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1 mas that originate from cells of the Schwann cell lineage.
2 tion, often culminates in the mortality of a cell lineage.
3 al control mechanisms arising in the myeloid cell lineage.
4 renewal and reduced HSPC commitment to the B cell lineage.
5 al, biallelic deletion of Nf1 in the Schwann cell lineage.
6 t action potentials, hallmarks of a neuronal cell lineage.
7 nd T cells that are diverted into the T(reg) cell lineage.
8 ed from a single dominant hematopoietic stem cell lineage.
9 asymmetric division that segregates the germ cell lineage.
10 on of self-reactive thymocytes into the Treg cell lineage.
11 e indefinitely, because of its immortal germ-cell lineage.
12 or OR signal transduction, likely because of cell lineage.
13 for either MyD88 or the IL-12Rbeta2 in the T cell lineage.
14 sticity in an otherwise invariant C. elegans cell lineage.
15 , and author online at cell.com/i3/cell-stem-cell/lineage.
16 e to incisor MTACs and the other mesenchymal cell lineages.
17 bute to cellular heterogeneity in dysplastic cell lineages.
18 mbryo, where they differentiate into various cell lineages.
19 rns, arising from specific oncogenotypes and cell lineages.
20 c gene expression that varies between clonal cell lineages.
21 ing and differentiation of airway epithelial cell lineages.
22 upregulated in the myeloid and follicular B cell lineages.
23 ing progenitor cell differentiation in other cell lineages.
24 roper division patterns of various embryonic cell lineages.
25 otency for all embryonic and extra-embryonic cell lineages.
26 types and the developmental trajectories of cell lineages.
27 te fate in favor of progenitor and secretory cell lineages.
28 loci that reconfigure to specify hippocampal cell lineages.
29 anelle and pathway markers in three distinct cell lineages.
30 ivision, which is comparable with other stem cell lineages.
31 hat are specific to developmental periods or cell lineages.
32 merged chromatin profiles from distinct stem cell lineages.
33 of neurulation, during the establishment of cell lineages.
34 ation of mesenchymal stem cells into various cell lineages.
35 of efficacy and contained all differentiated cell lineages.
36 stance in EGFR-dependent cancers of multiple cell lineages.
37 erentiation and function of other effector T cell lineages.
38 ot and coldspot motifs in the evolution of B-cell lineages.
39 can present alternative antigens to other T cell lineages.
40 xpressed predominantly in the hematolymphoid cell lineages.
41 lly modified or differentiated into multiple cell lineages.
42 anti-cancer agents on multiple hematopoietic cell lineages.
43 unicellular microspore segregates these two cell lineages.
44 -specific expansion within different myeloid cell lineages.
45 h, despite the underlying variability of the cell lineages.
46 ctive of the cell division rate of different cell lineages.
47 itiating segregation of somatic and germline cell lineages.
48 ic cell fate, including differentiation of B-cell lineages.
49 underlying the development of hematopoietic cell lineages.
