ライフサイエンスコーパス: cell clone

1 eive chemotherapy targeting the underlying B-cell clone.

2 CR) isolated from a hemophilia A subject's T-cell clone.

3 nce analysis of correctly gene-edited single-cell clones.

4 or their ability to stimulate human CD4(+) T cell clones.

5 tigens may serve to activate self-reactive B cell clones.

6 ensitivity and specificity for identifying B cell clones.

7 fforts to eradicate therapy-resistant cancer cell clones.

8 th macrophages and expanded populations of T-cell clones.

9 f viral lytic genes in BCBL-1-derived single-cell clones.

10 s decreased in peripherally expanded naive T-cell clones.

11 ells is sufficient to identify predominant T-cell clones.

12 ia-alpha1a- and DQ2.5-glia-omega1-reactive T-cell clones.

13 n, somatic hypermutation, and selection of B cell clones.

14 n furthermore activate primary KIR2DS1(+) NK cell clones.

15 myeloma plasma cell clones than MGUS plasma cell clones.

16 mokine secretion than "ineffective" CD8(+) T-cell clones.

17 peptide-stimulated PBMCs, and IFX-specific T cell clones.

18 to prevent the expansion of self-reactive B cell clones.

19 and IFN-gamma expression in plaque-derived T cell clones.

20 viral capacity of some HIV-specific CD8(+) T-cell clones.

21 nstitutive expression of HIV RNA in infected cell clones.

22 therapy are present in only some MGUS plasma cell clones.

23 werful technology with which to track single-cell clones.

24 s in emerging cisplatin-resistant tumours or cell clones.

25 lting in retention of the highest-affinity B cell clones.

26 on factor Bcl-6 and selected high-affinity B cell clones.

27 nd among highly expanded provirus-containing cell clones.

28 in Ca(2+) signaling in some lymphomas and T cell clones.

29 dditional members of the allergen-specific B-cell clones.

30 also operates at the level of germline stem cell clones.

31 esistance to infection present in some CD4 T-cell clones.

32 nce of competitive somatic and germline stem cell clones.

33 ical role in the elimination of HPV-infected cell clones.

34 g the presence of similar Ara h 2-specific B-cell clones.

35 rithm that detected significantly expanded T cell clones.

36 s characterized by many, often very large, B-cell clones.

37 toire but does not eliminate self-reactive T cell clones.

38 pooled stable cell lines and isolated single-cell clones.

39 cted by 'cell competition' between different cell clones.

40 itive fitness of specific hematopoietic stem cell clones.

41 o persistent circulating thymus-associated B cell clones.

42 expansion and contraction of infected CD4+ T cell clones.

43 HV genome in one of two characterized single cell clones.

44 expression vector in combination with single-cell cloning.

45 multiple rounds of cell selection and single-cell cloning.

46 ulin reactive, MHC class-I-restricted CD8+ T cell clone (1E6) that can recognize over 1 million diffe

47 ns and differential reactivity of human MAIT cell clones according to the bacteria.

48 ction of atabecestat metabolite-responsive T-cell clones activated via a pharmacological interactions

49 CD4(+) T-cell clones activated with the DIAT metabolite were dete

50 Tumor-derived single-cell clones also give rise to both SCCB and urothelial c

51 R) is the individual identity card of each T cell clone and can help to follow single specificities.

52 tibodies are produced by a single expanded B-cell clone and carry distinct somatic mutations in the L

53 chains were produced by an intrapulmonary B-cell clone and that this clone shared a stereotyped anti

54 There, competition between B cell clones and among somatic mutants of each clone driv

55 Autoantigen-reactive CD4(+) memory T cell clones and an APS-derived, pathogenic monoclonal an

56 a consequential reduction of autoreactive B cell clones and autoantibodies.

57 -RLGL-WE14 tetramers bind to ChgA-specific T-cell clones and easily detect ChgA-specific T cells in t

58 We generated NONO-silenced HeLa cell clones and found that lack of NONO decreased cell g

59 ccurate partitioning of sequence data into B-cell clones and identification of the starting point of

60 leading to the expansion of certain myeloid cell clones and induces changes in myeloid cell function

61 T1D patient-derived beta cell-autoreactive T cell clones and lines, but, when screening for pathogeni

62 Multiple T-cell clones and polyclonal lines having different avidit

63 (DeltaNPM1) and then generate high-avidity T cell clones and retrovirally transduced T cell populatio

64 Prospective studies targeting plasma cell clones and/or fibrotic pathways are warranted for l

65 ction (5 h), cells were processed for single-cell cloning and analyzed for chromosomally integrated H

66 and memory T cell libraries, combined with T cell cloning and TCR sequencing, to dissect the human na

67 compare acute CRISPR-based knockout, single cell clones, and small-molecule inhibition.

