ライフサイエンスコーパス: cell responsiveness

1 y in CVID patients correlated with reduced T cell responsiveness.

2 osphatase SHP-1 as a critical regulator of T cell responsiveness.

3 ic phosphatase 1 (SHP-1) digitally regulates cell responsiveness.

4 actions as the central parameter governing T cell responsiveness.

5 /-) mice was not caused by a deficiency in T cell responsiveness.

6 n is by maintaining and/or re-establishing T cell responsiveness.

7 and number of mature B cells, and reduced B cell responsiveness.

8 o understanding the factors that determine T cell responsiveness.

9 regulated is required to fully understand T cell responsiveness.

10 growth factor bioavailability and/or Muller cell responsiveness.

11 lerance to missing-self without resetting NK cell responsiveness.

12 may be important for regulating naive CD4 T cell responsiveness.

13 und to A2 cause large changes in AHIII12.2 T cell responsiveness.

14 uld be utilized as an additional marker of T cell responsiveness.

15 ynapse may contribute to the regulation of T cell responsiveness.

16 f a viral infection technique that preserves cell responsiveness.

17 egulation of this molecule in facilitating B cell responsiveness.

18 CTLA-4-B7 interactions restores memory CD4 T cell responsiveness.

19 rably in elucidating the mechanisms behind T cell responsiveness.

20 f mice and humans, is essential for normal B cell responsiveness.

21 ated mitomycin C-treated T cells to induce B cell responsiveness.

22 ddition of exogenous rIL-2 did not restore T cell responsiveness.

23 ammed death-ligand 1 or 2, correlated with T cell responsiveness.

24 alidated by single-cell analysis of human NK cell responsiveness.

25 antigen processing to elicit drug-induced T cell responsiveness.

26 fects and disease setting which regulates NK cell responsiveness.

27 pled receptors (GPCRs) play pivotal roles in cell responsiveness.

28 nic TCR signaling recalibrate naive CD8(+) T cell responsiveness.

29 n oxidative stress, and the stimulation of B-cell responsiveness.

30 xidative stress, and the stimulation of beta-cell responsiveness.

31 abrogation of MDSC-mediated suppression of B-cell responsiveness.

32 plex set of signals determines the fate of B cell responsiveness.

33 selection, and PTPN22-R620W alters mature T cell responsiveness.

34 ontributes to membrane fusion may modulate T-cell responsiveness.

35 receptors for MHC-I results in diminished NK cell responsiveness.

36 icense model for the reversible tuning of NK cell responsiveness.

37 , resulting in ROS-mediated suppression of T-cell responsiveness.

38 cell IL-21 production and increased IL-21 B cell responsiveness.

39 lly associated with increased HBV-specific T cell responsiveness.

40 th cognate peptide concentration on CD8(+) T cell responsiveness.

41 ures of TB-LM contribute to its diminished T cell responsiveness.

42 h a varying degree of correlation with the T-cell responsiveness.

43 "translate" BCR affinity for antigen into B cell responsiveness.

44 finities and rapid kinetics that determine T-cell responsiveness.

45 tion, indicating a central defect in early B cell responsiveness.

46 lation between cancer clinical outcome and T-cell responsiveness after therapeutic vaccination in hum

47 ty of manipulating donor cells to maximize T cell responsiveness against lymphoma.

48 y genes in surrounding regions controlling B cell responsiveness and anergy induction.

49 e tumor, but reflected mutual paralysis of T-cell responsiveness and antigen processing by tumor cell

50 ying the differential regulation of memory T cell responsiveness and has clinical implications for va

51 ar basis for TbetaR-mediated inhibition of B cell responsiveness and indicate that TbetaR maintains h

52 t CD5-CK2 signaling sets the threshold for T cell responsiveness and is necessary for efficient gener

53 was associated with antigen-specific spleen cell responsiveness and markedly increased levels of IFN

54 m autoimmune disease by down-regulation of B-cell responsiveness and myeloid cell activation.

