ライフサイエンスコーパス: cell cycle checkpoint

1 genetic alterations that deregulate the G1/S cell cycle checkpoint.

2 on, rather than an indirect consequence of a cell cycle checkpoint.

3 tial mediator of the DNA damage response and cell cycle checkpoint.

4 step in the initiation and amplification of cell cycle checkpoint.

5 at PGCs prior to sex determination lack a G1 cell cycle checkpoint.

6 specific mitotic arrest mediated by the Mad2 cell cycle checkpoint.

7 Rad3 related) and CHK1 kinases to induce the cell cycle checkpoint.

8 escribed as important regulators of the G2-M cell cycle checkpoint.

9 grade signals to specifically enforce a G1-S cell cycle checkpoint.

10 Gln checkpoint and before the mTOR-mediated cell cycle checkpoint.

11 bition of ATR or CHK1, but also defects G2-M cell cycle checkpoint.

12 system ensures mitotic entry independent of cell cycle checkpoint.

13 n of cellular DNA damage and activation of a cell cycle checkpoint.

14 caspase-8 to override the p53-dependent G2/M cell-cycle checkpoint.

15 in sensing general DNA damage and mediating cell-cycle checkpoint.

16 cer cells to override the p53-dependent G2/M cell-cycle checkpoint.

17 f cyclin-dependent kinases 2 and 4/6 at G1/S cell-cycle checkpoint.

18 s normally triggers a precise precytokinesis cell-cycle checkpoint.

19 oprotein from HPV degrades p53 and abrogates cell cycle checkpoints.

20 enome integrity by regulating DNA repair and cell cycle checkpoints.

21 Human cells contain G1 and G2 cell cycle checkpoints.

22 cute homology-directed DNA damage repair and cell cycle checkpoints.

23 rades the tumor suppressor p53 and abrogates cell cycle checkpoints.

24 ontrol of DNA damage repair and signaling to cell cycle checkpoints.

25 g in ATM/Chk2 inactivation and abrogation of cell cycle checkpoints.

26 t timer to trigger the MBT and activation of cell cycle checkpoints.

27 DDR) activates downstream pathways including cell cycle checkpoints.

28 ns, including DNA breaks, and can compromise cell cycle checkpoints.

29 M/Chk2 and ATR/Chk1 pathways and appropriate cell cycle checkpoints.

30 ive proteins and reverses DNA damage-induced cell cycle checkpoints.

31 critical residues of EBNA3C in bypassing the cell cycle checkpoints.

32 n the initiation of both DNA replication and cell cycle checkpoints.

33 cluding the initiation of DNA damage-induced cell cycle checkpoints.

34 tered cell cycle dynamics and the failure of cell cycle checkpoints.

35 ng is known about how T. brucei controls its cell cycle checkpoints.

36 351 activates CHK1 as well as the S and G2/M cell cycle checkpoints.

37 Biologically, these conditions correspond to cell cycle checkpoints.

38 n actionable dependence on ATR/CHK1-mediated cell cycle checkpoints.

39 pigenetic silencing of CDKN1A and release of cell cycle checkpoints.

40 ously described, but also regulates multiple cell cycle checkpoints.

41 ontrols progression of mitosis by activating cell cycle checkpoints.

42 mosome instability in cancer cells that lack cell cycle checkpoints.

43 nous cell divisions without growth phases or cell cycle checkpoints.

44 lar oncogenes need to circumvent DDR-induced cell-cycle checkpoints.

45 protein involved in DNA repair pathways and cell-cycle checkpoints.

46 response to DNA damage and is essential for cell-cycle checkpoints.

47 nment, as well as an amplification of G(1)/S cell-cycle checkpoints.

48 tors that normally coordinate DNA repair and cell-cycle checkpoints.

49 ponse and, in particular, intra-S and G(2)/M cell-cycle checkpoints.

50 s illegitimate joining of DSBs and activates cell-cycle checkpoints.

51 pt and irreversible nature of three specific cell-cycle checkpoints.

52 y M. oryzae requires two independent S-phase cell-cycle checkpoints.

