ライフサイエンスコーパス: cellular

1 ariation on enzyme activity and steady-state cellular abundance with a large, well-curated clinical c

2 ption of genes, including those that lead to cellular accumulation of protective organic osmolytes.

3 e vitamin D receptor (VDR) that mediates the cellular actions of 1,25(OH)(2)D.

4 ar polymers with essential roles in numerous cellular activities.

5 ATPases associated with various cellular activity are a set of protein assemblies that f

6 Hyperreflective foci and HRS are markers of cellular activity associated with visual dysfunction, es

7 molecular pathways that are the backbone of cellular activity drive the cell to certain outcomes and

8 onist bicuculline methiodide while recording cellular activity in PFC of male rhesus monkeys performi

9 This article discloses the in vitro and cellular activity profiles of GSK789, a potent, cell-per

10 Our data in cellular AD models indicates that increased levels of un

11 heir biological function, in terms of, e.g., cellular adhesion, endo/exocytosis, cellular uptake, and

12 Cellular aging is a multifactorial process that is chara

13 d PTSD have been associated with accelerated cellular aging.

14 ASD-associated cellular and behavioral deficits could be rescued by pha

15 We have investigated cellular and behavioral outcomes in genetically engineer

16 le of reversibly inducing transient NPC-like cellular and biochemical phenotypes, constitute plausibl

17 sesses an impressive diversity of molecular, cellular and circuit mechanisms, embedded in a dynamic,

18 ve shown that MAGE proteins regulate diverse cellular and developmental pathways, implicating them in

19 nelles for egress provides insights into the cellular and immunological abnormalities observed in pat

20 In vitro, selumetinib downregulated cellular and membrane levels of PD-L1 in tumor cells by

21 fundamental split, our current knowledge of cellular and molecular mechanism driving root developmen

22 We show the cellular and molecular mechanisms contributing to the dy

23 gs and explore mechanistic links between the cellular and network properties of, and the computations

24 enabling high-resolution reconstructions of cellular and organelle geometries.

25 to highlight key distinctions of venom gland cellular and physiological function.

26 iously reported enzyme kinetic parameters of cellular and viral DNA and RNA polymerases with respect

27 are now recognized as key regulators of both cellular and viral mRNA function.

28 nase kinase-2 (CaMKK2) is a key regulator of cellular and whole-body energy metabolism.

29 neurons that spatially covary in molecular, cellular, and circuit properties.

30 omotes PPARgamma/RXR signaling in cell-free, cellular, and in vivo settings.

31 nd primed pluripotency and harbor molecular, cellular, and phenotypic features characteristic of form

32 ucidating drug-induced changes at molecular, cellular, and physiologic scales of analysis.

33 ion and their heterogeneity, and enabled the cellular architecture of breast cancer tissue to be char

34 cond messenger," may be linked to changes in cellular architecture that favor pathogen-host interacti

35 Its validity was demonstrated in cellular assays and a murine colitis model expressing hP

36 le showcases distinctive features, including cellular asymmetry and differentiation during the cell c

37 As results, cellular ATP and reactive oxygen species (ROS) levels ar

38 Cellular ATP levels did not change.

39 ndrial ATP production, but a net decrease in cellular ATP levels.

40 No vascular invasion or cellular atypia were evident.

41 Cellular-based studies revealed the GR domain as being n

42 her, these findings provide insight into the cellular basis of islet development.

43 e glycoforms of BCR subunits, reducing total cellular BCR levels.

44 y chemical tools that can direct and control cellular behavior.

45 f the complex molecular networks that govern cellular behavior.

46 re the coordinated output of many individual cellular behaviors.

47 ount for inattentional blindness grounded in cellular biochemistry.

48 orrelated with a protection from TAC-induced cellular Ca(2+) signaling alterations (increased SOCE, d

49 therefore poised to become a main pillar of cellular cancer immunotherapies.

