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1  defense mechanisms, such as classical 'cell-cell competition'.
2 ila S2 cells to investigate the mechanism of cell competition.
3 s cells and suggest an apoptosis pathway for cell competition.
4 red by DCs, providing a possible basis for T cell competition.
5 ulated in G1, and underwent apoptosis due to cell competition.
6 ry choices can regulate cellular fitness and cell competition.
7  cell-extracellular matrix adhesion mediated cell competition.
8 show that reduced translation does not cause cell competition.
9 y types of oncogenic cells are eliminated by cell competition.
10 ls were not themselves sufficient to trigger cell competition.
11 ferring lactate to their neighbors nullifies cell competition.
12 winner/loser interaction, a prerequisite for cell competition.
13  and cellular redox are strong modulators of cell competition.
14 m losers to winners abrogates NMDAR-mediated cell competition.
15  deleterious mutation, is controlled through cell competition.
16 gins for mechanical and biochemical modes of cell competition.
17 ng cells' genotype and is thus distinct from cell competition.
18 osomal stresses and is the key instigator of cell competition.
19 iminate loser cells in multiple scenarios of cell competition.
20 reased eIF2alpha phosphorylation and enabled cell competition.
21 peline by applying it to the study of Minute cell competition.
22 ation of ed clones by a mechanism resembling cell competition.
23  epithelial closure, they were eliminated by cell competition.
24 ll birth and death rates, and the details of cell competition.
25  part be accounted for by their influence on cell competition.
26 ed Toll ligands that induce apoptosis during cell competition.
27 a promotes tumorigenesis by abrogating local cell competition.
28 opment, stem cell biology, regeneration, and cell competition.
29 that this promotes tumor growth, in part via cell competition.
30 ue and is required for both tumor growth and cell competition.
31 embryonic development through the process of cell competition.
32  mechanisms, and immune system mechanisms of cell competition.
33 by their neighbours through a process termed cell competition.
34  and non-autonomous mechanisms distinct from cell competition.
35 rp1 DNA binding domains and is necessary for cell competition.
36 lleys and ridges through processes like cell-cell competition.
37 s) repopulate livers of normal recipients by cell competition.
38         We show for the first time that cell-cell competition, a developmental paradigm, can be used
39 ht into this problem by showing that through cell competition, a fitness-sensing process that usually
40  many tissues, homeostasis is shaped by stem cell competition, a process in which stem cells compete
41 of cells of different phenotypes can trigger cell competition, a process whereby one type of cell dri
42  Here, we will discuss the contribution that cell competition, a quality control that eliminates viab
43                                    I examine cell competition, a quality-control mechanism that remov
44 d from the growing Drosophila tissue through cell competition, a tumor-suppressing mechanism that ens
45                  These results indicate that cell competition acts as a previously unidentified tissu
46                       In metazoan organisms, cell competition acts as a quality control mechanism to
47                                              Cell competition acts as a quality-control mechanism tha
48                                        Thus, cell competition acts as a tumor-suppressing mechanism b
49 ing and biophysical modeling and address how cell competition affects stem cell and tissue population
50                                              Cell competition allows winner cells to eliminate less f
51 th through a proteostasis-based mechanism of cell competition and cell selection.
52 d adenoma formation resulting from augmented cell competition and clonal expansion.
53 ight be a regulatory mechanism that balances cell competition and cooperation in dense yeast populati
54 unrecognized role for RNA innate immunity in cell competition and demonstrates that targeting host im
55 perplastic tumor suppressors, interfere with cell competition and elevate Dpp signaling.
56 f multiple stress signalling pathways before cell competition and find that these pathways collective
57                                              Cell competition and fitness comparison between cancer a
58             Modulating dmyc levels to create cell competition and hid-dependent cell death may be a m
59 erstanding of the molecular underpinnings of cell competition and its role in tissue development and
60  homolog of the c-myc protooncogene, induces cell competition and leads to the death of nearby wild-t
61 tocrine glutamate signaling are required for cell competition and Myc-driven super-competition in the
62  manipulation and enable the study of mutant cell competition and selection in three-dimensional epit
63                               More recently, cell competition and super-competition were recognized i
64 ogramming to pluripotency, the regulation of cell competition and the control of embryonic diapause.