53 ncluding the onset of bulk transcription and cell-cycle checkpoints.

54 nonical regulatory mechanisms that establish cell-cycle checkpoints.

55 iminating pre-cancerous cells with disrupted cell cycle checkpoints(1).

56 These include altered cell cycle checkpoints, aberrations of the centrosome, a

57 tify strong synergistic interactions between cell-cycle checkpoint-abrogating Chk1- and MK2 inhibitor

58 The mitotic checkpoint is the major cell cycle checkpoint acting during mitosis to prevent a

59 Activation of ATM/ATR triggers cell cycle checkpoint activation and adaptive responses

60 horylation, induced PARP cleavage, abrogated cell cycle checkpoint activation and attenuated the form

61 Hus1-Rad1 complex is known to participate in cell cycle checkpoint activation and DNA repair.

62 Arrest results from cell cycle checkpoint activation due to persistent signa

63 ults demonstrate that targeted inhibition of cell cycle checkpoint activation following ionizing radi

64 l an important role for RECQ1 in controlling cell cycle checkpoint activation in response to gemcitab

65 umerous substrates important for DNA repair, cell cycle checkpoint activation, and apoptosis.

66 rivaled by marked activation of DNA damage, cell cycle checkpoint activation, and mitotic catastroph

67 tranded DNA and may determine telomere size, cell cycle checkpoint activation, and, ultimately, tempe

68 on of Mcm10 leads to chromosome breakage and cell cycle checkpoint activation.

69 during DNA damage response and ATM-dependent cell cycle checkpoint activation.

70 rous substrates implicated in DNA repair and cell cycle checkpoint activation.

71 homologous recombination and damage-induced cell cycle checkpoint activation.

72 trol ultimately causes extensive DNA damage, cell-cycle checkpoint activation and cell death whereas

73 Consequently, GSCs exhibit rapid G2-M cell-cycle checkpoint activation and enhanced DNA repair

74 WAC-dependent transcription is important for cell-cycle checkpoint activation in response to genotoxi

75 of signaling cascades, chromatin remodeling, cell-cycle checkpoint activation, and repair of the DSB.

76 ular functions, including DNA damage repair, cell-cycle checkpoint activation, gene transcriptional r

77 The 9-1-1 complex facilitates cell cycle checkpoint activity and coordinates this acti

78 reduces IR-induced apoptosis by influencing cell-cycle checkpoint activity, potentially allowing for

79 broblasts demonstrated a defective G(0)/G(1) cell cycle checkpoint after gamma-irradiation.

80 nonhomologous end-joining and regulation of cell-cycle checkpoints after DNA damage.

81 , supernumerary centrosomes, and compromised cell-cycle checkpoints, allowing accumulation of chromos

82 ted tissue, and through deactivation of G2/M cell-cycle checkpoint allows the cell-cycle progression

83 It partially abolished the G2 cell cycle checkpoint and caused DNA replication stress

84 AKT, activation of the p53 tumor suppressor cell cycle checkpoint and cell death.

85 ologous recombination DNA repair and Chk1 in cell cycle checkpoint and DNA repair, creating opportuni

86 E7 abrogates the G1 cell cycle checkpoint and induces genomic instability, b

87 g that ATM mediates the effect of miR-421 on cell cycle checkpoint and radiosensitivity.

88 These events are required for cell cycle checkpoint and repair responses to ionizing r

89 ry syndrome that implicates dysregulation of cell cycle checkpoint and T cell signaling.

90 of the conventional DNA damage-induced G2/M cell cycle checkpoint and the spindle assembly checkpoin

91 d enrichment of DNA replication, cell cycle, cell cycle checkpoint and TNF pathways in selinexor trea

92 BRCA1 E3 ligase activity regulates the G2/M cell cycle checkpoint and, thus, contributes to maintena

93 BRCA1 E3 ligase activity regulates the G2/M cell cycle checkpoint and, thus, contributes to maintena

94 The mammalian MMR proteins also activate cell cycle checkpoints and apoptosis in response to pers

95 d in the regulation of the G(1)-S and G(2)-M cell cycle checkpoints and death receptor/apoptosis sign

96 /2-bound genes involved in the regulation of cell cycle checkpoints and DNA damage response.