68 toring the fate and function of individual T cell clones, and the adoptive transfer of protective eff

69 e isogenic pairs of cells that avoids single cell cloning, and screen these pairs with genome-wide CR

70 Members of a B cell clone are descended from a common ancestor and shar

71 moral responses and whether tumor-resident T cell clones are amplified following treatment.

72 Infected T cell clones are detected at low frequencies in the long-

73 To define how B-cell clones are distributed in the body, we sequenced 93

74 e hypothesis that to maintain homeostasis, T cell clones are expelled from the repertoire, reducing T

75 reviously published chlamydia-specific CD8 T-cell clones are MHC class II restricted.

76 alterations that affect whether MGUS plasma cell clones are responsive to anti-multiple myeloma ther

77 IV-1 latency model using autologous CD8(+) T cell clones as biosensors of antigen presentation, neith

78 al autoreactive, flow cytometric, and single-cell cloning assays have proven to be critical in deciph

79 humoral immune response when an expanding B cell clone assumes multiple cell fates, including class-

80 SPF) mice contain highly dominant 'winner' B cell clones at steady state, despite rapid turnover of g

81 By analysing the antibody-producing B cell clones at the protein, cDNA and gDNA levels, we cha

82 The diabetogenic CD4 T cell clone BDC-2.5, originally isolated from a NOD mouse

83 egins with a diverse and expanded group of B cell clones bearing a wide range of antibody affinities.

84 tes are observed in a minority of anti-NET B cell clones but can strongly influence NET-Ag binding.

85 e extent of fluctuation of dominant CD8(+) T-cell clones, but not of CD4(+) counterparts, correlated

86 ates a virtually unique IgH locus in every B cell clone by intrachromosomal recombination between two

87 Isolation of T cell clones by limiting dilution from tumor-infiltrating

88 Aldh1l1(-/-) mice were generated using an ES cell clone (C57BL/6N background) from KOMP repository.

89 ready reflects selection for those malignant cell clones capable of evading immune recognition ("immu

90 We identified an expanded T cell clone carrying an intact provirus that matched a va

91 These data show that HTLV-1-infected T-cell clones carrying key oncogenic driver mutations can

92 For 3 distinct T-cell clones, CD79b specificity was confirmed through CD7

93 Several expanded B cell clones, characterized by their uniquely rearranged

94 the model to address expansion of multiple T cell clones competing for antigen, we find that higher-a

95 In addition, in total, 663 T-cell clones (containing at least 91 unique clones expres

96 We report that a highly expanded CD4(+) T-cell clone contains an intact provirus.

97 al tissues, and absolute numbers of unique T-cell clones correlated with respective T-cell counts.

98 In 6 of 8 patients, a malignant T-cell clone could be identified in lesional skin, and a s

99 nnexin A2-specific Vdelta2(neg) gammadelta T-cell clones could be derived from peripheral blood monon

100 lete RHV life cycle, but replicon-containing cell clones could be selected with and without acquired

101 ith MM is associated with the large CD8(+) T cell clone count 21 d after treatment and agnostic to cl

102 nhanced by mutations in NS4B and NS5A and in cell clones cured of replicon RNA.

103 that the immunodominance of high-affinity T cell clones declined during the chronic infection phase,

104 rom HA-1Hneg/HLA-A*02:01pos donors and one T-cell clone derived from an HA-1Hpos/HLA-A*02:01pos donor

105 unique HA-1H-specific T-cell clones, five T-cell clones derived from HA-1Hneg/HLA-A*02:01pos donors

106 on TCR/CD8:pMHC avidity, as tumor-reactive T cell clones derived from patients vaccinated with the lo

107 Using a panel of diabetogenic CD4 T cell clones derived from the NOD mouse, we recently iden

108 Some large infected cell clones detected by QVOA carried neutralization-sens

109 By contrast, vaccine-induced B cell clones detected only in the germinal centre compart

110 utated common ancestor knock-in mice Env(+)B cell clones develop anergy and partial deletion at the t

