ライフサイエンスコーパス: cell junction

1 orces along different parts of an individual cell junction.

2 nanodisc system, mimicking a native cell-to-cell junction.

3 n-4-dependent recruitment of vinculin to the cell junction.

4 the retinal Muller glia (RMG)/photoreceptor cell junction.

5 esion as well as insight on dynamics of cell-cell junction.

6 nd each protein localized as a ring near the cell junction.

7 lly localized in the cuticular plate and the cell junction.

8 er effect or both together may break stomium cell junctions.

9 Rap1-dependent rearrangement of endothelial cell junctions.

10 nation, controlled by cadherin-mediated cell-cell junctions.

11 srupts the targeting of microtubules to cell-cell junctions.

12 lial cell interactions and inter-endothelial cell junctions.

13 epithelial monolayers with compromised cell-cell junctions.

14 that regulates tensional homeostasis at cell-cell junctions.

15 ression, as well as breakdown of endothelial cell junctions.

16 atial distribution of RhoA signaling at cell-cell junctions.

17 RHGAP18 in endothelial cells is important in cell junctions.

18 suggesting a common feature for signaling at cell junctions.

19 masks the motif, stabilizing the cadherin at cell junctions.

20 ension probes to visualize tensile forces at cell junctions.

21 depend on the regulation of endothelial cell-cell junctions.

22 malformed vascular walls with leaky cell-to-cell junctions.

23 -dependent formation of epithelial-like cell-cell junctions.

24 ylation and subsequent transmigration across cell junctions.

25 ction by contracting while connected to cell-cell junctions.

26 ed tube stability, and disrupted endothelial cell junctions.

27 he levels of phosphorylated Src42A (pSrc) at cell junctions.

28 formin-mediated actin polymerization at cell-cell junctions.

29 VE-cadherin clusters Pals1 at cell-cell junctions.

30 nt of Rasip1 to and stabilization of EC cell-cell junctions.

31 dissociating VEGFR2 from VE-cadherin at the cell junctions.

32 syndecan-4 rescues focal adhesions and cell-cell junctions.

33 ate endothelial permeability via endothelial cell junctions.

34 nculin-dependent mechanotransduction at cell-cell junctions.

35 gues accumulate at mammalian epithelial cell-cell junctions.

36 r integrity by affecting the organization of cell junctions.

37 isplayed increased elongation and tighter EC-cell junctions.

38 well as DSG1, a component of desmosomal cell-cell junctions.

39 he cleavage furrow and RhoA and Rac1 at cell-cell junctions.

40 thyltransferase activity, cell adhesion, and cell junctions.

41 on of polysaccharide from pores close to the cell junctions.

42 wnstream destabilization of endothelial cell-cell junctions.

43 inesis and formation and maintenance of cell-cell junctions.

44 ive of the composition and stability of cell-cell junctions.

45 to generate tangential forces to break cell-cell junctions.

46 that invade luminally along neighboring cell-cell junctions.

47 complex transduces mechanical forces at cell-cell junctions.

48 tently appearing lamellipodia at established cell junctions.

49 formation and disruption of endothelial cell-cell junctions.

50 y system maintained through endothelial cell-cell junctions.

51 le for Anillin in regulating epithelial cell-cell junctions.

52 iled to support normal localization of gE to cell junctions.

53 localization at the level of individual cell-cell junctions.

54 ompetitively removed Dia1 and Dia2 from cell-cell junctions.

55 co-localised with Claudin-1 and ZO1 at cell-cell junctions.

56 for albumin and dextran uniformly along the cell junctions.

57 disruptive effect of thrombin on endothelial cell junctions.

58 mplete reorganization of cadherin-based cell-cell junctions.

59 arrier function was due to an effect on cell-cell junctions.

60 rminal web and impairs its interactions with cell junctions.

61 d Dlg1 and targeting RhoG activation to cell-cell junctions.

62 (PAK2 and PAK3) also fail to target to cell-cell junctions.

63 nctional actomyosin ring underneath the cell-cell junctions.

64 ells trigger an increase in tension at these cell junctions.

65 nase domain, inhibits PAK1 targeting to cell-cell junctions.

66 internalization/traffic at endothelial cell-cell junctions.

