ライフサイエンスコーパス: cell type

1 us conditions (cell-free and cell-based, two cell types).

2 y shows very little variation within a given cell type.

3 al regulation networks encoded in a specific cell type.

4 ctivation of NFkB and a resultant aggressive cell type.

5 types and transcriptomic signatures of each cell type.

6 almost all transcriptomically defined neural cell types.

7 twork of interconnected systemic signals and cell types.

8 ring, and extensions to different tissue and cell types.

9 poxia via HIF-1 promoter-binding in multiple cell types.

10 lution including expression switches between cell types.

11 ses to identify novel network connections or cell types.

12 s of messenger ribonucleoproteins in several cell types.

13 ng the CC-susceptibility variants in various cell types.

14 ctivity of TDRD7 in multiple human and mouse cell types.

15 entiated cells or the production of a mix of cell types.

16 mental transition from stem cells to various cell types.

17 ing capacities for interactions with stromal cell types.

18 ties of cortical neurons without considering cell types.

19 erpin the generation of different pancreatic cell types.

20 lylation of the death receptor TNFR1 in many cell types.

21 egy can be applied to other cancer or normal cell types.

22 eductal gray (vlPAG), which contains diverse cell types.

23 tion acts at the resolution of the different cell types.

24 tes, microglia, astrocytes, and endothelial) cell types.

25 ehavior studies have extended into mammalian cell types.

26 or of autophagic flux in multiple Drosophila cell types.

27 unoprecipitating with the target, in several cell types.

28 retrotransposons called B2 SINEs in multiple cell types.

29 eed for DNA methylation profiles of purified cell types.

30 red these maps to over 100 human tissues and cell types.

31 ch less is known about its function in other cell types.

32 tive of differential network activity across cell types.

33 nd its components in different neurovascular cell types.

34 dress lineage restriction of closely related cell types.

35 y to deliver a cytotoxic payload to specific cell types.

36 lity to deliver them in vivo to the relevant cell types.

37 human gene regulation in diverse tissues and cell types.

38 life cycle consisting of two differentiated cell types.

39 cells with their capacity to generate mature cell types.

40 than 100 clusters corresponding to putative cell types.

41 ing more than 100 transcriptionally distinct cell types.

42 the spatial organization of its constituent cell types.

43 ely abrogates the expression of IL-3 in both cell types.

44 calibration standard among laboratories and cell types.

45 lacking the CD103(+) conventional dendritic cell type 1 (cDC1) subpopulation important for antigen c

46 verse and morphologically disparate range of cell types [1].

47 (BCG) and to observe interactions with each cell type, alongside cytokine release.

48 eaken MYC's oncogenic potential depending on cell type and biological context.

49 n a highly disease-relevant primary cultured cell type and provide novel insights into their function

50 269 single cardiac nuclei, revealing 9 major cell types and 20 subclusters of cell types within the h

51 profiles, revealing extensive plasticity of cell types and cell-type-specific gene expression during

52 llaborations are generating major surveys of cell types and connections in the mouse brain, collectin

53 ironment using functionally distinct layers, cell types and extracellular matrix.

54 2+) is a fundamental second messenger in all cell types and is required for numerous essential cellul

55 lular distribution vary significantly across cell types and physiological states of the cell.

56 data with bulk expression profiles from six cell types and prior marker information of only three ce

57 he dynamic interactions between the numerous cell types and regions of the central nervous system, ha

58 and therefore, their target genes, affected cell types and regulatory mechanisms remain unknown.

59 tion of the location patterns across various cell types and states is still challenging.

60 framework to more diverse, disease-relevant cell types and states.

61 ur ability to study the origin of individual cell types and stem cell units.

62 ring methods were applied to identify immune cell types and subsets significantly associated with PBC

63 ar content of the nervous system in terms of cell types and the rules of their connectivity represent

64 a roadmap for understanding the diversity of cell types and their functional role in cortical computa

65 om dissociated tissues provide insights into cell types and their gene expression and may harbor addi

66 mune response in whole animals with multiple cell types and tissues.

67 on tissue complexity including the number of cell types and transcriptomic signatures of each cell ty

68 sedimentation, improve viability of multiple cell types, and enhance mechanical stability in hydrogel

69 of ZIKV when they are released from specific cell types, and enhances virus attachment and entry into

70 ate, spanning multiple time and size scales, cell types, and organ systems, rendering systems biology

71 exosomes, their ubiquitous production by all cell types, and their biological features in liquid biop

72 trophy but also shed light on strategies for cell type- and stage-specific intervention in cardiac di

73 ived from small intestinal organoids reveals cell-type- and cell-state-specific signaling networks in

74 on estimations when markers from partial/all cell types are available.