50 Cellular cholesterol levels are regulated through crosst

51 between the plasma membrane (PM), where most cellular cholesterol resides, and the endoplasmic reticu

52 lexoform, it remains unclear how and whether cellular circuits control the distribution of a complexo

53 cellular trophic relationships and shifts in cellular communication after angiotensin II treatment th

54 on interfacial protein action, ranging from cellular communication to immune responses and the prote

55 t cells and then released in the appropriate cellular compartment to function.

56 nd disassembly of many molecules in multiple cellular compartments and their transport among compartm

57 , the molecular connection between these two cellular compartments has not been clearly elucidated.

58 The cellular complexity and scale of the early liver have co

59 mphasize the potential prominent role of the cellular component of the immune system in the developme

60 Centering and decentering of cellular components is essential for internal organizati

61 Hippo pathway is activated in major cellular components of the blood-brain barrier, includin

62 ls to the higher strain rate imposed by xDC, cellular components other than the actin cytoskeleton do

63 n species (ROS), which oxidize DNA and other cellular components.

64 r tissue to be characterized on the basis of cellular composition and tissue organization.

65 he TME remain obscure because of its complex cellular composition.

66 We focus on the cellular compositions within functional niches, cell-cel

67 ion is formed from the Fenton reaction under cellular conditions and from decomposition of nitrosoper

68 notypes are strongly modulated by changes in cellular conditions or genetic context, the latter deter

69 ce helps bridge the gap between high-density cellular connectivity studies in rodents and imaging-bas

70 lly expressed") to explore the molecular and cellular consequences of imprinted miRNA activity.

71 The cellular consequences of these pathological NOTCH3 fragm

72 This advanced cellular construct based on a combinatorial nano-enginee

73 entified were also active enhancers in other cellular contexts.

74 cay rate, lower SR Ca(2+) load and depressed cellular contractility) and SERCA2a downregulation in ve

75 Hepatic stellate cells (HSC) are the major cellular contributors to excess extracellular matrix dep

76 links ceramide accumulation in podocytes to cellular damage and nephrotic syndrome.

77 Blue light-induced RPE cellular damage preceded the photoreceptors loss.

78 9 formations; ROS production; and ultimately cellular death of beta-endorphin neurons.

79 lity control mechanisms are all hallmarks of cellular decline.

80 The main line of cellular defense against these electrophilic molecules i

81 ear conditions, despite obvious decrement of cellular deformation at moderate-to-higher shear stresse

82 x have shed light on the importance of WNK's cellular degradation on renal ion transport.

83 Phosphorylation makes cyclin L2 amenable to cellular degradation, leading to restriction of HIV repl

84 l light-dependent FAS regulation to meet the cellular demand for acyl chains.

85 a lesser degree UBR4, were down-regulated as cellular demand for antibody expression increased in CHO

86 ases SOD2 activity as an early adaptation to cellular detachment, which is followed by SIRT3-dependen

87 Here, we traced the cellular development of a recently evolved morphological

88 with cell type-specific machinery to control cellular differentiation.

89 Cellular DNA can be damaged by spontaneous hydrolysis, r

90 However, little is known about the cellular dynamics that mediate postnatal growth.

91 how therapy-induced adaptation of the multi-cellular ecosystem of metastatic cancer shapes clinical

92 Brain tumors (gliomas) are heterogeneous cellular ecosystems, where non-neoplastic monocytic cell

93 uate over the course of the day, observed at cellular (eg, transcription, translation, and signaling)

94 e electron transport chain that functions in cellular energy metabolism and as a membrane antioxidant

95 association, cell type of origin, and by the cellular environment (Dorrbaum et al., 2018).

96 discernible trends in the data suggest that cellular environment is a major factor dictating stabili

97 spectrometers from salty solutions to mimic cellular environments.

98 of BrdU lead to the activation of apoptotic cellular events as evidenced by both terminal deoxynucle

99 These cellular extensions are homologous structures that diffe

100 e of the Arf-activating proteins, GBF1, is a cellular factor required for enterovirus replication.

101 s important to identify and characterize the cellular factors that control HIV multiplication in thes

102 e amino acid starvation response and altered cellular fatty acid composition.

