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1 , thereby preventing IgE clustering and mast cell degranulation.
2 ion on human NK cells, leading to altered NK-cell degranulation.
3 ented by the inhibited calcium flux and mast cell degranulation.
4 iacidal levels; the second is dependent on T cell degranulation.
5 ons and surpassed attenuation of tissue mast cell degranulation.
6 therefore, appear to be independent of mast cell degranulation.
7 and was superior to blockage of tissue mast cell degranulation.
8 ity IgE receptors, leading to immediate mast cell degranulation.
9 tes, decreased collagen deposition, and mast cell degranulation.
10 ng an iNOS-independent mechanism requiring T cell degranulation.
11 educed acute allergic skin reaction and mast cell degranulation.
12 pendent stimulus for IgE production and mast cell degranulation.
13 iak-Higashi syndrome had abnormal resting NK-cell degranulation.
14 g events, necessary for antigen-induced mast cell degranulation.
15 nd GRK3) had no effect on LL-37-induced mast cell degranulation.
16 no immune suppression, showed diminished NK cell degranulation.
17 he receptor specificity for C5a-induced mast cell degranulation.
18 hat C5a does not use MrgX1 or MrgX2 for mast cell degranulation.
19 nking of IgE-bound FcepsilonRI triggers mast cell degranulation.
20 the peptide epitope triggered KIR2DS4(+) NK cell degranulation.
21 nst life-threatening anaphylaxis during mast cell degranulation.
22 hepatocytes, preferentially stimulated CD8 T-cell degranulation.
23 yperplasia by a mechanism that involves mast cell degranulation.
24 nhibit ASM cell-mediated enhancement of mast cell degranulation.
25 contributor in coupling FcepsilonRI to mast cell degranulation.
26 otaxis, whereas S1P(2) is important for mast cell degranulation.
27 significant enhancement of C3a-induced mast cell degranulation.
28 cell apoptosis, expression of Kit, and mast cell degranulation.
29 by FcepsilonRI aggregation that lead to mast cell degranulation.
30 ated by these receptors, culminating in mast cell degranulation.
31 I) 3-kinases are critical regulators of mast cell degranulation.
32 ve cutaneous anaphylaxis, and decreased mast cell degranulation.
33 id not induce measurable increases in goblet cell degranulation.
34 role in adenosine-mediated murine lung mast cell degranulation.
35 hey developed marked intestinal mucosal mast cell degranulation.
36 pathways will lead to new insights into mast cell degranulation.
37 or its initiation, but is necessary for mast cell degranulation.
38 less effect on Fc epsilon RI-dependent mast cell degranulation.
39 ation of early events that culminate in mast cell degranulation.
40 ment was shown histologically to induce mast cell degranulation.
41 ce P is involved in neurotensin-induced mast cell degranulation.
42 lavage, suggesting a role for MCP-1 in mast cell degranulation.
43 rmation for the design of inhibitors of mast cell degranulation.
44 late vascular smooth muscle and inhibit mast cell degranulation.
45 mM levels in ischemic tissues, triggers mast cell degranulation.
46 le-1 mAb inhibited the adhesion-induced mast cell degranulation.
47 heparin may be related to prevention of mast-cell degranulation.
48 colon during conditions associated with mast cell degranulation.
49 triction and inhibits anti-IgE-mediated mast-cell degranulation.
50 or dephosphorylation and an abrupt arrest of cell degranulation.
51 her TRPV4-mediated Ca(++)-influx evokes mast cell degranulation.
52 NM physicochemical properties influence mast cell degranulation.
53 nct feature of CSU, which could enhance mast cell degranulation.
54 n by mast cells was not correlated with mast cell degranulation.
55 cellular activation and natural killer (NK) cell degranulation.
56 that TRPV4 loss of function attenuates mast cell degranulation.
57 migration and survival, and suppressing mast cell degranulation.
58 n diseases associated with IgE-mediated mast cell degranulation.
59 odulate early immune events that impact mast cell degranulation.
60 and extracellular Mg(2+) sensitivity of mast cell degranulation.
61 s to identify genes that regulate human mast cell degranulation.
62 n this study as a negative regulator of mast cell degranulation.
63 mino acid residues were also able to trigger cell degranulation.
64 c reaction, regulate different steps in mast cell degranulation.
65 ts on smooth muscle cell and effects on mast cell degranulation.
66 mast cell number, indicative of greater mast cell degranulation.
67 OCK1 and ROCK2 insufficiency attenuated mast cell degranulation.
68 -specific IgE, basophil activation, and mast cell degranulation.
69 nterior segment inflammation paralleled mast cell degranulation.
70 ls, and AYP caused a 2-fold increase in mast cell degranulation.
71 itochondria, resulting in inhibition of mast cell degranulation.
