ライフサイエンスコーパス: cell-permeable

1 oxy)acetic acid (PEG) moiety that makes them cell permeable.

2 (KLAKLAK)(2) peptide that on its own was not cell permeable.

3 udies, from which we infer that the cycle is cell permeable.

4 TAT-RasGAP317-326, a cell-permeable 10-amino acid-long peptide derived from t

5 A synthetic soluble, cell-permeable, 23-amino acid peptide termed kinesin-der

6 Introduction of either mutant IDH or cell-permeable 2HG was associated with repression of the

7 After addition of the cell-permeable 3,5-difluoro-4-hydroxybenzylidene imidazo

8 These compounds are cell permeable, able to decrease inflammatory activation

9 ET as well as a cell-permeable activator of PKA induce Notch target gene

10 ivation are still missing due to the lack of cell-permeable activators.

11 ut not by DN-MyD88, findings confirmed using cell-permeable, adapter-specific BB loop blocking peptid

12 re, preclinical mouse studies suggested that cell-permeable aKG displays a good biosafety profile, el

13 hanism for the metabolite aKG and identifies cell-permeable aKG, either by itself or in combination w

14 A cell-permeable alpha7 helix peptide competitively inhibi

15 In vitro, supplementation with cell-permeable alphaKG directly supports ES-cell self-re

16 e partially recapitulated by the addition of cell-permeable alphaKG.

17 gh glutamine has many intracellular fates, a cell permeable analog of a tricarboxylic acid cycle (TCA

18 Indeed, selective activation of Epac by the cell-permeable analog 8-(4-chlorophenylthio)-2'-O-methyl

19 Selective activation of PKA by the cell-permeable analog N(6)-benzoyladenosine-3',5'-cyclic

20 8Br-cAMP, a cell-permeable analog of cAMP, had no effect on inhibiti

21 endent transcription, we developed synthetic cell-permeable analogs of beta-catenin's helix C, which

22 Its cell-permeable analogue DC432 (IC(50) of 54 +/- 4 nM) de

23 and that this 90-amino acid mini-protein is cell permeable and can inhibit proliferation of Myc-depe

24 Furthermore, dimeric aryl diketoacids are cell permeable and enhance insulin signaling in hepatoma

25 The resulting cyclic peptides are cell permeable and have improved proteolytic stability.

26 o compounds, RB-2-cb and RB-11-ca, which are cell permeable and highly selective covalent modifiers f

27 BI-9564 (2) is a cell permeable and noncytotoxic BRD9 inhibitor provided

28 The modularly assembled compounds are cell permeable and nontoxic as determined by flow cytome

29 ts, but our understanding of what makes them cell permeable and orally bioavailable is limited.

30 To be useful in live cells, probes must be cell permeable and provide a read-out that can be measur

31 d His residues, given that these agents were cell permeable and stable in aqueous buffer and in plasm

32 pplied to imaging acidic tissues, delivering cell-permeable and impermeable molecules to the cytoplas

33 In this work, we report a cell-permeable and metabolically stable nonphosphorylate

34 the synthesis and evaluation of a series of cell-permeable and N- versus O-selective sialyltransfera

35 r that becomes fluorescent upon binding of a cell-permeable and non-toxic fluorophore.

36 ists of four steps: (i) loading cells with a cell-permeable and photo-activatable fluorophore, NPE-HC

37 ing PDIA1, suggesting that the compounds are cell-permeable and reach the intended target.

38 peptide produces bicyclic peptides that are cell-permeable and retain the ability to recognize speci

39 enzyme activity requires that substrates are cell-permeable and that the generated products are easil

40 and in vivo mice studies, the probe is safe, cell permeable, and capable of producing a "turn-on" lum

41 ive hit needs simultaneously to be nontoxic, cell permeable, and inhibiting precursor autoprocessing.