111 However, the expansion of T cell clones did not derive from pre-existing tumor-infil

112 ll markers (Foxp3(+) CD25(+)) and cultured T cell clones did not express a cytokine profile that indi

113 T-cell clones directed against the HLA*02:01-restricted Mi

114 KK10-stimulated "effective" CD8(+) T-cell clones displayed significantly more rapid TCR signa

115 Finally, IL-10-producing drug-specific T cell clones downregulated the response of autologous eff

116 here the presence of a single autoreactive B cell clone drives the TLR7-dependent activation, expansi

117 ecific B cells and track the fate of these B-cell clones during SIT.

118 mans possess a vast diversity of distinct NK cell clones, each with the capacity to vary along this f

119 % efficiency and a 96 +/- 4% postsort single-cell cloning efficiency.

120 me alterations 13q14-, 6q- and 12q+ in early cell clones, elimination of clonal populations following

121 ributing to developmental failure in somatic cell cloned embryos.

122 mphoproliferation and generates many large B-cell clones, especially among non-class-switched memory

123 From a CD8(+) T cell clone established by stimulation of HLA-A2(+) CD8(+

124 t cotransfer of MPO431-439-specific CD8(+) T cell clones exacerbated disease mediated by MPO-specific

125 are the main sites where antigen-activated B-cell clones expand and undergo immunoglobulin gene hyper

126 Furthermore, phenotypically aberrant stem cell clones expanded during transformation and stem cell

127 system that effectively generates mammalian cell clones expressing biopharmaceutically relevant or o

128 Of the 16 unique HA-1H-specific T-cell clones, five T-cell clones derived from HA-1Hneg/HL

129 ns and efficient selection of low-affinity B cell clones for proliferative clonal expansion.

130 al T cells and of cells of an autoreactive T-cell clone found in inflamed organs, while maintaining a

131 etramer from a synovial Vdelta1 gammadelta T cell clone from a Lyme arthritis patient.

132 vity to wheat, rye, and barley peptides as T-cell clones from adults with celiac disease.

133 m one effective and two ineffective CD8(+) T-cell clones from an elite controller into TCR-expressing

134 About half of the generated T-cell clones from children and adults reacted to unknown

135 inst gluten by generating T-cell lines and T-cell clones from intestinal biopsies of adults and child

136 ctivity was observed for individual CD8(+) T-cell clones from mice bearing BPTF-silenced tumors.

137 cterize atabecestat(metabolite)-responsive T-cell clones from patients with liver injury.

138 ermore, we demonstrated that MiHA-specific T cell clones from patients with selective GVL reactivity

139 rized 24 unique proinsulin-specific CD4(+) T cell clones from the peripheral blood of 17 individuals

140 receptor beta (TCRB) gene sequencing of 15 T-cell clones from the severe HA subject revealed that all

141 nterselection, and anergy among individual B cell clones from two distinct BCR transgenic mouse model

142 s, we isolated and characterized 53 CD4(+) T-cell clones from within the residual pancreatic islets o

143 s the antigen specificity and phenotype of T-cell clones generated from patients with AX-Clav-induced

144 sition, with particular patterns of memory B-cell clone generation in GC reactions.

145 These shared B cell clones had high frequencies of somatic hypermutatio

146 identical intact sequences, suggestive of a cell clone harboring a replication-competent provirus.

147 of DM on stimulation of the two groups of T cell clones implies differences in DQ2 presentation path

148 as the presence of an expanded somatic blood-cell clone in persons without other hematologic abnormal

149 lood draws, indicating persistence of this T-cell clone in the peripheral blood.

150 rapid expansion or enrichment of relevant T-cell clones in <2 weeks, and is applicable for T-cell ma

151 itopes are recognized by numerous distinct B-cell clones in a patient.

152 2-3 irAEs also had expansion of >/=55 CD8 T-cell clones in blood samples collected before the onset

153 tegration events in genomic DNA and expanded cell clones in five dogs, with 44% of the integrations n

154 ffers the potential to eliminate residual MM cell clones in low-disease-burden settings, including MR

155 Because B-cell clones in MC and lymphomas derive from this B-cell

156 e TCR sequences of the proinsulin-specific T cell clones in pancreatic lymph node samples compared wi

157 oncentrations and phenotypes of individual T-cell clones in response to primary and secondary yellow

158 s of NK cells (83% vs 50% of patients) and T-cell clones in the blood (83% vs 30% of patients).