53 oids resembled blastocysts in morphology and cell-lineage allocation and recapitulated key morphogene
58 ructed differentiation trajectories for each cell lineage and identified gene modules and putative re
59 Finally, differences in infection status, cell lineage and MHC class II expression by antigen-bear
61 an EE cell fate at the expense of the Paneth cell lineage and the effect ceases as cells mature to EE
62 y excess accumulation of one or more myeloid cell lineages and a tendency to transform to acute myelo
63 ing (scRNA-seq) technologies for identifying cell lineages and bona fide transcriptional signals, it
64 complex mixtures of cancer cells by tracing cell lineages and discovering cryptic genetic variations
66 unt's capabilities, we track intestinal stem cell lineages and gut microbial colonization in single a
67 ols the differentiation of most, if not all, cell lineages and many aspects of cell and tissue physio
68 ntiviral vector integration, thereby marking cell lineages and modifying the cellular genome by inser
69 development alongside the emergence of mural cell lineages and persists throughout adulthood across b
70 e (Zea mays) that includes several different cell lineages and present whole-genome replication timin
71 tperforms existing algorithms in identifying cell lineages and recapitulating gene expression trends
72 mice demonstrated deficiencies in multiple B-cell lineages and reduced serum IgA and elevated IgM lev
74 gnatures of evolution are evident in human B cell lineages and reveal how antibodies evolve somatical
75 improbable mutations, could initiate bnAb B cell lineages and select for key improbable mutations re
76 EPS-blastoids contained all three blastocyst cell lineages and shared transcriptional similarity with
77 ther, these recent advances in understanding cell lineages and the signaling factors that drive cell
78 these seven cell populations, covering major cell lineages and tissues in the worm, reveal the comple
79 and similarities between gene expression in cell lineages and tissues should be of great value to th
81 aneous reconstruction of neuronal cell type, cell lineage, and sequential neuronal formation ("birthd
82 orks based on the order of RT changes within cell lineages, and identified master regulators of diffe
83 ted the developmental trajectory of distinct cell lineages, and thereby identified the genetic cascad
84 f Tregs and that NRF2 activation in multiple cell lineages appears to be required for sufficient anti
85 yonic reproducibility: Their early embryonic cell lineages are considered invariant and are conserved
86 mental properties that distinguish these two cell lineages are often confusing and difficult to disse
89 Concurrently, germ layers are formed and cell lineages are specified, leading to the establishmen
90 c crypt depth and lower numbers of secretory cell lineages, as well as impaired epithelial cells in t
91 T2 was not expressed within the developing B cell lineage at either the transcript or protein level.
93 s issue of Cancer Cell, Wang et al. define a cell-lineage-based stratification model for glioblastoma
94 nomously by CC axons or by the IG astroglial cell lineage, but rather acts non-cell autonomously to s
95 entiation of multiple innate and innate-like cell lineages, but how Zbtb16 itself is regulated remain
96 therefore be used to deconstruct an extended cell lineage by tracking the reporters expressed in the
97 expression frequency was a function of the T cell lineage (CD8 > CD4) and a function of the memory di
101 l thymic epithelial cells (cTECs) regulate T cell lineage commitment and positive selection, while me
102 fy an unexplored pathway that controls liver cell lineage commitment and whose dysregulation may play
103 tive medicine, techniques which control stem cell lineage commitment are a rapidly expanding field of
105 ween H3K27me3 and telomere integrity in stem cell lineage commitment that may have implications in ag
106 mTEC) lineages are essential for inducing T cell lineage commitment, T cell positive selection and t
112 lecular stratification provides insight into cell lineage correlates of non-functional PNETs, accurat
113 a powerful new methodology to predict single cell lineage decisions by integrating high content super
114 ed, as well as which signaling factors drive cell lineage decisions, provides specific targets to man
116 eromones correct heterochronic developmental cell lineage defects caused by insufficient expression o
119 (SCRM) platform was able to identify neural cell lineages derived from clinically relevant human ind
120 using transcriptomic data from the different cell lineages derived from the hPSC-epi delivered a core
121 an elaborate developmental program involving cell lineage determination, morphogenesis, and dynamic s
122 In mammals, recent experiments suggest that cell lineage determines the connectivity of pyramidal ne
126 lecular pathways governing the hemangiogenic cell lineage development.How haematopoietic and endothel
129 report that, unlike previously characterized cell lineages, differentiation of syncytiotrophoblast (S
130 /-) mice lacking PTP1B in the innate myeloid cell lineage displayed a dysregulation of bone marrow ce
131 ts, numerous questions remain regarding tuft cell lineage, diversity and effector mechanisms and how
133 function of colonic epithelia and secretory cell lineages, EP4 cKO colon stroma showed enhanced immu
134 us, SOX2 is a master regulator of the acinar cell lineage essential to the establishment of a functio
135 ammalian blastocysts comprise three distinct cell lineages essential for development beyond implantat
136 therefore expected to evolve only when the B cell lineage evolving breadth is consistently capturing
138 type evolved by outcompeting other embryonic cell lineages for an essential signaling ligand that reg
140 sequencing, we have separated four distinct cell lineages from the Anopheles gambiae male gonads: pr
141 ssor (VHL) protein in the forkhead box FOXD1 cell lineage, from which stromal progenitors arise.