75 sks for the scRNA-seq data, where labels for cell types are costly and often impossible to acquire.

76 numerous as reported by light level studies; cell types are stereotyped, but not identical, in cell a

77 We identified one of the involved cell types as sustained ON alpha-ganglion cells.

78 pendymal cells were the most FGF1-responsive cell type at Day 1, but astrocytes and oligodendrocyte l

79 ta aggregation could serve as an example for cell type atlases in other parts of the body.

80 We propose CITE-sort, an artificial-cell-type aware surface marker clustering method for CIT

81 ved a broad range of heteroplasmy across all cell types but also found markedly reduced heteroplasmy

82 common set of targets among different neural cell types but also operates in a cell type-specific man

83 Trypanosoma cruzi infects many cell types but preferentially persists in muscle, and we

84 of T. evanescens is not formed by a separate cell type, but by extensions of the lateral rim pigment

85 -Seq from matched samples recovered the same cell types, but at different proportions.

86 ncreased cell-free infectivity of TR in both cell types, but spread in fibroblasts was impaired.

87 ctions between tissue-specific ECs and other cell types by analyzing ligand and receptor expression p

88 Here we introduce probabilistic cell typing by in situ sequencing (pciSeq), an approach

89 populations of mature differentiated primary cell types can display variable responsiveness to extrac

90 features as well as therapeutically relevant cell types, cell states, and cellular interactions acros

91 plicing events with subtle difference across cell types compared to Census and DEXSeq.

92 led that enhancers are more distinct between cell-types compared to other chromatin states.

93 CR attenuated aging-related changes in cell type composition, gene expression, and core transcr

94 Complexity of cell-type composition has created much skepticism surrou

95 arity, ethnicity, neonate sex, and predicted cell-type composition.

96 dy not only illustrated dynamically changing cell type crosstalk during pathological cardiac hypertro

97 taxonomies and was applied herein to diverse cell type datasets derived from multiple quantifiable mo

98 tes defined in this study with epigenomes of cell-types defined by the Roadmap Epigenomics project re

99 Human organoids recapitulating the cell-type diversity and function of their target organ a

100 seq) has allowed high-resolution analysis of cell-type diversity and transcriptional networks control

101 ages.IMPORTANCE Macrophages are an important cell type during coronavirus infections because they "no

102 omplex interactions that occur between brain cell types during neurodegeneration.

103 ng because of sparse sampling of the various cell types during the analytical procedure, contaminatio

104 iferative and differential state of multiple cell types, during both development and adulthood.

105 The neural crest gives rise to numerous cell types, dysfunction of which contributes to many dis

106 the context-dependent crosstalk of different cell types enables physiological processes to proceed, w

107 in the respiratory epithelium, more than one cell type expresses CFTR and the molecular mechanisms co

108 Because of their restricted cell type expression and roles as checkpoints in immune

109 aetiological understanding by associating SN cell type expression profiles with specific disease risk

110 ve bulk-tissue cortical expression data into cell-type expression maps, we link anatomical change map

111 anges in composition and expression based on cell type, external stimuli, and genetic factors.

112 doption of a transcriptome-based taxonomy of cell types for mammalian neocortex.

113 llular organisms robustly generate different cell types from one zygote.

114 that input patterns are highly dependent on cell type (GABAergic/non-GABAergic) and location (module

115 Although many cell types have been subjected to CRISPR/Cas9-mediated g

116 Tumor cell-type heterogeneity, defined as the proportion of th

117 and macrophages are likely targets as these cell types highly expressed 15-PGDH.

118 ntiation of committed progenitors into these cell types, however, are incompletely understood.

119 o identify active regulons within a specific cell type, i.e., cell-type-specific regulons (CTSR), pro

120 d disorders, particularly in the mouse brain cell types implicated by the expression patterns of asso

121 of fate decisions that leads to each mature cell type in a tissue or organism.

122 lar stress and phenotypic modulation of this cell type in coronary artery disease risk.

123 expression of any checkpoint molecule on any cell type in five or fewer studies.

124 0002 for urate) and confirmed as the primary cell type in microdissected tubules and organoids.

125 nt integration scheme compared with the same cell type in somatosensory cortex, which has important i

126 e circadian genes operate in virtually every cell type in the body.

127 lar functions of a gene within an identified cell type in the brain, and enable the application of op

128 Astrocytes are the most abundant cell type in the central nervous system (CNS), performin

129 rine cells (EECs) identified as a permissive cell type in this patient.