103 these specialized plasma membrane domains in cellular feedback via the Hippo pathway.

104 ar NADPH-binding domain and does not exhibit cellular ferric reductase activity.

105 e have characterized the binding site of the cellular FHL1 protein in CHIKV HVD and defined the biolo

106 ce the sensitivity and spatial resolution of cellular force imaging, we developed a force-activatable

107 -molecular tension events and the associated cellular force nanoscopy (CFN).

108 strategy can readily be adapted for studying cellular forces in a wide range of applications.

109 n indicative of an inflammatory response and cellular function deficits.

110 Cellular function requires molecular motors to transport

111 However, its cellular function(s) and whether it plays a role in main

112 increasingly understood to be important for cellular function.

113 tic mechanism to result in new molecular and cellular functionality.

114 Emerging methods to infer cellular functions are beginning to shed new light on th

115 lear pore complexes (NPCs) are important for cellular functions beyond nucleocytoplasmic trafficking,

116 of cells and their ability to perform basic cellular functions such as division and motility.

117 various protein complexes to confer distinct cellular functions, but how the multi-subunit complexes

118 necks, a process that is essential for many cellular functions, from cell division to lysosome degra

119 ls such as iron and copper are essential for cellular functions, others such as cadmium and arsenic a

120 ting death domain protein, regulates various cellular functions, such as vesicle trafficking, activit

121 These cellular genes contribute to lytic susceptibility to var

122 s catalog, we characterize shared and unique cellular genes, proteins, and pathways targeted by parti

123 Complex cellular geometries based on the combination of many dif

124 HSPA1A and HSPA1L, have opposing effects on cellular handling of various substrates.

125 and integration (scAI) method to deconvolute cellular heterogeneity from parallel transcriptomic and

126 tophagy is a cellular process that preserves cellular homeostasis and promotes cellular survival duri

127 be boosted by light driven perturbations of cellular homeostasis and that this biosensing concept is

128 TRADD modulates cellular homeostasis by inhibiting K63-linked ubiquitina

129 that PC2 plays in the regulation of general cellular homeostasis remains unclear.

130 anelle whose correct assembly is crucial for cellular homeostasis.

131 of the endoplasmic reticulum (ER), the main cellular hub of lipid biosynthesis and the entry site fo

132 scopy, thus expanding the scope of cryogenic cellular imaging.

133 ved resistance by developing a more reactive cellular immune response.

134 Ebola VLP vaccine elicits strong humoral and cellular immune responses against pathogenic Ebola virus

135 So far, viral targets of cellular immunity and factors determining successful mou

136 into the basic biology of adjuvant-elicited cellular immunity and have clear implications for the sc

137 sphingosine suspended in 0.9% NaCl prevents cellular infection with pp-SARS-CoV-2 spike.

138 glioblastoma (GBM) is characterized by rapid cellular infiltration of brain tissue, raising the possi

139 s of type-2 immune activation, inflammation, cellular infiltration, tissue repair enzymes, pathways o

140 gated radiation-induced oxidative stress and cellular injury.

141 Cellular integrity, migration, and genome-wide gene expr

142 ically relevant cell types, cell states, and cellular interactions across transitions.

143 everal mesenchymal-like properties including cellular invasion and colony formation in vitro, as well

144 cognized mechanism involved in regulation of cellular iron homeostasis.

145 nt on their intracellular activation by host cellular kinases to yield ultimately the bioactive nucle

146 g of its spatial and temporal sensing at the cellular level is still an open challenge.

147 Cellular levels and stability of intermediate signaling

148 In summary, the cellular levels of oligomeric proteins such as Hsp20 are

149 iral DNA and RNA polymerases with respect to cellular levels of their nucleotide substrates.

150 The cellular lineages identified by pigment presence or abse

151 synergistic H3-tail binding causing distinct cellular localization and enhanced H3K9me3-nucleosome ub

152 une RNA structure-targeting compounds to the cellular localization of the target.

