ライフサイエンスコーパス: cell surface receptor

1 but was absent in mice lacking the ligand's cell surface receptor.

2 ells that differentially produce the alphaDG cell surface receptor.

3 therapeutics targeting virus binding to this cell surface receptor.

4 h GPI-APs enable the signaling capacity of a cell surface receptor.

5 tion of envelope protein (Env) with specific cell surface receptors.

6 t can bind ligand, sequestering it away from cell surface receptors.

7 ens stems from the broad diversity of immune cell surface receptors.

8 hat directly target neutrophils via specific cell surface receptors.

9 an be mobilized in response to activation of cell surface receptors.

10 and activation via signaling through various cell surface receptors.

11 r signalling is dependent on the presence of cell surface receptors.

12 ated upon its binding to uPAR/CD87 and other cell surface receptors.

13 ate with their environment, in part, through cell surface receptors.

14 eter in the allosteric regulation of diverse cell surface receptors.

15 which disrupts the virus' ability to bind to cell surface receptors.

16 cytokines only when they are bound to their cell surface receptors.

17 erception of conserved microbial patterns by cell surface receptors.

18 autocrine or paracrine fashion via specific cell surface receptors.

19 he local environment through numerous innate cell surface receptors.

20 , with activation typically mediated through cell surface receptors.

21 atty acids act directly on intracellular and cell surface receptors.

22 ed by signals cells receive from outside via cell surface receptors.

23 s to a potential regulation of G proteins by cell surface receptors.

24 y on specific binding of secreted ligands to cell surface receptors.

25 are triggered by CoV entry mediated by host cell surface receptors.

26 us deploys this strategy to bind strongly to cell surface receptors.

27 nteractions between viral proteins and their cell surface receptors.

28 tivation of, and signal integration between, cell surface receptors.

29 conformation that is no longer able to bind cell surface receptors.

30 hydrolytic release before they can activate cell surface receptors.

31 ation of specific mRNAs in growing axons via cell surface receptors.

32 at least 20 IFNs, there are only three known cell surface receptors.

33 nse to extracellular spatial cues relayed by cell-surface receptors.

34 rix proteins, growth factors, proteases, and cell-surface receptors.

35 es, indicating that eNAD(+) may be sensed by cell-surface receptors.

36 GNE activity might affect signaling through cell-surface receptors.

37 ignaling, cell migration and presentation of cell-surface receptors.

38 in regulating the trafficking of a number of cell-surface receptors.

39 s target the extracellular regions (ECRs) of cell-surface receptors.

40 and highly selective binding to their target cell-surface receptors.

41 ttenuation of signalling by kinase-activated cell-surface receptors.

42 d by interactions between viral proteins and cell-surface receptors.

43 lpha-linked sialic acid (alpha-SA) and JAM-A cell-surface receptors.

44 t role in the assembly and signaling of many cell-surface receptors.

45 s for many diseases to inhibit signalling by cell-surface receptors(1).

46 2) is initiated by virus binding to the ACE2 cell-surface receptors(1-4), followed by fusion of the v

47 After HPV binding to cell surface receptors, a cascade of molecular interacti

48 In many families of cell surface receptors, a single transmembrane (TM) alph

49 Both cell surface receptor accumulation and LTP facilitation

50 rgdorferi internalization and that different cell surface receptors act simultaneously in cooperation

51 LL), signaling through several prosurvival B cell surface receptors activates the PI3K signaling path

52 the membrane microenvironment in modulating cell surface receptor activation.

53 tivating mutations in the type I BMP/TGFbeta cell surface receptor ACVR1, which over-activates signal

54 ing affinity of Nodal ligands to their major cell surface receptor, Acvr2b, and to the Nodal inhibito

55 te with each other by direct binding between cell surface receptor and ligand pairs.