142 Hierarchical clustering using pancreatic cell lineage genes was used to assign cells into cell-ty
143 ro-B cells express transcripts of many non-B cell lineage genes, including genes that are characteris
147 e self-renewal and differentiation of a stem cell lineage have been extensively studied, it remains p
148 us infection and systemic diseases such as B-cell lineage hematologic malignancies and connective tis
149 characterization of the prostate epithelial cell lineage hierarchy are critical for understanding pr
152 ells and to both supporting and interstitial cell lineages, implying that cells in the CE domain are
153 These results highlight the importance of cell lineage in glioblastoma independent of driver mutat
154 ed with early commitment to the follicular T-cell lineage in IgA-deficient CVID subjects, particularl
155 us highlighting an instructive role of tumor cell lineage in reprogramming the stromal microenvironme
157 clear phagocyte system (MPS) is defined as a cell lineage in which committed marrow progenitors give
161 to assess changes in expression in multiple cell lineages in MS lesions and validated the results us
165 ive cells within the parenchymal epithelium, cell lineages in the stroma that may directly contribute
166 at later developmental stage in the Schwann cell lineage, in addition to biallelic Nf2 gene inactiva
167 n the ability to differentiate down multiple cell lineages including chondrocytes, adipocytes, osteob
168 genes that were associated with the innate T cell lineage, including Zbtb16, which encodes PLZF, and
169 identified >30 populations representing nine cell lineages, including a previously undescribed fibrob
170 sor after loss of BMP signaling in the Gli1+ cell lineage, indicating that BMP signaling is required
171 gree of functional differentiation of the NK cell lineage influences the magnitude and specificity of
172 In addition, BMP signaling in the Gli1+ cell lineage is also required for the maintenance of qui
173 ed thymocytes into the regulatory T (T(reg)) cell lineage is driven by intrathymic encounter of agoni
174 self-renewal and migration of developmental cell lineages is closely linked to the proliferative and
175 required for differentiation of other blood cell lineages, its function during granulopoiesis has re
176 Fundamentally, the autoantigen-specific B cell lineage leads to production of the pathogenic autoa
177 profound upregulation of markers of non-mast cell lineages, loss of proliferative control, chromatin
178 stood how tissues that contain multiple stem cell lineages maintain balanced proliferation among dist
179 nscriptome trajectories to construct virtual cell-lineage maps and provisional gene networks for 41 n
181 nested spontaneous DNA somatic mutations as cell lineage markers, identified from joint analysis of
183 ression and reduced expression of key Merkel cell lineage/MCC marker genes, including HES6, SOX2, ATO
185 veloped to infer clusters, marker genes, and cell lineage, none yet integrate these within a mathemat
189 dy evidenced the heterogeneous nature of the cell lineage output from HSPCs and provided methods for
190 erentiation and maturation of multiple blood cell lineages over 4 weeks while improving CD34(+) cell
191 nderstanding of ZEB regulation across immune cell lineages, particularly in mice, highlighting presen
192 atform can characterize tens of thousands of cell lineages per day, making it possible to accurately
193 to SFTS, and identified antibody-producing B cell-lineage plasmablasts and macrophages as principal t
194 ecursors, while constraining their dendritic cell lineage potential and enforcing commitment to ILC f
197 approach to discern early divergence in stem cell lineage progression via temporal dynamics of the cy
199 tations in mitochondrial DNA can reconstruct cell lineage relationships at single cell resolution wit
200 Continuity, robustness, and regeneration of cell lineages relies on stem cell pools that are establi
202 rains by demonstrating a rapid assessment of cell lineage requirements (AB versus P1) for a set of ge
203 and paracrine fashion, and as such, the host cell lineage responsible for the production of RA metabo
204 1) by Mb1-Cre (designated DKO mice) in the B cell lineage resulted in severe defects in the developme
205 ression, with pseudotime analysis of several cell lineages revealing both known and novel genes that
206 t of in vivo automated techniques for single-cell lineaging, sequencing and analysis of gene expressi
207 t of in vivo automated techniques for single-cell lineaging, sequencing, and analysis of gene express
209 inity-mature large numbers of Env-specific B cell lineages simultaneously, supporting the use of regi
211 velopmental trajectories, identified pigment cell-lineage specific responses to TH, and assessed role
212 ene loci that underpins appropriate CD8(+) T cell lineage-specific commitment and differentiation.