42 These molecules proved to be soluble, cell-permeable, and active in a disease relevant functio

43 lular activity profiles of GSK789, a potent, cell-permeable, and highly selective inhibitor of the fi

44 e report the development of a highly potent, cell-permeable, and metabolically stable peptidyl inhibi

45 or rapidly identifying synthetic, miniature, cell-permeable, and reversible inhibitors against both S

46 s new probe is water-soluble, non-cytotoxic, cell-permeable, and useful for mitochondrial imaging.

47 in RA, was then analyzed by knockdown using cell-permeable antisense oligonucleotides.

48 display a highly increased response to a new cell-permeable APC/C inhibitor, apcin, but not to the sp

49 Herein, we report the first cell-permeable ATP analogue, ATP-polyamine-biotin (APB).

50 s Plk4 can be specifically inhibited using a cell-permeable ATP analogue.

51 foundation for the development of additional cell-permeable ATP analogues for cell-signaling research

52 ere we report the first predictive model for cell permeable background-free probe development through

53 ABT-737, a small molecule cell-permeable Bcl-2 antagonist that acts by mimicking B

54 In this work we report the development of cell-permeable beta1i and beta5i selective inhibitors th

55 This strategy was applied to generate a cell-permeable bicyclic peptidyl inhibitor against the N

56 Here, we introduce a cell-permeable, biocompatible, viscosity-responsive, sma

57 ration, the various strategies for designing cell-permeable, biologically active cyclic peptides agai

58 iopharmaceuticals and for the development of cell-permeable biomolecules.

59 Pretreatment of wild-type cells with the cell-permeable biotinylated general caspase inhibitor b-

60 By pretreating the cells with a cell-permeable, biotinylated pan-caspase inhibitor that

61 By pretreating the cells with a cell-permeable, biotinylated pan-caspase inhibitor, we i

62 that stapled peptides can be rendered highly cell-permeable by conjugating a cyclic cell-penetrating

63 The cell-permeable Ca(2+) buffer BAPTA-AM, the IP(3) recepto

64 In the present study, pretreatment with a cell-permeable Ca2+-chelating compound (BAPTA-AM) signif

65 The cell-permeable calcium chelator 1,2-bis(2-aminophenoxy)e

66 We introduce a selective and cell-permeable calcium sensor for photoacoustics (CaSPA)

67 We show that addition of different cell permeable CaM antagonists to cultured cells or load

68 studied in isolated rat hepatocytes using a cell-permeable cAMP analog, CPT-cAMP.

69 specific agonist, butaprost, or 8-Br-cAMP, a cell-permeable cAMP analog, promoted parasite survival.

70 with stumpy characteristics when exposed to cell-permeable cAMP and AMP analogues.

71 oying active caveolin-1 fragments coupled to cell-permeable carrier peptides may represent a novel ap

72 We have synthesized a highly cell-permeable caspase-3 substrate, DEVD-NucView488, by

73 storation of functional CAV1 domains using a cell-permeable CAV1 scaffolding domain peptide.

74 ther hand, increasing cellular ceramide with cell-permeable ceramide treatment resulted in attenuatio

75 Our results revealed that treatment with cell permeable cGMP derivatives, or the cGMP phosphodies

76 first reported low-nanomolar, selective and cell permeable chemical probe for ATAD2.

77 poxic angiogenesis during adipogenesis using cell-permeable chemical conjugates composed of antisense

78 copy with newly developed, freely diffusing, cell-permeable chemical probes with targeted affinity fo

79 ts rapid timescale of action and the lack of cell-permeable, chemical modulators.

80 ch was partially reversed by the addition of cell-permeable cholesterol.

81 Here, we show that a cell-permeable competing peptide (P6) functions as a spe

82 s a direct sensor for guest binding and as a cell-permeable compound for imaging applications.

83 ortunities for the rational design of future cell-permeable compounds and for the optimization of del

84 Cell-permeable compounds that bind effectively and selec

85 -binding peptides into more serum-stable and cell-permeable compounds.