56 et al. (2017) identify neuropilin (NRP)-2 as cell surface receptor and the tetraspannin protein CD63

57 Extracellular Reelin binds to cell surface receptors and activates phosphorylation of

58 sceral endoderm epithelium involves specific cell surface receptors and an extensive sub-membrane ves

59 1 regulates inflammation by engaging several cell surface receptors and by modulating activities of o

60 way that serves as an essential link between cell surface receptors and cellular processes including

61 d behavior by mediating interactions between cell surface receptors and downstream signaling effector

62 inin (HA) mediates virus entry by binding to cell surface receptors and fusing the viral and endosoma

63 Linking the activity of cell surface receptors and ion channels in defined neura

64 refolding inclusion-body-based, recombinant cell surface receptors and ligands in one day, a speed e

65 nteraction that is driven by its adhesion to cell surface receptors and resisted by membrane bending

66 We hypothesized that DSP interacts with cell surface receptors and subsequently activates intrac

67 nitiated upon TGF-beta ligand binding to its cell surface receptors and the dependence of the signali

68 aling lymphocytic activation molecule family cell surface receptors and the X-chromosome-defined sign

69 Cell surface receptors and their interactions play a cen

70 Production of membrane-associated cell surface receptors and their ligands is often a cumb

71 ein mediates virus entry by first binding to cell surface receptors and then fusing viral and endosom

72 cules derived from microbes are perceived by cell surface receptors and upon signaling to the nucleus

73 f oligomeric transmembrane domains (TMDs) of cell surface receptors and viral membrane proteins.

74 addition, they should bind reversibly to the cell-surface receptor and give rise to a large change in

75 ugh Rab5 GTPases that control endocytosis of cell-surface receptors and Abl nonreceptor tyrosine kina

76 e glycoproteins bind the infecting virion to cell-surface receptors and mediate membrane fusion.

77 ect relevance to the interaction of HCV with cell-surface receptors and neutralising antibodies.

78 Cell-surface receptors and their ligands have traditiona

79 Blocking the interaction between cell-surface receptors and their ligands is a proven the

80 s, an attachment protein (G), which binds to cell surface receptors, and a fusion (F) protein, which

81 Such machines exist in nature, for example cell surface receptors, and have been artificially engin

82 ling, increased the expression of inhibitory cell surface receptors, and interfered with the ability

83 ightly regulated network of plasma proteins, cell surface receptors, and regulators.

84 t from a latent extracellular complex to its cell-surface receptor, and point to a broader paradigm o

85 ent MPNs, (iii) modular targeting of MPNs to cell-surface receptors, and (iv) control of spatial and

86 cotinic receptor has been a model system for cell-surface receptors, and specifically for ligand-gate

87 ylated trimeric Spike protein to bind to the cell surface receptor angiotensin converting enzyme 2 (A

88 Antibody combinations targeting cell surface receptors are a new modality of cancer ther

89 Cell surface receptors are central to the cell's ability

90 tracellular protein interactions mediated by cell surface receptors are essential for intercellular c

91 Many viral surface glycoproteins and cell surface receptors are homo-oligomers, and thus can

92 mers and the manner in which they cross-link cell surface receptors are suggested herein.

93 Although a range of different cell-surface receptors are bound by different picornavir

94 Given that all cell-surface receptors are glycosylated, we expect that

95 ay for MYXO-CTERM proteins by using the TraA cell surface receptor as a paradigm.

96 ical for ISG15 signaling, and identified the cell surface receptor as LFA-1 (CD11a/CD18; alphaLbeta2

97 However, the extracellular cues, cell surface receptors as well as underlying signaling m

98 ional to receptor concentration) of EGFR - a cell-surface receptor associated with cancer - was estim

99 igration to the lymph nodes, where IL-10 and cell-surface receptors associated with immune-suppressio

100 Cytokines activate signaling via assembly of cell surface receptors, but it is unclear whether modula

101 ated with aberrant O-glycosylation of cancer cell surface receptors, but the functional impact of suc

102 and facilitation of their interactions with cell-surface receptors, but deciphering the specific mol

103 As such, CME regulates signaling from cell-surface receptors, but whether and how specific sig

104 Engagement of cell surface receptors by viruses is a critical determin

105 demonstrated variability in expression of a cell surface receptor, CD244 (SlamF4, 2B4), that correla

106 we demonstrated that LY6E downregulates the cell surface receptor CD4, thus impairing the virus bind

107 matrix polysaccharide hyaluronan to its main cell surface receptor CD44 is controlled by the affinity

108 the binding of this glycosaminoglycan to its cell surface receptor, CD44.

