ライフサイエンスコーパス: cell metabolism

1 role in regulating mitochondrial fusion and cell metabolism.

2 hrough poorly defined mechanisms to modulate cell metabolism.

3 d hierarchical organization of breast cancer cell metabolism.

4 his occurs through alteration of endothelial cell metabolism.

5 repair, cell migration and invasiveness, and cell metabolism.

6 ver previously unexplored roles of TDP-43 in cell metabolism.

7 collagen-derived proline contributes to PDAC cell metabolism.

8 tabolic pathways with an influence on cancer cell metabolism.

9 to monitor the effect of therapy on myeloma-cell metabolism.

10 in live cells and gaining new insights into cell metabolism.

11 phorylation, signaling, gene regulation, and cell metabolism.

12 as long been considered a hallmark of cancer cell metabolism.

13 for HPV-associated malignancies by targeting cell metabolism.

14 rtunity to discover drugs that target cancer cell metabolism.

15 ignificant alteration of pathways related to cell metabolism.

16 tions including phagocytosis, autophagy, and cell metabolism.

17 in to assess the effects of 380 compounds on cell metabolism.

18 ents that specifically interfere with cancer cell metabolism.

19 tores, increases autophagy and restores beta-cell metabolism.

20 inositol biosynthesis, with broad effects on cell metabolism.

21 ce due to specific changes in energy and fat cell metabolism.

22 nes likely to be involved in rewiring cancer cell metabolism.

23 ld represent a new role for Wnt signaling in cell metabolism.

24 sregulated pathway that is critical for TNBC cell metabolism.

25 ed whether mitochondrial dynamics controls T cell metabolism.

26 ramming, naive/primed pluripotency, and stem cell metabolism.

27 are implicated in the regulation of RNA and cell metabolism.

28 ion and acts as critical regulator of tumour cell metabolism.

29 agy as a salvage pathway supporting leukemia cell metabolism.

30 by the DNA damage that arises during normal cell metabolism.

31 , were predicted to be dispensable in normal cell metabolism.

32 1-alpha degradation and takes control of Tr1 cell metabolism.

33 iciency, acts as central metabolic switch in cell metabolism.

34 nt demands of cancer cannot be met by normal cell metabolism.

35 sis, cytokine secretion, gene expression and cell metabolism.

36 ols mitochondrial Ca(2+) entry and regulates cell metabolism.

37 administered medications by targeting cancer cell metabolism.

38 glucose (2DG), a pharmaceutical that targets cell metabolism.

39 ng how C. trachomatis is able to hijack host cell metabolism.

40 factors play a major role in shaping cancer cell metabolism.

41 and how diet and nutrition influence cancer cell metabolism.

42 (also called LKB1) regulates stem cells and cell metabolism.

43 ery which dynamically and actively regulates cell metabolism.

44 rs for tumor suppression by targeting cancer cell metabolism.

45 deadly lymphoma in chickens and hijacks host cell metabolism.

46 al processes important for cancer, including cell metabolism.

47 rged as key components in determining cancer cell metabolism.

48 and 19 downregulated proteins with roles in cell metabolism.

49 he emerging functions of the complosome in T cell metabolism.

50 al of adoptive cell therapies by enhancing T cell metabolism.

51 media could revolutionize the monitoring of cell-metabolism.

52 lishes miR-22 as a novel regulator of tumour cell metabolism, a function that could contribute to the

53 synthetic demands of activated cells, immune cell metabolism also has direct roles in controlling the

54 Thus, changes in cell metabolism alter Hh signalling through their effect

55 In a recent paper in Cell Metabolism, Altman et al. (2015) report that MYC di

56 sophila to investigate the interplay between cell metabolism and a key developmental regulator-the He

57 is as a regulator of resting CD8(+) memory T cell metabolism and activity in humans.

58 s-2 signaling preferentially regulates tumor cell metabolism and adds to our understanding of how thi

59 regulates biological activities, involved in cell metabolism and aging.

60 y receptors present in the TME can inhibit T cell metabolism and alter T cell signaling both directly

61 ated protein kinase is a master regulator of cell metabolism and an attractive drug target for cancer

62 ligase Peli1 as an important regulator of T cell metabolism and antitumor immunity.

