ライフサイエンスコーパス: cellular enzyme

1 active protein or enzymatic activity of this cellular enzyme.

2 nisms modulate the activity of this critical cellular enzyme.

3 e and convenient model for understanding the cellular enzyme.

4 role in host-pathogen interactions for this cellular enzyme.

5 due to low-level genome circularization by a cellular enzyme.

6 it is itself an RNase or somehow activates a cellular enzyme.

7 only slightly but increased the affinity for cellular enzymes.

8 tic co-factors in a wide variety of critical cellular enzymes.

9 the processing of protein-DNA cross-links by cellular enzymes.

10 and its intensity was used for assessment of cellular enzymes.

11 time scales, for example, substrates of many cellular enzymes.

12 sed by antibody aldolases but not by natural cellular enzymes.

13 ostasis and the activity of NAD(+)-dependent cellular enzymes.

14 s that serve as cofactors for many essential cellular enzymes.

15 e the functional links between the viral and cellular enzymes.

16 her essential nutrient required for numerous cellular enzymes.

17 yQ repeat fragments for degradation by other cellular enzymes.

18 les and controlling the activity of multiple cellular enzymes.

19 RNA polymerases are key multisubunit cellular enzymes.

20 move potentially toxic secondary products of cellular enzymes.

21 a required cofactor for a number of critical cellular enzymes.

22 ore completion of the integration process by cellular enzymes.

23 ressed by using small molecule inhibitors of cellular enzymes.

24 at is hypothesized to prevent debranching by cellular enzymes.

25 d cannot be efficiently substituted by other cellular enzymes.

26 s are derived largely through the actions of cellular enzymes.

27 tudies and reveals reversible modulations of cellular enzyme activities under different metabolic con

28 Our results identify a heretofore unknown cellular enzyme activity associated with Sts-1 and indic

29 Most cellular enzyme activity was thought to arise from the p

30 tion rate [fV ]), metabolic rate (M O2), and cellular enzyme activity were measured.

31 cross cells, which rendered intra- and trans-cellular enzyme activity.

32 , due to reduced expression of JAR1 mRNA and cellular enzyme activity.

33 se and temporally regulated interaction of a cellular enzyme and a noncoding RNA provides a new parad

34 ocesses, groups that include the majority of cellular enzymes and components of amino acid, carbohydr

35 oteins, which can activate a wide variety of cellular enzymes and ion channels.

36 the peroxynitrite avoids the inactivation of cellular enzymes and modification of the cytoskeleton.

37 otin and used as markers in the detection of cellular enzymes and receptors.

38 kinetic profile, instability, degradation by cellular enzymes and their low cellular uptake.

39 Copper is a cofactor for many cellular enzymes and transporters.

40 ction and time-varying concentrations of the cellular enzymes are used as decision variables.

41 ith and inhibiting adenosine kinase (ADK), a cellular enzyme associated with the methyl cycle that ge

42 The recruitment of these cellular enzymes by the co-opted retromer is critical fo

43 fe cycle and is a homolog of three conserved cellular enzymes called vaccinia virus-related kinases (

44 In vitro mutagenesis of normal cellular enzymes can be exploited to identify mutations

45 Cellular enzymes can instruct in situ biomineralization

46 atalytic function of IkappaB kinase (IKK), a cellular enzyme complex that phosphorylates and inactiva

47 M2 bound to TopoII and resulted in decreased cellular enzyme content.

48 with mAspAT mRNA (r = .90), reaching 808% of cellular enzyme content/24 hours at 80 mmol/L.

49 There are some P. aeruginosa cellular enzymes controlled by quorum sensing, and we sh

50 ver, this TNTase was later purported to be a cellular enzyme copurifying with the HCV RdRp.

51 ke structure is subsequently resolved by the cellular enzyme DBR1, leaving a 5' phosphate.

52 itriptyline, which induce degradation of the cellular enzyme, did not significantly inhibit BoHV-1 en

53 Cellular enzymes exist to cope with these structures who

54 poptosis-related genes, zinc finger protein, cellular enzymes, expressed sequence tag clones, and CpG

55 polyglutamylated, as mediated in vivo by the cellular enzyme folyl polyglutamate synthetase.

