotic tension induced the dispersion of caveolin-1 from the caveolae, possibly through flattened

164 Here we studied how this mutation alters caveolin-1 function using patient-derived fibroblasts.

165 Here we studied how this mutation alters caveolin-1 function, using patient-derived fibroblasts.

166 Ligand 1 will permit targeted study of caveolin-1 function.

167 Similarly, caveolin-1/galectin-3-dependent EGF signaling induces mo

168 was to screen subjects for variation in the Caveolin-1 gene (Cav1), previously shown to correlate wi

169 Like mice lacking caveolin-1 globally, (RPE)CAV1(-/-) mice developed a nor

170 Here, we show that the scaffolding protein caveolin-1 has a profound effect on receptor-driven Ca(2

171 Caveolin-1 has been primarily described as a major compo

172 e formation of lipid rafts and activation of caveolin-1; however, no such observations were made upon

173 fatty acids were immunoprecipitated by anti-caveolin-1 IgG and analyzed with GC/MS.

174 Neuron-targeted caveolin-1 improves neuromuscular function and extends s

175 roximately one-quarter of the density of the caveolin-1 in a flask-shaped caveola.

176 The caveolin-1 in a flattened caveola is assumed to have app

177 tion of Sirt1 expression or re-expression of caveolin-1 in caveolin-1 null MEFs restores reactive oxy

178 Expression of mutated caveolin-1 in caveolin-1-null mouse fibroblasts failed t

179 Finally, we show that overexpression of caveolin-1 in colon cancer cells inhibits oxidant-induce

180 extracellular domain and co-sedimented with caveolin-1 in lipid rafts.

181 critical role of the final 20 amino acids of caveolin-1 in modulating fibroblast proliferation by dam

182 critical role of the final 20 amino acids of caveolin-1 in modulating fibroblast proliferation throug

183 esults reveal a novel role for intracellular caveolin-1 in modulating phagolysosomal function.

184 Cavin-1 expression is associated with caveolin-1 in pancreatic cancer tissue samples and cell

185 Overexpression of caveolin-1 in ST2 cells resulted in increased expression

186 and formed a continuous population with the caveolin-1 in the caveolae of cells under isotonic cultu

187 ng with insulin receptor isoforms binding to caveolin-1 in the PM.

188 of this study was to investigate the role of caveolin-1 in treadmill-exercise-induced angiogenesis in

189 ive critical molecules (cavin-1/-2/-3/-4 and caveolin-1) in the cavins/caveolin-1 axis were screened

190 the EPA-induced lipid raft disorganization, caveolin-1 inactivation, and cellular cytotoxicity were

191 The proportion of one-quarter-density caveolin-1 increased after increasing the tension of the

192 Overexpression of caveolin-1 increased receptor-phospholipase C coupling,

193 In addition, overexpression of caveolin-1 induces stress induced premature senescence i

194 bitor groups received an IP injection of the caveolin-1 inhibitor, daidzein (0.4 mg/kg), every 24 h f

195 demonstrate that the combination of TIE2 and caveolin-1 inhibitors resulted in significant radiosensi

196 Furthermore, abolishing the KSR1-caveolin-1 interaction increases growth factor demands t

197 nd suggests that the interruption of cavin-1/caveolin-1 interaction is a promising therapeutic strate

198 show that the lipid raft scaffolding protein caveolin-1 interacts with the STIM1-Orai1 complex to inc

199 Our results reveal that caveolin-1 is a bimodal regulator of receptor-dependent

200 We demonstrate that caveolin-1 is a direct binding partner of Nrf2, as shown

201 These results suggest that caveolin-1 is a mediator of nonestrogenic SPI effects on

202 Caveolin-1 is a target for academic and pharmaceutical r

203 Caveolin-1 is an integral membrane protein that is the p

204 The interaction between KSR1 and caveolin-1 is essential for optimal activation of ERK as

205 While caveolin-1 is known to participate in a myriad of vital

206 These data show that caveolin-1 is necessary for optimal KSR1-dependent ERK a

207 Caveolin-1 is the primary structural component of endoth

208 In contrast, in caveolin-1 KD (Cav1-KD) cells, >87% of adiponectin-induc

209 tosis required dynamin but was unaffected by caveolin-1 knockdown or cholesterol depletion.