63 and downstream mTORC1-mediated actions on T cell metabolism and antitumor immunity.

64 himeric antigen receptor (CAR) can control T cell metabolism and balance the response toward long-liv

65 Because our understanding of immune cell metabolism and cancer metabolism has grown signific

66 , including intracellular Ca(2+) signalling, cell metabolism and cell death.

67 of adoptive cell therapy by reprogramming T-cell metabolism and cytokine expression.

68 t of organic acids plays a key role in plant cell metabolism and demonstrate that AtQUAC1 reduce diff

69 erstanding miRNA signaling underlying cancer cell metabolism and development of new strategies for th

70 WNT signaling in the reprogramming of cancer cell metabolism and examines the role of these signaling

71 function, the mechanisms that regulate Treg cell metabolism and function remain unclear.

72 ever, how nutrient availability influences T cell metabolism and function remains poorly understood.

73 te P2Y11 receptor stimulation that impairs T cell metabolism and functions.

74 iological networks including cell signaling, cell metabolism and gene regulation.

75 The lysosomal Ragulator complex regulates cell metabolism and growth by coordinating the activitie

76 oles in normal cells (including coordinating cell metabolism and growth), highlighting the features o

77 a pleiotropic role in the control of cancer cell metabolism and has been associated with a good prog

78 enes important for general functions such as cell metabolism and homeostasis.

79 tions between oncogenic signaling and cancer cell metabolism and how these links may be exploited for

80 Ndfip1 restricts Treg cell metabolism and IL-4 production via distinct mechani

81 ng able to unravel the interaction of cancer cell metabolism and immune metabolism in therapeutically

82 e microbial pathogenesis as well as the host cell metabolism and immune responses.

83 er cell biology, particularly altered cancer cell metabolism and impaired DNA repair processes, is pr

84 ups reduce the perturbations caused by GO on cell metabolism and increase biocompatibility.

85 pamycin (mTOR) regulates stem and progenitor cell metabolism and is frequently dysregulated in human

86 The complex cell metabolism and its link to oncogenic signaling path

87 repressor Zbtb20 negatively regulates CD8 T cell metabolism and memory differentiation in mice.

88 ls were enriched in proteins associated with cell metabolism and MFM223 cells enriched in proteins as

89 arboxylate transporters (MCT) modulate tumor cell metabolism and offer promising therapeutic targets

90 gy is demonstrated here in the analysis of T cell metabolism and other large-scale metabolomic studie

91 g this loss of secretion are defects in beta-cell metabolism and perturbed mitochondrial structure.

92 ious consequences for the colonic epithelial cell metabolism and physiology in terms of mitochondrial

93 gnificant correlations between measures of T cell metabolism and plasma cytokine abundance that diffe

94 Changes in cell metabolism and plasma membrane potential have been

95 ctivation of an immune response, a switch in cell metabolism and processes related to muscle contract

96 support a novel role for Itch in limiting B cell metabolism and proliferation to suppress antigen-dr

97 For example, HIV-induced changes in immune cell metabolism and redox state are associated with CD4(

98 ith increased expression of genes related to cell metabolism and respiration.

99 oints towards its overall effect in lowering cell metabolism and RNA processing and modification.

100 cing agents, which are currently involved in cell metabolism and signaling pathways, can regulate fas

101 all inositol compounds, has pivotal roles in cell metabolism and signaling pathways.

102 mineral for both prokaryotic and eukaryotic cell metabolism and structure.

103 encing both cardiac contractile function and cell metabolism and survival and contributing to HF inde

104 rcuits highlight pathways involved in immune cell metabolism and the cell cycle, including mTOR signa

105 A causal relationship between cell metabolism and the fate of pluripotent stem cells t

106 dependent NAD(+) biosynthesis contributes to cell metabolism and to the DNA repair process in a subse

107 (PKM), which plays a critical role in cancer cell metabolism and tumor growth.

108 hosphate pathway (PPP) is crucial for cancer cell metabolism and tumor growth.

109 rein), in Myc-mediated alterations in cancer cell metabolism and tumorigenesis.

110 sting a sophisticated interplay between host cell metabolism and virus replication.

111 t vector titres due to biological effects on cell metabolism and/or on the vector virion itself.