215 ted with increased expression of the myeloid cell lineage-specific transcription factor IRF8 in MDSCs
216 acted in ETPs to establish and maintain a T-cell-lineage-specific enhancer repertoire, including reg
220 h ligand Delta-like ligand-4 to facilitate T cell lineage specification of mouse and human hematopoie
221 the NFI proteins may play distinct roles in cell lineage specification or maintenance, and establish
225 tly, RB1 specifies epigenetically determined cell lineage states that are disrupted during therapy re
226 en by an edition sequence), a technology for cell lineage studies based on CRISPR-Cas9 techniques.
227 e to subtle temporal changes within the same cell lineage, successfully integrating functionally simi
228 ture that can be differentiated into various cells lineages such as adipogenic, osteogenic, and chond
229 ides by immunogen design can be applied to B cell lineages targeting other pathogens where guided aff
230 Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and ca
232 iple transposition bursts in a given somatic cell lineage that later contributes to differentiation o
234 rospores, enabling formation of the two male cell lineages that are essential for sexual reproduction
235 The thymus supports multiple alphabeta T cell lineages that are functionally distinct, but mechan
237 ultidimensional approach to isolate specific cell lineages that can be used for the targeted analysis
240 permatogenesis is a classic model of cycling cell lineages that depend on a balance between stem cell
242 networks, enabling reconstruction of complex cell lineages that include feedback or feedforward inter
245 us, the mammalian embryo first specifies two cell lineages: the pluripotent inner cell mass that form
246 75NTR) is a key regulator of the melanocytic cell lineage through its ability to mediate cell growth,
248 d stem cells are differentiated into desired cell lineages through biochemical, biological, and biome
257 as (TCGA), functional approaches, and single-cell lineage tracing to derive a unified model of cellul
259 sion, glandular fission, and more rapid stem cell lineage tracing, a process that can be suppressed b
270 his fact using (i) averages over an isolated cell lineage tracked over many generations as observed i
271 this Review, we discuss these techniques for cell lineage tracking, with attention both to those that
274 ee implements a fast heuristic for inferring cell lineage tree and calling the genotypes that allow t
275 e a new method called ScisTree, which infers cell lineage tree and calls genotypes from noisy single
277 Biologists have long sought to trace this cell lineage tree in individual organisms and have devel
283 Here we describe EMBLEM, a strategy to track cell lineage using endogenous mitochondrial DNA variants
285 istical method, LinTIMaT, which reconstructs cell lineages using a maximum-likelihood framework by in
286 ng differentiation of the monolayers, the EC cell lineage was significantly altered by both the cultu
287 d contribute progeny to all major pancreatic cell lineages, we also identify numerous unipotent endoc
288 rive cellular differentiation into secretory cell lineages, we show that although goblet cells resist
289 shape will strongly influence the fate of a cell lineage: we describe a mechanism through which cocc
290 x1 expression becomes restricted to the beta-cell lineage, where it plays a central role in beta-cell
291 rent rates of clones that arose from B and T cell lineages, which predicted the relative rates of B a
292 ells acquire phenotypic characteristics of a cell lineage whose survival no longer depends on the dru
293 ate that progenitor cells generate pyramidal cell lineages with a wide range of sizes and laminar con
294 indicate that the development of numerous B cell lineages with antibody features associated with aut
295 e chromosomal mosaicism, defined by multiple cell lineages with distinct chromosome complements.
296 ntaining versatile clinically relevant tumor cell lineages with regard to the expression of AR and th
297 mpact of previous immune activity on various cell lineages with the goal of presenting a unified view
298 introduces variability in the wild-type seam cell lineage, with a proportion of animals showing an in
299 iling revealed an overall increase in innate cell lineages, with a concomitant reduction in T cell nu
300 d a methodology for live imaging of the germ cell lineage within floral organs of Arabidopsis using l