ライフサイエンスコーパス: cell generation

1 V a powerful tool for inducible regulatory T cell generation.

2 nuclear IkappaBNS is crucial for murine Th17 cell generation.

3 , which was associated with a defect in Th17 cell generation.

4 transcription factor serves to restrain Tfh cell generation.

5 e approach for deriving specific therapeutic cell generation.

6 T-bet induction and counteracts regulatory T cell generation.

7 cy did not alter the rate of memory CD8(+) T cell generation.

8 croenvironment instructed pDC-driven Th9/Th2 cell generation.

9 tion for ADAP in the suppression of MP CD8 T cell generation.

10 A miR-31, which negatively regulates pT(reg)-cell generation.

11 failed to provide signals necessary for beta-cell generation.

12 ntiation despite the lack of effector CD4+ T cell generation.

13 -mediated autoimmunity, greatly enhances TFH-cell generation.

14 DCs in the spleen are essential for CD8(+) T cell generation.

15 affecting MG dedifferentiation or progenitor cell generation.

16 e, promoted goblet cell and inhibited paneth cell generation.

17 efficiency of induced pluripotent stem (iPS) cell generation.

18 renewal of ESCs and induced pluripotent stem cell generation.

19 o stimulate T-helper cell 1/T-helper cell 17 cell generation.

20 lls from apoptosis and thereby promotes Treg cell generation.

21 , transcription factors programming effector-cell generation.

22 actors necessary for amacrine and horizontal cell generation.

23 IL-17 production but is dispensable for Th17 cell generation.

24 of transcription factors required for plasma cell generation.

25 -specific T-cell priming as well as memory T-cell generation.

26 cells and must be silenced to allow bipolar cell generation.

27 thymus is the primary vertebrate organ for T-cell generation.

28 creased Erk1/2 activity promotes gammadeltaT cell generation.

29 development, and extrafollicular T-bet(+) B cell generation.

30 ce of RasGRP1 is compatible with gammadeltaT cell generation.

31 injuries, is shown to be inhibitory on Th17 cell generation.

32 te cellular potentials: stem cell vs. cancer cell generation.

33 ed T(H)17 development while promoting T(reg) cell generation.

34 ligand (ICOSL), a molecule required for Tfh cell generation.

35 impaired trafficking promotes local effector cell generation.

36 paracrine IL-2-mediated suppression of Th17 cell generation.

37 because TCR stimulation is required for Treg cell generation.

38 sm may shed light on the improvements of iPS cell generation.

39 s a chemical factor capable of promoting iPS cell generation.

40 Rgammat) and enhanced RORgammat-induced Th17 cell generation.

41 e capable of enhancing the efficiency of iPS cell generation.

42 cells resulting in overall decreased memory cell generation.

43 the reciprocal regulatory and inflammatory T cell generation.

44 new insight into the process of memory CD8 T cell generation.

45 lls were used to track allospecific memory T-cell generation.

46 lity and suppresses induced pluripotent stem cell generation.

47 at Bcl6 is required for programming of T(FH) cell generation.

48 oregulatory capacities may impair effector T cell generation.

49 cyte-derived DC, 3 relevant molecules for Th-cell generation.

50 th markedly more IFN-gamma(+) and IL-17(+) T cell generation.

51 editing, germinal center reaction and plasma cell generation.

52 ransient results at times equal to that of a cell generation.

53 ing Treg generation and promoting effector T cell generation.

54 BEC secretome did not promote Th1 cell generation.

55 et distributions, or regulatory/suppressor T cell generation.

56 lopment of Th17 cells at the expense of Treg cell generation.

57 nal thymic tissue and a decline in de novo T cell generation.

58 locus at the earliest stages of progenitor B cell generation.

59 re-TCR increased the efficacy of alphabeta T cell generation.

60 to erythroid fate, and increased endothelial cell generation.

61 of future vaccine strategies to maximize MEM cell generation.

62 tely expressed as mutations per day than per cell generation.

63 spleen, inducing FDC development and plasma cell generation.