112 developing principles in the regulation of T cell metabolism, and discuss how these processes are aff

113 ysis ((13)C-MFA), offer direct insights into cell metabolism, and have been widely used to characteri

114 energetics, and redox homeostasis in immune cell metabolism, and how these factors are reflected in

115 is reduced lipid storage, reprogrammed tumor cell metabolism, and inhibited invasive migration in vit

116 long been considered a "waste" by-product of cell metabolism, and it accumulates at sites of inflamma

117 ancer-related signaling networks, intestinal cell metabolism, and physiology in a three-dimensional e

118 ffles, is critical for antigen presentation, cell metabolism, and signaling.

119 s, cell growth and proliferation, autophagy, cell metabolism, and stress responses, whereas mTORC2 se

120 used in the care of patients with SLE affect cell metabolism, and the development of novel therapeuti

121 Obesity-associated changes in T-cell metabolism are associated with impaired T-cell resp

122 Given that coordinated shifts in T cell metabolism are essential for T cell responses to nu

123 ts that activate autophagy and reprogram PDA cell metabolism are unknown.

124 nd activation, but recent findings highlight cell metabolism as a crucial regulator of these processe

125 rently, the effect of HCMV infection on host cell metabolism as an increase in glycolysis during infe

126 which is provided by the cytoskeleton, using cell metabolism as its energy source, and the dynamic in

127 d postembryonic development and critical for cell metabolism at all stages of life.

128 rial dysfunction, methods for studying brain cell metabolism at high spatial resolution are needed to

129 hagy actively suppresses haematopoietic stem-cell metabolism by clearing active, healthy mitochondria

130 y be generated endogenously in the course of cell metabolism by cytochrome P450, by oxidative stress

131 contributed to dysfunction, as a rescue of T cell metabolism by genetically increasing Akt/mTORC1 sig

132 Photosynthetic organisms support cell metabolism by harvesting sunlight to fuel the photo

133 article centers on the manipulation of host cell metabolism by human cytomegalovirus (HCMV).

134 A recent study published in Cell Metabolism by Wu et al. (2019) shows that DR repres

135 Emerging evidence suggests that cancer cell metabolism can be regulated by cancer-associated fi

136 ccumulation impacts longevity, and how aging cell metabolism can be rewired to modulate lipid accumul

137 Changes in cancer cell metabolism can directly impact epigenetic regulatio

138 Oncogene-driven changes in tumor cell metabolism can impact the TME to limit immune respo

139 le applications including dynamic control of cell metabolism, cell biology and synthetic gene circuit

140 technology that provides direct insight into cell metabolism, cell dynamics and protein activity.

141 h inspire a novel top-down approach to study cell metabolism, combining mass balance and proteomic co

142 data indicate that patients have impaired T cell metabolism consistent with ongoing immune alteratio

143 Eukaryotic cell metabolism consists of processes that generate avai

144 t that programmed differences in infant stem cell metabolism correspond with differences in body comp

145 dependent N-reductive detoxication of HAP in cell metabolism could be demonstrated.

146 Here, we investigated whether cancer cell metabolism defines its susceptibility to OV and if

147 Beyond their role in cell metabolism, development, and reproduction, hormones

148 However, although the roles of glucose in T cell metabolism, diabetes and obesity are well character

149 mary role of LIN28A and LIN28B in modulating cell metabolism, differentiation, and invasion, we hypot

150 Importantly, impaired T cell metabolism directly contributed to dysfunction, as

151 or immunity, suggest that TGF-beta targets T cell metabolism directly, thus diminishing T cell functi

152 k is a systemic inflammation associated with cell metabolism disorders and cardiovascular dysfunction

153 MCJ also adapted effector CD8(+) T cell metabolism during the contraction phase.

154 a pivotal role in biological events such as cell metabolism, early stage apoptosis, and cell differe

155 odulated gradients of cell proliferation and cell metabolism emerging in response to fluid convection

156 iological processes such as abnormalities in cell metabolism, energy production and oxidative stress

157 actor (HIF) transcription factors to control cell metabolism, erythrogenesis, and angiogenesis.