97 karyotic genomic integrity is safeguarded by cell cycle checkpoints and DNA repair pathways, collecti

98 hat sense stalled replication forks activate cell cycle checkpoints and DNA repair processes, which m

99 RAD9 participates in DNA damage-induced cell cycle checkpoints and DNA repair.

100 osphorylate downstream targets important for cell cycle checkpoints and DNA repair.

101 This response includes activation of cell cycle checkpoints and engagement of pathways that r

102 pathway that regulates cell cycle arrest at cell cycle checkpoints and facilitates the repair of dsD

103 1 (Chk1) is an essential kinase required for cell cycle checkpoints and for coordination of DNA synth

104 polyomaviruses in primary cells with intact cell cycle checkpoints and how the activation might be l

105 CML progenitors demonstrated active cell cycle checkpoints and increased nonhomologous end j

106 1 kinase inhibitor AZD1775 (WEE1i) overrides cell cycle checkpoints and is being studied in HNSCC reg

107 le regulators, bypasses the need for S-phase cell cycle checkpoints and predisposes to genomic instab

108 intenance of genomic integrity by activating cell cycle checkpoints and promoting repair of DNA doubl

109 ibition of CHK1 abrogates DNA damage-induced cell cycle checkpoints and sensitizes p53 deficient canc

110 hibitor Pif1 resulted in the inactivation of cell cycle checkpoints and the subsequent rescue of temp

111 responses to DNA damage caused by defective cell cycle checkpoints and/or DNA repair.

112 ioresistance and that combined inhibition of cell-cycle checkpoint and DNA repair targets provides th

113 ivities results in inefficient p53-dependent cell-cycle checkpoint and exit responses.

114 bed as a tumor suppressor with proapoptotic, cell-cycle checkpoint and mitotic functions.

115 tivation of signal transducers that regulate cell-cycle checkpoints and cell survival.

116 ptional programs known primarily to regulate cell-cycle checkpoints and cell survival.

117 ine protein kinase, is centrally involved in cell-cycle checkpoints and cellular response to DNA dama

118 multiple pathways, including DDR signaling, cell-cycle checkpoints and damage repair, ESC differenti

119 ATM activates multiple cell-cycle checkpoints and DNA repair after DNA damage,

120 Cell-cycle checkpoints and DNA repair processes protect

121 concepts emerged around kinases involved in cell-cycle checkpoints and DNA-damage repair.

122 eregulated cell-cycle progression, bypass of cell-cycle checkpoints and genome instability.

123 ATR is a key regulator of cell-cycle checkpoints and homologous recombination (HR)

124 rolling cell proliferation processes such as cell-cycle checkpoints and inducing apoptosis.

125 at orchestrate chromatin structural changes, cell-cycle checkpoints and multiple enzymatic activities

126 suppression at the cross-roads of apoptosis, cell cycle checkpoint, and NF-kappaB pathways.

127 age, propagate injury DNA messages, regulate cell cycle checkpoints, and alter the microenvironment.

128 signaling kinase that regulates DNA repair, cell cycle checkpoints, and apoptosis.

129 relevant pathways including stress response, cell cycle checkpoints, and cell migration/adhesion.

130 of genes involved in the apoptotic response, cell cycle checkpoints, and cellular metabolism.

131 d cellular gene expression, activates G(2)-M cell cycle checkpoints, and is essential for viral sprea

132 s, cellular signaling, nuclear architecture, cell cycle checkpoints, and other cellular activities co

133 n origin firing, replication-fork stability, cell-cycle checkpoints, and DNA repair.