72 d morphological changes associated with mast cell degranulation, 3) reduced the tyrosine phosphorylat
75 second messengers that together effect mast cell degranulation after allergen cross-linking of immun
76 We may also conclude that triggering of mast cell degranulation after incubation with the solutions o
78 of sialic acid from IgE attenuates effector-cell degranulation and anaphylaxis in several functional
80 ells (Tregs) have been shown to inhibit mast cell degranulation and anaphylaxis, but their influence
82 spase-independent apoptosis that requires NK cell degranulation and causes mitochondrial dysfunction
84 ion of SHIP-2 results in both increased mast cell degranulation and cytokine (IL-4 and IL-13) gene ex
85 main (GRK2-RH) enhanced antigen-induced mast cell degranulation and cytokine generation without affec
86 rom EBV(+) individuals triggered vigorous NK cell degranulation and cytokine production (i.e., TNF-al
87 ggest that Itk differentially modulates mast cell degranulation and cytokine production in part by re
90 igand results in a potent inhibition of mast cell degranulation and cytokine secretion responses.
93 f the JAK3 inhibitor WHI-P131 prevented mast cell degranulation and development of cutaneous as well
94 uccessfully interferes with allergen-induced cell degranulation and efficiently inhibits systemic ana
98 e investigated the function of TRPM7 on mast cell degranulation and histamine release using wild-type
101 nes for effects on FcepsilonRI-mediated mast cell degranulation and identified 15 potential regulator
103 Hepatic IR induced small intestinal Paneth cell degranulation and increased interleukin-17A (IL-17A
104 een shown to bind inosine, resulting in mast cell degranulation and increased vascular permeability.
105 to induce skin swelling and can enhance mast cell degranulation and inflammation during IgE-dependent
107 eta-cells into alpha-cells occurs after beta-cell degranulation and is characterized by the presence
108 vitamin D3 suppression of IgE-mediated mast cell degranulation and mediator production in vitro, as
110 ating FcgammaRIIIa signaling and enhanced NK cell degranulation and NK cell-mediated antibody-depende
111 Consequently, expression of gD suppressed NK cell degranulation and NK cell-mediated lysis of PRV- or
112 utologous and allogeneic natural killer (NK)-cell degranulation and NK-cell-mediated antibody-depende
115 or C5a and the extent of IgE-dependent mast cell degranulation and PCA responses in mice containing
117 ibited a significantly reduced level of mast cell degranulation and polymorphonuclear neutrophil (PMN
118 ed articular inflammation via promoting mast cell degranulation and proinflammatory cytokine producti
119 sh that TRPM7 kinase activity regulates mast cell degranulation and release of histamine independentl
120 FcepsilonRI on effector cells, resulting in cell degranulation and release of proinflammatory mediat
122 affinity receptor (FcepsilonRI) induces mast cell degranulation and subsequent symptom development.
123 tify delta-toxin as a potent inducer of mast cell degranulation and suggest a mechanistic link betwee
124 ed with enhanced Fc gammaRIII-dependent mast cell degranulation and systemic anaphylactic responses.
126 to bystander B cells trigger Ab-dependent NK cell degranulation and TNF-alpha but not cytotoxicity or
127 cytes also promoted specific Ab-dependent NK cell degranulation and TNF-alpha production but induced
129 mice leads to a significant increase of mast cell degranulation and to accelerated hair follicle regr
130 myeloma cells more efficient to activate NK cell degranulation and to enhance the ability of myeloma
132 direct effect was associated with local mast cell degranulation and was absent in histamine-deficient
133 Lyn B was found to be a poor inducer of mast cell degranulation and was less potent in both inositol
134 , mice deficient in PEP showed impaired mast cell degranulation and were less susceptible to PSA.
136 , airway hyperresponsiveness (AHR), and mast-cell degranulation, and compared its antiallergic activi
137 6A-Ig blocked IC-induced inflammation, mast- cell degranulation, and extravasation of neutrophils in
140 in eosinophil apoptosis, inhibition of mast cell degranulation, and suppression of inflammation.
141 noms contain components that can induce mast cell degranulation, and this has been thought to contrib
142 itionally, IFN-gamma-licensed MSCs inhibit T cell degranulation as well as single, double, and triple
143 es in circulating IgE, which can induce mast cell degranulation, as well as Mcpt-1 and Mcpt-4, were o
144 ivation, we developed a high-throughput mast cell degranulation assay suitable for RNA interference e
145 orms in degranulation itself, using a single-cell degranulation assay that measures the binding of fl
147 studies indicated that C5a could cause mast cell degranulation, at least in part, via a mechanism si
149 ing CD81 inhibit Fc epsilon RI-mediated mast cell degranulation but, surprisingly, without affecting
150 as a blocking antibody, and inhibiting mast cell degranulation, but a deleterious role in malignant
151 TSC1-deficiency results in impaired mast cell degranulation, but enhanced cytokine production in
152 n (LAMP) 1/CD107a is used as a marker for NK-cell degranulation, but its role in NK-cell biology is u
153 inhibited by ketotifen, an inhibitor of mast cell degranulation, but not by azelastine, a histamine r
154 ro experiments show that RSV can induce mast cell degranulation, but only if these cells are sensitiz
155 d substantial inhibition of HDP-induced mast cell degranulation, but PgLPS1435/1449 had no effect.