158 ng device to evaluate the cell viability and cell metabolism for a healthy cell line (Human Dermal Fi

159 Engineering cell metabolism for bioproduction not only consumes buil

160 , but little is understood about the role of cell metabolism for natural killer T (NKT) cell survival

161 ueled anaplerosis that reverses basal Muller cell metabolism from production to consumption of glutam

162 n to boost FAO in other tissues, on CD8(+) T-cell metabolism, function, and efficacy in a murine ACT

163 domains, and the minimal effects observed on cell metabolism, further studies are warranted to assess

164 ork and functional information for over 2000 cell metabolism genes in more than 30 cancer types.

165 Thus, a systematic annotation of cancer cell metabolism genes is imperative.

166 some of the osmoregulatory pathways in guard cell metabolism, genes and signals that determine stomat

167 ine to glutamate, plays a key role in cancer cell metabolism, growth, and proliferation.

168 signals and serves as a central regulator of cell metabolism, growth, survival, and stress responses.

169 T cell metabolism has a central role in supporting and sha

170 The role of metabolites produced from stem cell metabolism has been emerged as signaling molecules

171 e tumor microenvironment dysregulated immune cell metabolism has emerged as a key mechanism of tumor

172 Immune cell metabolism has therefore become an attractive targe

173 Contemporary analyses of cell metabolism have called out three metabolites: ATP,

174 Besides its effects on cell metabolism, HO-1 is also capable of modulating host

175 l screening of candidate compounds targeting cell metabolism in a microplate-reader-based assay, alon

176 apshot analysis, allowing spatial mapping of cell metabolism in concert with cell phenotype.

177 and environmental parameters that influence cell metabolism in culture.

178 vident that genetic modifications can affect cell metabolism in HGG; however, it is currently unclear

179 ce of the mutual regulation of autophagy and cell metabolism in maintaining cell homeostasis.

180 disease (GVHD), yet little is known about T cell metabolism in response to alloantigens after hemato

181 Here we report plasticity in effector T cell metabolism in response to changing nutrient availab

182 Our study provides novel insight into cancer cell metabolism in the context of the endothelial microe

183 osis of T cells, little is known regarding T cell metabolism in the progression of human type 1 diabe

184 e effects on flagellar sterol enrichment and cell metabolism in the two life cycle stages.

185 nderstanding of the role of inflammation and cell metabolism in tissue-regenerative responses, highli

186 pact of the MCT1 inhibitor AZD3965 on cancer cell metabolism in vitro and in vivo Exposing human lymp

187 ULBP2 expression was linked to altered host cell metabolism, including increased cytoplasmic (iso)ci

188 whereby stromal fibroblasts regulate cancer cell metabolism independent of genetic mutations in canc

189 ecies and other toxic mediators that disrupt cell metabolism, induce apoptosis, and exacerbate ischem

190 Immune cells' metabolism influences their differentiation and f

191 f insulin that parallel oscillations in beta-cell metabolism, intracellular Ca(2+) concentration, and

192 ia telangiectasia mutated), those within the cell metabolism (IR-alpha, IR-beta, and AMP-activated pr

193 Cancer cell metabolism is a targetable vulnerability; however,

194 Cell metabolism is adaptive to extrinsic demands; howeve

195 ermodynamic modeling, we show that the plant cell metabolism is affected predominantly by hydroxo-spe

196 it remains unclear how lymphatic endothelial cell metabolism is altered in the tumor microenvironment

197 It now becomes clear that cell metabolism is an integral part of the complex lands

198 Immune cell metabolism is dynamically regulated in parallel wit

199 his study, we demonstrate that altered tumor cell metabolism is essential for the regulation of drug

200 Strict regulation of stem cell metabolism is essential for tissue functions and tu

201 e mechanisms of how autophagy supports tumor cell metabolism is essential.

202 Cancer cell metabolism is heavily influenced by microenvironmen

203 nce fumaric acid esters are metabolites, and cell metabolism is highly intertwined with the epigeneti

204 t of different mutant p53 proteins on cancer cell metabolism is largely unknown.

205 T cell metabolism is normally held under tight regulation

206 the interplay between PD-1 inhibition and T cell metabolism is not well studied.

207 t or "passenger" of cell-fate determination, cell metabolism is now starting to take center stage as

208 ytical tools for the investigation of living cell metabolism is still a challenge to be faced.