134 excision repair (NER) and the ATR-dependent cell cycle checkpoint are the major pathways responsible

135 p53-dependent G(1) and G(2) cell cycle checkpoints are activated in response DNA dam

136 , is crisis, the state that cells reach when cell cycle checkpoints are impaired and cells can no lon

137 Cell cycle checkpoints are implemented to safeguard the

138 In p53-mutant tumors, cell cycle checkpoints are rewired, leading to dependenc

139 Cell-cycle checkpoints are essential for maintaining gen

140 ismatch repair (MMR) triggers prolonged G(2) cell cycle checkpoint arrest after alkylation damage fro

141 nal DNA mismatch repair (MMR) stimulate G(2) cell cycle checkpoint arrest and apoptosis in response t

142 omplexes of protein interactions that govern cell cycle checkpoint arrest and repair of the DNA lesio

143 However, recovery from cell cycle checkpoint arrest when the DSB is repaired by

144 they are highly reliant on the Chk1-mediated cell cycle checkpoint arrest, indicating that HR repair

145 has on DDR proteins and signals that enforce cell cycle checkpoint arrest.

146 cle progression, focusing on the G1 and G2/M cell cycle checkpoints, as well as on related essential

147 igger a characteristic 'VSG synthesis block' cell-cycle checkpoint, as some cells reinitiated S phase

148 es typically lead to progression through the cell-cycle checkpoints, as well as increased cell migrat

149 ion mutants, the latter of which affects the cell cycle checkpoint ATAXIA TELANGIECTASIA-MUTATED AND

150 her than erasing their signalling history at cell-cycle checkpoints before mitosis, mother cells tran

151 To explore this idea, cell cycle checkpoints, biological clocks, and signaling

152 ability of ATR inhibition to abrogate the G2 cell cycle checkpoint both contributed to the synergisti

153 dl922-947 can override multiple cell cycle checkpoints but induces cell death by a non-a

154 s, replication inhibitors did not activate a cell cycle checkpoint, but they did activate a process t

155 s predominantly engaged in the regulation of cell cycle checkpoints by p21Cip1 and does not trigger a

156 The inactivation of critical cell cycle checkpoints by the human papillomavirus (HPV)

157 LMP2A affected apoptosis and cell-cycle checkpoints by dysregulating the expression o

158 ic expression of miR-421 resulted in S-phase cell cycle checkpoint changes and an increased sensitivi

159 2IP-deficient cells enforced a robust G(2)-M cell cycle checkpoint compared with control cells.

160 The Rad9-Rad1-Hus1 (9-1-1) cell cycle checkpoint complex plays a key role in the DN

161 f transcription, cell cycle lengthening, and cell cycle checkpoints comprise the midblastula transiti

162 ified over two decades ago and linked to the cell cycle checkpoint concept proposed by Weinert and Ha

163 r to MRL mice, providing a firm link between cell cycle checkpoint control and tissue regeneration.

164 f MK2 in inflammation, Hsp27 regulation, and cell cycle checkpoint control with a focus on brain path

165 le cellular functions such as DNA repair and cell cycle checkpoint control.

166 ology-directed DNA repair responses but also cell cycle checkpoint control.

167 he DNA damage response comprises DNA repair, cell-cycle checkpoint control, and DNA damage-induced ap

168 es BCL6-mediated repression of p53 and other cell cycle checkpoint-control genes.

169 s of p53 function is well known to influence cell cycle checkpoint controls and apoptosis.

170 and conveys that information to the parasite cell cycle checkpoint controls.

171 n of ATM function resulted in characteristic cell cycle checkpoint defects.

172 copy BRCA1 loss in centrosome amplification, cell-cycle checkpoint defects, DNA damage and genomic in

173 but not all, of the proteins contributing to cell cycle checkpoint deficiencies in RA T cells, via a

174 nation of multiple cellular events including cell cycle checkpoint, DNA repair, transcription, and ap

175 ys that maintain genomic stability including cell cycle checkpoints, DNA repair, protein ubiquitinati

176 with increased genetic load, which included cell-cycle checkpoints, DNA damage and apoptosis.

177 The DNA damage response triggers cell-cycle checkpoints, DNA repair and apoptosis using m

178 ing to apoptotic resistance and induction of cell cycle checkpoint/DNA repair.

179 YC2 in controlling a G1-to-S light-dependent cell cycle checkpoint, dsCYC2 silencing decreases the ra

180 rapeutic strategies include targeting of the cell cycle checkpoints, e.g., ATR and CHK1.

