ライフサイエンスコーパス: cell self-renewal

1 n blots for Bmi-1 expression (marker of stem cell self-renewal).

2 or normal mammary gland development and stem cell self-renewal.

3 r with its assembly factor CAL1, drives stem cell self-renewal.

4 nin signaling, which is involved in leukemia cell self-renewal.

5 reates an essential "niche" to maintain stem cell self-renewal.

6 metastasis by regulating breast cancer stem cell self-renewal.

7 at are involved in maintenance of progenitor cell self-renewal.

8 further dissect the networks underlying stem cell self-renewal.

9 es organ size, tissue regeneration, and stem cell self-renewal.

10 s, suggesting an autocrine mechanism of stem cell self-renewal.

11 modifier proteins that is essential for stem cell self-renewal.

12 d the TWEAK-mediated inhibition of satellite cell self-renewal.

13 osines mediates an interaction central to ES cell self-renewal.

14 ed properties of tumor stem cells, including cell self-renewal.

15 cell cycle, senescence, DNA damage, and stem cell self-renewal.

16 the inhibitory effect of TWEAK on satellite cell self-renewal.

17 ption factors supporting embryonic stem (ES) cell self-renewal.

18 S transition to promote rapid embryonic stem cell self-renewal.

19 d with multiple target genes related to stem cell self-renewal.

20 l H3K27me3 level, Hox gene expression, or ES cell self-renewal.

21 the response to muscle injury with satellite cell self-renewal.

22 ifferentiated state and is a regulator of ES cell self-renewal.

23 reased cell proliferation and decreased stem cell self-renewal.

24 ics of neurosphere formation and neurosphere cell self-renewal.

25 s in many cellular processes, including stem cell self-renewal.

26 ther Notch1 nor Notch2 affected repopulating cell self-renewal.

27 ral mechanism of organ size control and stem cell self-renewal.

28 ptide surfaces that sustain pluripotent stem cell self-renewal.

29 eration, differentiation, and embryonic stem cell self-renewal.

30 t role for TCFAP2C, SMARCA4, and EOMES in TS cell self-renewal.

31 s, Nr5a receptors play no evident role in ES cell self-renewal.

32 ctions, including organ development and stem cell self-renewal.

33 cells to control germ line and somatic stem cell self-renewal.

34 several genes that control cell division and cell self-renewal.

35 r Klf family proteins in embryonic stem (ES) cell self-renewal.

36 e and is necessary for trophoblast stem (TS) cell self-renewal.

37 of transcriptional networks that regulate TS cell self-renewal.

38 identify regulators of human embryonic stem-cell self-renewal.

39 r cells, may also be crucial for cancer stem cell self-renewal.

40 cal for the regulation of hematopoietic stem cell self-renewal.

41 ion previously shown to be critical for stem cell self-renewal.

42 eptors that are essential for embryonic stem cell self-renewal.

43 vel, whereas low nuclear POP-1 promotes seam cell self-renewal.

44 K1/2-STAT3 axis and enhances tumor stem-like cell self-renewal.

45 mines the efficiency of mouse embryonic stem cell self-renewal.

46 Notch signaling, a key governor of satellite cell self-renewal.

47 ch signaling, a key determinant of satellite cell self-renewal.

48 ntify miR-99 as a critical regulator of stem cell self-renewal.

49 by Wnt signaling are proliferation and stem cell self-renewal.

50 nes involved in fetal hematopoiesis and stem cell self-renewal.

51 ey transcription factor for pluripotent stem cell self-renewal.

52 (Fgf) signalling and is critical to drive TS cell self-renewal.

53 including important regulators of ES and TS cells self-renewal.

54 ight into epigenetic mechanisms of ES and TS cells self-renewal.

55 ive endoderm, and inhibiting ERK supports ES cell self-renewal(1).

56 -hEGFR increased SCP/neurofibroma-initiating cell self-renewal, a surrogate for tumour initiation, an

57 RAS to TAZ protein stability supports cancer cell self-renewal abilities in both in vitro and in vivo

58 ine (5-hmC) and increased hematopoietic stem cell self-renewal accompanied by defective differentiati

59 regulations, and impairs haematopoietic stem-cell self-renewal activity and regenerative potential.

60 naling pathways that regulate mammalian stem cell self-renewal, adhesion, and migration.