65 multi-scale agent-based model for epithelial cell competition and use it to gain a conceptual underst
66 s critical for scrib(-) clone elimination by cell competition, and experimental elevation of Yki acti
67 ate to survey cell fitness, regulate natural cell competition, and optimize brain size during neurode
68 rant but viable cells are eliminated through cell competition, and the resulting loss of local tissue
69  Cell death, compensatory proliferation, and cell competition are fundamental interconnected processe
70 (2017) proposes that this death results from cell competition arising from differences in cellular di
71 milar roles in cell killing during classical cell competition as in eliminating tumors.
72                                              Cell competition assays further showed that MmuPV1 E6 ex
73 ar or high-fat diet and inflammation, impact cell competition-based host defences, suggesting that th
74                               We report that cell competition between scrib(-) and wild-type cells pr
75 y and uncovered a previously unknown mode of cell competition between species.
76  of cells within tissues can be affected by 'cell competition' between different cell clones.
77  of ligand-receptor binding in living HEK293 cells, competition binding experiments using commerciall
78 enes in HEK293 cells, gene silencing in THP1 cells, competition binding, and signaling studies with t
79 t only elimination of aberrant cells through cell competition but also proper organ-size control that
80 cking ph function and found that many suffer cell competition but are not completely eliminated.
81 ng mechanisms shared with other instances of cell competition, but that differ, reportedly, in the in
82 r communication, which notably buffered cell-cell competition by averaging gene expression.
83 An, we identify several genes with a role in cell competition by conducting an RNAi-based screen.
84  Importantly, we demonstrate that preventing cell competition, by expressing apoptosis inhibitors, re
85   Studies in recent years have revealed that cell competition can either be driven by short-range bio
86                                              Cell competition can occur when cells of different genot
87 occur in a number of pathological conditions.Cell competition causes the removal of less fit cells ('
88                                              Cell competition (CC) is a fitness-based selection mecha
89                                              Cell competition (CC), often referred to as 'survival of
90 the presence of more competent neighbors via cell competition (CC).
91                                    In Minute cell competition, cells with a heterozygous mutation in
92                                       During cell competition, cells with lower translation rates or
93 indings demonstrate that spatial context and cell competition cooperate to determine the fate of a mu
94 d at modifying the strength and direction of cell competition could induce cancer cell killing and fo
95 iferate under a biological challenge such as cell competition, drug treatment or viral infection.
96         Two new studies highlight a role for cell competition during adulthood as a surveillance mech
97                   Most mutations that rescue cell competition elevated Dpp-signaling activity, and th
98  of embryonic differentiation in mice, where cell competition eliminates 35% of embryonic cells.
99                          During development, cell competition enables healthy cells to eliminate less
100 omenon, which have shed light on how and why cell competition exists in developing and adult organism
101 inated PROCR-expressing endothelial cells in cell competition experiments.
102 ess does not involve Myc, a well-established cell competition factor.
103 ency of TR-->FO selection by increasing TR B cell competition for follicular entry in NOD mice.
104 te the role of the CD21/CD35 coreceptor in B cell competition for follicular retention and survival w
105 al hematopoietic progenitors is regulated by cell competition for limited amounts of mSCF.
106 ells, resulting in somatic chimeras and stem cell competitions for gonadal niches.
107 diation-induced genome damage often required cell competition genes.
108   Our findings demonstrate that inter-tissue cell competition, governed by a Snail/Yap rheostat, orch
109                                     Although cell competition has been proposed as a selection mechan
110                                              Cell competition has been proposed as a surveillance mec
111                                         Stem cell competition has emerged as a mechanism for selectin
112                                     To date, cell competition has generally been characterised at the
113                                              Cell competition has led to the discovery of multiple pa
114                                     However, cell competition has not been studied in an interspecies
115            This process, referred to as cell-cell competition, has been described previously in Droso
116                                         Stem cell competitions have allowed the emergence of competit
117 However, the quality of PSCs, and donor-host cell competition in chimeras often present strong barrie
118                                   Studies of cell competition in Drosophila have identified an active
119 erved functional role of EphA2 in Ras-driven cell competition in epithelial tissues and suggests that
120 d by winners to maintain their status during cell competition in malignant tumors to overtake healthy
121  further dissect how metabolic states affect cell competition in normal physiology and in tumorigenes
122 we review the regulation, roles and risks of cell competition in organism development, ageing and dis
123 uggest two reasons for the incompleteness of cell competition in ph mutant cells: 1) These cells are
124 cell interactions govern differentiation and cell competition in pluripotent cells during early devel
125 l transplant patients allowed us to assess T cell competition in response to cytomegalovirus (CMV) re
126  results have implications for understanding cell competition in response to stresses involved in ste
127       We then consider somatic evolution and cell competition in stem-cell compartments and their bou
128           However, assessing the effect of T cell competition in the context of a human infection req
129 teractions that recapitulate many aspects of cell competition in the developing wing.