86 Here we synthesized a cell permeable curcumin probe (Cur-P) with an alkyne moi

87 Treatment of BeWo cells with the cell permeable cyclic AMP analogue dibutyryl cyclic AMP

88 These cell-permeable cyclic peptides inhibit Ras signaling by

89 A cell-permeable decoy peptide corresponding to the same p

90 the utility of this chemistry in creating a cell-permeable derivative of a high-affinity HIV Rev pro

91 Preincubation with a cell-permeable derivative of C3 transferase that blocks

92 Calcein AM, the cell-permeable derivative of calcein, shows significant

93 nd subsequently culturing these cells with a cell-permeable, diazirine-modified form of GlcNAc-1-phos

94 ewly designed and structurally characterized cell permeable diformyl-p-cresol based receptor (HL) sel

95 -imidazole (Py-Im) polyamides are a class of cell-permeable DNA-binding small molecules that can disr

96 y manipulating actin dynamics are limited to cell-permeable drugs that preclude single-cell perturbat

97 Using SYTO62, a biocompatible and cell-permeable dye, we demonstrate photoconversion in a

98 Compound 3 is cell-permeable, effectively activates caspases in whole

99 We have developed a panel of cell-permeable energy transfer probes to quantify target

100 Importantly, SKI-1 inhibition by the cell-permeable enzyme inhibitor decanoyl-RRLL-chlorometh

101 A cell-permeable ester of alpha-ketoglutarate reversed the

102 ased during hyperammonaemia, and providing a cell-permeable ester of alphaKG reversed the lower TCA c

103 e-specific agonists were measured by using a cell-permeable fluorescent Ca(2+) indicator dye.

104 ments have historically been performed using cell-permeable fluorescent dyes, although the use of the

105 lar labeling using these techniques requires cell-permeable fluorescent ligands, however, limiting ut

106 4,5-diaminofluorescein diacetate, a cell-permeable fluorescent molecule, was used to detect

107 oved selectivity toward MALT1 and results in cell-permeable fluorescent probes.

108 Cell-permeable fluorescent tracers are used in a competi

109 we report the synthesis and application of a cell permeable, fluorescent small molecule (SR101-F-araN

110 work, we designed and synthesized a new live-cell-permeable, fluorescent light-up probe for real-time

111 These cell-permeable fluorophores are exceptionally bright, wi

112 reported a general method to improve small, cell-permeable fluorophores which resulted in the azetid

113 Moreover, treatment with a cell-permeable form of 2-HG sensitized wild-type IDH1 AM

114 um release events, which was suppressed by a cell-permeable form of AIP.

115 ophagy response to ammonia is abrogated by a cell-permeable form of pyruvate resulting from the scave

116 hat systemic or transdermal application of a cell-permeable form of the cytoplasmic domain of CTLA-4

117 Cell-permeable formulations of metabolites, such as fuma

118 addition of several arginines resulted in a cell-permeable FRET substrate SM-P124 (Ac-GRRRK(Dabcyl)-

119 of fumarate hydratase-proficient cells with cell-permeable fumarate.

120 vator of transcription peptide (TAT)-GILZ, a cell-permeable GILZ fusion protein, shortened resolution

121 Here we developed cell-permeable GIV-CT peptides by fusing a TAT-peptide t

122 ophages and was blocked by administration of cell-permeable glutathione.

123 eased markedly during apoptosis induced by a cell permeable glyoxalase 1 inhibitor.

124 ity was largely prevented by incubation with cell-permeable GSH monoethylester but not malate.

125 nanomolar versus micromolar sensitivity to a cell-permeable GSi (Z-LLNle-CHO) across 60 diverse tumor

126 anic carbon pool contains more of the highly cell-permeable H2CO3, necessitating a substantial expend

127 llular studies confirm that this molecule is cell permeable, has low cytotoxicity and localizes prima

128 The design scheme starts with a cell-permeable heterocyclic cation that binds to AT base

129 contrast, protein kinase A inhibition with a cell-permeable highly selective peptide blocker did not

130 beta-peptides are usually not cell-permeable, however, and this feature limits their u

131 relevance of phosphorylated BAD BH3 by using cell-permeable, hydrocarbon-stapled BAD BH3 helices that