61 role in promoting preleukemic hematopoietic cell self-renewal, AE represses DNA repair genes, which

62 tion of LRCs in vitro and impaired satellite cell self-renewal after muscle injury.

63 ormalities including a severe defect in stem cell self-renewal, alterations in thymocyte maturation a

64 short noncoding RNAs that are implicated in cell self- renewal and cancer development.

65 avenue for investigating mechanisms of stem cell self-renewal and achieving clinically significant e

66 onversely, Yap overexpression increases stem cell self-renewal and blocks terminal differentiation, r

67 cal processes associated with embryonic stem cell self-renewal and cell fate determination.

68 Here we investigate whether EG cell self-renewal and derivation are supported by 2i.

69 transcriptional changes associated with stem cell self-renewal and differentiation and followed the m

70 tion, but the mechanisms by which progenitor cell self-renewal and differentiation are regulated duri

71 he cell and molecular biology of neural stem cell self-renewal and differentiation between invertebra

72 The search for genes that regulate stem cell self-renewal and differentiation has been hindered

73 The niche controls stem cell self-renewal and differentiation in animal tissues.

74 Although the principles that balance stem cell self-renewal and differentiation in normal tissue h

75 etworks that control the switch between stem cell self-renewal and differentiation in the germline.

76 The signals that regulate stem cell self-renewal and differentiation in the lung remain

77 The balance between stem cell self-renewal and differentiation is controlled by i

78 Neural stem cell self-renewal and differentiation is orchestrated by

79 role of matrix mechanics in regulating stem cell self-renewal and differentiation processes.

80 nferred rates of bronchiolar club progenitor cell self-renewal and differentiation were reduced, indi

81 derstanding of the networks controlling stem cell self-renewal and differentiation, however, has not

82 e development and homeostasis depend on stem cell self-renewal and differentiation, the mechanisms th

83 ormal developmental processes including stem cell self-renewal and differentiation.

84 a delicate balance between renal progenitor cell self-renewal and differentiation.

85 ism for controlling the balance between stem cell self-renewal and differentiation.

86 tors that influence the balance between stem cell self-renewal and differentiation.

87 on its functions in regulating hematopoietic cell self-renewal and differentiation.

88 mechanisms underlying human pluripotent stem cell self-renewal and differentiation.

89 expression, cell cycle progression, and stem cell self-renewal and differentiation.

90 cells are vital for proper control over stem cell self-renewal and differentiation.

91 g pathway is a key player in regulating stem cell self-renewal and differentiation.

92 oward understanding the coordination of stem cell self-renewal and differentiation.

93 f translational repression in balancing stem cell self-renewal and differentiation.

94 y regulated balance between renal progenitor cell self-renewal and differentiation.

95 l enhance our ability to control pluripotent cell self-renewal and differentiation.

96 cluding spermatogenesis, metabolism and stem cell self-renewal and differentiation.

97 ely unknown how DNA damage affects both stem cell self-renewal and differentiation.

98 known about Mediator function in adult stem cell self-renewal and differentiation.

99 transcriptional regulation of epidermal stem cell self-renewal and differentiation.

100 ics plays critical roles in controlling stem cell self-renewal and differentiation.

101 sion of a key transcription factor for basal cell self-renewal and differentiation: SOX2.

102 tem cells (neuroblasts) are a model for stem cell self-renewal and differentiation; they divide asymm

103 ever, Tspan3 deletion impaired leukemia stem cell self-renewal and disease propagation and markedly i

104 tments that maintain redox balance promote T cell self-renewal and enhance anti-tumor immunity.

105 has been shown to enhance hematopoietic stem cell self-renewal and expansion ex vivo and in vivo.

106 lator of essential mechanisms governing stem cell self-renewal and fate decisions through transcripti

107 role in controlling the balance between stem cell self-renewal and fate determination by regulating t

108 re process of neurogenesis, from neural stem cell self-renewal and fate determination to neuronal mat

109 provides a unique model to study neural stem cell self-renewal and fate determination.

110 implicated in regulating pluripotency, stem cell self-renewal and fate specification.