159 ght (typically between 104 and 105 HTLV-1+ T cell clones in the body of an asymptomatic carrier or pa

160 vity improves the developmental fitness of B cell clones in the context of a diverse population of B

161 moral TCR repertoire revealed expansion of T cell clones in the setting of neoantigen loss.

162 We show that co-existence of different cell clones in the tumor, as often found in experiments,

163 M5alpha transduction of virus-specific CD4 T-cell clones increased and prolonged their ability to sup

164 of the main factors limiting entry of new B cell clones into ongoing immunization-triggered GC respo

165 tor obtained from a hemophilia A subject's T-cell clone, into expanded human FoxP3(+) Tregs.

166 A T cell clone is able to distinguish Ags in the form of pep

167 The repertoire of alloreactive T cell clones is distinct for every donor-recipient pair a

168 ng a large number of sufficiently abundant T cell clones is important for adequate protection against

169 Identification of the lethal tumour cell clones is required to improve survival of patients

170 n recognized by an HLA-E-restricted CD8(+) T cell clone isolated from an Mtb latently infected indivi

171 ptides recognized by a bona fide murine Treg cell clone isolated from the visceral adipose tissue (VA

172 High-avidity CD8+ T cell clones isolated from healthy donors killed CBFB-MYH

173 We found that diabetes-inducing CD4 T cell clones isolated from nonobese diabetic mice recogni

174 d recognition by the H-2D(b)/Trh4-specific T cell clone LnB5.

175 es such as (epi-)genetic differences between cells, clone location and the geometry of tumor growth a

176 s suggest that chemotherapy adapted to the B-cell clone may constitute an efficient strategy for C3G

177 that targeting of specific epitopes and/or T-cell clones may be a promising approach to achieve toler

178 An MR1-restricted T cell clone mediated in vivo regression of leukemia and c

179 Using a dye dilution-based T cell cloning method, we generated and characterized 24 u

180 loid light chain (AL) amyloidosis, a small B-cell clone, most commonly a plasma cell clone, produces

181 solated six nonredundant, antigen-specific T-cell clones, most of which reacting to their target HIPs

182 PBMC and T-cell clones (n = 570, 84% CD4(+)) from blood of piperaci

183 had reconstituted from an epidermal CD8(+) T cell clone of an HLA-C*06:02-positive psoriasis patient

184 In line with this, a highly HBV permissive cell clone of HepAD38 cells showed a prominent associati

185 to sequence immunoglobulin genes from single-cell clones of dominantly expanded plasmablasts and gene

186 Further, T cell clones of tetramer-sorted memory cells of healthy i

187 except for five patients (6%) with minute T-cell clones of uncertain significance accounting for 53-

188 We found that two recurrent Treg cell clones, one prevalent in prostate tumors and the ot

189 results in the emergence of resistant cancer cell clones only in the presence of IFN-gamma within the

190 and 88% of the responding germinal centre B cell clones overlapped with B cells detected among early

191 We show that large B-cell clones partition into two broad networks-one spans

192 NAb repertoires, encompassing thousands of B cell clones per individual, with correlated T cell pheno

193 g Ag-specific T cells of interest for single cell cloning, phenotyping, and transcriptomics.

194 We demonstrate that a subset of T cell clones possesses a heightened capacity to form TRM,

195 ults suggested that expansion of >/=55 CD8 T-cell clones preceded the development of severe irAEs.

196 grees, we find that although individual stem-cell clones produce descendants that are in transcriptio

197 HIP-reactive T-cell clones produced Th1-associated cytokines and prolif

198 a small B-cell clone, most commonly a plasma cell clone, produces monoclonal light chains that exert

199 loidosis is caused by a usually small plasma cell clone producing a misfolded light chain that deposi

200 kemia (CLL) is a disease in which a single B-cell clone proliferates relentlessly in peripheral lymph

201 VLD-specific and one NY-eso-1-SLL-specific T-cell clone provoked interferon-gamma production and/or c

202 Fab-N-linked glycosylation in RA synovial B cell clones reactive to NETs and NET-derived Ags such as

203 ous HLA-DR-restricted and Bet v 1-specific T-cell clones reactive with epitopes in different regions

204 In melanoma patients, T cell clones recognizing naturally processed cancer antig

205 metric cluster analysis of multiple CD8(+) T-cell clones recognizing the identical HLA-B*2705-restric

206 veness of effective and ineffective CD8(+) T-cell clones recognizing the identical HLA-B*2705-restric

207 he factors that influence the diversity of B cell clones recruited into GCs are unclear.