109 ical UPR(ER) pathways but dependent upon the cell-surface receptor, CD44, a putative HA receptor, and

110 s are protected from bystander damage by the cell surface receptor CD59, which is offered a maximum t

111 The cell surface receptor CD6 regulates T cell activation in

112 induction of intracellular signaling via its cell surface receptor CD63, a tetraspanin.

113 inating from cardiac tissue that express the cell surface receptor cKit are undergoing clinical testi

114 From metabolic enzymes to cell surface receptors, connecting the function of a pro

115 This approach compels cis-ligation of cell-surface receptors containing ITAM, ITIM or ITSM tyr

116 Siglec-1/CD169 is a myeloid-cell surface receptor critical for HIV-1 capture and inf

117 er cells as defined by the expression of the cell surface receptors CXCR5 and PD-1, are the major sou

118 while simultaneously reducing the remaining cell surface receptor density.

119 d-induced internalization through changes in cell-surface receptor density.

120 ich hitherto has not been reported for other cell-surface receptors, depended on AKT activation and T

121 g virus spike interactions with the MERS-CoV cell surface receptor dipeptidyl peptidase 4 (DPP4), and

122 es in endocytic trafficking and signaling of cell surface receptors downstream of gain-of-function (G

123 d most pharmacologically important family of cell-surface receptors encoded by the human genome.

124 how this African HNV targets the same human cell-surface receptor (ephrinB2) as the Asiatic HNVs.

125 ell production, erythropoietin (EPO) and its cell surface receptor (EPO receptor [EPOR]) have been in

126 Ig-like transcript 3 (ILT3) is an inhibitory cell surface receptor expressed by tolerogenic human den

127 lect pathogenic interactions between RAGE, a cell surface receptor expressed on malignant cells in ad

128 same cell, and interactions between JAM and cell surface receptors expressed on adjacent cells.

129 involved in cell adhesion, axonal guidance, cell surface receptor expression and actin (dis)assembly

130 MDSCs were phenotyped for cell surface receptor expression and enriched by cell so

131 ction in signaling is due to lower levels of cell surface receptor expression.

132 Consistent with its predicted role as a cell-surface receptor, Fat3 functions cell-autonomously

133 ions between the Fc region and two principal cell surface receptors FcepsilonRI and CD23.

134 binds transferrin receptor 1 (TfR1)-the host cell surface receptor for all New World hemorrhagic feve

135 While the cell surface receptor for MERS-CoV has been identified a

136 -converting enzyme 2 (ACE2) is the canonical cell surface receptor for SARS-CoV-2.

137 factor-inducible 14 (Fn14; TNFRSF12A) is the cell surface receptor for the tumor necrosis factor (TNF

138 LAD-I) patient identified CD18 as a putative cell surface receptor for uptake of live P. aeruginosa H

139 nd mucin domain (TIM) family proteins act as cell surface receptors for EBOV, and that the interactio

140 tigen-presenting cells equipped with various cell surface receptors for the direct or indirect recogn

141 gamma receptor III (FcgammaRIII or CD16) are cell surface receptors for the Fc portion of IgG and imp

142 extracellular signaling mechanism whereby a cell-surface receptor for a chemorepellent confers speci

143 of immunoglobulin M (IgM) can function as a cell-surface receptor for secreted IgM on a variety of c

144 CD74 is a cell-surface receptor for the cytokine macrophage migrat

145 coded elements has been explored, exploiting cell-surface receptors for boosting selectivity has not

146 By investigating the role of cell-surface receptors for coagulation factors in mouse

147 By serving as cell-surface receptors for numerous extracellular ligand

148 no known host cell receptors for TcdA, three cell-surface receptors for TcdB have been identified: CS

149 c acid-binding Ig-type lectins (Siglecs) are cell surface receptors found on immune cells and inhibit

150 play crucial roles in endocytic recycling of cell surface receptors from endosomes to the plasma memb

151 ed crops and, more generally, for inhibiting cell surface receptor function and manipulating signalin

152 r of granulocyte lineage development via its cell surface receptor (G-CSFR), can play a role in infla

153 Cell surface receptors govern a multitude of signalling

154 umans or animals, attenuation of the colonic cell surface receptor guanylyl cyclase C (GUCY2C) that o

155 er understanding of endocytosis of different cell surface receptors has implications in designing str

156 on of ATP as an extracellular transmitter at cell-surface receptors has evolved from somewhat of a no

157 The Siglec family of cell surface receptors have emerged as attractive target

158 d Flo11A domains, provide a rationale of how cell surface receptors have evolved in microorganisms to

159 ive activity of an anti-tyrosine kinase-type cell-surface receptor HER2 mAb.