209 inhibitor protein of F1F0-ATPase) in cancer cell metabolism is still uncertain.

210 Cell metabolism is strongly influenced by mechano-enviro

211 It is recognized that cell metabolism is tightly connected to other cellular p

212 Inflammation-driven changes in host cell metabolism lead to the release of l-lactate and mol

213 increase our understanding of TSC2-deficient cell metabolism, leading to novel potential therapeutic

214 Cancer cell metabolism leads to a uniquely acidic microenvironm

215 rcadian clock and output pathways regulating cell metabolism (lipids and xenobiotics), extracellular

216 Recently in Cell Metabolism, Logan et al. (2016) exploit membrane po

217 standing the impact of MCT blockade on tumor cell metabolism may help develop combination strategies

218 to drugs, genetic variation of patients and cell metabolism may help managing side effects by person

219 ar nutrient signaling pathways regulate beta-cell metabolism may thus offer new targets to improve be

220 Altered beta-cell metabolism may underlie both the progressive impair

221 the CAR costimulatory domain can alter the T cell metabolism, memory differentiation, and influence l

222 late multiple pathways of cancer or parasite cell metabolism, might lead to more effective treatments

223 een TET and two critical enzymes involved in cell metabolism: O-linked beta-N-acetylglucosamine trans

224 the profound (anoikis-independent) impact of cell metabolism on the viability of ECM-detached cells.

225 flammatory effect, with itaconate connecting cell metabolism, oxidative and electrophilic stress resp

226 cer development, the emerging role of p53 in cell metabolism, oxidative responses, and ferroptotic ce

227 uniquely targeting a HIF1alpha/LEO1-mediated cell metabolism pathway.

228 ; however, recent findings suggest that stem cell metabolism plays an important role in the regulatio

229 e a powerful tool to noninvasively analyze T cell metabolism, possibly in vivo.

230 dent deacetylase Sirtuin 1 (SIRT1) regulates cell metabolism, proliferation, and DNA repair and acts

231 r-activated receptor delta (PPARD) regulates cell metabolism, proliferation, and inflammation and has

232 in (CREB) plays key transcriptional roles in cell metabolism, proliferation, and survival.

233 , EGFL9 regulates COX activity and modulates cell metabolism, promoting a Warburg-like metabolic phen

234 assumptions in enzymology, biochemistry and cell metabolism regarding the fate of transiently genera

235 ssed proteins were predominantly involved in cell metabolism, regulation of focal and intracellular c

236 Our knowledge of T cell metabolism relies primarily on studies performed in

237 l understood, whereas our knowledge of guard cell metabolism remains limited, despite several decades

238 , through its ability to link cell cycle and cell metabolism, represents a particularly powerful onco

239 finding has been attributed to altered tumor cell metabolism resulting from these mutations and does

240 Environmental nutrient levels impact cancer cell metabolism, resulting in context-dependent gene ess

241 sphorylation (OXPHOS) and glycolytic rate in cell metabolism studies.

242 hway and C3 being a driver and programmer of cell metabolism suggest that the complement system utili

243 Recently in Cell Metabolism, Szabat et al. (2015) present evidence t

244 tool to provide more detailed information on cell metabolism that are unprecedented in cell biology.

245 o multiple processes and plasticity in guard cell metabolism that enable these cells to function effe

246 novel role for RhoC as a regulator of tumor cell metabolism that extends beyond its well known role

247 to insufficient vascular exchange and cancer cell metabolism that leads to hypoxia, depletion of nutr

248 ablishes a link between nutrition and tumour cell metabolism that may allow for tumour-specific metab

249 Despite their fundamental importance to cell metabolism, the mechanisms by which regions of the

250 A key transcriptional regulator of cell metabolism, the peroxisome proliferator-activated r

251 rties of these key metabolites power much of cell metabolism, the underlying molecular logic remains

252 glycolysis and consequently rescues leukemic cell metabolism, thereby abrogating the antileukemic eff

253 ating the integration of systemic and immune cell metabolism through in-depth analysis of immune cell

254 se phosphate pathway (oxiPPP) contributes to cell metabolism through not only the production of metab

255 Here we show that CAFs regulate malignant cell metabolism through pathways under the control of FA

256 nscription factor HIF1alpha and reprogrammed cell metabolism to a glycolytic state.