181 hibits alterations in DNA repair enzymes and cell-cycle checkpoints, elucidation of factors enabling

182 Cell cycle checkpoints ensure genome integrity and are f

183 Cell cycle checkpoints ensure that proliferation occurs

184 ant, als3-1, resulted in identification of a cell cycle checkpoint factor, ALUMINUM TOLERANT2 (ALT2),

185 CKOalpha mice displayed keratinocyte cell cycle checkpoint failure in vivo in response to UVB

186 was integral to signaling that regulated the cell cycle checkpoint, focal adhesion, and actin remodel

187 rexpress oncogenes that specifically perturb cell-cycle checkpoints (for example, E7 from human papil

188 ATR-deficient CGNPs had impaired cell cycle checkpoint function and continued to prolifer

189 Thus, we hypothesize that ATM performs a cell cycle checkpoint function to protect post-mitotic n

190 ir that is mechanistically distinct from its cell cycle checkpoint function.

191 NA repair, tumor suppression, apoptosis, and cell cycle checkpoint function.

192 molecular level, NONO bound to the p16-Ink4A cell cycle checkpoint gene and potentiated its circadian

193 s from this mouse pointed to the role of the cell cycle checkpoint gene CDKN1a, or p21(cip1/waf1).

194 Mutations in grp, a cell cycle checkpoint gene, and puc, a negative regulato

195 ilar to the loss-of-function mutants for the cell cycle checkpoint genes ATAXIA TELANGIECTASIA AND RA

196 y response genes, and abnormal expression of cell cycle checkpoint genes.

197 provides additional insight into the role of cell-cycle checkpoint genes in neurodevelopmental disord

198 free survival and resistance to knockdown of cell-cycle checkpoint genes in triple-negative/basal-lik

199 ive signals, based in part on derangement of cell cycle checkpoints governed by cilia and centrosomes

200 gene and protein expression that reestablish cell cycle checkpoints, halt protein translation, and pr

201 e 1 (CHK1)-mediated S-phase and G(2)-M-phase cell-cycle checkpoints has been a promising therapeutic

202 Overriding cell cycle checkpoint in combination with the inhibition

203 the apical protein kinase that initiates the cell cycle checkpoint in response to DNA damage and repl

204 ortholog of human ATM kinase and initiates a cell cycle checkpoint in response to dsDNA breaks (DSBs)

205 e part of a signaling cascade that induces a cell cycle checkpoint in response to ROS-induced DNA dam

206 echanism for co-targeting DNA damage-induced cell cycle checkpoints in combination with repair of cis

207 d Skp2 expression may overcome p53-dependent cell cycle checkpoints in melanoma cells and highlight S

208 tive in appropriate downstream signaling and cell cycle checkpoints in response to DNA damage.

209 in phosphatase 2C (PP2C) family and controls cell cycle checkpoints in response to DNA damage.

210 on of G arrest by p18 bypasses a homeostatic cell-cycle checkpoint in iPCs for PC differentiation.

211 s, mechanisms that attenuate DDR and disrupt cell-cycle checkpoints in sporadic cancers are not well

212 ion of HPV1 E4 in cells is known to activate cell cycle checkpoints, inhibiting G(2)-to-M transition

213 rrest, which is cytotoxic when combined with cell-cycle checkpoint inhibition and constitutes a novel

214 increased micronuclei formation utilizing a cell cycle checkpoint inhibitor to drive cell cycle prog

215 trial, by itself and in combination with the cell-cycle checkpoint inhibitor AZD7762.

216 our findings show a rationale for combining cell-cycle checkpoint inhibitors with the novel non-CPT

217 ive regulator of p53 stability when the G(1) cell cycle checkpoint is activated and provides an expla

218 When bacteria encounter DNA damage, a cell cycle checkpoint is activated by expressing a cell

219 ponse to UV irradiation, suggesting that the cell cycle checkpoint is intact in these cells.

