ライフサイエンスコーパス: cell reprogramming

1 atic function of TET proteins during somatic cell reprogramming.

2 ich may be responsible for promoting somatic cell reprogramming.

3 lated molecular mechanisms affecting somatic cell reprogramming.

4 and the molecular pathways governing somatic cell reprogramming.

5 eling of dementia disorders based on somatic cell reprogramming.

6 nic stem cell (ESC) self-renewal and somatic cell reprogramming.

7 embryonic and somatic stem cell biology and cell reprogramming.

8 ntrolling stem cell pluripotency and somatic cell reprogramming.

9 ation of embryonic stem cells or via somatic cell reprogramming.

10 the contexts of stem cell specification and cell reprogramming.

11 ing ground state pluripotency during somatic cell reprogramming.

12 l Akt1 signaling was required during somatic cell reprogramming.

13 enetic barrier during the process of somatic cell reprogramming.

14 rticipates in induced pluripotent stem (iPS) cell reprogramming.

15 can partially substitute for Ascl1 during iN cell reprogramming.

16 s in the subset of nucleolar proteins during cell reprogramming.

17 ecosystem management, emergency response and cell reprogramming.

18 on presents a roadblock to efficient somatic cell reprogramming.

19 ctivity favors the entire process of somatic cell reprogramming.

20 maintenance of ESC self-renewal and somatic cell reprogramming.

21 g mechanisms of ESC pluripotency and somatic cell reprogramming.

22 nduction at pluripotency loci during somatic cell reprogramming.

23 them from embryonic stem cells or by somatic cell reprogramming.

24 was indentified to be induced during somatic cell reprogramming.

25 examination of mechanisms governing somatic cell reprogramming.

26 f self-renewal, differentiation, and somatic cell reprogramming.

27 ficient to cause Arx-dependent beta-to-alpha-cell reprogramming.

28 R-302b and hsa-miR-372 promote human somatic cell reprogramming.

29 otency factors with the capacity for somatic cell reprogramming.

30 hymal gene expression in OSKM-mediated human cell reprogramming.

31 ntenance of ES cell self-renewal and somatic cell reprogramming.

32 l-mediated tumorigenic mechanism involving B cell reprogramming.

33 self-renewal and differentiation and somatic cell reprogramming.

34 ration, differentiation, apoptosis, and stem cell reprogramming.

35 evated during induced pluripotent stem (iPS) cell reprogramming.

36 f hES cells is acquired as an early event in cell reprogramming.

37 ike factor 4 (Klf4) is essential for somatic cell reprogramming.

38 ing a critical difference in human and mouse cell reprogramming.

39 Pluripotency can be recreated by somatic cell reprogramming.

40 recapitulated in the culmination of somatic cell reprogramming.

41 hift is predominantly caused by a B-2 to B-1 cell reprogramming.

42 a (MEL) cells is a dramatic example of tumor-cell reprogramming.

43 such, pioneer factors are useful in directed cell reprogramming.

44 s disrupts gene activation and smooth muscle cell reprogramming.

45 ets, and novel techniques for in situ immune cell reprogramming.

46 ts of human primed to naive pluripotent stem cell reprogramming.

47 talk between chronic inflammatory milieu and cell reprogramming.

48 and gene regulatory factors to ensure naive cell reprogramming.

49 redicts experimental observations of somatic cell reprogramming.

50 is a crucial pioneer factor that can induce cell reprogramming.

51 pluripotency factors involved in cancer stem cell reprogramming.

52 ns rescues gene activation and smooth muscle cell reprogramming.

53 urrence of macrophage-mediated inhibition of cell reprogramming.

54 lications in cell biology, bioproduction and cell reprogramming.

55 rules necessary to achieve complete somatic cell reprogramming.

56 anticancer agents, and scaffolds for immune cell reprogramming.

57 wiring with cytoplasmic restructuring during cell reprogramming.

58 cantly reduced the efficiency of endothelial cell reprogramming.

59 binding lncRNA that is activated in somatic cell reprogramming.

60 f ectopically induced factors during somatic cell reprogramming.

61 ong with active transcription during somatic cell reprogramming.

62 cient to increase p53 levels and impair stem cell reprogramming.

63 nd, conversely, acts as a barrier to somatic-cell reprogramming.

64 on steps, examining their effects on somatic cell reprogramming.

65 ll regeneration therapies relying upon alpha-cell reprogramming.

66 tion (TD) is a recent advancement in somatic cell reprogramming.

67 y of embryonic stem cells (ESCs) and somatic cell reprogramming.