153 PIs) is fundamental for the understanding of cellular machineries.

154 Molecular motors are at the heart of cellular machinery, and they are involved in converting

155 a priori knowledge of tumor antigen, ex vivo cellular manipulation, or cellular manufacture, could dr

156 r antigen, ex vivo cellular manipulation, or cellular manufacture, could dramatically reduce costs an

157 compliant structures such as the own-tissue cellular matrix or other surrounding tissues.

158 These findings establish a cellular mechanism for the representation of temporal in

159 These findings represent a novel cellular mechanism that supports reliable synaptic trans

160 types (e.g., hepatitis C) and add additional cellular mechanisms (tissue recovery and variable cell s

161 ings have implications for the molecular and cellular mechanisms of cerebral cavernous malformation p

162 Among the many cellular mechanisms that regulate mRNA fate, covalent nu

163 cuit changes in several brain areas, but the cellular mechanisms that underlie these defects are not

164 st responses to phages can occur via diverse cellular mechanisms.

165 itical insights into the phase separation of cellular membranes and, more generally, two-dimensional

166 ough the host endomembrane system, penetrate cellular membranes, and undergo capsid disassembly to re

167 otential of NBD-Bu for detection of abnormal cellular metabolic activity.

168 the different nanoparticles modestly affects cellular metabolic activity.

169 ated with this novel scaffold that increased cellular metabolic rates in vitro using changes in oxyge

170 Current methods for imaging cellular metabolism are limited by low sensitivities, co

171 chondrogenesis, SOX9 acts as a regulator of cellular metabolism by suppressing oxidation of fatty ac

172 ydrolysis, reactive oxygen species, aberrant cellular metabolism or other perturbations that cause DN

173 hondrial morphology shifts rapidly to manage cellular metabolism, organelle integrity, and cell fate.

174 inner mitochondrial membrane that regulates cellular metabolism.

175 hat promote the development of a profibrotic cellular microenvironment.

176 and characterized the first biochemical and cellular microgravity responsive device using an enginee

177 s, we have simulated numerically a confluent cellular monolayer spreading on an empty space and the c

178 dented approach to untangle the dysregulated cellular network in the vicinity of pathogenic hallmarks

179 nty in the allocation of proteins to new sub-cellular niches, as well as in the number of newly disco

180 domain from PtsP makes cells "blind" to the cellular nitrogen status.

181 ways, and distal alveoli, is a complex multi-cellular organ that intimately links with the cardiovasc

182 Global insights into cellular organization and genome function require compre

183 Phosphoinositides (PI) are key regulators of cellular organization in eukaryotes and genes that tune

184 that improves systems-level understanding of cellular organization in health and disease through inte

185 Planar cell polarity (PCP) reflects cellular orientation within the plane of an epithelium.

186 To directly assess the impact of cellular p53 status on CRISPR-Cas9 screen performance, w

187 standing the mechanisms of HPgammaCD-induced cellular pathways could contribute to effective NPC ther

188 We identified 11 cellular pathways required for HIV-1 reactivation as dru

189 ligate parasites, all viruses exploit common cellular pathways, providing the possibility to develop

190 s support engraftment and maintenance of the cellular phenotype of injected tissue-resident macrophag

191 rotein stability changes that cause dramatic cellular phenotypes observed at nonpermissive temperatur

192 ponent of homologous recombination deficient cellular phenotypes, the image-based algorithm was studi

193 ed treatments, indicating durable changes in cellular physiologic identity.

194 istributing the computational labor across a cellular population.

195 less, robust application of these methods in cellular populations without side effects has remained c

196 ctive representatives combined submicromolar cellular potency and nanomolar target affinity with bala

197 d characterize novel compounds with specific cellular potency for either WT or mutant SHP2.

198 esign concepts, coupled with optimization of cellular potency, in vitro drug-target residence times,

199 The cellular prion protein (PrP(C)) comprises two domains: a

200 Cellular prion protein interacts with copper, Cu(II), th

201 mposed of multichain assemblies of misfolded cellular prion protein.