64 cell receptor stimulation on CD4 effector T cell generation.

65 pears to result from cumulative defects of T cell generation.

66 cells, is developmentally required for T(FR) cell generation.

67 glucose-induced TGF-beta activation and Th17 cell generation.

68 nduced tolerance through regulatory T (Treg) cell generation.

69 T cells, CCR4 supports short-lived effector cell generation.

70 ligoclonality but also interfere with memory cell generation.

71 Mink1 as a novel negative regulator of Th17 cell generation.

72 e-mediated Parkin depletion attenuates CD44H cell generation.

73 analogous to T-cell effector cell and memory cell generation.

74 g thymic atrophy positively influences tTreg cell generation.

75 through both thymic clonal deletion and Treg cell generation.

76 ntiation (CD) 4+ thymic regulatory T (tTreg) cell generation.

77 T cell subset differentiation, and memory T cell generation.

78 ropriate balance of effector/memory CD8(+) T cell generation.

79 t contains sufficient resources for daughter cell generation.

80 l proliferation, differentiation, and plasma cell generation.

81 of an extrafollicular pathway for effector T cell generation.

82 is informed by in vitro models of T- and NK cell generation.

83 ory T cell generation, led to autoreactive T cell generation.

84 cetyl cysteine (NAC) treatment restored Th17 cell generation.

85 4 to suppress T cell proliferation and T reg cell generation.

86 ransmits faithfully across mammalian somatic cell generations.

87 ectively silence transcription over multiple cell generations.

88 n the cell and potentially maintained across cell generations.

89 ental CHO cells over the course of three CHO cell generations.

90 repositioning of Cnp1 nucleosomes throughout cell generations.

91 imate the age of individual tumor lineage in cell generations.

92 y transmitted, undiminished through multiple cell generations.

93 ieved to carry regulatory information across cell generations.

94 nt expression and sustained function over 50 cell generations.

95 evolved in identical environments for 20,000 cell generations.

96 methylation occurs gradually through several cell generations.

97 not necessarily increase with the number of cell generations.

98 e rostral features: (1) increased progenitor cell generation, (2) extended progenitor cell proliferat

99 he above, we show here that antiviral CD4+ T cell generation after infection is reduced in the absenc

100 e and promotes T cell expansion and effector cell generation after initial activation via TCR signali

101 lation of blood vessels did not prevent beta-cell generation after severe pancreas injury by partial

102 sue damage, but also late effects in several cell generations after the initial exposure.

103 tic alterations in the progeny of irradiated cells generations after the initial insult.

104 3 (GSK3), previously reported to reduce Th17 cell generation, also alter Th1 cell production or allev

105 n vitro is a novel mechanism of T regulatory cell generation, although questions regarding the role o

106 lpha4beta7(high) subsets enhanced Th1/Th17 T cell generation and accumulation in the intestine, and t

107 ut it exerts different roles for gammadeltaT cell generation and activation.

108 hat underlie inducible/adaptive regulatory T cell generation and airway tolerance are not well unders

109 EMT was accompanied by stably enhanced stem cell generation and anticancer drug resistance.

110 vating factor that highly accelerated plasma cell generation and antigen-specific antibody production

111 ogenitors, BMCs increased donor chimerism, T cell generation and antigen-specific T cell responses to

112 ctivated CD4(+) T cells led to increased Tfh cell generation and B cell priming, whereas KLF2 overexp

113 s immune tolerance by promoting regulatory T cell generation and blocking Th17 differentiation.

114 nuous IL-2 production sustained thymic T reg cell generation and control of systemic immune activatio

115 and extracellular requirements for memory NK cell generation and describe the emerging evidence for m

116 These data identify defective Bcl-6(+) T(FH) cell generation and dysregulated humoral immune inductio

117 ocyte accumulation, lipid accumulation, foam cell generation and endothelial cell injury were all inc

118 role of blood vessels to preserve adult beta-cell generation and function, restricting their importan

119 the effect of low-affinity priming on memory cell generation and function, which is particularly impo

120 and with a defect in inducible regulatory T-cell generation and function.