160 ich induce cellular activities by binding to cell surface receptors IFNAR1 and IFNAR2.

161 internalization of apoD involves a specific cell surface receptor in 293T cells, identified as the t

162 asis, mechanisms underlying the role of this cell surface receptor in CRC have not been defined.

163 rated signals from inhibitory and activating cell surface receptors in a process termed NK cell educa

164 tance and underlying molecular mechanisms of cell surface receptors in HCV cell-free and cell-to-cell

165 results place atomic, A-scale structures of cell surface receptors in the context of functional and

166 st decade, monospecific antibodies targeting cell-surface receptors in different tumour types have ac

167 mechanical control over genetically encoded cell-surface receptors in live cells.

168 autocrine or paracrine fashion via specific cell surface receptors, in a variety of pathways that pr

169 WNT16B recognizes cancer cell surface receptors including frizzled (FZD) 3/4/6, a

170 hether and how APP may regulate functions of cell surface receptors, including GPCRs, remains largely

171 It was long thought that most cell surface receptors, including the BCR, were freely d

172 est was the increased expression of numerous cell surface receptors, including TLR4 and TLR15, which

173 chemical effect on cells through an array of cell-surface receptors, including CD44, RHAMM/CD168, and

174 A diverse group of cell-surface receptors, including many G protein-coupled

175 ll-cycle entry and reduced expression of the cell-surface receptor inducible T-cell costimulator liga

176 on is how the spatiotemporal distribution of cell surface receptors influences the transmembrane sign

177 the peptide A20FMDV2 selectively target the cell surface receptor integrin alphavbeta6.

178 Neuropilins (Nrps) are a family of essential cell surface receptors involved in multiple fundamental

179 -coupled receptors (GPCRs), a superfamily of cell-surface receptors involved in virtually all physiol

180 n) abrogated entry, indicating that the SHFV cell surface receptor is a protein.

181 tion of influenza A virus glycoproteins with cell surface receptors is a major determinant of infecti

182 The imaging of dysregulated cell-surface receptors is a potential means of identifyi

183 The cell surface receptors IsdB and IsdH bind hemoproteins a

184 to specific types of cells, by altering the cell-surface receptor it binds, is desirable to generate

185 P4 complex (holo-RBP) can be recognized by a cell-surface receptor known as stimulated by retinoic ac

186 S can detect shedding in chimeras of diverse cell surface receptors, leading to new, testable hypothe

187 irst layer of plant immunity is activated by cell surface receptor-like kinases (RLKs) and proteins (

188 We identified the cell surface receptor-like protein CUSCUTA RECEPTOR 1 (C

189 ecent cloning of the elicitin response (ELR) cell surface receptor-like protein, from the wild potato

190 Not much is known about which cell surface receptors may be involved in the cell-to-ce

191 Differential expression of cell surface receptors may result in altered thresholds

192 Integrin alphabeta heterodimer cell surface receptors mediate adhesive interactions tha

193 gnal triggers cell polarization by promoting cell surface receptor-mediated nanoclustering of signali

194 affects endosomal receptor-mediated, but not cell surface receptor-mediated, recognition of Toll-like

195 nly cells that express the cognate chemokine cell surface receptor, migrate under the spot containing

196 cells, but signals they carry and deliver to cell surface receptors modulate gene expression and func

197 These mediators activate specific cell-surface receptors-namely, purinergic 1 and 2 (P1 an

198 to both BMP2 and the ubiquitously expressed cell surface receptor neogenin.

199 and found that DSP is a ligand and binds to cell surface receptor, occludin.