67 d the platform to measure forces of (1) cell-cell junctions, (2) single cells undergoing cyclic pertu

68 s of </=200 mum; these included an arborised cell junction, a diagonal-plane junction and an osteocho

69 creased presence of luminal endothelial cell-cell junctions, a transient configuration in the forming

70 e)-coated particles reduces the area of cell-cell junctions-a change that correlates with increased l

71 ed with various cellular functions including cell junction, adhesion and neurogenesis.

72 hanism by which the AMPK-GIV axis reinforces cell junctions against stress-induced collapse and also

73 (invade) either singularly by breaking cell-cell junctions analogous to release of a stretched rubbe

74 trafficking of at least four cell polarity, cell junction and apical extracellular matrix proteins i

75 pend on protein-protein interactions in cell-cell junction and cell attachment complexes and on inter

76 characterized the structural determinants in cell junction and communication.

77 or pennaceous vanes, mediated by asymmetric cell junction and keratin expression.

78 onset blockage near the terminal cell-stalk cell junction and the ectopic extension of autocellular,

79 r (VEGF), have been reported to disrupt cell-cell junctions and abolish GJIC.

80 N-WASP depletion increased the width of cell-cell junctions and altered the organization of F-actin a

81 co analysis also showed that tension on cell-cell junctions and apical stress is not homogeneous acro

82 DAPLE colocalized with MPDZ at apical cell junctions and bound directly to the PDZ3 domain of

83 in a dose-dependent decrease of endothelial cell junctions and foam cell transformation of monocytes

84 ired for proper Rho-GTP distribution at cell-cell junctions and for maintenance of a robust apical ac

85 vivo evidence for mechanosensitivity of cell-cell junctions and imply that myosin-mediated tension ca

86 as a scaffolding or adaptor protein at cell-cell junctions and in the cytosol, supporting normal blo

87 TPRK phosphatase activity leads to disrupted cell junctions and increased invasive characteristics.

88 FA PSC-EORs harbored diminished cell-cell junctions and increased proliferation in the basal

89 mechanical disruption of retinal endothelial cell junctions and increased vasopermeability, as well a

90 in epithelial-like tumor cells perturbs cell:cell junctions and increases membrane protrusion and ove

91 ology and dynamics of native epithelial cell-cell junctions and induced the same polarity transition

92 demonstrate that force transmission at cell-cell junctions and its coupling to cell polarity are piv

93 na-intercellular compartments sealed by cell-cell junctions and lined with microvilli-like protrusion

94 y sensor of metabolic stress stabilizes cell-cell junctions and maintains epithelial polarity; its ac

95 CM were associated with further weakening of cell junctions and more robust EC hyperpermeability.

96 of Crumbs in regulating actomyosin dynamics, cell junctions and morphogenesis.

97 nvasion of cell groups with coordinated cell-cell junctions and multicellular cytoskeletal activity.

98 k synergized with interferon-beta to tighten cell junctions and prevent virus transit across brain mi

99 sly in mBECs to concentrate Wnt ligands near cell junctions and promote maturation of their barrier p

100 ocalized at the basal cortex and apical cell-cell junctions and promoted CD59 uptake from the apical

101 t RASSF1C targets SRC/YES to epithelial cell-cell junctions and promotes tyrosine phosphorylation of

102 teins has implications for signaling at cell-cell junctions and protein sorting at intracellular cont

103 tion, endothelial cells (ECs) establish cell-cell junctions and rearrange to form multicellular tubes

104 on, as its loss results in disorganized cell-cell junctions and reduced focal adhesions.

105 Antagonizing VE-cadherin widened cell-cell junctions and reduced the applied shear stress for

106 Scribble (SCRIB) localizes to cell-cell junctions and regulates establishment of epithelial

107 alizes to forming endothelial cell (EC) cell-cell junctions and silencing HEG1 prevents this localiza

108 3 and DDR1-Par3 differentially regulate cell-cell junctions and the actin cytoskeleton to mediate inv

109 p of cells that require coordination of cell-cell junctions and the actin cytoskeleton.

110 ib/Erbin/Lano knockout disorganizes the cell-cell junctions and the cytoskeleton.