220 The G(2)/M cell cycle checkpoint is regulated by a multitude of sig

221 Understanding the regulatory principles of cell cycle checkpoints is important because loss of chec

222 cytotoxicity when depleted, with loss of the cell cycle checkpoint kinase 1 (CHK1/CHEK1) being the mo

223 ough ataxia-telangiectasia mutated (ATM) and cell cycle checkpoint kinase 2 (CHK2), a DNA damage resp

224 enes identified 23 candidates, including the cell cycle checkpoint kinase ATM.

225 Particularly CHEK1, which encodes for the cell cycle checkpoint kinase CHK1, is significantly over

226 trate that phosphorylation at Thr-288 by the cell cycle checkpoint kinase CHK2 is involved in this pr

227 P-1, Ser-473, which is phosphorylated by the cell cycle checkpoint kinase Chk2.

228 CRAF pS338 recruits CHK2, a cell cycle checkpoint kinase involved in DNA repair, and

229 hetic lethal relationship exists between the cell cycle checkpoint kinase MK2 and the tumor suppresso

230 The Wee1 cell cycle checkpoint kinase prevents premature mitotic

231 small-molecule inhibitors targeting the G2/M cell cycle checkpoint kinase, CHK1, in a variety of non-

232 ed DNA, and the ATR targets RPA2 and Chk1, a cell cycle checkpoint kinase, were not phosphorylated.

233 eting ataxia-telangiectasia and Rad3-related/cell-cycle checkpoint kinase 1 (CHK1)-mediated S-phase a

234 ficacy evoked by targeting the overexpressed cell-cycle checkpoint kinase CHK1 in SCLC.

235 Combining cell-cycle checkpoint kinase inhibitors with the DNA-dam

236 ayor players in the DNA damage response: the cell cycle checkpoint kinases ATR and ATM.

237 een GLUT1-mediated glucose transport and the cell-cycle checkpoint kinases ATR and CHK1.

238 matin alterations recruit the DNA repair and cell cycle checkpoint machinery to restore genome integr

239 of PKCdelta in the DNA damage-induced G(2)/M cell cycle checkpoint may be a critical component of its

240 These results suggest that a p53-dependent cell cycle checkpoint monitors changes of cellular NS le

241 atory cytokine mRNA decay, AUF1 destabilizes cell-cycle checkpoint mRNAs, preventing cellular senesce

242 ordinate cell-signaling pathways involved in cell-cycle checkpoints, nuclear localization, gene trans

243 umerous tumor cell lines by inducing the ATM cell cycle checkpoint pathway.

244 which show an induction of the p53-dependent cell cycle checkpoint pathway.

245 ed response including several DNA repair and cell cycle checkpoint pathways is activated to ensure fa

246 damage response, including highly conserved cell cycle checkpoint pathways that prevent cells with D

247 tenance mechanisms, involving DNA repair and cell-cycle checkpoint pathways, initiate genetic instabi

248 ation and coordinates diverse DNA repair and cell-cycle checkpoint pathways.

249 ar homeostasis in addition to DNA repair and cell-cycle checkpoint pathways.

250 is heterogeneity may reflect a relaxation of cell cycle checkpoints, possibly increasing the ability

251 implicate a novel mechanism by which loss of cell cycle checkpoints promotes BRCA1-associated tumorig

252 In addition, deletion of Ku80 along with the cell cycle checkpoint protein, p53, dramatically increas

253 stabilizes quadruplex mRNA that encodes the cell-cycle checkpoint protein kinase Aurora A to a great

254 ntified CDK2-interacting protein (CINP) as a cell-cycle checkpoint protein.

255 vealed that pathways involved in cell cycle, cell cycle checkpoints, protein-ubiquitination, and apop

256 nd BRCT domain of the tandem BRCT repeats of cell cycle checkpoint proteins MDC1 (mediator of DNA dam

257 Because cell cycle checkpoint proteins stabilize the genome, the

258 gamma-H2AX stabilizes cell-cycle checkpoint proteins and DNA repair factors at

259 ermore, SpHst4 interacts with SpMyh1 and the cell cycle checkpoint Rad9-Rad1-Hus1 (9-1-1) complex.