111 Nanog has been identified as critical for ES cell self-renewal and for stabilizing a pluripotent gene

112 atopoietic stem cell (HSC) and leukemic stem cell self-renewal and functions in the context of the Po

113 Through H1.0, Quisinostat inhibits cancer cell self-renewal and halts tumor maintenance without af

114 Bmi1 is implicated in the control of stem cell self-renewal and has been shown to regulate cell pr

115 ing development that may participate in stem cell self-renewal and hematopoietic differentiation.

116 that FTO plays critical roles in cancer stem cell self-renewal and immune evasion and highlights the

117 that Klf4 functions upstream of Nanog in ES cell self-renewal and in preventing ES cell differentiat

118 ncing Satb1 or Satb2 expression decreased TS cell self-renewal and increased differentiation, whereas

119 Nanog facilitates embryonic stem cell self-renewal and induced pluripotent stem cell gene

120 Balancing stem cell self-renewal and initiation of lineage specificatio

121 stem cell-niche adhesion is crucial for stem cell self-renewal and is dynamically regulated.

122 Furthermore, TAF1 is required for leukemic cell self-renewal and its reduction promotes the differe

123 1-ETO-induced haematopoietic stem/progenitor cell self-renewal and leukaemogenesis.

124 ectively, elucidates new key players in stem cell self-renewal and leukemic transformation.

125 ng the molecular cues controlling progenitor cell self-renewal and lineage commitment is critical for

126 Both stem cell self-renewal and lineage differentiation are contro

127 attractive model in which to study both stem cell self-renewal and lineage differentiation at the mol

128 DNA damage-mediated disruption of adult stem cell self-renewal and lineage differentiation, and might

129 we report that Klf4 is required for both ES cell self-renewal and maintenance of pluripotency and th

130 0-15 somatic cells that is required for stem cell self-renewal and maintenance.

131 n 4 (ID4) is a key regulator of mammary stem cell self-renewal and marks a subset of BLBC with a puta

132 r dissecting the signalling pathways of stem cell self-renewal and may help develop more effective ch

133 coordinately to regulate haematopoietic stem cell self-renewal and mobilization.

134 ved pathway that promotes hematopoietic stem cell self-renewal and multipotency by limiting stem cell

135 ory features of the network that underpin NS cell self-renewal and multipotency.

136 has been found to be a key regulator of stem cell self-renewal and myogenesis in normal skeletal musc

137 y diminished progenitor pools, impaired stem cell self-renewal and nearly complete loss of competitiv

138 here that Wnt7a is essential for neural stem cell self-renewal and neural progenitor cell cycle progr

139 nt advances in the regulation of neural stem cell self-renewal and neurogenesis by microRNAs.

140 (Sox2), a well established regulator of stem cell self-renewal and neurogenesis.

141 microRNAs (miRNAs) are dispensable for stem-cell self-renewal and neuron production but essential fo

142 tnatal lethality with defects in neural stem cell self-renewal and neuronal/glial cell fate specifica

143 of RNA binding proteins act to promote stem cell self-renewal and oppose cell differentiation predom

144 ulators are required for embryonic stem (ES) cell self-renewal and pluripotency, but few have been st

145 cluding TF occupancy of genes involved in ES cell self-renewal and pluripotency, co-occupancy of TCFA

146 In contrast to the in-depth studies of ES cell self-renewal and pluripotency, few TE-specific regu

147 nscription factors play a major role in stem cell self-renewal and pluripotency, their integration wi

148 licated as regulators of embryonic stem (ES) cell self-renewal and pluripotency.

149 ical role in controlling embryonic stem (ES) cell self-renewal and pluripotency.

150 The niche controls stem cell self-renewal and progenitor differentiation for mai

151 to moderate ROS levels is required for stem cell self-renewal and proliferation.

152 -2 (Msi2) RNA-binding protein maintains stem cell self-renewal and promotes oncogenesis by enhancing

153 eration in aged muscles, decreased satellite cell self-renewal and regenerative potential, and increa

154 matically attenuate leukemia stem/initiating cell self-renewal and reprogram immune response by suppr

155 However, how Klf4 regulates ES cell self-renewal and somatic cell reprogramming is stil

156 lect trxG members, for the maintenance of ES cell self-renewal and somatic cell reprogramming.

157 e niche is compartmentalized to control stem cell self-renewal and stepwise progeny differentiation.