55 with decreased MSC retention, altered immune cell responsiveness and reduced vascularization in the h

56 mma production in HCV infection, and that NK cell responsiveness and refractoriness correlate to the

57 r current understanding of what determines T cell responsiveness and resistance to immunotherapy and

58 Grail or PD-1, in W131AOTII mice restored T cell responsiveness and signaling.

59 by which endothelial cells (EC) influence T cell responsiveness and that the Th-2 cytokine skewing s

60 I(T), plays a pivotal role in thalamic relay cell responsiveness and thus in the nature of the thalam

61 lular Asc redox state, which in turn affects cell responsiveness and tolerance to environmental ROS.

62 g the need to identify biomarkers for immune cell responsiveness and tumor susceptibility to be able

63 reased production of factors that suppress T cell responsiveness and underproduction of positive regu

64 ent for 8 wk to insulin sensitivity and beta cell responsiveness and whether effects of diet would va

65 acid is critical for maintaining long-term T cell responsiveness, and its loss may contribute to decr

66 Confirming the shift in B cell responsiveness, antigen-receptor-mediated activatio

67 uding the strong direct MDSC inhibition of B-cell responsiveness, are novel for murine retrovirus-ind

68 providing CD4(+) T cell help would improve T cell responsiveness as a function of effector T cell avi

69 ents then revealed significantly decreased B-cell responsiveness as levels of background chronic infl

70 stribution resulted in a global dampening of cell responsiveness, as illustrated by reduced ligand-me

71 topril did not directly affect Ag-specific T cell responsiveness because neither in vivo nor in vitro

72 Three weeks after the onset of egg laying, T-cell responsiveness began to increase and bacterial numb

73 atory T cells (Treg) and enhanced effector T-cell responsiveness, both associated with poorer outcome

74 signaling is a major determinant of CD8(+) T cell responsiveness, but the mechanisms underlying this

75 The inhibition of T-cell responsiveness by HCV core may have important impli

76 lative proportion to T cells, may suppress T-cell responsiveness by secretion of IL-10.

77 ber of CD14 monocytes in G-PBMCs may limit T-cell responsiveness by suppressing the induction of the

78 Despite this, T cell responsiveness can be induced by vaccination with c

79 The fall in T-cell responsiveness coincided with the increase in numbe

80 sphingosine kinases are determinants of mast cell responsiveness, demonstrating a previously unrecogn

81 vide functional evidence for differential NK cell responsiveness depending on KIR/HLA genotype and ma

82 The effects of intestinal microbes on iNKT cell responsiveness did not require Toll-like receptor s

83 gically active, must function at a step in T cell responsiveness distinct from the acute production o

84 these data indicate that the decline in Th2 cell responsiveness during chronic schistosomiasis is th

85 gulating epithelial cell dynamics and immune cell responsiveness during damage repair in vivo.

86 have critical implications for sustaining T cell responsiveness during immunotherapy, as the develop

87 derived from studies on the regulation of T cell responsiveness during mammalian gestation are consi

88 Decreased T cell responsiveness during prolonged therapy was associa

89 V-1 infection demonstrated a reduction of NK cell responsiveness following stimulation with TLR ligan

90 that CD28 interaction with B7-2 regulates T cell responsiveness in anti-CD3-treated animals.

91 r innate and adaptive signals that promote B cell responsiveness in conjunction with newly developed

92 objective of this study was to measure beta-cell responsiveness in hypoglycaemic (H) fetal sheep and

93 Increased 1a-specific CD4 T-cell responsiveness in non-1a-infected patients was not

94 central B cell tolerance, whereas residual B cell responsiveness in patients with one, but not two, T

95 ced CALMODULIN: transcription and impaired T-cell responsiveness in RA.

96 re integrated to control natural killer (NK) cell responsiveness in the absence of antigen-specific r

97 ation, to what extent dietary lipids alter T cell responsiveness in the absence of obesity and inflam

98 with a lasting enhancement of HCV-specific T-cell responsiveness in the blood.

99 We therefore hypothesized that memory CD8 T-cell responsiveness in the context of T2D is negatively

100 espite a documented decline in general CD8 T-cell responsiveness in the elderly, a subset of CD8 T ce

101 ance is the physiologic down-regulation of T cell responsiveness in the face of persistent antigenic

102 he endogenous peptide repertoire modulates T cell responsiveness in the thymus in order to enforce to

103 rone after HCG, confirm pituitary and Leydig cell responsiveness in these subjects.