156 ty showed no significant correlation with NK cell degranulation, but was positively correlated with I
157 TRPM7 kinase activity regulates murine mast cell degranulation by changing its sensitivity to intrac
158 Pak2 plays a unique inhibitory role in mast cell degranulation by down-regulating RhoA via GEF-H1.
160 Another SFK, Fyn, also contributes to mast cell degranulation by inducing Gab2-dependent microtubul
162 differential regulation of HDP-induced mast cell degranulation by PgLPS1690 and PgLPS1435/1449 may c
163 IgGs are known to inhibit IgE-mediated mast cell degranulation by two mechanisms, allergen-neutraliz
164 ls triggered activation events that included cell degranulation, Ca(2+) response, dephosphorylation o
165 We developed an imaging system in which mast cell degranulation can be visualized in single cells sub
171 mmation induced by HDP/MRGPRX2-mediated mast cell degranulation contributes to gingival homeostasis b
173 a production in an NFAT-dependent manner, NK cell degranulation/cytotoxicity and tumor rejection in v
174 broadly in the immune system, blocking mast cell degranulation, dampening the humoral immune respons
175 mice, disodium cromoglycate attenuated mast cell degranulation, development of autoimmunity, and dev
177 microM); (e) stimulate RBL-2H3 rat mast-like cell degranulation (ED50 = 2.3+/-0.9 microM); and (f) ca
180 potent CD4 T cell clones were dependent on T cell degranulation for replication control with only a m
182 eficiency impaired FcepsilonRI-mediated mast cell degranulation; however, PLD2 deficiency enhanced it
184 prevented neutrophil recruitment and goblet cell degranulation, implicating leukocytes in the respon
185 gE- and non-IgE-mediated human or mouse mast cell degranulation in a concentration-dependent manner.
186 ate type hypersensitivity, anaphylactic mast cell degranulation in bronchial rings resulted in ANG II
187 r results show that neurotensin-induced mast cell degranulation in colonic explants is inhibited by t
189 eta-glucan (a DECTIN-1 agonist) induced mast cell degranulation in mesenteric windows and HMC-1 cells
190 ma histamine level, and tracheal tissue mast cell degranulation in mice in a dose-dependent manner.
195 ed NK-1R(-/-) mice also exhibit bladder mast cell degranulation in response to antigen challenge.
196 ral tissues of CX3CR1-deficient mice, and NK cell degranulation in response to sensitive target cell
197 t cell recruitment in lean subjects and mast cell degranulation in SC WAT of all research participant
203 tor activity correlated positively with mast cell degranulation in the meninges but not in the thalam
204 ion between behavioral activity and the mast cell degranulation in the meninges suggests that these p
205 for IgE made HBI a potent inhibitor of mast cell degranulation in the rat basophilic leukemia mast c
206 ar spinal cord and plasma and decreased mast cell degranulation in the tibialis anterior muscle of tr
207 -33 also enhanced autoantibody-mediated mast cell degranulation in vitro and in synovial tissue in vi
208 nly 6'-sialyllactose directly inhibited mast cell degranulation in vitro, at high concentrations.