111 n proteins form critical connections between cell junctions and the cytoskeleton; their disruption wi

112 of desmoglein 2-specific interactions along cell junctions and the mean desmoglein 2-mediated bindin

113 in that expresses markers labeling epidermal cell junctions and the neuronal cell surface.

114 classification and analysis of lobes at two-cell junctions and three-cell junctions, respectively.

115 s is crucial to direct the formation of cell-cell junctions and tissue barriers.

116 expression leading to an increased level of cell-junction and extracellular matrix proteins and an a

117 ight junction markers, disorganized the cell-cell junction, and increased permeability.

118 f hepatocyte polarity, specification of cell-cell junctions, and canalicular formation.

119 precisely identified features such as cells, cell junctions, and cell types within skin to enable mul

120 red to occur paracellularly, or between cell-cell junctions, and driven by local pressure and concent

121 e present promising results for nuclei, cell-cell junctions, and fine feature reconstruction; provide

122 dentifying previously unreported proteins at cell junctions, and for gene expression analysis in mult

123 gnaling pathways regulating focal adhesions, cell junctions, and maintenance of the cytoskeleton.

124 on induces EMT progression by modifying cell-cell junctions, and thereby contributes to CRC aggressiv

125 eeded for direct spread of the virus through cell junctions, and these studies show that UL21 is requ

126 After triggering UJT, cell-cell junctions, apico-basal polarity, and barrier functi

127 Membrane interfaces formed at cell-cell junctions are associated with characteristic patter

128 nd the putative PilA protein to rings at the cell junctions are consistent with the hypothesis that t

129 ion of multicellular systems, even when cell-cell junctions are disrupted.

130 Furthermore, we reveal that cell-cell junctions are key players in this aECM patterning a

131 However, it is still unclear how cell-cell junctions are regulated during wound closure (WC).

132 Cell junctions are scaffolds that integrate mechanical a

133 es associated with the establishment of cell-cell junctions are transduced across the cell cortex via

134 single transmembrane domain and localize to cell junction area at the apical surface of epithelia.

135 ted with cell migration, cell communication, cell junction assembly and regulation of cell death.

136 Loss of the cell junction-associated Motin protein Amotl2a leads to

137 nes and at the slit diaphragm, a specialized cell junction at the filtration slit of glomerular podoc

138 cin is a key component of the slit diaphragm cell junction at the kidney filtration barrier and part

139 Whereas podocin resides at a specialized cell junction at the podocyte slit diaphragm, MEC-2 is f

140 cal tissues depend on the remodeling of cell-cell junctions at the microscopic scale.

141 flammation, acinar cell differentiation, and cell junctions being specifically targeted.

142 Loss of crumbs function disrupts the apical cell junction belt and crumbs overexpression expands the

143 erized by pericyte loss and endothelial cell-cell junction breakdown.

144 ificantly influenced by the strength of cell-cell junctions but is an emergent property, similar to c

145 forms lateral clusters within adherens cell-cell junctions, but its association state outside these

146 de neutralizing antibodies by moving through cell junctions, but the mechanism of direct cell-to-cell

147 In MDCK cells, Yap1 was sequestered to cell-cell junctions by Amot, and aPKC overexpression resulted

148 llective migration and the formation of cell-cell junctions by C6 glioma cells seeded on top of elect

149 f local prevention of cell adhesion at three-cell junctions by fluidlike extracellular material and a

150 force-activatable mechanotransducer at cell-cell junctions by using an engineered alpha-catenin conf

151 It is a cell-to-cell junction cardiomyopathy, typically caused by geneti

152 ortant for insulin secretion, cell polarity, cell junction, cilia, cytoskeleton, vesicular traffickin

153 for genes encoding components of three cell-cell junction complexes, CDH1, PKP2, and TJP1.

154 eciprocal dysregulation of epithelial genes, cell junction components and actomyosin properties in Gr

155 Cell permeability was measured by cell-cell junction confocal microscopy and a dextran permeabi

156 margins, FAT1 is localized at earliest cell-cell junctions, consistent with a role in facilitating o

157 ECs tightly regulate their cell-cell junctions, controlling the passage of soluble mater

158 to ask whether changes in forces across cell-cell junctions correlated with E-cadherin molecular tens

159 Maintenance and remodeling of endothelial cell junctions critically depend on the VE-cadherin/cate

160 within the lymphatic vasculature led to cell-cell junction defects, regression of valves, and focal v

161 n HLEC(DeltaGATA2) significantly rescues the cell junction defects.