132 e Notch transactivation complex by using the cell-permeable, hydrocarbon-stapled synthetic peptide st

133 uman primary CD4(+) T cells, exposure to the cell-permeable IKKbeta inhibitor PS-1145 or genetic abla

134 wild-type active caspase-3 for detection and cell permeable inhibition is a valuable proof-of-concept

135 microtubule dynamics, we identified Pyr1, a cell permeable inhibitor of LIM kinase, which is the enz

136 CatS inhibition by a cell-permeable inhibitor abrogated the release of the he

137 By establishing 5-nitroisatin as a cell-permeable inhibitor for Torsin processing, we provi

138 h was repressed by Rp-8-pCPT-cGMPS, a potent cell-permeable inhibitor of cGKs.

139 Importantly, through treatment with cell-permeable inhibitors (4,5,6,7-tetrabromo-1H-benzotr

140 enylation as judged in experiments employing cell-permeable inhibitors of protein farnesyl transferas

141 lead structure for the design of potent and cell-permeable inhibitors of the menin-MLL1 interaction.

142 be a general approach for the development of cell-permeable inhibitors of thioester-forming E3 ubiqui

143 ene expression, yet there are few selective, cell-permeable inhibitors or suitable tool compounds for

144 5 years ago, their selective perturbation by cell-permeable inhibitors remains a fundamental challeng

145 eptides as potent, metabolically stable, and cell-permeable inhibitors to target the beta-catenin and

146 evel and applied it to the identification of cell-permeable inhibitors.

147 isoform-specific small interfering RNAs and cell-permeable inhibitory peptides.

148 knock-in mouse lacking the PDZ motif, and a cell-permeable interfering peptide, we found that this m

149 thyl ester)phenylphosphine borane complex, a cell-permeable intracellular disulfide-reducing drug, sl

150 ER Ca2+ release in permeabilized cells, and cell-permeable IP3 ester-induced Ca2+ elevation in intac

151 n of some yggX gshA mutant phenotypes by the cell-permeable iron chelator deferoxamine allowed the co

152 neuronal injury could be ameliorated with a cell-permeable iron chelator.

153 In contrast, exogenous cell permeable itaconate, 4-octyl itaconate (OI) attenua

154 ementation of KG can treat Ndufs4-KO mice, a cell-permeable KG, dimethyl ketoglutarate (DMKG) was adm

155 this work, we have successfully developed a cell-permeable kinase probe (DA-2) capable of proteome-w

156 Sirtinol, a cell-permeable lactone ring derived from naphthol, is a

157 ity is rescued by binding to a high affinity cell-permeable ligand.

158 Understanding how to design cell permeable ligands for intracellular targets that ha

159 Thus, cell permeable ligands that bind repetitive RNAs have be

160 -34 motor neuron-like cells indicated that a cell-permeable LK-ester, LKE, was nontoxic and protectiv

161 in stem-cell conditions, we demonstrate that cell permeable MARCKS effector domain (ED) peptides pote

162 S-adenosyl-L-methionine (SAM) analogues from cell-permeable methionine analogues by engineered SAM sy

163 We have developed the first cell-permeable, mitochondrially targeted modulators of t

164 In contrast, the cell-permeable, mitochondrially targeted PKCdelta-dF(1)F

165 orted protection against hypoxic injury by a cell-permeable, mitochondrially-targeted deltaPKC-d subu

166 pound for a more soluble equivalent led to a cell-permeable molecule that selectively and efficiently

167 ent of a photocleavable analog of AP20187, a cell-permeable molecule used to dimerize FK506-binding p

168 , control of gene expression with synthetic, cell-permeable molecules is within reach.

169 can also be efficiently inhibited by small, cell-permeable molecules.

170 A water-soluble, cell-permeable naphthalene-based tetrazole was identifie

171 attenuated by pretreatment with tat-VIVIT, a cell-permeable NFAT inhibitory peptide.

