ライフサイエンスコーパス: cell cycle machinery

1 se mechanism between mitogen stimulation and cell cycle machinery.

2 vents depend on local regulators that impact cell cycle machinery.

3 vide a link between estrogen, c-Myc, and the cell cycle machinery.

4 proteins that can modulate components of the cell cycle machinery.

5 e promoted without activation of the mitotic cell cycle machinery.

6 not yet clear how these signals contact the cell cycle machinery.

7 mal receptor signaling events to more distal cell cycle machinery.

8 ne and growth factor receptors to downstream cell cycle machinery.

9 links between cell environment and the core cell cycle machinery.

10 , genetically controlled, and independent of cell cycle machinery.

11 s D1, D2, and D3) are components of the core cell cycle machinery.

12 neling of specific signaling pathways to the cell cycle machinery.

13 wth by regulating specific components of the cell cycle machinery.

14 in integrating the signals from BCR with the cell cycle machinery.

15 k between the ETS family of proteins and the cell cycle machinery.

16 ring mitosis appears to be controlled by the cell cycle machinery.

17 ing networks that ultimately converge on the cell cycle machinery.

18 es very well with a number of changes in the cell cycle machinery.

19 between cytosolic signal transducers and the cell cycle machinery.

20 on of growth control pathways with the basic cell cycle machinery.

21 control, we examined various aspects of the cell cycle machinery.

22 ecular mechanism(s) of PF4 interference with cell cycle machinery.

23 ween cell surface signaling cascades and the cell cycle machinery.

24 a profound effect on several aspects of the cell cycle machinery.

25 ablishing a direct link between Mek1 and the cell cycle machinery.

26 iated in part through modulation of the host cell cycle machinery.

27 iated link between the IL-2 teceptor and the cell cycle machinery.

28 sma membrane with the proteins that form the cell cycle machinery.

29 eton that is itself under the control of the cell cycle machinery.

30 rovide a link between growth factors and the cell cycle machinery.

31 n the Cyclin-Cdk complexes that comprise the cell cycle machinery.

32 the extracellular environment with the core cell cycle machinery.

33 clin E, represent key components of the core cell cycle machinery.

34 the transmission of mitogenic stimuli to the cell cycle machinery.

35 tritional cues with the activity of the core cell cycle machinery.

36 leting and exiting mitosis and resetting the cell cycle machinery.

37 D-cyclins represent components of cell cycle machinery.

38 Cyclin D1 is a component of the core cell cycle machinery.

39 rences between mP-RBs are evident beyond the cell cycle machinery.

40 LP1 facilitates ER signaling cross talk with cell cycle machinery.

41 -mammalian target of rapamycin signaling and cell cycle machinery.

42 rs the neuronal nucleus and re-activates the cell cycle machinery.

43 Many of these genes are components of the cell cycle machinery.

44 sting a new link between cell growth and the cell cycle machinery.

45 cumulation and engagement with the canonical cell cycle machinery.

46 ilize or otherwise deregulate the coresident cell cycle machinery.

47 r and linking extracellular signaling to the cell cycle machinery.

48 ight link developmental controls to the core cell cycle machinery.

49 P2 serves to link Notch1 activation with the cell cycle machinery.

50 es in vitro growth and does not obstruct the cell-cycle machinery.

51 erexpress cyclin D1, a component of the core cell-cycle machinery.

52 use of changes in expression and activity of cell-cycle machinery.

53 causes inappropriate activation of neuronal cell-cycle machinery.

54 , the Chk1 protein couples DNA repair to the cell-cycle machinery.

55 stablish a direct link between HIF-1 and the cell-cycle machinery.

56 onnections between development and the basic cell-cycle machinery.

57 )], PI3K signaling [18.1% (80/442)], and the cell-cycle machinery [10.4% (46/442)].

58 expression and activity of components of the cell cycle machinery after culture in RA.