158 that MUC1-C function is of importance to AML cell self-renewal and that inhibition of MUC1-C represen

159 est that Cdkn2c plays a critical role in B1a cell self-renewal and that its impaired expression leads

160 Cell self-renewal and the capacity to differentiate into

161 oblasts are a model system for studying stem cell self-renewal and the establishment of cortical pola

162 ulation of Arf by BCL6 is required for pre-B cell self-renewal and the formation of a diverse polyclo

163 in unearthing new molecules that govern stem cell self-renewal and tissue-regenerative potential.

164 eptor kinase inhibitor increases early BFU-E cell self-renewal and total erythroblast production, sug

165 therefore confer temporal changes upon stem cell self-renewal and tumor suppressor mechanisms.

166 ycomb repressive complexes also control stem cell self-renewal and tumorigenesis, but so far, no form

167 riptional regulation plays key roles in stem cell self-renewal and tumorigenesis.

168 he Notch signaling pathway and mediates stem cell self-renewal and vascular development.

169 issue type, the Wnt pathway can promote stem cell self-renewal and/or direct lineage commitment.

170 tworks that regulate embryonic stem cell (ES cell) self-renewal and pluripotency, little is know abou

171 often overexpressed and participated in stem cells self-renewal and tumorigenesis initiating of prost

172 icate that Sox2 is required for osteosarcoma cell self renewal, and that Sox2 antagonizes the pro-dif

173 ized our understanding of regeneration, stem cell self-renewal, and cancer; yet models for direct ima

174 egulating Pax7, a key regulator of satellite cell self-renewal, and downregulating MyoD and myogenin.

175 mTORC1 non-cell-autonomously regulates stem-cell self-renewal, and highlight a significant role of t

176 reen has implicated over 100 new genes in ES cell self-renewal, and illustrates the power of RNAi and

177 cal processes, including embryogenesis, stem cell self-renewal, and postnatal survival.

178 in ES cells, maintains trophoblast stem (TS) cell self-renewal, and promotes further trophoblastic di

179 of miRs in reprogramming and embryonic stem cell self-renewal, and specifically addresses the regula

180 erprint" is necessary for maintenance of hES cell self-renewal, and synthetic culture systems must ca

181 ut the signaling pathways that regulate stem cell self-renewal are largely unknown.

182 ivision, the mechanisms regulating satellite cell self-renewal are not understood.

183 he mechanisms that control adult neural stem cell self-renewal are still largely unknown.

184 lls that inhibit stem-cell division and stem-cell self-renewal, as documented in the olfactory epithe

185 stem cells continued to show defects in stem cell self-renewal assays, suggesting a requirement for M

186 was required for normal haematopoietic stem cell self-renewal, Asxl2 loss promoted AML1-ETO leukemog

187 The network also controls embryonic stem cell self-renewal but is associated with distinct embryo

188 or protein LNK suppresses hematopoietic stem cell self-renewal, but its presence and role in the brai

189 pel-like factor 5 regulates pluripotent stem cell self-renewal, but its role in somatic stem cells is

190 his TF makes an important contribution to NS cell self-renewal by concurrently activating pro-prolife

191 that linc-RoR maintains human embryonic stem cell self-renewal by functioning as a sponge to trap miR

192 in cellular proliferation and regulate stem cell self-renewal by maintaining expression of key pluri

193 Thus, although it promotes stem cell self-renewal by repressing a bam-dependent process,

194 ion factor is an important regulator of stem cell self-renewal, cancer cell survival, and inflammatio

195 unity, the regulation of autophagy, and stem cell self-renewal capacity, where evidence suggests an i

196 ghter cells, one of which retains the parent cell self-renewal capacity, while the other is committed

197 ata3 enhances adult prostate stem/progenitor cells self-renewal capacity in both organoid and allogra

198 in embryonic development that controls stem cell self-renewal, chromatin organization, and the DNA d

199 However, the mechanisms of cell self-renewal, commitment, and functional integratio

200 rine/paracrine mediators of glioma stem-like cell self-renewal could potentially contribute to the tr

201 the role of Activin/Nodal signalling in stem cell self-renewal, differentiation and proliferation.

202 findings connect sexual identity to the stem cell self-renewal/differentiation decision and highlight

203 Precise regulation of stem cell self-renewal/differentiation is essential for embry

204 ed transcription is a driving force for stem cell self-renewal during adult tissue homeostasis.

205 as a central player in promoting progenitor cell self-renewal during cortical development.