68 velopmental differentiation can help improve cell reprogramming.

69 e splicing regulatory network during somatic cell reprogramming.

70 (MBNL) RNA binding proteins, is involved in cell reprogramming.

71 fate, such as disease therapeutics and stem cell reprogramming.

72 complex in stem cell maintenance and somatic cell reprogramming.

73 ing has been implicated in promoting somatic cell reprogramming.

74 erexpression of Tet2 enhances OSKM-induced B-cell reprogramming.

75 slation of p21, a known inhibitor of somatic cell reprogramming.

76 -cell pluripotency, cell differentiation and cell reprogramming(1,2).

77 ic strategies that interfere with the cancer cell reprogramming activity of such microenvironmental c

78 Identifying means to enhance Schwann cell reprogramming after nerve injury could be used to f

79 Somatic cell reprogramming also has been achieved more recently

80 induced plasticity of respiratory epithelial cells, reprogramming alveolar cells into epithelial cell

81 uring late lung development leads to AT1-AT2 cell reprogramming and altered pulmonary architecture, w

82 Tet2 provides a mechanistic link between iPS cell reprogramming and B-cell transdifferentiation.

83 Recent advances in cell reprogramming and beta cell differentiation now all

84 ency, because its depletion inhibits somatic cell reprogramming and blastocyst development.

85 TGFbeta is a key upstream regulator of T cell reprogramming and contributes to intratumoral Tcell

86 d overlapping roles in both pluripotent stem cell reprogramming and embryonic heart development, indu

87 fness regulates chromatin reorganization and cell reprogramming and find that matrix stiffness acts a

88 organoids to accurately quantitate beta-like cell reprogramming and fine-tune a combination treatment

89 rs in biological processes including somatic cell reprogramming and guided differentiation.

90 ths of epigenetic reorganization during stem cell reprogramming and identified key transcription fact

91 The advent of cell reprogramming and induced pluripotent stem cells (i

92 Thus, this unexpected link between cell reprogramming and infection opens up a new premise

93 ion of true hiPSCs immediately after somatic cell reprogramming and involves column-based positive se

94 rteporfin reverses fibrotic alveolar type II cell reprogramming and LOX expression in experimental lu

95 sma cells (PCs) is associated with extensive cell reprogramming and new cell functions.

96 genomic manipulation could provide a path to cell reprogramming and novel cell replacement-based ther

97 epigenetic modification, stem cell function, cell reprogramming and other processes.

98 f certain mechanisms, such as acinar-to-beta-cell reprogramming and pancreatitis.

99 enes, cell differentiation, stem and somatic cell reprogramming and response to environmental stimuli

100 10) controls stem cell self-renewal, somatic cell reprogramming and senescence, and tumorigenesis.

101 The discovery of cell reprogramming and the development of approaches for

102 nisms of pluripotency, cell differentiation, cell reprogramming and transdifferentiation, among other

103 ellular plasticity in the context of somatic cell reprogramming and tumorigenesis.

104 es as diverse as gene therapy, cell therapy, cell reprogramming, and bioengineering of human tissue a

105 atin remodeler, in ESC self-renewal, somatic cell reprogramming, and blastocyst development.

106 ulator in embryonic stem (ES) cells, somatic cell reprogramming, and cancer.

107 s multistage developmental defects, impaired cell reprogramming, and hematopoietic malignancies.

108 nally, Rif1 acts as a barrier during somatic cell reprogramming, and its depletion significantly enha

109 datasets including cancer drug therapy, stem cell reprogramming, and organoid differentiation.

110 ld open a new avenue for immunotherapy, stem cell reprogramming, and other therapeutic applications.

111 n essential component of TCR-initiated T reg cell reprogramming, and Rag GTPase activities may be tit

112 ionary developmental biology questions, stem cell reprogramming, and the biology of nonvascular plant

113 ing non-viral and non-integrating methods of cell reprogramming, and using novel gene editing techniq

114 Although isolated examples of adult cell reprogramming are known, there is no general unders

115 me, although its functional roles in somatic cell reprogramming are largely unexplored.

116 The signaling mechanisms controlling somatic cell reprogramming are not fully understood.

117 RNA metabolism, the roles of RBPs in somatic cell reprogramming are poorly understood.

118 35 is an important tool for inducing somatic cell reprogramming, as well as for dissecting the other

119 creased variability in the efficiency of iPS cell reprogramming between mice.

120 s of reprogramming impediments improve naive cell reprogramming beyond current methods.