202 l link between the Hofmeister series and the cellular process of neurotransmitter release via exocyto

203 Autophagy is a cellular process that preserves cellular homeostasis and

204 to proteins and lipids, regulates nearly all cellular processes and is critical in the development an

205 om tissues to characterize physiological and cellular processes associated with venom production and

206 ity of genes undergo pre-mRNA splicing, most cellular processes depend on proper spliceosome function

207 stimulatory influences of electric fields on cellular processes in tissue and regenerative engineerin

208 ver, the role of such proteins in regulating cellular processes in vivo and development in metazoans

209 Through these interactions, RNAs mediate cellular processes such as the regulation of gene transc

210 e differential effects of YAP and TAZ on key cellular processes were also associated with differentia

211 atory cell polarization and controls dynamic cellular processes, such as focal adhesion formation and

212 s a critical signaling node for a variety of cellular processes, which are mediated by protein comple

213 y and versatility of WW domain-PPXY mediated cellular processes.

214 accurately understanding protein function in cellular processes.

215 es and collectively they regulate nearly all cellular processes.

216 that uses scRNA-seq to characterize dynamic cellular programs and their molecular drivers, and apply

217 sion, potency, and function, particularly in cellular proliferation and differentiation, as well as i

218 studies implicate Gal-9 in the regulation of cellular proliferation and epithelial restitution after

219 The contribution of cellular proliferation to viral persistence is particula

220 It can provide clonal-level insights into cellular proliferation, development, differentiation, mi

221 ollowed by culture in TSC medium to maintain cellular proliferation.

222 sensing motif and its capacity for providing cellular protection against oxidative stress while servi

223 In human papillomavirus (HPV) infection, the cellular protein complex known as retromer binds to the

224 is is the first study reporting the distinct cellular protein targets of mHAAs and mHAMs at the prote

225 In an effort to search for the host cellular protein(s) mediating the differential susceptib

226 antigen 6 family member E (LY6E), the three cellular proteins identified to function in interference

227 ool for the precise chemical modification of cellular proteins with spatial and temporal control.

228 oading reduces non-specific encapsulation of cellular proteins, particularly nucleic-acid-binding pro

229 ttaching identifying DNA oligonucleotides to cellular proteins.

230 unds (ouabain and CdCl(2)) demonstrates that cellular reactivity can be boosted by light driven pertu

231 te noisy morphogen signaling and large-scale cellular rearrangements during morphogenesis and growth.

232 RH/AKH-like receptors GNRR-3 and GNRR-6 in a cellular receptor activation assay.

233 ke, allowing us to decouple aggregation from cellular, receptor-mediated internalization.

234 lication-associated DNA damage and promoting cellular recovery.

235 NADH and NAD(+) are a ubiquitous cellular redox couple.

236 Levels of glutathione, a key regulator of cellular redox status, are reduced in the medial prefron

237 Using two well-characterized cellular reference samples (breast cancer cells and B ce

238 Cellular regulation of protein functions involves differ

239 bleweed, and Pebble are all used during this cellular repair, each has a unique localization pattern

240 In parallel, cellular reprogramming and organoid engineering are expa

241 scence lifetime imaging targets that require cellular resolution and molecular specificity.

242 of PD-L1 positive tumor cells and CTLs with cellular resolution by non-invasive NIR-IIb light sheet

243 tor of INterferon Genes) mediates protective cellular response to microbial infection and tissue dama

244 tion that regulates protein synthesis during cellular response to oxidative stress.

245 died were more likely to have not mounted a cellular response to the proteins.

246 iviral activity, whereas others regulate the cellular response.

247 ess and autophagy plays an important role in cellular responses to a wide variety of physiological an

248 ntracellular targets lead to similarities in cellular responses.

249 ntosaceus suppressed Ag-specific humoral and cellular responses.

250 g to detect the abundance and positioning of cellular RNA and DNA molecules in fixed samples.

251 e learning to detect secondary structures in cellular RNAs.

252 to enable mechanistic understanding of RAD51 cellular roles.