121 splicing forms, and an impairment in T(reg) cell generation and function.

122 xplore the role of DNA replication in immune cell generation and function.

123 receptor (TCR) signaling in CD8(+) memory T-cell generation and homeostasis are poorly defined.

124 In this study, pathways that influence B10 cell generation and IL-10 production were identified and

125 ore, BMCs promoted donor CD4(+) regulatory T cell generation and improved survival after allogeneic H

126 r (ICOS), which in turn was required for TFR cell generation and inhibition of antibody responses.

127 a1-producing T cell subset required for Th17 cell generation and its cellular mechanism of action rem

128 he receptor TNFRSF14 (HVEM), can support TH2 cell generation and longevity and promote airway remodel

129 ontribute to optimal protective memory CD8 T cell generation and maintenance in humans will inform ef

130 ransition, in tumour metastasis, cancer stem cell generation and maintenance, and therapeutic resista

131 he critical role of Glis3 in pancreatic beta-cell generation and maintenance, the elevated Glis3 expr

132 asion, and dissemination, and increased stem cell generation and mammosphere formation, dependent upo

133 ed an activation cascade leading to memory B-cell generation and particularly IgG1, but also IgA, IgG

134 ation, and inhibition of LFA-1 abolished Tfh cell generation and prevented protective humoral immunit

135 here to the present dogma regarding memory T cell generation and provide a means for identifying fact

136 r MyD88 is required for optimal memory CD8 T-cell generation and responses after lymphocytic choriome

137 tion alone does not prime MHC-E-restricted T cell generation and suggests that other, currently unkno

138 e the isoform-selective effects of GSK3 on T cell generation and the therapeutic effects of GSK3 inhi

139 n implicated in coordinating both effector T cell generation and trafficking.

140 We provide an integrated model of cell generation and turnover in the human heart.

141 oping personalized strategies to improve iPS cell generation and wound healing in elderly individuals

142 ic choice at RAMA elements was stable across cell generations and bookmarked through mitosis.

143 ersists in differentiated cells through many cell generations and changes in transcriptional state.

144 tracing vital stain that is retained through cell generations and effectively reads out migration rel

145 g-term maintenance of memory for at least 90 cell generations and the ability to interrogate the stat

146 o electroporation in mice, enhanced memory T-cell generation, and elicited 140-fold higher gene expre

147 oduce inflammatory cytokines, stimulate Th17 cell generation, and fail to secrete IFN-alpha on Toll-l

148 gfbr2 expression rescued P2RX7-deficient Trm cell generation, and TGF-beta sensitivity was dictated b

149 g implications about neonatal immunity, Treg cell generation, and tolerance establishment early in li

150 erminal center (GC) B cell phenotype, plasma cell generation, and virus-specific Ab responses.

151 r acquisition of GC B cell phenotype, plasma cell generation, and virus-specific neutralizing Ab resp

152 on observations of single cells over several cell generations, and then extrapolated in time.

153 expansion of memory B cells and Ab-secreting cell generation are inhibited.

154 er, the molecular mechanisms governing taste cell generation are not well understood.

155 barrier tissues, but the cues promoting Trm cell generation are poorly understood.

156 These 2 pathways for memory T cell generation are quite distinct.

157 The mechanisms of human outer radial glial cell generation are unknown, but are proposed to involve

158 ated Smo cannot overcome impaired cerebellar cell generation, arguing for an epistatic role of Pals1

159 YAP gene (YAP 5SA) causes productive GFAP(+) cell generation at late embryonic periods, and this acti

160 n multipotential progenitor cells directed B cell generation at the expense of myeloid cell fates.

161 or pharmacological interference with IgA(+) cell generation attenuates liver carcinogenesis and indu

162 rs interacting to control hematopoietic stem cell generation, both in time and space in vivo, includi

163 ists not only inhibits Th1 and Th17 effector cell generation but also promotes the generation of Foxp

164 Such extensive and rapid mature CNS cell generation by a relatively small number of transpla

165 Here we showed that P2RX7 supported Trm cell generation by enhancing CD8(+) T cell sensing of TG

166 sity compromises the mechanisms regulating T-cell generation by inducing premature thymic involution.