162 cadherin-dependent adhesion forces for cell-cell junction development and enhance local integrin-dep

163 es toward pericellular collagen degradation, cell junction disassembly, and blood endothelial transmi

164 arrhythmogenic cardiomyopathy as desmosome, cell junction disease.

165 um are unable to capture these results, with cell junctions displaying purely elastic or fluid-like b

166 evant low-magnitude CS promotes resealing of cell junctions disrupted by pathologic, high-magnitude C

167 y that Wnt5a specifically activates Cdc42 at cell junctions downstream of ROR2 to reinforce coupling

168 nkage of the actomyosin cytoskeleton to cell-cell junctions drives cell shape change in development a

169 helium is dependent on the formation of cell-cell junctions during levitation and contrasts with the

170 ormation may reduce tension building at cell-cell junctions during morphogenesis.

171 agen chains in the BM, was found to modulate cell junction dynamics at the BTB and apical ES.

172 n vivo through the regulation of endothelial cell-junction dynamics and collective migration.

173 We show that tension at cell junctions equilibrates over a few seconds, a short

174 embryos lacking both Canoe and Polychaetoid, cell junctions fail early, with multicellular junctions

175 lly related processes, including cell cycle, cell junction, focal adhesion, and WNT signaling.

176 hgef7b/Pak signaling, which helps coordinate cell junction formation between atrioventricular cardiom

177 individual cells, lateral migration and cell-cell junction formation precede matrix invasion.

178 equired for focal adhesions, epithelial cell-cell junction formation, and microfibril deposition.

179 e extracellular matrix while preserving cell-cell junctions, forming patent structures that support b

180 ased N-cadherin internalization and abnormal cell junctions, generating an ectopic neuronal layer tha

181 enes were upregulated, whereas expression of cell junction genes was reduced.

182 Maintenance of nephrin within this unique cell junction has been proposed to require dynamic phosp

183 Cadherin-based cell-cell junctions help metazoans form polarized sheets of c

184 Polychaetoid stabilize Bazooka/Par3 at cell-cell junctions, helping maintain balanced apical contrac

185 At the level of cell-to-cell junctions, HGF attenuates the linkage of stress fib

186 lpha-actinin-4 and actin accumulation at the cell junction in a time- and tension-dependent manner du

187 g the plasma membrane (PM) at the PD cell-to-cell junction in Arabidopsis thaliana.

188 and increases E-cadherin expression and cell-cell junction in epithelial cells.

189 ma - which suggests the pivotal role of cell-cell junction in the pathological changes of asthma.

190 after cell wall degradation weakens stomium cell junctions in each anther locule, and desiccation cr

191 the apical region (zonula adherens) of cell-cell junctions in epithelia, where clusters of the adhes

192 ibronectin-induced focal adhesions, and cell-cell junctions in epithelial cultures.

193 , leading to disruption of inter-endothelial cell junctions in human brain microvascular endothelial

194 essed, and protein is mislocalized from cell-cell junctions in human breast cancers.

195 colocalizes with keratin filaments near cell-cell junctions in migrating mesendoderm.

196 N-WASP was not present at cell-cell junctions in monolayers under resting conditions, b

197 wed reduced localization at endothelial cell-cell junctions in postnatal retinas after Vegfr3 deletio

198 tion may contribute to dynamic regulation of cell junctions in processes such as embryogenesis and wo

199 aracellular diapedesis by opening their cell-cell junctions in response to the presence of an adherin

200 demonstrate an enhanced dissociation of cell-cell junctions in stiffer and more confined three-dimens

201 robe the mechanical properties of epithelial cell junctions in the early Drosophila embryo.

202 DAPLE localizes to apical cell-cell junctions in the neuroepithelium, where it activate

203 ostaining revealed impaired endothelial cell-cell junctions in the presence of either metastatic TCM

204 Retinoschisin (RS1) is involved in cell-cell junctions in the retina, but is unique among known

205 5A expressing cells showed Claudin-1 at cell-cell junctions, in the cytoplasm and nuclei.