172 ction byproduct; and we synthesized a novel, cell permeable nitrone, 2-2-3,4-dihydro-2H-pyrrole 1-oxi

173 d atherosclerosis development and identifies cell-permeable NLS peptide as a potential anti-atheroscl

174 To inhibit the protein function, cell-permeable, non-helical constrained proteomimetics t

175 e function, we developed inhibitors that are cell permeable, nontoxic, and selectively bind to the in

176 l-based studies show that treatment with the cell-permeable nucleoside counterpart of 5-MeCITP leads

177 transporter loss or supplementation with the cell-permeable nutrient, methyl pyruvate, reversed ceram

178 rmal fibroblasts (HDFs) with combinations of cell-permeable OCT4, SOX2, KLF4, CMYC and either NANOG o

179 In this study, we developed a nontoxic cell-permeable ORF45-derived peptide from the RSK-bindin

180 uent selective bioorthogonal reaction with a cell-permeable organic dye enables live cell imaging of

181 Cell-permeable orthosteric ligands can assist folding of

182 are increased by increasing GSH adducts with cell-permeable oxidized GSH (GSSG-ethyl ester) or 2-acet

183 In addition, cell permeable pentapeptides designed from Ku70, termed

184 nistered blocking anti-PAR2 antibodies, or a cell permeable peptide inhibitor of PAR2 signalling, pep

185 Syk substrate preference motifs linked to a cell permeable peptide, resulting in a biosensor that is

186 Strikingly, a cell-permeable peptide (CPP) containing the C-terminal s

187 tion of the protein/protein interaction by a cell-permeable peptide (CTTN-I peptide) attenuated actin

188 ely, preventing D1R/GluN1 association with a cell-permeable peptide (TAT-GluN1C1) left individual D1R

189 e RSK1/PKARIalpha interactions with a small, cell-permeable peptide activates RSK1 and recapitulates

190 olin bioavailability employing penetratin, a cell-permeable peptide carrier for a bioactive caveolin-

191 nsitive to amino acid deprivation, whereas a cell-permeable peptide containing the GDI motif inhibits

192 flammatory and atheroprotective effects of a cell-permeable peptide containing the NF-kappaB nuclear

193 enzymatic inhibitor of LSD1, or TAT-SNAG, a cell-permeable peptide corresponding to the SNAG domain

194 A cell-permeable peptide corresponding to this region disr

195 We designed a nontoxic cell-permeable peptide derived from ORF45, TAT-10F10, wh

196 A myristylated cell-permeable peptide derived from residues 395-407 of

197 nhibition of the CFTR/CAL interaction with a cell-permeable peptide improves the function of rescued

198 Cell-permeable peptide inhibitor and siRNA against caspa

199 This information was used to develop a cell-permeable peptide inhibitor that selectively inhibi

200 Dapk1, that is blocked by a neuroprotective cell-permeable peptide mimetic of the region.

201 This study examined whether a cell-permeable peptide mimicking the kinase-inhibitory r

202 To do this, we utilized a cell-permeable peptide of the outer mitochondrial membra

203 filing and leads for developing enhanced and cell-permeable peptide or small-molecule inhibitors.

204 This strategy was applied to generate a cell-permeable peptide substrate for real-time detection

205 We designed a cell-permeable peptide that competes for the unique PDZ

206 rent results showed that administration of a cell-permeable peptide that disrupts GluR2 trafficking (

207 Here, we utilized a polyarginine-rich, cell-permeable peptide that represents the portion of th

208 teraction between JNK and Sab, we utilized a cell-permeable peptide to demonstrate that ischemia/repe

209 We have shown that a cell-permeable peptide, a hormone (melanocyte stimulatin

210 Here we identify a cell-permeable peptide, dNP2, which efficiently delivers

211 Activation of Akt1 with a cell-permeable peptide, TAT-TCL1, blocks the amino-Nogo

212 ng of PKA on cardiac function, we designed a cell-permeable peptide, which we termed trans-activator

213 storation of functional CAV1 domains using a cell-permeable peptide.