121 l regulator that functions in mammalian stem cell reprogramming, brain development, and cancer.

122 Non-invasive evaluation of cell reprogramming by advanced image analysis is require

123 mors, where the inflammatory stroma promotes cell reprogramming by enhancing Wnt signaling through nu

124 n of the pluripotency network during somatic cell reprogramming by exogenous transcription factors in

125 onic stem (ES) to trophoblast stem (TS)-like cell reprogramming by introducing individual TS cell-spe

126 he MKL1-actin pathway weakens during somatic cell reprogramming by pluripotency transcription factors

127 e importance of defining trajectories during cell reprogramming by various methods.

128 his study uncovers mechanistic links between cell reprogramming, bystander inflammatory macrophages,

129 TME cell reprogramming can regulate cell differentiation, pr

130 nt in vitro and, increasingly due to somatic cell reprogramming, cellular and molecular mechanisms of

131 Thus, such CD8+ T cell reprogramming, combined with other available immuno

132 enomic findings suggested that alpha to beta cell reprogramming could be promoted by manipulating the

133 his article reviews landmark developments in cell reprogramming, current knowledge, and technological

134 cell regeneration but the efficiency of hair cell reprogramming declines rapidly as the cochlea matur

135 nistically, Bmp4 abrogated regenerative stem cell reprogramming despite a convergent impact of YAP/TA

136 Somatic cell reprogramming, directed differentiation of pluripot

137 We believe that scDEAL could help study cell reprogramming, drug selection, and repurposing for

138 oses, reflecting common mechanisms for plant cell reprogramming during endosymbiosis.

139 Because somatic cell reprogramming during induced pluripotent stem cell

140 the gene regulatory network responsible for cell reprogramming during somatic embryogenesis are stil

141 ions showed differential effects on the stem cell reprogramming efficiency in a c-Myc dependent manne

142 ctivation induces a 100-fold increase in iPS cell reprogramming efficiency, involving 95% of the popu

143 ondrial Akt1 signaling that enhanced somatic cell reprogramming efficiency.

144 Recent advances in cell reprogramming enable investigators to generate plur

145 indicating that this is a true irreversible cell reprogramming event.

146 ine transcription factors, including somatic cell reprogramming factors (Oct4, Sox2, Klf4, and c-Myc)

147 ancreatic beta cells, and expression of beta cell reprogramming factors in vivo converts antral cells

148 al. show that the cyclic expression of stem cell reprogramming factors in vivo increases the lifespa

149 ganization of binding motifs for the Sertoli cell reprogramming factors SOX9, GATA4 and DMRT1.

150 stem and progenitor cell biology and somatic cell reprogramming for applications directed to the vess

151 Cell reprogramming from a quiescent to proliferative sta

152 f similarities between cancer genes and stem cell reprogramming genes, widespread mutations in epigen

153 ion compromises ESC self-renewal and somatic cell reprogramming, globally increases m(6)A RNA levels,

154 Somatic cell reprogramming has generated enormous interest, foll

155 In vivo cell reprogramming has the potential to enable more-effe

156 Therefore, a detailed study of cell reprogramming has the potential to shed light on un

157 Recent advances in cell reprogramming have permitted the development of dif

158 and the metabolic pathways governing myeloid cell reprogramming, highlighting the influence of cytoki

159 atin responses in leukemic and host CD4(+) T cells, reprogramming host T cells toward normalcy.

160 Glycolysis is critical for cancer stem cell reprogramming; however, the underlying regulatory m

161 rsRNAs that are downregulated during somatic cell reprogramming impact cellular translation in ESCs,

162 ck of cell intermediates and enables somatic cell reprogramming in absence of otherwise essential plu

163 t cell types, and have implications for beta-cell reprogramming in diabetes and diagnosis of beta-cel

164 as a novel marker for reversible human beta-cell reprogramming in diabetes.

165 the ability of ES cells to initiate somatic cell reprogramming in heterokaryons.

166 results provide evidence of basal epithelial cell reprogramming in long-term COVID-19 and thereby yie

167 elopment and give further insights into germ cell reprogramming in mice.

168 to suggest at least two impediments to hair cell reprogramming in older animals.

169 Nanog enables somatic cell reprogramming in serum-free medium supplemented wit

170 miRNAs in the regulation of pluripotency and cell reprogramming in the laboratory rat.