56 that these drugs require a minimal set of 5 cellular enzymes for activation to their common 5'-triph

57 that typically encode no proteins and hijack cellular enzymes for replication.

58 s that inhibit vitamin B9 (folic acid)-using cellular enzymes, have been used over several decades fo

59 Therefore, modulation of the cellular enzyme HO-1 may represent a novel therapeutic s

60 ith and inactivate adenosine kinase (ADK), a cellular enzyme important for adenosine salvage and meth

61 Cyclooxygenase-2 (COX-2) is a cellular enzyme in the eicosanoid synthetic pathway that

62 lins revealed little, if any, role for these cellular enzymes in the modulation of furin cleavage.

63 ry (SOCE) regulates several Ca(2+)-sensitive cellular enzymes, including certain adenylyl cyclases (A

64 Cellular enzymes interact in a post-translationally regu

65 ldehyde 3-phosphate dehydrogenase (GAPDH), a cellular enzyme involved in glycolysis, binds specifical

66 HeLa extracts, we identified several of the cellular enzymes involved in AAV DNA replication.

67 In this study, potential cellular enzymes involved in encephalomyocarditis virus

68 ellular leukotriene production by activating cellular enzymes involved in leukotriene formation.

69 Iron is an essential cofactor for many cellular enzymes involved in myelin synthesis, and iron

70 est itself when the adducts are processed by cellular enzymes involved in replication, repair, and tr

71 ons are corrected in a reaction catalyzed by cellular enzymes involved in various DNA repair processe

72 thermore, there is no evidence that the same cellular enzyme is involved in the synthesis of both RNA

73 mic phosphorylation involving both viral and cellular enzymes is likely a key regulator of multiple B

74 n involving the vaccinia virus B1 kinase and cellular enzymes is likely a key regulator of multiple B

75 ifications can be modulated by more than one cellular enzyme, it is not always clear whether changes

76 ite is thought to be catalyzed by one of the cellular enzymes known as adenosine deaminases that act

77 hought to be catalyzed by one or more of the cellular enzymes known as adenosine deaminases that act

78 a limited number of genes encoding "private" cellular enzymes like Nuh, an enzyme involved in adenosi

79 IgM- and IgG-AECA were determined by cellular enzyme-linked immunosorbent assay using fixed c

80 Immunofluorescence microscopy and a cellular enzyme-linked immunosorbent assay using purifie

81 Thymidine phosphorylase, a cellular enzyme markedly induced by ORFK13/vFLIP, can me

82 is and that pharmacologic targeting of these cellular enzymes may facilitate the cure of chronic hepa

83 While cellular enzymes may take part in mediating this recombi

84 e that phosphoregulation of BAF by viral and cellular enzymes modulates this protein at multiple mole

85 Therefore, targeting cellular enzymes necessary for HIV-1 transcription, whic

86 of Epstein-Barr virus (EBV) is replicated by cellular enzymes only once per cell cycle in human cells

87 igens using a mechanism that did not involve cellular enzymes or lipid cleavage, but was regulated by

88 the endogenous baculovirus gene product or a cellular enzyme, point mutations were introduced into a

89 We show that the cellular enzyme "Prolidase" plays a key role in cocaine-

90 The drug targets in this assay are viral and cellular enzymes required for HCV replication, which are

91 Co-opting cellular enzymes required for lipid biosynthesis and lip

92 nine adenosyltransferase (MAT), an essential cellular enzyme responsible for S-adenosylmethionine bio

93 GLO1 is a ubiquitous cellular enzyme responsible for the detoxification of th

94 polymerase, the identity of the (presumably cellular) enzyme responsible for this reaction remains u

95 These results support the hypothesis that cellular enzyme(s) may catalyze the late steps of retrov

96 ng that these modifications can be made by a cellular enzyme(s).