59 ctly regulate the G2/M component of the host cell cycle machinery, allowing for the release of the ch

60 sistently, pharmacological inhibition of the cell cycle machinery also blocked differentiation in viv

61 point, and linkage of mitogenic signaling to cell cycle machinery, also implicates one of these cell-

62 Whether stem cells have unique cell cycle machineries and how they integrate with niche

63 S phase event and provide a link between the cell cycle machinery and activation of histone gene tran

64 levels of major components of the molecular cell cycle machinery and alter the levels of several tum

65 These observations link the cell cycle machinery and angiogenesis and reveal the pre

66 whereas normal cells maintain an integrated cell cycle machinery and are subject to cell cycle check

67 rowth in part by suppressing elements of the cell cycle machinery and bud-autonomous IAA biosynthesis

68 nk between transcriptional regulation of the cell cycle machinery and cell differentiation.

69 regulated at the initiation step by both the cell cycle machinery and checkpoint pathways.

70 in enhances mESCs self-renewal by regulating cell cycle machinery and core pluripotency transcription

71 ases, integrin, IL8, and reversed changes in cell cycle machinery and cytoskeleton.

72 istinguish between ZM's effects on the basic cell cycle machinery and its effects on checkpoints.

73 Aberrant cell cycle machinery and loss of the CDKN2A tumor suppre

74 ce, the precise molecular interplays between cell cycle machinery and master regulators of cell fate

75 cytoskeletal signaling pathways and the core cell cycle machinery and may represent a general mechani

76 n D1 and HNF4alpha coordinately controls the cell cycle machinery and metabolism in the liver.

77 results show that Ca(2+) modulates both the cell cycle machinery and nuclear maturation during meios

78 titumor agents; effects of FTIs and GGTIs on cell cycle machinery and progression and potential mecha

79 RB serves as a transducer between the cell cycle machinery and promoter-specific transcription

80 rating oncogenic signaling pathways with the cell cycle machinery and promoting optimal cell cycle pr

81 involved in DNA replication, transcription, cell cycle machinery and regulation of its own expressio

82 understanding of HCMV's interaction with the cell cycle machinery and reveal a new cellular pattern o

83 t that ECT2 is an important link between the cell cycle machinery and Rho signaling pathways involved

84 horylation of pRb2/p130 is controlled by the cell cycle machinery and that pRb2/p130 may indeed be an

85 utilizes multiple pathways to signal to the cell cycle machinery and that these pathways synergize t

86 Cdh1 and c-Src in the crosstalk between the cell cycle machinery and the c-Src signaling pathway.

87 The links between the cell cycle machinery and the cytoskeletal proteins contr

88 Expression of components of the cell cycle machinery and the Notch pathway, as well as o

89 Mechanistic changes in regulation of the cell-cycle machinery and Akt-mTOR signaling were consist

90 tients who have driving abnormalities in the cell-cycle machinery and are thus more likely to respond

91 ic and muscarinic receptors may regulate the cell-cycle machinery and consequently the expansion of t

92 Our findings reveal how the cell-cycle machinery and cytokine signaling can be adapt

93 indicate disrupted coordination between the cell-cycle machinery and cytoskeletal function.

94 nsport and demonstrate a direct link between cell-cycle machinery and dynein pathway activity.

95 and D3) are components of the mammalian core cell-cycle machinery and function to drive cell prolifer

96 accompanied by corresponding alterations in cell-cycle machinery and in pathways associated with cel

97 Cyclin D1 is a component of the core cell-cycle machinery and is frequently overexpressed in

98 ental regulators, specific components of the cell-cycle machinery and organ patterning.

99 te decisions are tightly associated with the cell-cycle machinery and reveal insights in the mechanis

100 bject to the regulatory controls of both the cell-cycle machinery and the Ran-signaling pathway.