167 This IL-2-dependent scaling of thymic T reg cell generation by overall self-reactivity of a mature p

168 In this study, we manipulated the number of cell generations by varying the rate at which cultures o

169 The effects of new hair cells generation by 5-aza were concentration dependent.

170 Il21 and less Il2 and exhibit enhanced Th17 cell generation compared with T cells from NOD.Idd3 cong

171 insufficient TCR signaling improved T-CD4 T-cell generation, consistent with rescue from negative se

172 We demonstrate that naive T-cell generation decreases with age because of a combinat

173 Grid cell generation depends upon theta rhythm, a 6-10 Hz ele

174 ertion at the epsG target site (2.7 x 10(-7)/cell/generation), determined by quantitative PCR, is 4 t

175 cidation of the mechanisms that regulate Tfh cell generation, differentiation and function should rev

176 MEK1 phosphorylates ERK1/2 and regulates T cell generation, differentiation, and function.

177 nsion and stochastic variability in effector cell generation due to an initially small naive repertoi

178 receptor (ER) signaling for stimulating beta-cell generation during embryonic development and in the

179 t DC subsets to effector and memory CD8(+) T cell generation during infection and the mechanism by wh

180 labeling have provided novel insights on B1a-cell generation during ontogeny.

181 ll self-renewal and induced pluripotent stem cell generation during the final stage of reprogramming.

182 faithfully propagated and maintained through cell generations even after the suppression of the expre

183 tional repression gradually increase for 3-5 cell generations, even though the intracellular level of

184 ion about the basic mechanisms of blood stem cell generation, expansion, and migration.

185 ar, quantitative examination of memory CD8 T cell generation following infection during pregnancy rem

186 edulla, a site that nurtures self-tolerant T-cell generation following positive selection events that

187 7-CD70 pathway was not required for pre-Treg cell generation, Foxp3 induction, or mature Treg cell fu

188 The linear model for memory T-cell generation from differentiated effector cells has b

189 clonal deletion and for regulatory T (Treg) cell generation from endogenous tissue-restricted antige

190 We recently reported efficient iPS cell generation from human fibroblasts using synthetic m

191 epresents a self-regulatory mechanism of Th2 cell generation from naive CD4 cells, in which the postt

192 Substantial suppression of Foxp3(+) T(reg) cell generation from retinoic acid receptor-related orph

193 tch plays a role in induced pluripotent stem cell generation from somatic cells.

194 With age, T-cell generation from the thymus is much reduced, yet a s

195 Importantly, this ability of Treg cell generation gradually diminishes within 2 wk of birt

196 Although Smad4 was dispensable for T cell generation, homeostasis, and effector function, it

197 ls (TECs) are crucial for thymopoiesis and T cell generation, how TEC development and function are co

198 thropoiesis is distinct from basal red blood cell generation; however, neither the cellular nor the m

199 ibited stimulation indices and CD4CD25 FOXP3 cell generation in both human leukocyte antigen DR-match

200 gase Hectd3 is necessary for pathogenic Th17 cell generation in experimental autoimmune encephalomyel

201 tiation, but has a prominent role in iT(reg) cell generation in gut-associated lymphoid tissues.

202 hown to be inhibitory on CAg-stimulated Th17 cell generation in healthy donor PBMC cultures; however,

203 tial signals via isoforms may control plasma-cell generation in humans.

204 Furthermore, IL-21 inhibited Treg cell generation in mice with colitis.

205 These findings suggest that compromised TR B cell generation in NOD mice yields relaxed TR selection,

206 of thymocytes may be as essential as T(reg) cell generation in preventing autoimmune diseases such a

207 proliferation, effector function, and memory cell generation in response to infection with lymphocyti

208 approach we showed that extensive Ab-forming cell generation in spleen, accompanied by somatic hyperm

209 tic drug metformin restored FAO and CD8 T(M)-cell generation in the absence of TRAF6.