210 in endothelial transport of macromolecules: caveolin-1 knockout (Cav1-/-) and FcRn knockout (FcRn-/-

211 nt of endothelial nitric oxide synthase from caveolin-1, leading to an impairment of nitric oxide sig

212 After oxidative stress, caveolin-1 limits the movement of Nrf2 from caveolar mem

213 Therefore, by inhibiting Sirt1, caveolin-1 links free radicals to the activation of the

214 Thus, by inhibiting Nrf2-mediated signaling, caveolin-1 links free radicals to the activation of the

215 n of caveolin-1 with claudin 2 suggests that caveolin-1 may act as a shuttle for the internalization

216 id compositions of caveolae and acylation of caveolin-1 may be important for caveolae formation and f

217 d TRPV5 activity by impairing dynamin-2- and caveolin-1-mediated endocytosis of TRPV5.

218 reted by senescent fibroblasts following the caveolin-1-mediated inhibition of Sirt1.

219 The caveolin-1-mediated secretion of IL-6 by senescent fibro

220 mbrane of microvascular endothelial cells in caveolin 1(-/-) mice is much more susceptible to acute r

221 Thus, overall, whereas a direct caveolin 1/Na,K-ATPase interaction is confirmed, the lac

222 beit with a low molar stoichiometry (1:15-30 caveolin 1/Na,K-ATPase).

223 eolin-1 complexes and was essential for TIE2/caveolin-1 nuclear translocation.

224 expression or re-expression of caveolin-1 in caveolin-1 null MEFs restores reactive oxygen species-in

225 nd premature senescence in wild-type but not caveolin-1 null mouse embryonic fibroblasts (MEFs).

226 -regulation of NQO1, an Nrf2 target gene, in caveolin-1-null MEFs and the activation or inhibition of

227 Consistent with these data, caveolin-1-null mice overexpressing K-Ras(G12D) display

228 K-Ras(G12D)-induced premature senescence in caveolin-1-null mice results in the formation of more ab

229 r senescence in the lung of wildtype but not caveolin-1-null mice.

230 nucleus before and after oxidative stress in caveolin-1-null mouse embryonic fibroblasts (MEFs), whic

231 Expression of mutated caveolin-1 in caveolin-1-null mouse fibroblasts failed to induce forma

232 vital cellular processes, structural data on caveolin-1 of any kind is severely limited.

233 small, high-affinity, selective disrupter of caveolin-1 oligomers.

234 Phosphorylation of caveolin-1 on tyrosine 14 promotes the sequestration of

235 YD1) and purified human Src kinase and human caveolin 1 or interactions between these proteins in nat

236 ma membrane domains structurally composed of caveolin-1 or -3 along with other proteins.

237 r or small interfering RNAs (siRNAs) against caveolin-1 or Tie2 inhibited their trafficking.

238 Neuron-specific caveolin-1 overexpression improves motor function and pr

239 2 cells exhibited a strong association among caveolin-1, p53, and mouse double minute 2 homologue (md

240 were associated with down-regulation of the caveolin-1/p53-mediated senescence pathway in bone.

241 Our findings suggest that the caveolin-1 pathway is involved in the regulation of VEGF

242 of a mutant form of Nrf2 that cannot bind to caveolin-1 (Phi-->A-Nrf2) hyperactivates ARE and inhibit

243 on of AMPK inhibits oxidative stress-induced caveolin-1 phosphorylation and endocytosis, and this eff

244 However, the regulatory mechanism of caveolin-1 phosphorylation remains unclear.

245 ly unexpected role for AMPK in inhibition of caveolin-1 phosphorylation under oxidative stress.

246 , ILK, and Src-dependent RhoA activation and caveolin-1 phosphorylation.

247 d galectin-3 also mediate EGF stimulation of caveolin-1 phosphorylation.

248 lished the inhibitory effect of AICAR on the caveolin-1 phosphorylation.

249 Phosphorylation of caveolin-1 plays a fundamental role in the mechanism of

250 ICs expressed caveolin-1, podoplanin and receptor for advanced glycati

251 and showed that combination of cavin-1 with caveolin-1 predicted worse survival in pancreatic cancer

252 olar deformation by measuring the density of caveolin-1 projected onto a two-dimensional (2D) plane.