101 significant reorganization of the canonical cell-cycle machinery and the use of meiosis-specific cel

102 mines cell fate is through regulation of the cell cycle machinery, and as such the cellular consequen

103 then influence differential gene expression, cell cycle machinery, and cytoskeletal organization of G

104 and are regulated by, core components of the cell cycle machinery, and focus our attention on the sol

105 Cyclin E is a component of the core cell cycle machinery, and it drives cell proliferation b

106 Cyclin D1 belongs to the core cell cycle machinery, and it is frequently overexpressed

107 h much evidence suggests that alterations in cell cycle machinery are implicated in the carcinogenic

108 Critical parts of the cell cycle machinery are the cyclin-dependent kinases (C

109 Genes encoding the core cell cycle machinery are transcriptionally regulated by

110 e lacking cyclin D3, a component of the core cell cycle machinery, are refractory to stimulation by t

111 yclosome (APC/C) and other components of the cell cycle machinery as key processes that drive pancrea

112 he cell-cycle arrest validates the bacterial cell-cycle machinery as an effective target for antimicr

113 f the computed molecular predictors with the cell cycle machinery, as well as the identification of h

114 ne the proliferation index and status of the cell cycle machinery at discrete stages of hematopoietic

115 wth regulation by coupling cell shape to the cell-cycle machinery at the level of signal transduction

116 th inhibition accounted for by disruption of cell cycle machinery; (b) is growth inhibition accompani

117 through cyclin D1, while Myc can impact the cell cycle machinery by transcriptionally upregulating c

118 lls, the Neu-Ras pathway is connected to the cell-cycle machinery by cyclin D1, explaining the absolu

119 y couples the nutritional environment to the cell-cycle machinery by regulating the activity of PP2A.

120 ulation of mass) and cell proliferation (the cell cycle machinery) by independent pathways.

121 Components of cell cycle machinery can play a key role in regulating s

122 hat stromal or therapy-induced regulation of cell cycle machinery can regulate both macrophage-mediat

123 ivity can be regulated coordinately with the cell cycle machinery (CDK2 and CDK4) and/or coordinately

124 layers of regulation imposed on core mitotic cell cycle machinery components by the program of germ c

125 Thus, therapies against cell cycle machinery components can not only repress the

126 iments revealed transcriptional increases in cell-cycle machinery components in sis2Delta background.

127 oliferative cells, whether components of the cell cycle machinery contribute to its metabolic action

128 zed, how the subcellular localization of the cell-cycle machinery contributes to timing is not well u

129 The cell cycle machinery controls diverse cellular pathways

130 re components of the DNA damage response and cell cycle machinery cooperate to help enforce IgH and T

131 f an alternative cell death modality and the cell cycle machinery could have a transformative impact

132 pigenetic regulators, tumor suppressors, and cell cycle machinery could provide novel opportunities f

133 These findings reveal that the cell-cycle machinery directly regulates the Ran-signalin

134 ent kinases and other components of the core cell cycle machinery drive cell division.

135 point to KIF14 as a critical node connecting cell cycle machinery, effective ciliogenesis, and HH sig

136 rrent understanding of the regulation of the cell cycle machinery especially as it relates to vascula

137 in ligases target numerous components of the cell cycle machinery for destruction.

138 d evolved mechanisms to manipulate the plant cell cycle machinery for DNA replication, and to optimiz

139 sms that link growth factor signaling to the cell cycle machinery have not been established.

140 ways through which these proteins impact the cell cycle machinery have not been explicitly determined

141 activity is regulated coordinately with the cell cycle machinery in bone cells.

142 y alleviating the negative constraint on the cell cycle machinery in cardiac myocytes.

143 ecently discovered that the nucleoli contain cell cycle machinery in close proximity to nascent ribos

144 entation 1 (HEF1; NEDD9) links PGE(2) to the cell cycle machinery in colorectal cancer cells.

145 coordination between cellular growth and the cell cycle machinery in eukaryotes.

146 ctural integrity of the microtubules and the cell cycle machinery in interphase cells.

147 (D1, D2, and D3) are components of the core cell cycle machinery in mammalian cells.

148 yclins D1, D2, and D3) are key components of cell cycle machinery in mammalian cells.