130 atically identify and localize all molecular cell types in individual organs to create a full molecul

131 ow they are mutually correlated in different cell types in mammalian tissue are largely unknown.

132 Cell types in organoids matured in vitro to a stable "de

133 We aimed to define cell types in PB and to analyze their relationship with

134 patial control to produce different daughter cell types in proper numbers and sequence.

135 ow Hopper's even representation of important cell types in small sketches, in contrast with prior ske

136 t beginning to catalog the vast diversity of cell types in the cerebral cortex.

137 se, noninvasive control over specific neural cell types in the deep brain would advance the study of

138 elp decipher the distinct roles of these two cell types in the diseasesettings of inherited retinal d

139 All cell types in the glomerulus were identified using unsup

140 f at least 130 neuronal types and nearly 140 cell types in the mouse retina.SIGNIFICANCE STATEMENT Th

141 sentation of the multiple mammary epithelial cell types in the organoids, and demonstrate that protei

142 model synthesizes information from multiple cell types in the peripheral blood and identifies critic

143 The main cell types in the portal tracts and lobules were CD3+ an

144 division timing of two different specialized cell types in the root stem cell niche.

145 glucose from among the diversely functioning cell types in the ventromedial hypothalamic nucleus (VMN

146 ty, defined as the proportion of the various cell-types in a tumor, can be inferred from DNA methylat

147 On the basis of immunofluorescence, infected cell types included CD68(+) type A (macrophage-like) syn

148 to selectively edit therapeutically relevant cell types including epithelial cells, endothelial cells

149 of cytoprotective genes, and exists in many cell types including osteoblasts and osteoclasts.

150 Some of these are shared by other cell types (including aspects of motility, membrane traf

151 pithelium consists of several differentiated cell types, including acinar, ductal and myoepithelial c

152 oE is abundantly expressed in multiple brain cell types, including astrocytes, microglia, and vascula

153 coordinated function of multiple specialized cell types, including basal stem cells, mucus-secreting

154 Most cell types, including immune cells, can secrete and upta

155 depletion occurred in a wide range of tumor cell types, including lymphoma, lung, glioblastoma, brea

156 essential for cellular viability in numerous cell types, including muscle.

157 native splicing-are lacking for most primary cell types, including platelets.

158 associated with gene expression, as well as cell-type-independent principles of chromatin organizati

159 Effects of LAM on resident pulmonary cell types indicated recruitment and activation of lymph

160 presence of neutralizing antibodies on both cell types, indicating that ME is not simply deficient a

161 Here, we supplement cell type information of human scRNA-seq data, with mous

162 f inference by 30-35%, and that selection of cell-type informative probes has similar effect.

163 dy demonstrates RUNX1 expression in critical cell types involved in a laser-induced model of CNV in m

164 better, such as the responding and producing cell types, its links with other mediators, its prosurvi

165 to understand how factors such as genotype, cell type, local environment and external perturbations

166 Given the great heterogeneity of cell types located in the PVH, we performed a detailed a

167 elium (RPE) is a highly polarized epithelial cell type maintained at a senescence state, and offers a

168 Here we employed stimulus-to-cell-type mapping using single-cell RNA sequencing to id

169 brary complexity and their ability to detect cell-type markers, impacting their predictive value and

170 isms by which the activity of multiple niche cell types may be coordinated to communicate signals to

171 Like most cell types, MEFs have the capacity to uncouple the glyco

172 ng of such homotypic neighbors; rather, this cell type modulates the extent of its dendritic branchin

173 rmed by data sourced from multiple unrelated cell types (mosaic data) or from purified enzyme data.

174 al) near the top 10 IR-loci in risk-relevant cell types, namely preadipocytes and adipocytes.

175 In both cell types, NiV infection resulted in the expression of

176 iptomic cartogram of SCC25, a representative cell type of mesenchymal HNSCC and its normal oral kerat

177 tion, protein function, complex association, cell type of origin, and by the cellular environment (Do

178 s allow targeted delivery of therapeutics to cell types of choice based on that antibody's specificit

179 tput from the hippocampus reaches both major cell types of deep entorhinal layers.

180 identified brain-specific ncRNAs with their cell types of origin.

181 udy was to morphologically identify neuronal cell types of the CX in the honeybee Apis mellifera.

182 gene expression patterns in distinct neural cell types of the Drosophila visual system using genetic

183 tor cells (NPCs) give rise to all epithelial cell types of the nephron, the filtering unit of the kid

184 drivers of all but the most highly polyploid cell types of the placenta.