210 ation suggests a potential route to new hair cell generation in the adult cochlea.

211 We mechanistically studied tTreg cell generation in the atrophied thymus by utilizing bot

212 h17 cells in intestinal mucosa, blocked Th17 cell generation in the lung after Francisella tularensis

213 In addition to butyrate, de novo Treg-cell generation in the periphery was potentiated by prop

214 and healthy controls; ex vivo models of Treg-cell generation in the presence or absence of Langerhans

215 n mice that lacked this X-linked gene, T reg cell generation in the thymus was intrinsically favored,

216 rfered with IL-15 signaling to suppress iNKT cell generation in the thymus.

217 ture T cell production and specifically iNKT cell generation in the thymus.

218 eptides blocked TGF-beta activation and Th17 cell generation in vitro and protected mice from EAE.

219 A modest defect in plasma cell generation in vitro was documented, which correlate

220 tokine rescues antibody responses and plasma cell generation in vitro.

221 lls, allowing those cells to assist FOXP3+ T cell generation in vitro.

222 Thymic regulatory T (Treg) cell generation in vivo was directly correlated with in

223 3, but not IL12RB1 or TYK2, also reduced Tfh cell generation in vivo, evidenced by decreased circulat

224 fferentiation upon virus infection, and Treg cell generation in vivo.

225 ew 'intersecting pathway' model for memory T-cell generation in which antigen-driven effector differe

226 the data support a model of memory CD8(+) T cell generation in which the chemokine-directed localiza

227 s depends on IL-6 to support pathologic Th17 cell generation in wild-type mice.

228 uces high rates of mutagenesis over multiple cell generations in genes under the control of a T7 prom

229 cell reprogramming to induce specific target cell generation including stem cells, brain cells and ca

230 ity of CD4+ T cells to promote memory CD8+ T-cell generation, indicating that an orchestrated series

231 eprogramming during induced pluripotent stem cell generation is accompanied by changes in DNA methyla

232 nsufficient evidence regarding whether tTreg cell generation is also impaired.

233 However, iPS cell generation is asynchronous and slow (2-3 weeks), th

234 Identifying pathways for beta-cell generation is essential for cell therapy in diabete

235 Thus, RS cell generation is related neither to cell fusion of unr

236 original size, and normal steady-state blood cell generation is sustained with <10% of normal LT-HSC

237 of self-reactivity that elicits thymic Treg cell generation is tuned to secure peripheral tolerance

238 Continued DNA damage for 40 cell generations is reproducibly associated with loss of

239 ssential for pTreg but dispensable for tTreg cell generation, is present only in placental mammals.

240 nsgene rescued DN1 survival and improved DN2 cell generation, it did not restore DN3 differentiation.

241 raded manner to regulate macrophage versus B cell generation; its higher concentration favors the mac

242 on of Aire rather than impaired regulatory T cell generation, led to autoreactive T cell generation.

243 l EML cell subsets generated during multiple cell generations maintain their distinct phenotypic and

244 Finally, T-cell generation, maintenance, and apoptosis depend upon

245 nalyze signaling mechanisms for memory CD4 T cell generation, maintenance, and homeostasis.

246 ce is characterized by excessive endothelial cell generation of potentially cytotoxic concentrations

247 The cell generation of reactive oxygen species (ROS), howeve

248 ntigens thought to identify tumor initiating cells, generation of 3D aggregates when grown as adheren

249 percentages of both CD4+ and CD8+ splenic T cells, generation of a greater number of IOE-specific, g

250 events occur several times in each cell and cell generation on average.