130  the establishment of naive pluripotency and cell competition in the epiblast.
131 impact of genetic variants that promote stem cell competition in the hematopoietic system.
132 We further discuss the clinical relevance of cell competition in the physiological processes of tissu
133 pressors, and novel cell death components in cell competition, in addition to the Dpp pathway implica
134 ll-cell communication pathway that regulates cell competition, in which fit cells eliminate less fit
135 ther for contribution to the adult, and stem cell competition, in which germline or somatic stem cell
136 ies have revealed that mechanisms underlying cell competition include the molecular recognition of 'd
137 iterature regarding the current landscape of cell competition, including classical pathways and model
138                                              Cell competition involves a conserved fitness-sensing pr
139                                              Cell competition is a cell fitness-sensing mechanism con
140                                              Cell competition is a conserved fitness quality control
141                                              Cell competition is a conserved mechanism that regulates
142                                              Cell competition is a fitness quality-control mechanism
143                                              Cell competition is a form of cell interaction that caus
144                                              Cell competition is a homeostatic mechanism that regulat
145                                              Cell competition is a homeostatic process that eliminate
146                                         Host cell competition is a major barrier to engraftment after
147                           Here, we show that cell competition is a mechanism regulating the fitness o
148  and antigen affinities impact interclonal B cell competition is a particularly relevant issue for ca
149                                              Cell competition is a quality control mechanism that eli
150                       Our findings show that cell competition is a selective force that optimizes ver
151                                              Cell competition is an emerging principle that eliminate
152                                              Cell competition is an evolutionarily conserved quality
153  contains adenoma expansion, indicating that cell competition is essential for tumor growth.
154                          We demonstrate that cell competition is executed via induction of the proapo
155       We demonstrate that the role of Fmi in cell competition is independent of PCP, and that it uses
156 ed and can be constrained by host tissues if cell competition is inhibited, suggesting novel possible
157                                              Cell competition is intricately linked to cell death and
158                  An important implication of cell competition is that cellular fitness is not only a
159                                              Cell competition is the short-range elimination of slow-
160               During growth and homeostasis, cell competition is thought to serve a quality control f
161                      The mechanism of this T cell competition is unclear, but may include competition
162             Although quality control through cell competition is well studied in epithelial tissues,
163                                              Cell competition is, therefore, a process that allows re
164                      This phenomenon, called cell competition, is an important mechanism for maintain
165 ogues have on proliferation serve to promote cell competition, leading to apoptosis in clones with a
166  the innermost zone induced Xrp1-independent cell competition-like death in the adjacent zones, revea
167                              Indeed, through cell competition many mutant cells are eliminated from t
168                           In some instances, cell competition may help host tissues to defend against
169 ess and Nrf2 are linked to several diseases, cell competition may occur in a number of pathological c
170 ells, indicating that within the same tissue cell competition may operate in opposite directions.
171      Here we discuss the mechanisms by which cell competition measures and communicates cell fitness
172 ranscriptomics and genetics, we identify two cell competition mechanisms that sequentially shape and
173 owever, 'super-fit' cancer cells can exploit cell competition mechanisms to expand and spread.
174                              We suggest that cell competition might occur during tumor development in
175                       Here, we use in vivo B cell competition models and intravital imaging to examin
176                       To model DC-specific T cell competition, normal mice were injected with one or
177                                   In rewired cells, competition occurred slowly and sometimes failed
178                Here, we show that endogenous cell competition occurs and intrinsically correlates wit
179 re we report that the NMDA receptor controls cell competition of epithelial cells and Myc supercompet
180 sphorylation was itself sufficient to enable cell competition of otherwise wild type cells, but throu
181 ts downstream mutant phenotypes and reverses cell-competition outcomes of both mutant models.