185 aling events and gene expression in multiple cell types of the tumor microenvironment, which could co

186 uch group of cells corresponds to a putative cell type or state, characterized by the feature genes a

187 Cis-eQTLs are largely specific to cell type or stimulation, and 31% and 52% of genes with

188 we have not examined gene expression in the cell types or conditions that are most relevant for dise

189 analysed to provide an in-depth view of the cell types or developmental trajectories in the sample o

190 Thus, infection of cell types other than hepatocytes likely contributes to

191 d in a unified taxonomy of neuronal or glial cell types, partly due to limited data.

192 Underlying this cell type patterning is a network of transcription facto

193 However, other cell types play critical roles in establishing where a l

194 lead to insights on the roles that specific cell types play during norovirus pathogenesis.

195 simultaneously along chromosomes and across cell types, precisely and comprehensively.

196 The wide range of cell types produced by single progenitors in the neocort

197 In both cell types, promoters with high basal H3K4me2/3 activate

198 evelop a benchmark pipeline for inference of cell-type proportions and implement it in the R package

199 A complete molecular atlas of retinal cell types provides an important foundation for these st

200 However, the relevant EP2-expressing cell types remain unclear.

201 as a function of their laminar position and cell type remains uninvestigated.

202 f bulk tissue DNA methylation data at single cell-type resolution for any solid tissue.

203 eQTLs and show mechanisms that explain their cell-type restriction.

204 mapped ligand-receptor networks to specific cell types, revealing TSK cells as a hub for intercellul

205 proach to help identify the CCL17 responding cell type(s) and the mediators downstream of CCL17 in th

206 ogies, biochemical composition, and affected cell types seen across these disorders.

207 isease mechanisms and causal determinants of cell type-selective vulnerability and to identify therap

208 data from 727 peripheral and nervous system cell types spanning 17 mouse organs with body mass index

209 (barrel field) of adult mice with different cell type specific genetic deletion of CB1 was studied.

210 The cell type specific sequences of transcriptional programs

211 While promoters and enhancers convey cell-type specific activating signals, insulators preven

212 Cell-type specific GSK3B knockdown, but not GSK3A knockd

213 t into the temporal regulation of genes in a cell-type specific manner during oogenesis and begin to

214 Control of gene expression is dictated by cell-type specific regulatory sequences that physically

215 ay represent a target for the development of cell-type specific, fast-acting antidepressants.

216 al neural network (CNN) could learn to infer cell type-specific chromatin accessibility solely from r

217 of regulatory effects per variant on several cell type-specific chromatin features.

218 xG) proteins are the central players in this cell type-specific chromatin organization.

219 such an approach has the potential to reveal cell type-specific differences in spike transmission in

220 rum has spurred further investigation of the cell type-specific effects of mTOR signaling in the CNS.

221 motor neurons and astrocytes to model early cell type-specific features of sporadic ALS.

222 Further, we describe the cell type-specific functions of this methylation and exp

223 Super enhancers (SEs) play critical roles in cell type-specific gene regulation.

224 on factor binding motifs in the promoters of cell type-specific genes.

225 ding of regulatory patterns underlying these cell type-specific immunity networks, we developed a too

226 eneral de novo m(6)A deposition and modulate cell type-specific m(6)A patterns, and we discuss the bi

227 ional RNA regulatory complex interfaces with cell type-specific machinery to control cellular differe

228 ent neural cell types but also operates in a cell type-specific manner targeting distinct sets of gen

229 and modulates gene expression in a dynamic, cell type-specific manner.

230 risk variants within myeloid enhancers in a cell type-specific manner.

231 we used epigenomic deconvolution to perform cell type-specific methylome-wide association studies wi

232 , we focus on delineating the ubiquitous and cell type-specific network of regulatory elements that p

233 d mouse models of Parkinson's disease, where cell type-specific optogenetic stimulation of PV(+) neur

234 We hypothesized that the cell type-specific synaptic plasticity is associated wit

235 However, lack of cell type-specific tools have limited our ability to stu

236 The ability to implement cell type-specific transcriptional programming with exqu

237 Cell type-specific translating ribosome affinity purific

238 This study explored how conditional cell-type-specific ablation of GSK-3beta in D(2)R+ neuro

239 architecture in metazoans that incorporates cell-type-specific active processes.

240 uced changes during disease progression in a cell-type-specific and genome-wide manner.

241 The cell-type-specific and/or context-dependent functional c

242 d in mouse fetal liver, and identify de novo cell-type-specific chromatin architectures associated wi

243 ce, RNAscope, and image analysis to validate cell-type-specific cis-regulatory elements in heterogene

244 rrent understanding of RA risk has suggested cell-type-specific contexts for causal variants, implica

245 ssively-parallel reporter assays (MPRA) with cell-type-specific epigenome and expression quantitative

246 dings illustrate the utility of studying the cell-type-specific epigenome in complex tissues like the

247 equencing did not detect up to two-thirds of cell-type-specific evolutionary differences.