104 The ability to modulate T-cell responsiveness in this manner may underlie the cont

105 Therefore, T cell responsiveness in tuberculoid leprosy may be mediat

106 eristic manifestations of impaired patient T-cell responsiveness in vitro.

107 hibitor, l-NMMA, restored antigen-specific T-cell responsiveness in vitro.

108 mmunization can therefore be used to probe T cell responsiveness in vivo and represents a tool to fur

109 Because its influence on CD8 T cell responsiveness in vivo is unknown, we investigated

110 sts a potential means of manipulating CD4+ T cell responsiveness in vivo.

111 study, we show in the murine system that NK cell responsiveness increases quantitatively with each a

112 liver does not significantly alter CD8(+) T cell responsiveness, indicating that CD103(+) DCs initia

113 roliferation suggests that the decrease in T cell responsiveness induced by rIL-16 may result from an

114 st cell activation, we examined whether mast cell responsiveness is altered in this model.

115 These findings suggest that NK cell responsiveness is comparable to a rheostat: it is t

116 Synergistically improving T-cell responsiveness is promising for favorable therapeut

117 sponsive to S1P gradients, suggesting that T cell responsiveness is regulated during their recirculat

118 To address whether NK cell responsiveness is set only during the NK cell diffe

119 of MAIDS-related pathology and maintained T-cell responsiveness longer than mice treated with contro

120 her alpha-MSH might similarly influence mast cell responsiveness, mast cells were examined to see if

121 iNKT cell responsiveness must be regulated to maintain effect

122 ural killer (NK) cells, we quantified the NK cell responsiveness of hundreds of molecularly annotated

123 ations in cellular immune markers, and (4) T cell responsiveness of the host using one-way mixed lymp

124 roles in regulating monocytes and dendritic cells, responsiveness of these cells to IFNalpha/beta in

125 llular signalling is limited by the range of cell responsiveness, often mediated by repressors.

126 clonal deletion acquired peptide-specific T cell responsiveness only when the vector-encoded TCR tra

127 Estrogen did not affect mast cell responsiveness or anaphylaxis onset.

128 Importantly, MPA did not globally suppress B cell responsiveness or simply induce cell death, but rat

129 wild type, suggesting that, by decreasing T-cell responsiveness, p12(I) curtails viral expression.

130 e suppression of not only T-cell, but also B-cell, responsiveness paralleled the immunodeficiency dur

131 o, mainly due to the effect of TGF-beta on T cell responsiveness rather than DC stimulatory capabilit

132 -responsive and nonresponsive ovarian cancer cells (responsiveness refers to the IL-8 response).

133 The underlying reason for T cell responsiveness remains elusive.

134 A second infection to assess CD8+ T-cell responsiveness resulted in rapid suppression of HCV

135 ction to induce apoptosis and to dampen mast cell responsiveness, S1P functions as a chemoattractant

136 ion of an endogenous Ag, failed to restore T cell responsiveness specific for this Ag in the context

137 reased, or unmodified, but also increased, T cell responsiveness (superagonist ligands).

138 r, our results suggest that the defects in T cell responsiveness that occur subsequent to severe burn

139 offers into the early events underpinning T-cell responsiveness that take place in the confined spac

140 c cell activation, macrophage function and T-cell responsiveness through the promotion of an immunore

141 d DNA methylation are key modulators of mast cell responsiveness to acute and chronic stimulation.

142 ce resulted in selective abolition of glomus cell responsiveness to acute hypoxia and the hypoxic ven

143 nted oral tolerance induction and restored T-cell responsiveness to Ag previously tolerized by oral a

144 s variant results in a profound deficit in T cell responsiveness to Ag stimulation.

145 e dosage may regulate the extent of CD8(+) T cell responsiveness to Ag.

146 ropriate alphabeta pairing confers optimal T cell responsiveness to Ag.

147 s of the anti-B7 antibodies in suppressing T cell responsiveness to alloantigen, their use does not r

148 ys an important role in primary and memory T cell responsiveness to allografts.