182 erface with mutant cells and drive different cell-competition outcomes.
183 ng donor allogeneic hematopoietic progenitor cell competition over limited numbers of host progenitor
184  X-linked competition in analogy to existing cell competition paradigms.
185 biquitous presence, the mechanisms governing cell competition, particularly those common to developme
186  excisions were eliminated by the RpS12-Xrp1 cell competition pathway if they differed from neighbori
187                          These insights into cell competition pave the way for the study of evolution
188                                   However, T cell competition played only a minor role in limiting T
189  We will do this by reviewing the roles that cell competition plays in the early mammalian embryo and
190 of bacteria and compounds before addition to cells (competition); pre-incubation of the cells with co
191              Tumour suppressor-mediated stem cell competition presented here could be a mechanism of
192       Lateral inhibition, a symmetrical cell-cell competition process, corresponds better to Waddingt
193          Our data support a model in which B cell competition-rather than an intrinsic requirement fo
194  but how environmental factors affect cancer cell competition remains largely unknown.
195                       This process, known as cell competition, represents one example of a diverse gr
196                               The process of cell competition results in the 'elimination of cells th
197                                       During cell competition, sporadic cell death occurs predictably
198  illuminate how a tissue dynamically adjusts cell competition strategies to preserve fitness as its a
199 this has not been observed in other cases of cell competition, suggesting that tissues recognize and
200                                For instance, cell competition surveys the fitness of cells within epi
201                                         This cell competition switch is physiologically relevant: whe
202 way functions in proliferation, survival and cell competition that are conserved between Drosophila a
203 limit of its present growth potential due to cell competition that either results in total birth rate
204 ur data suggest a new model of mahj-mediated cell competition that is independent of apical-basal pol
205 termines synapse density by mediating a cell-cell competition that requires ephrin-B-EphB signaling.
206                                              Cell competition, the elimination of cells surrounded by
207                                              Cell competition-the sensing and elimination of less fit
208 igenic role in purging early tumours through cell competition, thereby preserving tissue integrity.
209                Under conditions of limited B cell competition, these B cells generated de novo antige
210 eportedly mediate fitness comparisons during cell competition through extracellular display of their
211 ifferentiation and lead to clonal expansion, cell competition, tissue colonization and tumour develop
212   Here, we discuss the possible relevance of cell competition to cancer.
213                                Interclonal B cell competition to complex antigens, particularly in ge
214  tissues actively employ a phenomenon called cell competition to drive the elimination and replacemen
215  that YAP and TAZ act through a mechanism of cell competition to eliminate tumor cells.
216 may be selected for their ability to exploit cell competition to kill neighbouring host cells, thereb
217            Malignant cells also benefit from cell competition to promote their expansion.
218     Animals have evolved mechanisms, such as cell competition, to remove dangerous or nonfunctional c
219                                        Thus, cell competition, triggered by differences in Rp gene do
220 ndent requirement for TERT in enhancing stem cell competition, uncover a genetic connection between T
221 we report that this quality control process, cell competition, uses specific components of the evolut
222 land culture system designed to isolate cell-cell competition, we find that eB3 determines winning an
223 , we found that nonmutant cells also undergo cell competition when surrounded by ph-deficient cells,
224    Here we report an orthogonal mechanism of cell competition, whereby cells compete through mechanic
225 mpetition between cells occur in Drosophila: cell competition, whereby somatic cells within a growing
226     Epithelial cells have an ability termed 'cell competition', which is an immune surveillance-like
227                               In particular, cell competition, which is a process in which viable cel
228 ess and Myc are major parallel regulators of cell competition, which may converge on signals that non
229                           The phenomenon of "cell competition," which manifests in apoptosis of slowe
230 al reproductive strategies, totipotency, and cell competition-while developmental biology must incorp
231  (Rp) gene mutations are also eliminated, by cell competition with normal cells.
232 d to a clonal expansion that induced lateral cell competition without dermal invasion and tumour form

 
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