253 oximately 2.5-fold) or decrease (by half) of caveolin-1 protein levels in RPE cells in culture was su

254 We show that halving caveolin-1 protein levels significantly alkalinized lyso

255 This frameshift mutation leads to a caveolin-1 protein that contains all known functional do

256 This frameshift mutation leads to caveolin-1 protein that contains all known functional do

257 Each caveola contains approximately 150 caveolin-1 proteins.

258 o reduced levels of occludin, claudin 5, and caveolin 1, proteins central to blood-brain-barrier inte

259 Phosphorylation of tyrosine 14 on caveolin-1 regulates CRAC channel-evoked c-fos activatio

260 a subcutaneous xenograft model that stromal caveolin-1 remodels the intratumoral microenvironment, w

261 cancer cells, which could not be restored by caveolin-1-rescue construct.

262 Complete backbone assignments of caveolin-1 (residues 62-178) were made, and it was deter

263 y small interfering RNA or overexpression of caveolin-1, respectively.

264 ression of wild-type caveolin-1 with mutated caveolin-1 restored the ability to form caveolae.

265 ression of wild type caveolin-1 with mutated caveolin-1 restored the ability to form caveolae.

266 Interestingly, overexpression of caveolin-1 restores cellular senescence in both A549 and

267 -induced IL-8 responses via the formation of caveolin-1-rich "signaling hubs" in the corneal cells th

268 esponsible for MEK and ERK redistribution to caveolin-1-rich fractions.

269 nd prevents the translocation of ICAM-1 into caveolin-1-rich membrane domains.

270 ion and induces translocation of ICAM-1 into caveolin-1-rich membrane domains.

271 Treatment with the caveolin-1 scaffolding domain peptide (CSP) reversed the

272 her, inhibition of Src kinase activity using caveolin-1 scaffolding domain peptide suppressed bleomyc

273 reveal that structurally distinct domains of caveolin-1 selectively regulate the ability of local cal

274 extent of caveolar formation and the role of caveolin-1 signalling were evaluated by immunohistochemi

275 ey show, for the first time, that organellar caveolin-1 significantly affects tissue functionality in

276 We also identified IL-6 as a caveolin-1-specific cytokine that is secreted by senesce

277 Therefore, eliminating caveolin-1 specifically impairs phagolysosomal degradati

278 Here we explored mice lacking caveolin-1 specifically in the retinal pigment epitheliu

279 cking of the microdomain-associated proteins caveolin-1, syntaxin-6, and multidrug resistance protein

280 ydrophobic domain (FQRQVWLLF) interacts with caveolin 1 targeting Kv1.3 to caveolar rafts.

281 A mutant form of caveolin-1 that fails to reach the cell surface augmente

282 can be increased by blocking its binding to Caveolin-1, the main coat protein of caveolae, using a h

283 and-induced TIE2 trafficking is dependent on caveolin-1, the main component of caveolae.

284 c function of caveolin-1 and cooperates with caveolin-1 to enhance pancreatic cancer aggressiveness.

285 mbrane and acts synergistically with phospho-caveolin-1 to promote integrin-dependent matrix remodeli

286 mouse fibroblasts, where it colocalizes with caveolin-1, under resting conditions.

287 ession of p53 and p21, whereas, knockdown of caveolin-1 using shRNA led to increases in mdm2 and elim

288 The caveolin-1/VEGF signaling pathway may be a potential tar

289 cally to augmented interaction of BMPR2 with caveolin-1 via elafin-mediated stabilization of endothel

290 hly enriched with saturated fatty acids, and caveolin-1 was acylated by palmitic acid and stearic aci

291 Unexpectedly, GC/MS analysis indicated that caveolin-1 was not acylated by myristic acid; instead, i

292 Endogenous caveolin-1 was recruited to maturing phagolysosomes in R

293 The one-quarter-density caveolin-1 was soluble in detergent and formed a continu

294 The distinct, dispersed lower-density caveolin-1 was soluble in detergent and increased after

295 membranes and the interaction of Sirt1 with caveolin-1, which lead to inhibition of Sirt1 activity.

296 Cavin 1 forms trimers and interacts with caveolin 1 with a molar ratio of about 1ratio4.

297 Co-immunoprecipitation of caveolin-1 with claudin 2 suggests that caveolin-1 may a

298 that K-Ras(G12V) promotes the interaction of caveolin-1 with MTH1, which results in inhibition of MTH

299 However, coexpression of wild-type caveolin-1 with mutated caveolin-1 restored the ability

300 However, co-expression of wild type caveolin-1 with mutated caveolin-1 restored the ability