149 T cell responsiveness to an epitope is affected both by it

150 Our study is the first to show T cell responsiveness to an inner ear-specific protein in

151 togens and antigen also is regained, as is B-cell responsiveness to anti-IgM.

152 on, we found no evidence for alteration of T-cell responsiveness to antigen by the gag, pol, vif, tat

153 ay have substantial deleterious effects on B cell responsiveness to antigenic stimulation.

154 tion may be a critical variable in malignant cell responsiveness to antiproliferative therapy.

155 role of the Akt pathway in modulating tumor cell responsiveness to Apo2L/TRAIL, delineate molecular

156 Finally, IFN-I treatment increased B cell responsiveness to APRIL, a cytokine involved in B c

157 receptor expression by flow cytometry; for B cell responsiveness to BAFF by in vitro culture; for ser

158 vaccines have been shown to improve B and T cell responsiveness to both mRNA- and adenovirus-based a

159 loops, drastically diminished binding and T cell responsiveness to BTNL3-BTNL8-expressing cells.

160 lts indicate that WNK1 signaling maintains B cell responsiveness to CXCL13 and suggest that pharmacol

161 y to tolerance loss through the shaping of B-cell responsiveness to cytokines and other environment f

162 he action of IFN-I, potentially increasing B cell responsiveness to cytokines.

163 teractions of BMP2 with HS and increased the cell responsiveness to endogenous and exogenous BMP prot

164 Thus, mucosal T cell responsiveness to environmental Ag is shaped in sit

165 BrCA cell responsiveness to exogenous Lcn2 was heightened in

166 but there was a persistent reduction of beta-cell responsiveness to glucose and arginine.

167 ation of the actin cytoskeleton, and reduced cell responsiveness to glucose stimulation.

168 mechanistic basis for enhancing host defense cell responsiveness to GM-CSF at transendothelial migrat

169 is a central node in the tonic regulation of cell responsiveness to GPCR stimulation, acting both as

170 te that in adults with type 1 diabetes, beta cell responsiveness to hyperglycemia and alpha cell resp

171 No effects on beta-cell responsiveness to hyperglycemia and GLP-1 infusion

172 ll responsiveness to hyperglycemia and alpha cell responsiveness to hypoglycemia are observed only at

173 CI) selectively abolishes the HVR and glomus cell responsiveness to hypoxia.

174 Consistent with STAT's limiting cell responsiveness to IFN, we found that 5-Aza-CdR trea

175 We conclude that myeloma cell responsiveness to IFN-alpha is heterogeneous and th

176 neither CD4(+) T cell-produced TNF nor host cell responsiveness to IFN-gamma were necessary.

177 type II IFN (IFN-gamma), and reduced myeloid cell responsiveness to IFN-gamma.

178 mune response to tumors by inhibiting immune cell responsiveness to IFNs.

179 ma factors in severe patients may increase T-cell responsiveness to IL-15-driven bystander activation

180 n of CD4(+) T-cell turnover and diminished T-cell responsiveness to IL-7 by IL-1beta and IL-6 exposur

181 increased IL-7 concentrations and enhanced T-cell responsiveness to IL-7 were observed throughout the

182 Importantly, Sle2 leads to a heightened B cell responsiveness to in vitro stimuli and to in vivo a

183 infection through modulation of the lymphoid cell responsiveness to infection, a condition that is cr

184 HHS), resulting in increased pancreatic beta-cell responsiveness to leucine and susceptibility to hyp

185 stem wherein cisplatin treatment has altered cell responsiveness to ligands of the erbB receptor fami

186 I MHC deprivation also enhanced naive CD8 T cell responsiveness to low-affinity (but not high-affini

187 fering with the expression of Bcl-3 restored cell responsiveness to LPS, thus confirming that CyPB ac

188 1/2(MAPK)) used as a prototypical marker for cell responsiveness to mechanical forces, Western blot a

189 psigargin-sensitive Ca(2+) stores as well as cell responsiveness to mitogens in terms of [Ca(2+)](i)

190 ld result in an enhancement of CA1 pyramidal cell responsiveness to nicotine.