206 forces and was evenly distributed along cell-cell junctions independent of cell spread area and total

207 lin plays a critical role in regulating cell-cell junction integrity.

208 actomyosin belt, which is required for cell-cell junction integrity.

209 ia is the subdivision of the cell surface by cell junctions into apical and basolateral domains.

210 er regulatory protein of cadherin-based cell-cell junctions, intracellular signaling, and tissue home

211 ability caused by distorted endothelial cell-cell junctions is associated with the no-reflow phenomen

212 show that formin activity at epithelial cell-cell junctions is important for adhesion and the mainten

213 stinal tract suggest that disruption of cell-cell junctions is required to initiate epithelial immune

214 embrane proteins localized on different cell-cell junctions, is of vital importance to the faithful d

215 ned between adjacent projections is a unique cell junction known as the slit diaphragm, which is phys

216 epithelium, the aberrant regulation of cell/cell junctions leads to intestinal barrier defects, whic

217 VE-cadherin at endothelial cell-cell junctions links the contractile acto-myosin cytoske

218 and the interacting kinesin Kif1B coordinate cell junction maintenance and planar spindle positioning

219 est that high E-cadherin in those supporting cell junctions may be responsible, in part, for the perm

220 C2-KD increased focal adherens and disrupted cell junctions, mediated by increased ROCK activation.

221 is also necessary for the expression of the cell junction molecules VE-cadherin and claudin 5 in lym

222 llel to the axis of channels lose their cell-cell junctions more readily than those oriented in the p

223 pathway inhibition via Y27632 disrupted cell-cell junction morphology, showing that cell contractilit

224 Rs were enriched among the genes involved in cell junction, neuronal morphogenesis and neurodevelopme

225 Chimeric reads that match a known virus-cell junction of HPV18 integrated in HeLa cells were als

226 measure the tension in individual epithelial cell junctions of cells in various locations and orienta

227 reover, we noted that IGPR-1 stabilizes cell-cell junctions of endothelial cells as determined by sta

228 3 but not p120-1 is highly expressed in cell-cell junctions of simple gastrointestinal epithelia such

229 Furthermore, Shp2 deletion impaired the cell junctions of the primary Sertoli cells and failed t

230 ected, Shp2 restoration largely restores the cell junctions of the primary Sertoli cells and the clon

231 beta-Catenin is reduced at the lateral cell-cell junctions of wound-edge epidermal cells in the earl

232 goblet cell exocytosis; however, LAP-induced cell junction opening may be an alternative bacterial st

233 ld is not impacted by the maturation of cell-cell junctions or pressure gradient across the monolayer

234 Epithelial (E)-cadherin-mediated cell-cell junctions play important roles in the development a

235 nosensitive tension remodeling of epithelial cell junctions promotes robust epithelial shape changes

236 cell cytosol, perturbing the localization of cell junction proteins (e.g., occluden-ZO-1, N-cadherin-

237 tic capillaries with upregulated endothelial cell junction proteins and a continuous basement membran

238 gment homeobox (Msx) genes alters epithelial cell junction proteins during embryo implantation.

239 ace ectoderm, in which up-regulation of cell-cell junction proteins is associated with an actomyosin-

240 ients exhibit changes in the distribution of cell junction proteins similar to those seen in the hear

241 echanisms linking mechanical strain and cell-cell junction proteins to cellular responses are poorly

242 Cell morphology and the abundance of cell-cell junction proteins were evaluated by confocal micros

243 st its PDZ-binding motif that interacts with cell junction proteins.

244 functions, including the maintenance of cell-cell junctions, regulation of the epithelial-mesenchymal

245 mechanical tugging force necessary for cell-cell junction reinforcement and maintenance.

246 However, force studies at cell-cell junctions remain a challenge.

247 isms regulating actin polymerization at cell-cell junctions remain poorly understood.

248 In addition, Mgc's function at cell-cell junctions remains unclear.

249 iched pathways in the CK5+ cell cluster were cell junction remodeling and signaling.

250 wed overexpression of genes involved in cell-cell junction remodeling, adhesion, and diapedesis, whic

251 ar processes, including cytokinesis and cell-cell junction remodeling.

252 functions from transcriptional regulation to cell junction remodelling.