200 symmetry breaking signals that interact with cell surface receptors of the FZD family to regulate a m

201 Cell surface receptors of the NOTCH family of proteins a

202 In our approach, a SNAP-tagged cell-surface receptor of interest is conjugated with a s

203 Plexins are key cell-surface receptors of the semaphorin family of cell-

204 al labeling of the extracellular domain of a cell surface receptor on living mammalian cells with a s

205 CTLA4 is a cell surface receptor on T cells that functions as an im

206 on adjacent cells, stabilization of adjacent cell surface receptors on the same cell, and interaction

207 y involves genetic determinants that provide cell surface receptors or diffusible signalling chemical

208 nown whether APP family proteins function as cell surface receptors, or mainly via shedding of their

209 Cell-surface-receptor pathways amplify weak, rare and lo

210 increased mean expression of the regulatory cell surface receptor PD1 by 62.2% in the effector CD4 T

211 of the coaggregation-mediating streptococcal cell-surface receptor polysaccharides (RPS).

212 CD229/LY9 is a cell surface receptor present on B and T lymphocytes tha

213 In uninfected cells, cell surface receptors recognize the secreted interferon

214 ubcellular localization, the identity of the cell surface receptor remains undefined.

215 ndocytosis regulates turnover of the various cell surface receptors remains unclear.

216 Following attachment to cell surface receptors, reovirus is internalized by rece

217 d increased expression of MuSK and Lrp4, two cell surface receptors required for NMJ formation.

218 the cytoskeleton and tissue factor (TF), the cell surface receptor responsible for coagulation activa

219 ing a relatively broad ligand specificity of cell-surface receptor(s).

220 Siglec-8 is a CD33 subfamily cell-surface receptor selectively expressed on human eos

221 The TraA cell surface receptor selects OME partners based on a va

222 between influenza hemagglutinin (HA) and its cell surface receptor sialic acid (SA) to identify a B c

223 lutinin (HA) and neuraminidase (NA) with the cell surface receptor sialic acid.

224 The cell surface receptor signal regulatory protein alpha (S

225 numbers of genes from the compendium encoded cell surface receptors, signaling molecules (hormones, n

226 ed from human AGM show similar expression of cell surface receptors, signaling molecules and transcri

227 the immune response, the host cell cycle and cell surface receptor signalling.

228 sent an alternative approach for attenuating cell-surface receptor signalling, termed receptor inhibi

229 effect on the binding affinity of IFN to the cell surface receptors, STAT phosphorylation, or gene in

230 sulting from the reliance of HCV on multiple cell surface receptors, suggesting that vaccine inductio

231 igen receptor biological activities for this cell-surface receptor system.

232 ceptor (ADR) selectively recognizes 4-1BB, a cell surface receptor temporarily upregulated by activat

233 mutations in the genes encoding the TGFbeta cell surface receptors (TGFBR1/ALK5 and TGFBR2) have bee

234 This behavior requires TraA, a homophilic cell surface receptor that identifies kin based on simil

235 In myxobacteria, TraA is a polymorphic cell surface receptor that identifies kin by homotypic b

236 g M protein (PAM) is a group A streptococcal cell surface receptor that is crucial for bacterial viru

237 s a molecular target; an epithelium-specific cell surface receptor that is low or undetectable in hea

238 protein 1 (LRP1) is a ubiquitously expressed cell surface receptor that protects from intracellular c

239 Heparan sulfate proteoglycans (HSPGs) are cell surface receptors that are involved in the cellular

240 Integrins are cell surface receptors that bind cells to their physical

241 ntegrins are a large family of heterodimeric cell surface receptors that bind prototypic ligands on n

242 G protein-coupled receptors (GPCRs) are cell surface receptors that detect a wide range of extra

243 n algorithm that predicts which species have cell surface receptors that make them susceptible to Mac

244 Several cell surface receptors that participate in B. burgdorfer

245 venger receptors (SRs) are a large family of cell-surface receptors that are diverse in their structu

246 mediated to a large extent by a multitude of cell-surface receptors that bind specific ligands.