149 that pre-mRNA splicing may be linked to the cell cycle machinery in mammalian cells.

150 HCMV lytic infection subverts the host cell cycle machinery in multiple ways.

151 Consequently, an ectopic activation of the cell cycle machinery in neurons has emerged as a potenti

152 ngs show that insulin uses components of the cell cycle machinery in post-mitotic cells to control gl

153 odegeneration involves the activation of the cell cycle machinery in postmitotic neurons.

154 w these mitogenic signals are coupled to the cell cycle machinery in primary T cells is not clear.

155 kinase ultimately leads to activation of the cell cycle machinery in response to FGF-2.

156 t that FADD is involved in the regulation of cell cycle machinery in T lymphocytes.

157 We propose that N-myc lies upstream of the cell cycle machinery in the developing mouse retina and

158 Strategies targeting the cell cycle machinery in the heart and vasculature offer

159 To determine the potential roles of the cell cycle machinery in the regulation of the terminal d

160 he way CD28 signaling is coupled to the core cell cycle machinery in these two T cell subsets.

161 stimuli, whereas prevalent disruption of the cell cycle machinery in tumor cells often confers resist

162 We report here that components of the cell cycle machinery in yeast, specifically the cell cyc

163 s targeting components of the DNA repair and cell-cycle machineries in cohorts of paired tumor sample

164 However, the role of cell-cycle machineries in this transition remains unknow

165 f Cks/Suc1, a highly conserved member of the cell-cycle machinery in eukaryotes [1,2].

166 RhoA, conveys the "cell shape signal" to the cell-cycle machinery in human capillary endothelial cell

167 is known about the overall importance of the cell-cycle machinery in maintaining ES cell identity.

168 e Polycomb system of cellular memory and the cell-cycle machinery in mammals.

169 ish a fundamental framework for study of the cell-cycle machinery in Phalaenopsis orchids.

170 We found that miR-34/449 suppresses the cell-cycle machinery in vivo and promotes cell-cycle exi

171 endently regulate multiple components of the cell cycle machinery, including expression of p21(Cip1)

172 cycle regulation in these cells and how the cell cycle machinery influences hESCs properties.

173 phogenesis, the mechanisms through which the cell cycle machinery integrates with differentiation sig

174 Deregulation of the cell cycle machinery is a hallmark of cancer.

175 this study we determined to what extent the cell cycle machinery is altered during epidermal prolife

176 Dysregulation of cell cycle machinery is implicated in a number of neuron

177 How the cell cycle machinery is modified to transform a mitotic

178 l cycle position, how it is regulated by the cell cycle machinery is not known.

179 An essential part of the cell cycle machinery is the cyclin-dependent kinases (CD

180 is [1] [2], but the link between Ras and the cell-cycle machinery is not clear.

181 Abnormal activity of the core cell-cycle machinery is seen in essentially all tumor ty

182 scriptional regulator of some members of the cell cycle machinery, is not induced following sIgM cros

183 the subsequent cell growth response, such as cell cycle machinery, is regulated in cardiac hypertroph

184 combination triggers a dual blockade of the cell cycle machinery, leading to apoptosis, and providin

185 Ca(2+)-dependent negative regulation of the cell cycle machinery (MAPK-MPF cascade) is due to Ca(2+)

186 alysis of common components of apoptotic and cell cycle machinery may provide insight into the coordi

187 Our data demonstrate that a component of the cell cycle machinery mediates TCRbeta protein-signaled f

188 Our findings support a model whereby the cell cycle machinery not only controls cell division but

189 findings demonstrate that IL-4 regulates the cell cycle machinery of astroglial cells via a p27Kip1 b

190 ensures correct segregation by informing the cell cycle machinery of potential errors in the interact

191 These viruses need the cell cycle machinery of the host cell to complete their

192 We also identify a cell-cycle machinery of p21 and CDKN2A as a molecular ba

193 is more insight into the reactivation of the cell cycle machinery, other prerequisites for successful

194 and suggest that additional elements of the cell cycle machinery participate in this mechanism.