260 esults in relaxed chromatin structure, rapid cell-cycle checkpoint recovery and enhanced survival aft

261 Inhibition of ATM had dual effects on cell-cycle checkpoint regulation and DNA repair that wer

262 The WEE1 kinase is an essential cell cycle checkpoint regulator in Arabidopsis thaliana

263 CHEK2 is a cell cycle checkpoint regulator, and the CHEK2*1100delC

264 f numerous proteins, including helicases and cell cycle checkpoint regulators.

265 Moreover, RAs control the expression of cell-cycle checkpoint regulators such as p27(Kip1), p57(

266 Activation of a cell cycle checkpoint response was evidenced by autophos

267 acts with CHK1, a key effector kinase in the cell cycle checkpoint response, and regulates its phosph

268 ting of CycG2 attenuates doxorubicin-induced cell cycle checkpoint responses in multiple cell lines.

269 chromosome stability and in the induction of cell cycle checkpoint responses.

270 A damage and a failure to efficiently invoke cell-cycle checkpoint responses.

271 n human cells but also adversely affects the cell cycle checkpoint, resulting in profound chromosomal

272 ed through into mitosis because of defective cell cycle checkpoints, resulting in cell death by mitot

273 ation (IR)-induced DNA damage, activation of cell cycle checkpoints results in cell cycle arrest, all

274 Cell-cycle checkpoints safeguard cells from such catastr

275 DNA damage-induced cell cycle checkpoints serve as surveillance mechanisms

276 generate regions of ssDNA that then trigger cell cycle checkpoint signaling and DSB repair by homolo

277 pon which to build additional aspects of the cell cycle checkpoint signaling network, including those

278 RCT) domains, present in many DNA repair and cell cycle checkpoint signaling proteins, are phosphopro

279 e essential for telomere length maintenance, cell cycle checkpoint signaling, meiotic recombination,

280 Thus targeting DNA replication and G2-M cell cycle checkpoint simultaneously by cisplatin and WE

281 aled that rtel1 mutant plants show activated cell cycle checkpoints, specific sensitivity to DNA cros

282 egulates cellulose production independent of cell cycle checkpoint systems that are controlled by div

283 ain reaction was used to identify changes in cell cycle checkpoint target genes.

284 f miR-221 and miR-222 is tightly linked to a cell cycle checkpoint that ensures cell survival by coor

285 her increase in E2F7, which induces a second cell cycle checkpoint that prevents unconstrained cell d

286 DRP-1-mediated mitotic fission is a cell-cycle checkpoint that can be therapeutically target

287 plays a well-characterized role in the major cell-cycle checkpoint that regulates chromosome segregat

288 oliferation and may also compromise multiple cell-cycle checkpoints that maintain genomic integrity,

289 ich mediates relaxation of the intra-S phase cell-cycle checkpoint; this facilitates viral oncogene-d

290 inase (MK2) and simultaneously controls both cell cycle checkpoints through distinct target mRNAs, bu

291 to simultaneously control the G1/S and G2/M cell cycle checkpoints through transcriptional induction

292 ty of Cre-LoxP conditional disruption of the cell cycle checkpoint tumor-suppressor genes Trp53 and R

293 threshold of YneA required to establish the cell cycle checkpoint, uncovering a new regulatory step

294 We showed here that E7 abrogated the G1 cell cycle checkpoint under hypoxia and analyzed key cel

295 Abrogation of these cell-cycle checkpoints using Chk1 inhibitors results in

296 ure of MYH activity is its coordination with cell cycle checkpoint via interaction with the Rad9-Rad1

297 s, where it functions in repair and triggers cell-cycle checkpoints via activation of the ataxia-tela

298 53 (via inhibition of MDM2) or impairment of cell cycle checkpoints (via inhibition of CHK1/2 or WEE1

299 lung cancer cells displayed a defective G1/S cell cycle checkpoint, were unable to resolve DNA damage

300 Cyclin-dependent kinases (CDKs) coordinate cell cycle checkpoints with DNA repair mechanisms that t