206 Embryonic stem (ES) cell self-renewal efficiency is determined by the Nanog

207 are essential for germline development, stem cell self-renewal, epigenetic regulation, and transposon

208 lpha signalling promotes haematopoietic stem-cell self-renewal, expanding splenic haematopoietic stem

209 omparison of GSC regulators with neural stem cell self-renewal factors identifies common and cell-typ

210 Despite expressing stem cell self-renewal factors, intermediate progenitor cells

211 attenuating their genomic responses to stem cell self-renewal factors.

212 neages that depend on a balance between stem cell self-renewal for continuity and the formation of pr

213 r without homeobox B4 (HOXB4), a potent stem cell self-renewal gene.

214 ork (GRN) that supports neural stem cell (NS cell) self-renewal has so far been poorly characterized.

215 Its specific role in mouse epiblast stem cell self-renewal, however, remains poorly understood.

216 chromosome 21q22 confers mouse progenitor B cell self renewal in vitro, maturation defects in vivo a

217 Retinoic acid (RA) has been linked to stem cell self-renewal in adults and also participates in yol

218 a but are required for maintaining satellite cell self-renewal in hypoxic environments.

219 r ROR overexpression leads to increased stem cell self-renewal in mammary stem cells.

220 agment of collagen VI alpha3, increased stem cell self-renewal in mammosphere assays and Wnt signalin

221 umor-suppressive factor that inhibits cancer cell self-renewal in many cancer types, can be broadly i

222 n nuclear receptor TLX regulates neural stem cell self-renewal in the adult brain and functions prima

223 ffect on long-term, but not short-term, stem cell self-renewal in vitro.

224 ished that allow near unlimited (>10(16)) EP cell self-renewal in which they display a morphology and

225 xpression of Bmi-1 (master regulator of stem cell self-renewal) in dental pulp stem cells.

226 es the expression of genes critical for stem cell self-renewal, including NOTCH1, and may be linked t

227 Pbx1 is required to maintain stem cell self-renewal, including that of mesenchymal stem ce

228 antly inhibit VEGF secretion, decreased stem cell self-renewal, inhibited tumor growth, and increased

229 Nin regulates neural stem cell self-renewal, interkinetic nuclear migration, and m

230 ion of small molecules in modulation of stem cell self-renewal is a promising approach to expand stem

231 Satellite cell self-renewal is an essential process to maintaining

232 Stem cell self-renewal is controlled by concerted actions of

233 Stem cell self-renewal is controlled by concerted actions of

234 Because abnormal stem cell self-renewal is frequently observed during tumor fo

235 how the transcriptional network promoting ES cell self-renewal is interrupted, allowing cellular diff

236 Stem cell self-renewal is intrinsically associated with cell

237 Stem cell self-renewal is tightly controlled by the concerted

238 L4, a gene involved in the maintenance of ES cell self-renewal, is aberrantly expressed in 47.7% of p

239 PTF appears to regulate tumor growth through cell self-renewal maintenance, and BPTF knockdown leads

240 loyment of gut epithelia as a niche for stem cell self-renewal may provide a mechanism for direct com

241 The stem cell self-renewal mediated by SALL4 is linked to epigene

242 hese findings provide new insights into stem cell self-renewal mediated by SALL4 via epigenetic machi

243 series of coordinated steps, including germ cell self-renewal, meiotic recombination, and terminal d

244 d with (1) embryonic development and/or stem cell self renewal (MSX, MEIS, ID, Hes1, and SIX homeodom

245 king Fgf/Erk activity is known to promote ES cell self-renewal, once cells have experienced a period

246 pment of exogenous molecules to control stem cell self-renewal or differentiation has arrived at natu

247 e plays a key role in the regulation of stem cell self-renewal or differentiation.

248 (SSCs); their progeny either remain as stem cells (self-renewal) or proliferate and differentiate to

249 ction of autophagy; augmentation of GBM stem cell self-renewal; possible implications of GBM-endothel

250 functions and are required to maintain stem cell self-renewal potential.