253 s revealed Afadin, a known component of cell-cell junctions required to couple intercellular adhesion

254 sis of lobes at two-cell junctions and three-cell junctions, respectively.

255 Cell-cell junctions respond to mechanical forces by changing

256 Closer examination of cell-cell junctions revealed that blebbistatin impaired adher

257 nding protein that also co-localizes to cell-cell junctions, reversed the effects of Galpha13 knockdo

258 C permeability was linked to dissociation of cell junction scaffold afadin from the adherens junction

259 ce to apoptosis, immune evasion, and loss of cell junctions seen in H. pylori-infected host cells.

260 re on lipid metabolism, oxidative stress and cell junction signaling in testes.

261 ecessary for successful cytokinesis and cell-cell junction structure.

262 Transmission electron microscopy reveals cell junction structures likely to be involved in interc

263 t was shown that HAX1 knockdown affects cell-cell junctions, substrate adhesion, and epithelial cell

264 rtion of extracellular matrix fluid at three-cell junctions such that cell adhesion is locally disrup

265 t the intercalated disk (ICD), a unique cell-cell junction that couples cardiomyocytes.

266 focal adhesion-like structures near the cell-cell junction that degrade force transmission between ce

267 functionally important interendothelial cell-cell junctions that form during lymphatic development.

268 Desmosomes are cell-cell junctions that link tissue cells experiencing inten

269 Desmosomes are macromolecular cell-cell junctions that provide adhesive strength in epithel

270 Desmosomes are cell-cell junctions that provide mechanical integrity to epit

271 h N25Q PECAM-1 concentrates normally at cell-cell junctions, the ability of this mutant form of PECAM

272 At acutely stretched cell-cell junctions, the immediate, reversible conformation c

273 er dynamic force loading at reannealing cell-cell junctions, the R551A mutant bound more vinculin tha

274 s are established and become cleared of cell-cell junctions, thereby allowing continuous central lume

275 t the concept that the ZO-1 shuttle from the cell junction to the cytonuclear compartment may affect

276 stalk cells coordinately remodel their cell-cell junctions to allow collective migration and extensi

277 This requires cell-cell junctions to allow dynamic remodeling while resisti

278 es machinery that enables it to move through cell junctions to avoid neutralizing antibodies.

279 e extracellular spread from axon tips across cell junctions to epithelial cells.

280 Epithelial cells connect via cell-cell junctions to form sheets of cells with separate cel

281 the Hippo pathway kinases Lats1/2 at apical cell junctions to induce Yap phosphorylation and cytopla

282 ivity operates continuously at cadherin cell-cell junctions to keep them shut and to prevent myosin I

283 rs (VEGFRs) that resides at endothelial cell-cell junctions transduces signals important for flow-dep

284 ontributes to the dynamic regulation of cell-cell junction turnover required for collective cell migr

285 g this experimental platform to mimic a cell-cell junction, we found that the signaling complex is no

286 ctivation and remodeling of endothelial cell-cell junctions were addressed by using human endothelial

287 anosensitive recruitment of vinculin to cell-cell junctions when anillin is overexpressed suggested t

288 mic "flares" of Rho-GTP are observed at cell-cell junctions, whereas overall junctional F-actin and m

289 and the attachment of actin networks to cell-cell junctions, which allows forces to be transmitted be

290 tegrity of cell clusters is dictated by cell-cell junctions, which depend on subcellular forces and a

291 cell-cell interfaces and measure tension at cell junctions, which is on the order of 100 pN.

292 tivation determines Src localization to cell-cell junctions, which then induces increased vascular en

293 Alp1 damages bronchiolar cell junctions, which triggers a calcium flux signaled t

294 undergo molecular specification and remodel cell junctions while remaining connected to their epithe

295 DLG1/ZO-1) domain scaffold present at apical cell junctions whose mutation in humans is linked to non

296 ates the linkage of stress fibers to cell-to-cell junctions with concomitant decrease in intercellula

297 earance of polarized apical microtubules and cell junctions with increased levels of stable PCP compo

298 al growth reduces cytoskeletal tension along cell junctions within faster-growing cells.

299 of cadherin-catenin complex proteins at cell-cell junctions within the cluster to keep border cells t

300 mistry confirmed the presence of markers for cell junction (ZO1, Desmoplakin), basement membrane asse