208 The diversity of B cell clones recruited into germinal center (GC) response

209 Recognition by the CD8(+) T cell clone required N-terminal O-linked mannosylation of

210 mparing how MGUS and multiple myeloma plasma cell clones respond to these therapies are scarce.

211 hat recognized the cross-reactive epitope, T cell clones responded robustly to cashew, hazelnut and/o

212 dentify how MGUS and multiple myeloma plasma cell clones responded to anti-multiple myeloma therapy i

213 It is secondary to the presence of a small B-cell clone, responsible for monoclonal immunoglobulin pr

214 Analysis of MR1T cell clones revealed specificity for distinct cell-deriv

215 Experiments with T-cell clones revealed that AgmTRIM5alpha could reproducib

216 Here, a single cell cloning revealed that HepAD38 cells, a widely-used

217 we show that tens to hundreds of distinct B cell clones seed each GC and that GCs lose clonal divers

218 Effective and ineffective CD8(+) T-cell clones segregated based on responses to HIV-1-infec

219 ometry-based unbiased analysis followed by T cell cloning, several findings were made.

220 trols and infectious cases; however, these T cell clones show very little overlap between subjects.

221 rization of a mutated CXCR7-expressing LNCaP cell clone showed altered intracellular signaling and re

222 ein analysis of an isolated corrected single cell clone showed secretion of the corrected type VII co

223 ypic and functional characterization of MR1T cell clones showed multiple chemokine receptor expressio

224 y clonal dynamics imprint the hierarchy of T cell clone sizes with implications for pathogen defense

225 ic signaling between heterogeneous malignant cell clones, some of which expressed PDGFRbeta.

226 rred to secondary recipients and was myeloma cell clone specific.

227 T-cell clones specific for dominant alpha- or omega-gliadi

228 We identified and enumerated unique CD8(+) T cell clones specifically induced by this vaccine through

229 tified TCR sequences from the autoreactive T cell clones, suggesting possible pathogenic TCRs that ca

230 s study was to generate clozapine-specific T cell clones (TCC) and characterize pathways of T cell ac

231 Here we apply single-cell cloning technologies to lung tissue of patients wit

232 ing serial dilutions of CD4(+) T cells and T cell-cloning technologies, we are able to demonstrate th

233 Here, we utilized a high-throughput single B cell cloning technology to longitudinally track the huma

234 of response against multiple myeloma plasma cell clones than MGUS plasma cell clones.

235 lexes (pMHCs), we examined the ILA1 CD8(+) T-cell clone that responds to a peptide sequence derived f

236 oliferation of peripherally expanded naive T-cell clones that accumulate with age.

237 hermore, we identified autoreactive CD4(+) T cell clones that can cross-react with HLA-DR-derived sel

238 t a germinal centre reaction that recruits B cell clones that can target new epitopes, thereby broade

239 n protein MLL-AF9 to generate several single-cell clones that demonstrate resistance, in vitro and in

240 We compared three cell clones that differ only in the genomic integration

241 edicine, Yost et al., 2019 report that the T cell clones that dominate the intra-tumoral T cell lands

242 stem is the prolific expansion of individual cell clones that encounter their cognate antigen.

243 porting the identity of activated effector T cell clones that expand in response to the YFV 2 weeks p

244 this route, we discovered that preinfusion T-cell clones that expressed the IL7 receptor (IL7R) and c

245 kade derives from a distinct repertoire of T cell clones that may have just recently entered the tumo

246 favor the production of untolerized IgG(+) B-cell clones that recognize both commensal bacteria and h

247 the thymus B cell repertoire and identify B cell clones that resided in the thymus and circulation b

248 We generated HLAnull K562 cell clones that were engineered to express CD1d and cos

249 d in vivo expansion of neoantigen-specific T cell clones that were reactive to mutant neopeptides fou

250 herent uncertainty in the number of B- and T-cell clones that will be missing from a blood or tissue

251 Here we show, using B6/Cast hybrid pre-B-cell clones, that a limited number of V segments on each

252 s for both the number and the abundance of T cell clones.) The causes of this observation are incompl

253 riptomics, the ability to track individual T cell clones through paired sequencing of the T cell rece

254 that the maintenance of large CMV-reactive T cell clones throughout life does not compromise the unde

255 performed with Tc1 clones and a CD8gamma13 T-cell clone to determine whether either influenced bacter

256 permit progression from the aberrant plasma cell clone to MGUS and overt MM.