248 aling extensive plasticity of cell types and cell-type-specific gene expression during organ evolutio

249 ptional loops to establish and reinforce the cell-type-specific gene-expression program; the ensemble

250 Expression of disease-associated genes was cell-type-specific in adult retina, and cell-type specif

251 Our study reveals a map of cell-type-specific interactions and the landscape of dys

252 ond previously unappreciated individual- and cell-type-specific interferon-stimulated gene upregulati

253 Behavioral studies using cell-type-specific KD in mPFC demonstrate that NMDAR-Glu

254 rovides a comprehensive understanding of the cell-type-specific mechanisms underlying primate ovarian

255 ich promotes enhanced maturation of a set of cell-type-specific miRNAs.

256 sition includes the formation of hundreds of cell-type-specific neuronal enhancers that appear to be

257 e models, methods to comprehensively analyze cell-type-specific post-translational modification (PTM)

258 regulons within a specific cell type, i.e., cell-type-specific regulons (CTSR), provides an extraord

259 he-art tools used to probe connectivity with cell-type-specific resolution have expanded the understa

260 ectrophysiological approaches to examine the cell-type-specific role of GluN2B-containing NMDAR in me

261 in transcription factor that plays a role in cell type specification in various tissues.

262 bout the transcriptional programs underlying cell-type specification in this clade.

263 easing expression over time and more diverse cell-type specificities.

264 was cell-type-specific in adult retina, and cell-type specificity was retained in organoids.

265 nce that influence the magnitude, timing and cell type-specificity of gene expression.

266 dentify causative genetic variants, relevant cell types/states, target genes, and mechanisms by which

267 ence in expression between distantly related cell types such as the immune-related genes that were si

268 s and prior marker information of only three cell types suggests that semi-CAM achieves more accurate

269 fferential gene expression between identical cell types (suprabasal, secretory, and multiciliated cel

270 se MNESmut was retained in the nuclei of all cell types tested.

271 gulated critical signaling events in various cell types that are not expected to support action poten

272 n and mouse data, we identified 17 molecular cell types that have been gained or lost during lung evo

273 single-cell RNA data identified 25 candidate cell types that included progenitor and differentiating

274 gion synchronization occurred among specific cell types that were defined based on their sensory and

275 The absence of one single murine dermal cell type, the innate neonatal-derived IL-17 producing g

276 To focus on specific cell types, the current paradigm is to physically isolat

277 tem using genetic lines to access individual cell types, the TAPIN-seq method to measure their transc

278 erlying the development and function of many cell types, tissues, organs and systems.

279 onstitutively express transgenes in specific cell types to examine their biological functions at defi

280 se nervous system to systematically identify cell types underlying brain complex traits.

281 measured the transcriptomes of the same four cell types upon FMR1 gene deletion.

282 revious scRNA-seq classification to identify cell types using multiplexed in situ RNA detection.

283 btype is novel and a corresponding FBN1+ FAP cell type was also found in single cell RNA-seq analysis

284 of chromatin accessibility across 81 immune cell types, we asked if a convolutional neural network (

285 ne expression signatures obtained from mouse cell types, we deconvolute bulk RNA-seq samples from 28

286 Raman spectra of each cell type were then analyzed to retrieve tissue-specific

287 eractions between these cells and intestinal cell types were associated with resistance to anti-TNF t

288 We found that when the 2 cell types were exposed simultaneously to the same subst

289 s species to reveal experiments, tissues and cell types where this gene is expressed or under which c

290 We identified the endosymbiotic cell type, which expresses a distinct set of genes that

291 e gene expression distribution of debris and cell types, which are estimated using EM.

292 Thus, the precise cell types whose loss of mitochondrial activity and alte

293 of chromatin interactions from 10 tissue or cell types with a focus on neurogenesis and brain tissue

294 intermingling but transcriptionally distinct cell types with differing capacities for interactions wi

295 Notably, cell types with divergent gene-expression profiles often

296 g repressors to gene upregulation in complex cell types with multiple possible differentiation fates.

297 r synaptic connections of distinct fastigial cell types with posturomotor, oromotor, positional-auton

298 ows dissociation of the coordination between cell types, with grid and speed cells, but not head dire

299 features such as cells, cell junctions, and cell types within skin to enable multifactorial analysis

300 ing 9 major cell types and 20 subclusters of cell types within the human heart.

301 is important for the motile behavior of many cell types, yet the mechanisms governing PKA activity du