171 Transcriptomic analysis suggests T cell reprogramming in the tumor microenvironment and sim

172 We hypothesize that immune cell reprogramming in these patients occurs at the level

173 These findings support a model of host cell reprogramming in which a bacterial pathogen uses th

174 Cell reprogramming, in which a differentiated cell is ma

175 imicry of human autoantigens; EBV-mediated B cell reprogramming, including EBV nuclear antigen 2-medi

176 pathway, a central regulator of the Schwann cell reprogramming induced by nerve injury.

177 In the context of somatic cell reprogramming, inhibition of ZNF398 abolishes activ

178 MicroRNAs (miRNAs) are critical to somatic cell reprogramming into induced pluripotent stem cells (

179 L1 regulates neurogenesis and drives somatic cell reprogramming into neurons.

180 scovered an unexpected phenomenon of somatic cell reprogramming into pluripotent cells by exposure to

181 clusion, we show that MEKi leads to CD8(+) T cell reprogramming into T(SCM) that acts as a reservoir

182 izing IL-6-specific antibody prevented iTreg cell reprogramming into TH17-like cells and protected ag

183 cesses underlying oral epithelial progenitor cell reprogramming into tumor initiating cells at single

184 Thus, injury-induced Schwann cell reprogramming involves down-regulation of myelin ge

185 Somatic cell reprogramming involves epigenomic reconfiguration,

186 ed pluripotent stem cells (iPSCs) by somatic cell reprogramming involves global epigenetic remodellin

187 These findings indicate that somatic cell reprogramming is associated with marked increases i

188 dentification of new pathways governing germ cell reprogramming is critical to understanding how cell

189 Cell reprogramming is largely mediated by DNA and RNA.

190 Patient-specific somatic cell reprogramming is likely to have a large impact on m

191 ulate this process and contribute to somatic cell reprogramming is not clear.

192 architecture is reconfigured during somatic cell reprogramming is poorly understood.

193 Research in stem cell biology and cell reprogramming is rapidly advancing, with the hope o

194 4 regulates ES cell self-renewal and somatic cell reprogramming is still poorly understood.

195 Somatic cell reprogramming is the process that allows differenti

196 d acquisition of pluripotency during somatic cell reprogramming is well-documented.

197 in bypass of cellular senescence and somatic cell reprogramming, is markedly overexpressed in human P

198 PDAC because it induces a process of acinar cell reprogramming known as acinar-to-ductal metaplasia

199 es promotes beta-cell regeneration and liver cell reprogramming, leading to restoration of normoglyce

200 ver regenerative cargo from mesenchymal stem cells, reprogramming macrophages to support liver regene

201 P4 secretion and downregulates CD24 on tumor cells, reprogramming macrophages toward a tumor-suppress

202 prehension of the complex process of somatic cell reprogramming, many questions regarding the molecul

203 Somatic cell reprogramming may afford models of nonfamilial "spo

204 Our results raise the prospect that blood cell reprogramming may be a strategy for derivation of t

205 Direct or indirect metabolic immune cell reprogramming may offer new approaches to modulate

206 drive cell killing by SFB, while glycolytic cell reprogramming may represent a resistance strategy p

207 However, during somatic cell reprogramming, mesenchymal-epithelial transition (M

208 ntext of most induced pluripotent stem (iPS) cell reprogramming methods, heterogeneous populations of

209 Cell reprogramming models appear particularly promising

210 During cell reprogramming, mutations represent an initial step

211 We established previously unidentified self-cell reprogramming NFkB- and OCT4-mediated inflammatory

212 o, we applied induced pluripotent stem (iPS) cell reprogramming of aged hematopoietic progenitors and

213 This study overall provides evidence of Th17 cell reprogramming of astrocytes, which may drive change

214 ed both pluripotency in ES cells and somatic cell reprogramming of fibroblasts to induced pluripotent

215 Interruption of Th2 cell reprogramming of Treg cells might thus provide cand

216 ation and expansion, which in turn drove Th2 cell reprogramming of Treg cells.

217 ve identified actionable gene targets for NK cell reprogramming, offering a path to design multi-engi

218 such abnormalities are intrinsic to somatic cell reprogramming or secondary to the reprogramming met

219 ent of early epigenetic marks during somatic cell reprogramming: Parp1 functions in the regulation of

220 binding affinities that correlate with their cell reprogramming potential.

221 hting broad and general roles for SMAD2/3 as cell-reprogramming potentiators.

222 ribe an early and essential stage of somatic cell reprogramming, preceding the induction of transcrip

223 Transdifferentiation (TD), a somatic cell reprogramming process that eliminates pluripotent i

224 keletal remodeling in modulating the somatic cell reprogramming process.