253 ostulated that increases in cAMP, a critical cellular "second messenger," may be linked to changes in

254 This Review examines cellular senescence in the context of ageing and AD, and

255 d AD, and discusses which of the processes - cellular senescence or AD - might come first.

256 tion of MC(1) is a viable strategy to induce cellular senescence, affording a distinct way to control

257 ole for skeletal muscle lamin A/C to prevent cellular senescence, IL-6 expression, hyperosteoclastoge

258 ssociated organ fibrosis, marked by elevated cellular senescence, is a growing health concern.

259 g the chronic infection phase, likely due to cellular senescence.

260 signaling pathways are enhanced, leading to cellular senescence.

261 r demonstrated that SOX9 knockdown increases cellular sensitivity to cisplatin, whereas its overexpre

262 y to study TNFR1 assembly directly in native cellular settings and at physiological cell surface abun

263 f integral membrane proteins responsible for cellular signal transductions.

264 l histopathology; (ii) Renal function; (iii) Cellular signaling changes; (iv) Oxidative stress and in

265 via pattern recognition receptors, internal cellular signaling pathways are induced to ultimately fe

266 e show that beta-HPV E6 more broadly impairs cellular signaling, indicating that the viral protein dy

267 ic regulatory factors and various downstream cellular signaling.

268 ted with immunoregulation and were the major cellular source of IL-22 binding protein (IL-22BP) at st

269 ss the potential causes of inflammaging, the cellular source of the inflammatory mediators, and the m

270 e fold-change and the ability to distinguish cellular states.

271 by caAKT1 and c-Myc and reveals an impact of cellular status on initiation of lineage plasticity.

272 It forms fibrils both under cellular stress and in mutated form in neurodegenerative

273 physiologically associated with significant cellular stress but, paradoxically, it favors tumor prog

274 gy responds to a variety of intra- and extra-cellular stress conditions including, but not limited to

275 Recent work showed that cellular stress created by neurotoxins such as MPTP and

276 gen and reactive nitrogen species as well as cellular stress induced by antibiotics.

277 ic) triggered by multiple factors, including cellular stress, DNA damage and immune surveillance.

278 We also demonstrate light- and cellular stress-gated switch function in cultured hippoc

279 s broadband absorption and does not generate cellular stress.

280 Our work will not only facilitate cellular studies of PTS, but also paves the way for econ

281 sodium channels cluster together in specific cellular subdomains.

282 Modification of cellular substrates with linear polyubiquitin chains is

283 urrently mediate the degradation of distinct cellular substrates.

284 he oxidized form of cysteine, as a source of cellular sulfur.

285 preserves cellular homeostasis and promotes cellular survival during times of stress.

286 ant splicing of tau pre-mRNA in a variety of cellular systems, including primary neurons.

287 RNA polymerase as well as a broader range of cellular target pathways controlled by (pp)pGpp, includi

288 ey are utilized in nature to accomplish many cellular tasks.

289 au with low nanomolar affinity, and inhibits cellular Tau aggregate propagation similarly to standard

290 oach to engender endogenous patient-specific cellular therapy, without the need for a priori knowledg

291 es with orthogonal orientation suggests that cellular transition rates depend on the cell polarizatio

292 Furthermore, we identify genes involved in cellular transport, including calcium transporters and c

293 beta-barrel proteins, which are important in cellular transport.

294 t transcriptional heterogeneity arising from cellular types, spatio-temporal contexts and environment

295 values were high enough to explain observed cellular uptake by passive diffusion with no need to pos

296 d that plasma membrane depolarization blocks cellular uptake of N-acylethanolamides-lipoprotein-borne

297 distinguish between those that measure total cellular uptake of RNA therapeutics, which includes both

298 apitulates full-length Abeta stereoselective cellular uptake, allowing us to decouple aggregation fro

299 f, e.g., cellular adhesion, endo/exocytosis, cellular uptake, and mechanosensing.

300 CCCs play roles in cellular volume regulation, neural development and funct