214 thways in cell lines and in vivo using small cell-permeable peptides confirms that the endogenous int

215 Both the cell-permeable peptides reduced L. major infection in BA

216 Exposure of VSMCs to cell-permeable peptides, which contained polyproline seq

217 tetraspanin-targeted reagents by the use of cell-permeable peptides.

218 Hsp90 targeting using a cell-permeable peptidomimetic agent resulted in marked a

219 n-regulation of CaMKII by KN-62, a selective cell-permeable pharmacological inhibitor or a dominant n

220 with subcellular spatial resolution using a cell-permeable, photoactivatable chemical inducer of dim

221 Cell-permeable photoswitchable small molecules, termed o

222 Moreover, we found that a cell-permeable PIER abrogated HSP90 function and caused

223 Finally, a second generation of cell permeable Pin1 inhibitors was designed by replacing

224 Importantly, cell-permeable Pin1-FOXM1-blocking peptides repressed th

225 by the higher-order polyamine spermine or by cell-permeable PIP2, but these interventions had no effe

226 We demonstrate that PFI-3 is a potent, cell-permeable probe capable of displacing ectopically e

227 Our results showed that photocaged cell-permeable probe represents a valuable new tool for

228 The new photocaged cell-permeable probe showed good reactivity toward purif

229 ve led to the characterization of a powerful cell-permeable probe to selectively image static, long-l

230 These carefully optimized, cell-permeable probes outperform commercial taxane-based

231 A set of phosphatase-stable, cell-permeable prodrug analogues inhibited cytokine-stim

232 This is a cell-permeable prodrug form of alpha-ketoglutarate, an i

233 ut-2-enyl diphosphate (HMBPP) or a synthetic cell-permeable prodrug, bis (pivaloyloxymethyl) (E)-4-hy

234 ed target biological analytes through use of cell-permeable profluorogenic probes is dependent on the

235 by chronic administration of MG132, a potent cell permeable proteasome inhibitor.

236 d their performance by screening against 160 cell-permeable protein kinase inhibitors.

237 TcpB is a cell-permeable protein with multiple functions, and its

238 agents, recombinant proteins, and artificial cell-permeable proteins have been developed to manipulat

239 tor with a cell-penetrating entity yielded a cell-permeable proteomimetic that activates cell prolife

240 y of acquiring potent, yet highly selective, cell permeable PTP inhibitory agents.

241 We report the development of a cell permeable, quenched squarine probe (CytoCy5S), whic

242 this study, the inhibitory mechanisms of the cell-permeable recombinant protein Hph-1-ctCTLA-4 on T c

243 s system that utilizes a light-programmable, cell-permeable reporter deliverable simultaneously to ma

244 nes Cas9 (SpCas9) that weigh <500 Da and are cell permeable, reversible, and stable under physiologic

245 Here, we used a cell-permeable, reversible inhibitor of the telomerase e

246 Toward this end, we have developed cell-permeable RF proteins (CP-RFs) incorporating newly

247 vitro treatment with the low molecular mass cell-permeable S-nitrosothiol S-nitrosocysteine ethyl es

248 dies demonstrate that potent, selective, and cell permeable S6K1 inhibitors can be prepared and provi

249 ll, our results demonstrate that many novel, cell permeable scaffolds exist beyond those found in ext

250 potential for development of small molecule cell-permeable serine hydrolase inhibitors that block MC

251 of human and rat NK-LGL leukemia cells with cell-permeable, short-chain C-ceramide (C) in nanoliposo

252 stingly, sialic acid supplementation using a cell-permeable sialic acid analogue (Ac(5)Neu5Ac) booste

253 ive inhibition of hypothalamic SIRT1 using a cell-permeable SIRT1 inhibitor or SIRT1-shRNA negated th

254 he derivation of novel, selective, druglike, cell permeable SMAC mimics with cellular activity.

255 e discovery of a number of highly potent and cell-permeable Smac mimetics and yielded important new i

256 sing lead compound for the design of potent, cell-permeable Smac mimetics for cancer treatment.