212 rthermore, CD81 antibodies also inhibit mast cell degranulation in vivo as measured by reduced passiv
214 Nebulized IB-MECA directly induced lung mast cell degranulation in wild-type mice while having no eff
215 ells were co-cultured with colonocytes, mast cell degranulation increased paracellular permeability o
216 , and eosinophils, shock (hypothermia), mast cell degranulation (increased serum mouse mast cell prot
217 rity of anaphylaxis was associated with mast cell degranulation, increased plasma heparin levels, the
218 thore et al. report that DENV can cause mast cell degranulation independently of mast cell infection,
221 an cultures of neonatal human foreskin, mast cell degranulation induced by either substance P or comp
222 analysis identified delta-toxin as the mast cell degranulation-inducing factor produced by S. aureus
223 MCS-01, which proved to be an effective mast cell degranulation inhibitor in vitro and can be deliver
224 ically varied to optimize inhibition of mast cell degranulation initiated by multivalent crossing of
226 addition to cytokine production, acute mast cell degranulation is a critical component of allergic r
229 We conclude that ovalbumin-induced goblet cell degranulation is due to neutrophil recruitment and
231 While A20 deficiency did not affect mast cell degranulation, it resulted in amplified pro-inflamm
232 t a model in which CCK release triggers mast cell degranulation, leading to increases in smooth muscl
234 glycolysis was not required directly for NK cell degranulation, limiting the rate of glycolysis sign
236 to HIV infection, while the loss of CD8(+) T cell degranulation may impede the proper killing of infe
238 3,3'- diaminobenzidine staining, and goblet cell degranulation measured with a semiautomatic compute
239 eta) participates in antigen-stimulated mast cell degranulation mediated by the high-affinity recepto
240 ay a major role in the regulation of BR mast cell degranulation, multiple AR subtypes and G proteins
241 or ligand superfamily member 14; sparse mast cell degranulation; numerous forkhead box protein P3 (Fo
243 y T. spiralis induces mastocytosis, and mast cell degranulation occurs when challenged rats exhibit r
244 response characterized by IgE-dependent mast cell degranulation of mediators, such as alpha-chymase a
245 r inflammation, but the consequences of mast cell degranulation on ocular pathology remain uncharacte
246 or Lyn B alone could completely restore mast cell degranulation or dampen the excessive cytokine prod
249 with HIV peptide stimulation increased CD8 T cell degranulation, production of intracellular cytokine
250 also exhibited reductions in peritoneal mast cell degranulation, production of TNF-alpha, neutrophil
251 sfection, Western blot, confocal microscopy, cell degranulation, prostaglandin D(2) secretion, and pr
252 lergic activity by blocking IgE-induced mast cell degranulation, providing a foundation for developin
253 ggers eosinophil apoptosis and inhibits mast cell degranulation, providing an endogenous mechanism to
255 th, whereas the magnitude of individual mast cell degranulation remained unchanged, suggesting an all
260 disodium cromoglycate blocks injurious mast cell degranulation specifically without affecting the im
261 In this study, we show that specific mast cell degranulation stimuli, given s.c. in mice with Ag a
262 a Y145F mutant, strongly reconstituted mast cell degranulation, suggesting a critical role for Y145
263 ex of suspicion is needed in those with mast cell-degranulation symptoms, including anaphylaxis follo
264 I, rendering IgE incapable of eliciting mast cell degranulation, thereby preventing anaphylaxis.
266 hibits Mrgprb2 and FcepsilonRI-mediated mast cell degranulation to attenuate pseudo-allergy and anaph
267 -culture-derived HCV (HCVcc) and measured NK cell degranulation, TRAIL, and phosphorylated extracellu
268 evaluated for the capacity to suppress mast cell degranulation using a RBL-2H3 degranulation assay.
269 e trigeminal ganglion is accompanied by mast cell degranulation, vasodilatation, increased endothelia
270 n this area include the ability to measure T-cell degranulation via cell surface exposure of CD107 an
271 lammation, stimulating vasodilation and mast cell degranulation via PAR-1, and activating cytokine/ch
273 mast cell stabilizer, cromolyn sodium, mast cell degranulation was blocked, and intestinal morpholog
281 or protein Gab2, which is essential for mast cell degranulation, was inhibited after Ag stimulation o
283 hether this interaction would result in mast cell degranulation, we examined the effect of EL-4, 2B4,
284 /METHODS: To determine the intensity of mast cell degranulation, we used an experimental model based
285 -dependent calcium signals required for mast cell degranulation were dampened, but the role of LAT2 i
287 less effective in enhancing C3a-induced mast cell degranulation when compared with untreated cells.
288 equired to stimulate high levels of effector cell degranulation when using the humanized RBL-SX38 cel
289 HLH, 13 of 59 (22%) had abnormal resting NK-cell degranulation, whereas 0 of 43 had abnormal degranu
290 te stress by immobilization led to dura mast cell degranulation which was prevented by pretreatment w
291 tyrosine phosphatase, SptP, suppresses mast cell degranulation, which enables bacterial disseminatio
292 of the hydrophobic pocket of Munc18 in mast cell degranulation, which include the regulation of synt
293 tivates Mrgprb2 and MRGPRX2, triggering mast cell degranulation, which inhibits bacterial growth and
294 plants to toxin A or neurotensin causes mast cell degranulation, which is inhibited by SR-48,692.
295 nsitive mechanism, enhances C3a-induced mast cell degranulation, which likely regulates ASM function,
296 Langendorff-perfused guinea pig hearts, mast cell degranulation with compound 48/80 released Ang I-fo
298 r disodium cromoglycate would attenuate mast cell degranulation without affecting IL-10 production.
299 rams that determine the requirement for mast cell degranulation would therefore have the potential to
300 ontrast to S1P, FTY720 has no effect on mast-cell degranulation, yet significantly reduces antigen-in