257 In addition, loss of KEAP1 altered cell metabolism to allow cells to proliferate in the abs

258 stabilized under energy shortage and reshape cell metabolism to allow energy regeneration, we propose

259 tBP1 is a critical factor linking changes in cell metabolism to cell phenotype in hypoxic and other f

260 Here we find that p53 remodels cancer-cell metabolism to enforce changes in chromatin and gene

261 ic structure that mediates the adaptation of cell metabolism to environmental cues.

262 ssion of ERRgamma reprograms prostate cancer cell metabolism to favor mitochondrial activity and cell

263 activity, and ATP production and also shifts cell metabolism to higher glycolytic activity.

264 exploring and potentially manipulating guard cell metabolism to improve plant water use and productiv

265 manipulation can specifically affect tumour-cell metabolism to mediate broad aspects of cancer outco

266 nd to various diets, how diet impacts cancer cell metabolism to mediate these responses and whether d

267 anner how viral oncoproteins hijack the host cell metabolism to meet their own energy demands and how

268 d checkpoint in linking immune signaling and cell metabolism to orchestrate memory CD8(+) T-cell deve

269 explore current strategies that shift immune cell metabolism to pro-inflammatory states in the TME an

270 Deregulated Myc transcriptionally reprograms cell metabolism to promote neoplasia.

271 whether PPARbeta/delta modulates endothelial cell metabolism to support the dynamic phenotype remains

272 f the actomyosin cytoskeleton, thus coupling cell metabolism to the mechanical properties of the surr

273 Finally, skewing T cell metabolism toward aerobic glycolysis by deleting mi

274 ppaB activation, leading to reprogramming of cell metabolism towards glycolysis and lactate dehydroge

275 king PKM2 in NK cells showed no defect in NK cell metabolism, transcription or antiviral responses to

276 stinct pathways such as hypoxia, glycolysis, cell metabolism, translation initiation, cell cycle, and

277 We present a study of beta-cell metabolism under increased fuel pressure using a st

278 , these data demonstrate that induction of T cell metabolism upon activation is dependent on systemic

279 tive, high-resolution technique for studying cell metabolism via endogenous fluorescence of reduced n

280 nocytes were studied in vitro with regard to cell metabolism, viability, growth, gene expression sign

281 NK cell metabolism was maintained due to compensatory PKM1

282 mpaired memory T-cell response nor altered T-cell metabolism was reversed with weight loss.

283 For many years, stem cell metabolism was viewed as a byproduct of cell fate s

284 To investigate the effects of age on beta-cell metabolism, we established a novel assay to directl

285 tty acid into mitochondria to support cancer cell metabolism, we tested several clinically relevant i

286 nsity and dispersion, free water, myelin and cell metabolism were assessed with Neurite Orientation D

287 luenza PR8, and memory T-cell function and T-cell metabolism were measured.

288 strumental function of Cdc25A in controlling cell metabolism, which is essential for EGFR-promoted tu

289 s suggest a more integrated view of vascular cell metabolism, which may open unique therapeutic prosp

290 (i.e. 20%) short wavelength light inhibited cell metabolism, while negligible effects were seen with

291 nges in droplet volume being used to measure cell metabolism, while simultaneously imaging the cells

292 on of a STAT3/c-Myc pathway and increased NK cell metabolism with a shift towards aerobic glycolysis.

293 regulator that connects changes in satellite cell metabolism with changes in the transcriptional mach

294 showed increased UCP1 protein abundance and cell metabolism with enhanced oxygen consumption and pro

295 AMPK acts as an energy sensor to coordinate cell metabolism with environmental status in species fro

296 tanding of hypoxia-induced changes in cancer cell metabolism, with an initial focus on HIF-mediated e

297 wing attention has been directed toward stem cell metabolism, with the key observation that the plast

298 y cholesterol and its derivatives, in cancer cell metabolism within intrinsically harsh tumor microen

299 Knowledge of single-cell metabolism would provide a powerful look into cell

300 In a recent issue of Cell Metabolism, Ying et al. (2018) report that two subp