225 fic protease 26 negatively regulates somatic cell-reprogramming process by stabilizing chromobox (CBX

226 Cell reprogramming promises to make characterization of

227 stem-cell differentiation or in adult islet cell reprogramming protocols.

228 pected tumor-promoting role of DDR in cancer cell reprogramming, providing novel therapeutic entry po

229 tity was the result of lymphatic endothelial cell reprogramming rather than replacement by blood endo

230 Direct cell reprogramming represents a promising new myocardial

231 Even though different methods of somatic cell reprogramming result in stem cell lines that are mo

232 ty with a sialyltransferase inhibitor during cell reprogramming resulted in a dose-dependent reductio

233 rces of breathing movements leads to AT1-AT2 cell reprogramming, revealing that normal respiration is

234 enhanced global demethylation during somatic cell reprogramming (SCR) of hHFCs.

235 highly accurate discrimination based on the cell reprogramming status.

236 on of GFI1 in hair cell development and hair cell reprogramming strategies.

237 I -> KDM1B axis as a potent engine of cancer cell reprogramming, supporting KDM1B targeting as an att

238 Human cell reprogramming technologies offer access to live hum

239 The advent of somatic cell reprogramming technologies-which enables the genera

240 restricted to animal models, but advances in cell reprogramming technology have enabled the generatio

241 af-dependent and SFB-induced T(H)17-to-T(FH) cell reprogramming that dominantly occurs in PPs.

242 limits of current knowledge in the field of cell reprogramming, the mechanistic elements that underl

243 Direct cell reprogramming, the process by which a somatic cell

244 rily arrested in mitosis can support somatic cell reprogramming, the production of embryonic stem cel

245 s cells - an approach exemplified by partial cell reprogramming through the expression of Yamanaka fa

246 actors, our approach achieves acinar-to-beta-cell reprogramming through transient cytokine exposure r

247 Somatic cell reprogramming to a pluripotent state continues to c

248 The recent description of somatic cell reprogramming to an embryonic stem (ES) cell-like p

249 Although somatic cell reprogramming to generate inducible pluripotent ste

250 In this review, we explore the RNA-mediated cell reprogramming to induce specific target cell genera

251 ouble-strand breaks, is required for somatic cell reprogramming to induced pluripotent stem cells (iP

252 is to identify kinases that regulate somatic cell reprogramming to iPSCs.

253 Somatic cell reprogramming to pluripotency requires an immediate

254 em cells, including the promotion of somatic cell reprogramming to pluripotency, the regulation of ce

255 n self-renewal, differentiation, and somatic cell reprogramming to pluripotency.

256 nutrient stress that results in cancer stem cell reprogramming to promote metabolic flexibility and

257 ncy of embryonic stem cells, and for somatic cell reprogramming to the pluripotent state.

258 ound that during the early stages of somatic cell reprogramming toward a pluripotent state, specific

259 MicroRNAs are potential candidates for cell reprogramming toward a proregenerative phenotype.

260 ammatory cytokine responses, greater myeloid cell reprogramming toward inflammatory and activated sta

261 sion are key contributors directing melanoma cell reprogramming toward specific therapeutic resistanc

262 ncer patients is widely attributed to cancer cell reprogramming towards drug resistance by cancer ass

263 Treg cell reprogramming, vaccine efficacy, and antitumor CD8(

264 ciated with early dissemination after cancer cell reprogramming via an epithelial-to-mesenchymal tran

265 The role of mitochondrial Akt1 in somatic cell reprogramming was investigated by transducing fibro

266 In hosts with established tumors, Treg cell reprogramming was suppressed by tumor-induced indol

267 Myeloid cell reprogramming was triggered by granulocyte colony-s

268 ng shore dynamics through embryonic and germ cell reprogramming, we found evidence of bookmarking, a

269 Using conditional cell reprogramming, we generated a stable cell culture o

270 Directed somatic cell reprogramming, which does not pass through typical

271 extensive TAD reorganization during somatic cell reprogramming, which is correlated with gene transc

272 juvenated by the maturation phase of somatic cell reprogramming, which suggests full reprogramming is

273 developed Cre-inducible mice to compare hair cell reprogramming with ATOH1 alone or in combination wi

274 l importance of the NHEJ pathway for somatic cell reprogramming, with a major role for LIG4 and DNA-P

275 viscoelasticity in epigenetic regulation and cell reprogramming, with implications for designing smar

276 nd suggests a general paradigm for directing cell reprogramming without reversion to a pluripotent st

277 ty and constitute a barrier to human somatic cell reprogramming; yet a comprehensive understanding of