247 Leukocytes express cell-surface receptors that bind to chemokines and trigg

248 Stimulation of cell-surface receptors that couple to phospholipase C to

249 Cytokine signaling is transmitted by cell-surface receptors that function as biological switc

250 It is important to characterize new cell-surface receptors that modulate IgE-mediated basoph

251 G protein-coupled receptors (aGPCRs) are key cell-surface receptors that regulate numerous pathophysi

252 e functions are mediated by ion channels and cell surface receptors, the expression of which varies w

253 covalently attached to a genetically encoded cell surface receptor to achieve voltage imaging from ge

254 athway that couples the alphavbeta6 integrin cell surface receptor to androgen receptor via activatio

255 Wnts are secreted proteins that bind to cell surface receptors to activate downstream signaling

256 med after the secreted proteins that bind to cell surface receptors to activate the pathway, plays cr

257 A BR signaling pathway from cell surface receptors to central transcription factors

258 Here we show that Sema7A utilizes different cell surface receptors to control the proliferation and

259 in trafficking and down-regulate a number of cell surface receptors to enhance replication and promot

260 major" and "minor" groups that use different cell surface receptors to enter host cells.

261 Plants depend on various cell surface receptors to integrate extracellular signal

262 rted previously that uPA is transported from cell surface receptors to nuclei through a mechanism tha

263 lian brain and controls functions of various cell surface receptors to regulate neurotransmission.

264 ogenic rheostat through a novel complex with cell surface receptors to regulate STAT3 activation, cyt

265 rward pathway that could link signaling from cell surface receptors to the regulation of CME.

266 step process that is initiated by binding of cell surface receptors to their ligands on the extracell

267 ism through which secreted proteins activate cell surface receptors to transmit essential biological

268 expression data and matched PPC chemotactic cell-surface receptors to cognate ligands expressed in t

269 iew is that SRC acts primarily downstream of cell-surface receptors to control intracellular signalin

270 plasma iron-binding molecule, interacts with cell-surface receptors to deliver iron, modulates hepcid

271 1P) is a bioactive lipid that interacts with cell-surface receptors to exert different cellular respo

272 Macrophages use various cell-surface receptors to sense their environment and un

273 ed that interlayer coordination required the cell-surface receptor TOO MANY MOUTHS (TMM).

274 By direct visualization of a cell surface receptor, TraA, we show how these myxobacte

275 fy related individuals through a polymorphic cell surface receptor, TraA.

276 Cell surface receptors, transcription factors, and the t

277 Rare sequence variants in the microglial cell surface receptor TREM2 have been shown to increase

278 Activation of various cell surface receptors triggers the reorganization of do

279 Its binding to CD47, a cell surface receptor, triggers programmed cell death.

280 Here, we identify that high levels of cell surface receptor Trop2 are predictive of recurrence

281 iple genes regulating vesicular trafficking, cell surface receptor turnover, and secretion of extrace

282 hrin type-A receptor 2 (EPHA2), an oncogenic cell-surface receptor tyrosine kinase, as a therapeutic

283 ll surfaces and allow ssMPs to interact with cell surface receptors under an environment closest to c

284 Cell surface receptor uptake via clathrin-mediated endoc

285 s have been shown to block signaling through cell surface receptors using several mechanisms.

286 To internalize nutrients and cell surface receptors via clathrin-mediated endocytosis

287 cally signal through homo- or hetero-dimeric cell surface receptors via Janus Kinase (JAK/TYK), or Re

288 Considering responses downstream of selected cell-surface receptors, we discuss how receptor internal

289 hat extra-cellular ligands activate specific cell surface receptors, which orchestrate downstream res

290 llular prion protein (PrP(C)) functions as a cell-surface receptor, which binds to Abeta oligomers an

291 nals by expressing an array of cytokines and cell-surface receptors, which shape subsequent immune re

292 (GPs) mainly engage alpha-dystroglycan as a cell-surface receptor, while New World arenaviruses hija

293 meable, making them useful for modulation of cell-surface receptors, while monosulfonated BODIPY reta

294 tate high-affinity binding to virus-specific cell-surface receptors, while other glycans function as

295 utic antibodies that block signaling through cell surface receptors whose ligands are also cell surfa

296 New tools that allow direct labeling of a cell surface receptor with synthetic probes would aid in

297 Modification of cell surface receptors with branched N-glycans coordinat

298 bind to either CD40 or LOX-1, two dendritic cell surface receptors with different functions and tiss

299 The assembly of cell surface receptors with downstream signaling molecul

300 se, delivering piconewton forces to specific cell surface receptors with high spatial and temporal re