257 Cell permeable small molecules that can be programmed to

258 Here we report a cell-permeable small molecule (JQ1) that binds competiti

259 PTP, confer upon TCPTP the ability to bind a cell-permeable small molecule (the biarsenical fluoresce

260 Instability is reversed when a cell-permeable small molecule binds this domain.

261 study, we investigated a novel non-peptide, cell-permeable small molecule, named LY5, to target STAT

262 ngineered destabilizing protein domain and a cell-permeable small molecule.

263 Chemical inducers of dimerization (CIDs) are cell-permeable small molecules capable of dimerizing two

264 Cell-permeable small molecules that enhance the stabilit

265 Development of cell-permeable small molecules that target enzymes invol

266 een hampered by the absence of PTP-specific, cell-permeable small-molecule agents.

267 These findings demonstrate that a synthetic, cell-permeable small-molecule can be developed as a SP-b

268 he development of DI-591 as a high-affinity, cell-permeable small-molecule inhibitor of the DCN1-UBC1

269 There is currently no highly specific, cell-permeable, small molecule inhibitor for ZAP-70; the

270 -dimethylxanthenone-4-acetic acid (DMXAA), a cell-permeable, small molecule that has anti-tumor activ

271 Here we report the design of synthetic, cell-permeable, stabilized alpha-helical peptides that t

272 Moellering et al. recently reported that a cell-permeable "stapled" synthetic peptide of the Notch

273 Application of a cell-permeable STEP-derived peptide that is resistant to

274 Using a cell-permeable substrate for caspase-3, the presence of

275 directly supports ES-cell self-renewal while cell-permeable succinate promotes differentiation.

276 In the presence of a cell-permeable syndecan-4-MLP disruptor peptide, the nuc

277 regulation of AKAP79/150 by microinjecting a cell-permeable synthetic AKAP (A-kinase anchor protein)

278 tem disease, using successive application of cell-permeable, synthetic CRISPR RNAs to activate and th

279 We have designed a cell-permeable T-sensitive fluorescence lifetime-based n

280 ery of ZFN proteins, which are intrinsically cell-permeable; TALEN proteins, which can be internalize

281 plication of Smad7 protein conjugated with a cell-permeable Tat tag to oral mucosa showed prophylacti

282 in pulse-chase labeling experiments with the cell-permeable tetramethylrhodamine HaloTag ligand.

283 involved the treatment of E. coli cells with cell-permeable tetrazoles followed by a brief photo irra

284 Because c-di-GMP is not cell permeable, the c-di-GMP hydrophobic analog 2'-O-di(

285 Also, the cell-permeable thiol N-acetyl l-cysteine, reverses DMF i

286 ulfide bond formation, we have synthesized a cell-permeable thiol-reactive affinity probe (TRAP) cons

287 ereby the intrinsic pore dilates, making the cell permeable to large organic cations, which eventuall

288 r studies show that the designed ligands are cell permeable to mouse myoblasts.

289 y cationic beta(3)-peptides are sufficiently cell permeable to upregulate p53-dependent genes in live

290 lso showed that alstotides are antiviral and cell-permeable to inhibit the early phase of infectious

291 ression, or preincubation of HMVEC-Ls with a cell-permeable TRAF6 decoy peptide decreased both LPS-in

292 y as a monosaccharide sensor, functions as a cell-permeable, turn-on fluorescent sensor for tetraseri

293 n intact HeLa cells using the new photocaged cell-permeable ubiquitin probe and identified DUBs captu

294 Importantly, the photocaged cell-permeable ubiquitin probe captured DUBs specificall

295 Photocaged cell-permeable ubiquitin probe holds promise in profilin

296 Here we report a new photocaged cell-permeable ubiquitin probe that undergoes photoactiv

297 In the future, cell-permeable variants of XY-69 represent promising can

298 onfocal microscopy confirmed that the 2AI is cell permeable, while pull-down assays identified BfmR,

299 To enhance NPC migration, we generated a cell-permeable wild-type p38 protein (PTD-p38WT) in whic

300 desirable labelling probes should be highly cell permeable without nonspecific interactions with oth