195 Because the cell cycle machinery participates in Saccharomyces cerev

196 vity, in part, by multifaceted regulation of cell cycle machinery, possibly via concomitant changes i

197 t of small molecule inhibitors (SMIs) of the cell cycle machinery, proteolysis targeting chimeras (PR

198 ated cyclin D1 and subsequent alterations in cell cycle machinery provides keratinocytes the ability

199 At the level of the cell cycle machinery, RAF and AKT cooperated to induce c

200 ying tumorigenesis, making regulators of the cell cycle machinery rational anticancer therapeutic tar

201 How cell cycle machinery regulates extracellular matrix (ECM

202 and the cell cycle are coupled, and how the cell cycle machinery regulates PAR protein function and

203 and proposes potential therapeutics aimed at cell-cycle machinery-relevant targets.

204 -Myc interacts with the intrinsic cyclin/Cdk cell cycle machinery remain undefined.

205 The model identified known components of the cell-cycle machinery, such as CCND1, CCNE2, and CDC25A,

206 nd cellular targets linking GR activation to cell cycle machinery suggest two distinct regulatory mec

207 s (CDK4 and CDK6) are components of the core cell cycle machinery that drives cell proliferation.

208 way required for activation of the canonical cell cycle machinery that is inhibited by P4.

209 a novel link between the transcriptional and cell cycle machinery that may be relevant to the pathoge

210 evels of cyclin D1 [2-5], a component of the cell cycle machinery that operates during G1 phase by ac

211 s been made in identifying components of the cell-cycle machinery that are impacted by the checkpoint

212 rounding, thus uncovering a link between the cell-cycle machinery that drives mitotic entry and its a

213 2+ influx is essential for activation of the cell cycle machinery, the processes that regulate Ca2+ i

214 ults explain the temporal specificity of the cell-cycle machinery, thereby providing a biochemical me

215 he Ras and Myc oncogenes can impact the core cell cycle machinery through all three D-cyclins.

216 he TSO1-MYB3R1 module is integrated with the cell cycle machinery to control cell division at the sho

217 However, the mechanisms linking the cell cycle machinery to metabolism are not well defined.

218 chromatin dynamics in co-ordination with the cell cycle machinery to promote genome duplication durin

219 rious microbial pathogens interfere with the cell cycle machinery to promote host cell colonization.

220 S595 phosphorylation may globally couple the cell cycle machinery to regulatory pathways that impact

221 additional layers of regulation on the core cell cycle machinery to set up an extended G2 period ter

222 K and provides a novel mechanism linking the cell cycle machinery to translational control.

223 , so is not a consequence of feedback by the cell-cycle machinery to maintain cell-cycle length.

224 al regulation of the TR life cycle with host cell-cycle machinery to protect chromosome ends in Droso

225 A hallmark of cancer is the deregulation of cell-cycle machinery, ultimately facilitating aberrant p

226 Strikingly, the major alterations in the cell cycle machinery underlying cervical carcinogenesis

227 c transcription factor communicates with the cell cycle machinery via cyclins D1 and D2, but not D3,

228 link environmental mitogenic stimuli to the cell cycle machinery via modulation of G1 cyclin express

229 Further investigation revealed that the cell cycle machinery was activated by FcgammaR cross-lin

230 link the signal transduction pathway and the cell cycle machinery, we developed a selection strategy

231 viously unknown small molecules that inhibit cell cycle machinery, we performed a chemical genetic sc

232 genous TGF-beta effects on the modulation of cell cycle machinery were analyzed previously.

233 3-regulated cell proliferation by modulating cell cycle machinery, while hyperactivation of RhoA furt

234 formative divisions rely first of all on the cell cycle machinery with centrally acting cyclin-depend

235 e is an integral component of the eukaryotic cell cycle machinery, yet very few centrosomal proteins