97 This report demonstrates that a cellular enzyme, SIRT1, is part of the HPV16 DNA replica

98 cleotide bases can be chemically modified by cellular enzymes such as methyltransferases to regulate

99 Cellular enzymes synthesize atRA from Vitamin A, which i

100 Telomere shortening is counteracted by the cellular enzyme telomerase.

101 by viral 2A protease (2A(pro)) or a putative cellular enzyme (termed eIF4Gase) which is activated by

102 Endonuclease G appears to be the only cellular enzyme that can specifically cleave the a seque

103 O-GlcNAc transferase (OGT) is an important cellular enzyme that catalyzes the posttranslational add

104 levels of Ty1 transposition require Dbr1p, a cellular enzyme that cleaves 2'-5' RNA bonds.

105 irtuin 2 (SIRT2) is a ubiquitously expressed cellular enzyme that deacylates protein lysine residues

106 SAMHD1 is a cellular enzyme that depletes intracellular deoxynucleos

107 Here we show that TET2, a cellular enzyme that initiates DNA demethylation by conv

108 have examined whether expression of TET2, a cellular enzyme that initiates DNA demethylation by conv

109 n likely is the inhibition of cathepsin L, a cellular enzyme that is essential for the processing of

110 APOBEC3G is a human cellular enzyme that is incorporated into retroviral par

111 belson (Abl) tyrosine kinase is an important cellular enzyme that is rendered constitutively active i

112 (O-GlcNAc) transferase (OGT) is an essential cellular enzyme that posttranslationally modifies nuclea

113 Tyrosyl-DNA phosphodiesterase I (Tdp1) is a cellular enzyme that repairs the irreversible topoisomer

114 One such factor, telomerase, is the cellular enzyme that synthesizes DNA repeats at the ends

115 Telomerase is a cellular enzyme that synthesizes nucleotide repeats at t

116 Fatty acid synthase (FAS), the cellular enzyme that synthesizes palmitate, is expressed

117 ten-eleven translocation (Tet) genes encode cellular enzymes that are not essential for postnatal mo

118 te extracts, we demonstrate the existence of cellular enzymes that can efficiently utilize O-acetyl-A

119 be universally adaptable to other viral and cellular enzymes that have deISGylating activities.

120 etic DNA analogs resistant to degradation by cellular enzymes that hybridize to single-stranded DNA (

121 Topoisomerases are essential cellular enzymes that maintain the appropriate topologic

122 infection with FeLV-B due to the activity of cellular enzymes that mutate the viral genome.

123 l-prolyl isomerases (PPIases) are ubiquitous cellular enzymes that play roles in cellular signaling a

124 However, the cellular enzymes that regulate the addition and removal

125 lear antigen (PCNA), and polymerase delta as cellular enzymes that were essential for AAV DNA replica

126 and trans-phosphorylations (by PKC and other cellular enzymes) that contribute to the spatiotemporal

127 ingers differ from the zinc finger motifs of cellular enzymes, the requirement for efficient hydrogen

128 dized NFI-C can be catalyzed in vitro by the cellular enzyme thioltransferase (glutaredoxin) coupled

129 ngle stranded RNA viruses, which hijack this cellular enzyme to remodel intracellular membranes of in

130 tructural motif of DDX3X not shared by other cellular enzymes to develop a theoretical model to aid i

131 ve site Cys and is one of the most sensitive cellular enzymes to oxidative inactivation and redox reg

132 iolabile groups, which need to be cleaved by cellular enzymes to release the parent molecules.

133 that, as opposed to what is observed for the cellular enzyme, two different mRNAs are encoded by the

134 (DDX/DHXs) are abundant and highly conserved cellular enzymes ubiquitously involved in RNA processing

135 In contrast, three IFN-induced cellular enzymes, viperin, ISG20, and double-stranded-RN

136 ze that these cdks regulate the functions of cellular enzymes which modify ICP0, and are, consequentl

137 infected cell lines, suggesting a role for a cellular enzyme, which was confirmed by reduction of the

138 Poly(ADP-ribose) polymerase 1 (PARP-1) is a cellular enzyme with a fundamental role in DNA repair an