257 nking specific characteristics of the plasma cell clone to response to different types of treatment,

258 sequencing of multiple isogenic chicken DT40 cell clones to precisely determine the consequences of B

259 similarities in the memory repertoire, the B-cell clones used in acute responses to ZOSTAVAX vaccinat

260 nd deposited from a fusion mixture as single-cell clones via FACS.

261 once the transcriptome of the Waldenstrom B-cell clone was compared with its normal phenotypic (CD25

262 ngly, the transcriptome of the Waldenstrom B-cell clone was highly different than that of normal CD25

263 One T-cell clone was isolated from the same patient on two dif

264 rise, an adoptively transferred CD8gamma13 T-cell clone was remarkably proficient at preventing chlam

265 k of focused TCR-peptide binding, the ILA1 T-cell clone was still cross-reactive.

266 mice derived from a different embryonic stem cell clone was tested.

267 acavir/abacavir analogue-responsive CD8(+) T-cell clones was measured using IFN-gamma ELIspot.

268 ic analyses and mixing experiments of single-cell clones, we dissect two characteristics of ITH: the

269 zing two independent conditionally mutant ES cell clones, we found that deletion of L1CAM dramaticall

270 using well-characterized UCP-specific CD4 T cell clones, we showed that hTERT processing and present

271 By using single-cell cloning, we identified genes that are associated wi

272 skin equivalents expanded from the corrected cell clone were grafted onto immunodeficient mice.

273 f the 70 most frequent putative pathogenic T cell clones were alphabeta T cells.

274 Jug r 2-specific T-cell clones were also generated, and mRNA transcription

275 Several T-cell clones were cross-reactive, especially clones that

276 Thus, antigen-reactive skin TRM and LN TCM cell clones were derived from a common naive T cell prec

277 Thymus-associated B cell clones were detected in the circulation by both mRN

278 Autoreactive T cell clones were detected in the periphery of Foxn1 cond

279 y and multiple DCK or SLC29A deficient human cell clones were established with one clone becoming pre

280 by IFX-specific T cells, T cell lines, and T cell clones were evaluated at the mRNA and protein level

281 ling of different T. parva-specific CD8(+) T cell clones were found to be significantly correlated wi

282 T-cell clones were generated from 4 hypersensitive patient

283 Drug-specific T-cell clones were generated from immediate hypersensitive

284 110 AX-specific and 96 Clav-specific T-cell clones were generated from seven patients with posi

285 The CD79b-specific T-cell clones were highly reactive against CD79b-expressin

286 Many circulating thymus-associated B cell clones were inferred to have originated and initial

287 Small T-cell clones were often observed in T- and NK-cell tumors

288 the active-TGFbeta was limited or when new T cell clones were recruited into the epidermis, antigen-s

289 Most (87%) top expanded lesional T-cell clones were shared with nonlesional tissues, and th

290 KRAS-mutated lung cancer cell clones were stably silenced for LSD1 expression.

291 We confirmed that MAIT cell clones were unable to respond to MR1(-/-) clones in

292 ficking of fluorescently labeled HAdV26 in a cell clone with stably increased expression of alphavbet

293 widely-used HBV-inducible cell line, contain cell clones with diverse permissiveness to HBV replicati

294 Cell clones with drivers often originate during the firs

295 In summary, IL-17-producing alphabeta T cell clones with psoriasis-specific antigen receptors ex

296 ould be recovered and maintained in culture, cell clones with simultaneously inactive GLT25D1 and GLT

297 abeled HAdV26 in A549 cells and A549-derived cell clones with stably increased expression of alphavbe

298 Pen m 1-specific T-cell clones, with specificity for regions highly conserv

299 Finally, both donor and recipient T cell clones within the rejecting kidney suggested lympho

300 In contrast, permanence of naive T cell clones would be determined by their affinity for co