251 Short-term memory persists within one cell generation or in postmitotic cells, while long-term

252 ostimulation was not needed for memory CD8 T cell generation or the ability to mount a recall respons

253 T cells involves an ongoing balance of new T cell generation, peripheral expansion, and turnover.

254 egation, inflammation, metabolic disruption, cell generation, physiology, and alterations in neurotra

255 lts newly identify RA as a cofactor in T reg cell generation, providing a mechanism via which functio

256 hough RasGRP1 is dispensable for gammadeltaT cell generation, RasGRP1-deficient gammadeltaT cells are

257 in aged individuals, coupled with falling B-cell generation rates and life-long homeostatic competit

258 ase APC maturation and suppress effector Th1 cell generation relative to saline-treated control.

259 Suppression of Treg cell generation required proteases and TLR-mediated sign

260 ing of CD28 costimulation showed that T(reg) cell generation requires a motif that binds the tyrosine

261 ical mechanisms essential for successful iPS cell generation requires both accurate capture of cells

262 Th17 cell generation requires exposure of naive T cells to th

263 Peripherally derived regulatory T (pT(reg)) cell generation requires T-cell receptor (TCR) signallin

264 fic roles for Bach2 in favoring regulatory T cell generation, restraining effector T cell differentia

265 Hair cell generation resulted from an increase in the level o

266 system unambiguously demonstrated that hair cell generation resulted from transdifferentiation of su

267 n acute psychosocial stressor at the time of cell generation resulted in a decreased number of newly

268 unrepaired, into daughter cells for multiple cell generations, resulting in the chromosome-scale phas

269 et Gprc5a as critical regulators for pT(reg)-cell generation, suggesting a previously unrecognized ep

270 an essential regulator of hematopoietic stem cell generation, survival and functionality.

271 ays involved in CD4 help for memory CD8(+) T cell generation that are independent of TRAIL, and it pr

272 el of circumsporozoite-specific memory CD8 T cell generation that protects mice against multiple P. b

273 Even so, through many cell generations the pro-T cells remain uncommitted to t

274 After 40 cell generations the pX-expressing polyploid cultures ex

275 a phosphomutant form of Ngn3 increases alpha cell generation, the earliest endocrine cell type to be

276 ally secreted BMP7 can directly promote Treg-cell generation through the BMP signaling cascade.

277 f DHA in reciprocally regulating Th and Treg cell generation through the modulating mTOR pathway.

278 r for applications ranging from ex vivo stem cell generation to in vivo gene therapy.

279 ective negative selection by enhancing tTreg cell generation to maintain central T-cell tolerance in

280 The contribution of cell generation to physiological heart growth and mainte

281 can transmit epigenetic information from one cell generation to the next.

282 herefore an epigenetic signal passed between cell generations to ensure that replication-associated t

283 n carcinogenesis, and by increased number of cell generations to the development of cancer.

284 During CD44H cell generation, transformed keratinocytes display evide

285 c diet highlighted DC efficacy in effector T-cell generation under hypercholesterolemic conditions.

286 duced polyploid cultures in the course of 70 cell generations undergo progressively increasing DNA da

287 cantly increases the efficiency of mouse iPS cell generation using the transcription factors Oct4, So

288 , we are able to enhance skin-specific tTreg cell generation using three approaches.

289 We found that the capacity of tTreg cell generation was not impaired compared to CD4+ thymic

290 ctivity, NO synthesis and induce endothelial cell generation was reduced.

291 Tfh cell generation was regulated by ICOS ligand (ICOSL) exp

292 ll compartment in CLL as it relates to CAR T-cell generation, we examined the phenotype and function

293 el mitotic and nonmitotic mechanisms of hair cell generation, we show that loss of LIN28B function, d

294 tely analyze the effect of DMXAA on CD8(+) T-cell generation, we treated mice bearing tumors derived

295 Fyn, and PKCtheta were essential for T-CD4 T cell generation, whereas mutations in the Ly108 receptor

296 ugh MVA induced accelerated central memory T cell generation, which could be efficiently boosted by s

297 at OX40 can concomitantly promote effector T cell generation while antagonizing the differentiation o

298 y control the expression of a gene over many cell generations with quantitative accuracy.

299 er expression is highly stable over multiple cell generations, with fluctuations within cycles confin

300 py episomal stability of the vector for >100 cell generations without selection.