191 These findings correlated with defective T-cell responsiveness to parasite stimulation in vivo and

192 ng alloreactivity while maintaining memory T-cell responsiveness to pathogens.

193 We show here that T cell responsiveness to peptide (termed "functional avidi

194 servations implicating impaired inflammatory cell responsiveness to PGE(2) as a pathogenetic mechanis

195 ting GLP-1 derivative, NN2211, restored beta-cell responsiveness to physiological hyperglycemia in ty

196 on of Raet1 on the lung epithelium primed NK cell responsiveness to poly(I:C), ssRNA40, or ODN1826 st

197 on defects, primarily due to reduced stromal cell responsiveness to progesterone.

198 e modeling by suppressing osteoclast lineage cell responsiveness to RANKL and coupling to bone format

199 late either the production of, or the target cell responsiveness to RANKL.

200 ease, we addressed the question of how CD8 T cell responsiveness to self-Ag is regulated during chron

201 Patients showed T cell responsiveness to snRNP polypeptides that parallele

202 re to Ag is correlated with a hierarchy of T cell responsiveness to Spry1.

203 pathways, and adaptor proteins governs mast cell responsiveness to stimuli.

204 NK cell responsiveness to target cells is tuned by interact

205 tion of the CD3 complex leads to increased T cell responsiveness to TCR/CD3 stimulation and sets the

206 ingly, the inhibition did not reduce overall cell responsiveness to texture stimulation in somatosens

207 bility to inhibit colitis, suggesting that T cell responsiveness to TGF-beta is not required for the

208 peripheral tolerance affected both T- and B-cell responsiveness to the autoantigen.

209 Zeb1-dependent EMT enhances tumor cell responsiveness to the ECM composition and activates

210 Endothelial cell responsiveness to these pro-angiogenic BMP ligands

211 We investigated the mechanism for T cell responsiveness to this Ag according to the trimolec

212 ion and Treg depletion allowed recovery of T-cell responsiveness to this cytokine.

213 nds are known to activate APCs, but direct T cell responsiveness to TLR ligands is controversial.

214 To assess B-cell responsiveness to TLR9 agonists in human immunodefi

215 ing this threshold confers enhanced CD8(+) T cell responsiveness to tumor.

216 tion of VEGFR-3, Notch increased endothelial cell responsiveness to VEGF-C, promoting endothelial cel

217 hat smoke exposure may aberrantly prime trNK cell responsiveness to viral infection.

218 xpression of C3aR or C5aR influences (1) the cells' responsiveness to intradermal injections of C3a o

219 The Kit(low)Cd44(+)Cd34(+) cells' responsiveness to Kit activation and blockade was

220 g transcriptional reprogramming enhanced the cells' responsiveness to osteogenic differentiation fact

221 ing the abundance of cell-surface TGFBRs and cells' responsiveness to TGF-beta signaling.

222 In other cells, responsiveness to microbial products requires exp

223 ring in vitro expansion boosts low-avidity T cell responsiveness, tumor regression, and prevents T ce

224 The regulatory circuits dictating CD8(+) T cell responsiveness versus exhaustion during anti-tumor

225 maintain the default potential to regulate T cell responsiveness via IDO.

226 Enhanced T-cell responsiveness was also observed upon immunization

227 Although originating in the spleen, T cell responsiveness was found to spread immediately and

228 ditionally, this ability of Eos to enhance B cell responsiveness was observed in both T-independent a

229 The 74-96-specific T cell responsiveness was revealed in the wild-type (V bet

230 cytokine IL-12 could account for enhanced T cell responsiveness, we investigated whether paclitaxel

231 Insulin sensitivity and beta cell responsiveness were assessed at baseline and 8 wk b

232 ct in concert to limit the magnitude of mast cell responsiveness when antigen is encountered.

233 for 8 wk resulted in down-regulation of beta cell responsiveness, which was influenced by baseline ph

234 cells is restraint of self-MHC-restricted T cell responsiveness, which, regardless of the presence o

235 Understanding the mechanisms that regulate T cell responsiveness will aid in the development of thera

236 Our findings link exaggerated stromal cell responsiveness with enhanced neutrophil and leukocy