251 ols both physiological and pathological stem cell self-renewal primarily by repressing target mRNAs t

252 al NSPCs can provide insight into basic stem cell self-renewal principles important for tissue homeos

253 ed a loss of the hematopoietic/leukemic stem cell self-renewal program and an increase in the differe

254 h Noggin is sufficient to foster hippocampal cell self-renewal, proliferation, and multipotentiality

255 Embryonic stem cell self-renewal properties are attributed to critical

256 t by providing a humanized environment, stem cell self-renewal properties were better maintained as d

257 ole for post-transcriptional control in stem cell self-renewal, provide mechanistic insight on APA re

258 We found that the stem cell self-renewal regulator SOX2 is a novel target of mi

259 The determinants of normal and leukemic stem cell self-renewal remain poorly characterized.

260 w repetitive antigenic stimulation impairs T cell self-renewal remains poorly defined.

261 t TLX, an essential regulator of neural stem cell self-renewal, represses the expression of miR-137 b

262 To identify strategies of stem cell self-renewal requires that different models of stem

263 KDM2B (also known as FBXL10) controls stem cell self-renewal, somatic cell reprogramming and senesc

264 powerful model system for investigating stem cell self-renewal, specification of temporal identity, a

265 the canonical asymmetric vs. symmetric stem cell self-renewal strategies and are distinguished by a

266 hallenges and opportunities to identify stem cell self-renewal strategies: while under asymptotic con

267 ion of several miRNAs involved in EMT and/or cell self-renewal such as miR-34a-5p, miR-34c-5p, miR-21

268 enes have been implicated in vertebrate stem cell self-renewal, suggesting that this core set of gene

269 T3 in the coordination of colonic epithelial cell self-renewal, suggesting this factor as a new bioma

270 ently described ability of p53 to limit stem cell self-renewal suppresses tumorigenesis in acute myel

271 lucidate a new role for beta-catenin in stem cell self-renewal that is independent of its transcripti

272 own to be required for postnatal neural stem cell self-renewal, the role of trxG genes remains unknow

273 demonstrates that TWEAK suppresses satellite cell self-renewal through activating NF-kappaB and repre

274 critical role in tooth development and stem cell self-renewal through beta-catenin.

275 Further, eliminating tumor cell self-renewal through deletion of Id1 has modest eff

276 Here we show that GV represses melanoma stem cell self-renewal through inhibition of SOX2.

277 aining stem cell identity and governing stem cell self-renewal through transcriptional repression.

278 enic effects, VEGF promotes tumor-initiating cell self-renewal through VEGFR-2/STAT3 signaling.

279 ell function and their consequences for stem cell self-renewal, tissue homeostasis, and regeneration.

280 However, the progression from stem cell self-renewal to overt signs of early differentiatio

281 imple isoform switch to regulate glioma stem cell self-renewal, tumorigenicity, and progression.

282 hed in the prostate, promoting prostate stem cell self-renewal upon proteolytic activation via a gamm

283 model to understand how the balance of stem cell self-renewal versus differentiation is achieved.

284 Stem cell self-renewal versus differentiation is regulated by

285 ifferent signaling pathways involved in stem cell self-renewal versus lineage-specific differentiatio

286 xpression of BMI1, a known regulator of stem cell self-renewal, was modulated by miR-200c.

287 Significantly for the maintenance of stem cell self-renewal, we detected a reduction in the expres

288 t into mechanisms controlling embryonic stem cell self-renewal, we explore the molecular and cellular

289 Low CMA activity promotes embryonic stem cell self-renewal, whereas its up-regulation enhances di

290 investigations showed that KANSL2 regulates cell self-renewal, which correlates with effects on expr

291 Asxl1 deletion reduces hematopoietic stem cell self-renewal, which is restored by concomitant dele

292 cell-permeable alphaKG directly supports ES-cell self-renewal while cell-permeable succinate promote

293 d showed that H3.3 K27M enhanced neural stem cell self-renewal while preserving regional identity.

294 during neural development in promoting NS/P cell self-renewal while restricting the generation and m

295 mechanisms that coordinate the rate of stem cell self-renewal with differentiation at a population l

296 re essential in regulating neural progenitor cell self-renewal, with the chromatin-modifying protein

297 ) leads to persistently enhanced neural stem cell self-renewal without sign of exhaustion.

298 ells responsible for tumorigenesis and tumor cell self-renewal would provide an important target for

299 Programs to Govern Human Hematopoietic Stem Cell Self-Renewal" (Xie et al., 2019).

300 ion factor implicated in embryonic stem (ES) cell self-renewal, yet its knockout causes intrauterine