ライフサイエンスコーパス: cellular localization

1 MN plays an important role in regulating its cellular localization.

2 ell corpses, coupling DNGR-1 function to its cellular localization.

3 ologously in mammalian cells retained normal cellular localization.

4 f transmembrane proteins can determine their cellular localization.

5 matic activities and/or mediate their proper cellular localization.

6 ogy and lamination but abnormal SIK1 protein cellular localization.

7 rder to alter their degradation rate and sub-cellular localization.

8 indispensable role for parkin in TDP-43 sub-cellular localization.

9 nd the importance of PRD in its function and cellular localization.

10 group II intron RNAs, from transcription to cellular localization.

11 d, isoelectric point, expression pattern and cellular localization.

12 ional abilities are largely dependent on its cellular localization.

13 ghly conserved sequence in the CTR to affect cellular localization.

14 , and these structures are important for sub-cellular localization.

15 o perturbing macromolecular interactions and cellular localization.

16 ested for altered ubiquitin modification and cellular localization.

17 osphorylation, and heparanase expression and cellular localization.

18 ly to share biological function, but not sub-cellular localization.

19 Myristoylation of HMGCLL1 affects its cellular localization.

20 tor (TfnR) exhibited changes in steady-state cellular localization.

21 yo1c tail, which is important for its proper cellular localization.

22 processes that are dependent on their proper cellular localization.

23 tional differences in the protein defined by cellular localization.

24 as residues in the amino domain involved in cellular localization.

25 d the FRQ regions that are important for its cellular localization.

26 ot play a significant role in regulating its cellular localization.

27 and domain deletions also influence DNMT3B's cellular localization.

28 ted by differential degradation and distinct cellular localization.

29 e been linked to protein multimerization and cellular localization.

30 ocumented to influence protein activity, and cellular localization.

31 cteristics including dynamics, morphology or cellular localization.

32 complex formation with gH or alterations in cellular localization.

33 P(C) remains elusive but may depend upon its cellular localization.

34 of BMPR1b expression and alterations of its cellular localization.

35 ally encoded HaloTag fusion protein of known cellular localization.

36 analysis was performed for WT or mutant AIRE cellular localization.

37 s, protein-protein interactions, and protein cellular localization.

38 une receptor activation, cooperation and sub-cellular localizations.

39 noelectron microscopy assessed CRF1 and CRF2 cellular localization 24 hours after the last stress.

40 Depletion of PDHK4 causes disruption of KRAS cellular localization, a reduction in KRAS activity whic

41 ity of the rare variants after assessment of cellular localization, ability to interact with GCK, and

42 tion, the ORF9 protein displays an identical cellular localization, accumulating in the trans-Golgi r

43 a to test how changes in PrP sequence and/or cellular localization affect the functional activity of

44 s through protein structure, mutagenesis and cellular localization analyses.

45 Cellular localization analysis of CT009 showed uniform m

46 though the CH domain is required for MICAL-1 cellular localization and actin-associated function, its

47 in-coupled receptors (GPCRs), as well as sub-cellular localization and activity of many other signali

48 G perturbs lysosomal activity, and disrupts cellular localization and activity of neutral and acid s

49 protein-protein interactions influencing DAT cellular localization and activity, suggesting that the

50 riptional regulatory programme, in which sub-cellular localization and alternative splicing play comp

51 Tradeoffs between cellular localization and ammonium toxicity lead to sele

52 Mammalian SIRTs (SIRT1-7) differ in their cellular localization and biologic functions.

53 grity of NSs is important for the stability, cellular localization and biological functions of RVFV N

54 first use of TOF-SIMS MS/MS imaging for the cellular localization and characterization of biosynthet

55 ions of human Chk1 that regulate its protein cellular localization and checkpoint function.

56 of odor detectors, MS4As, that have similar cellular localization and chemodetection ability as ORs

57 lycosphingolipid metabolism as a function of cellular localization and chloroquine treatment.

58 The cellular localization and deposition of H2A-H2B into chr

59 of LRAP adaptors as key determinants of MRCK cellular localization and downstream specificities.

60 synergistic H3-tail binding causing distinct cellular localization and enhanced H3K9me3-nucleosome ub

61 Here we studied the stability, cellular localization and enzymatic activity of the PNKD

62 rtantly, the transgenic whirlin restored the cellular localization and expression level of both USH2A

63 roaches have provided data on the diversity, cellular localization and expression patterns of differe

64 However, regulation of Rho-GAP cellular localization and function is not fully understo

65 SUMOylation has been shown to regulate cellular localization and function of a variety of prote

66 d Rng9 are binding partners that dictate the cellular localization and function of Myo51.

67 that disrupting PKHD1 results in altered sub-cellular localization and function of the C2-WWW-HECT do

68 We analyzed the cellular localization and function of the N-truncated NS

69 Our results show that cellular localization and function of the Rho-GAP Rga7 a

70 ological applications, but concerns that sub-cellular localization and functional integrity of delive

71 Ggamma subunits provide proper cellular localization and functional specificity to the

72 mic (gamma-CYA) actins, which have different cellular localization and functions.

73 to be conferred by specific isoforms, by sub-cellular localization and in cell-type-specific contexts

74 The cellular localization and in vitro activity of two P450

75 no acid changes on THOC6 protein expression, cellular localization and interaction with the other THO

76 hemoproteomic strategy for interrogating the cellular localization and interactomes of inhibitor-boun

77 Based upon its cellular localization and its dominant response to zinc

78 We examined the cellular localization and potential interactions of IGFB

79 used for modifying proteins to control their cellular localization and potentially alter their biolog

80 of mutated PopZ proteins for defects in sub-cellular localization and recruitment activity.

81 fly is an exciting new resource for studying cellular localization and regulation of EGFR in tissues.

82 The cellular localization and regulation of the AMTs suggest

83 a series of kinases that can control the sub-cellular localization and stability of YAP or TAZ, homol

84 ns that influence miRNA stability, their sub-cellular localization and target selection.

85 dendrimers and dendritic polyglycerols) for cellular localization and targeting of specific tissues

86 munoblot analyses were used to determine the cellular localization and the amount of ClC-2 expressed

87 The cellular localization and the cytoskeletal association o

88 ual nonstructural protein and examined their cellular localization and their disruption of endoplasmi

89 es suggested potential variations of the sub-cellular localization and their functional regulations.

90 tational framework that employs a battery of cellular localization and topological prediction tools t

91 For different CA isoforms, cellular localization and total gene expression as a fun

92 tt fragments have been shown to modulate Htt cellular localization and toxicity.

93 al role in the regulation of mRNA stability, cellular localization and translation efficiency.

94 ult myocytes feature dramatic differences in cellular localization and translocation in mediating hyp

95 that play critical roles in the biogenesis, cellular localization and transport of RNA.

96 Os and intracellular proteins that may alter cellular localization and/or potency of ASOs.

97 set of 40 target proteins of various sizes, cellular localizations and host organisms.

98 nfocal imaging were performed for signaling, cellular localization, and coassociation studies.

99 ontrolling the assembly state of NMII-A, its cellular localization, and focal adhesion assembly.

100 Here, we report on the interaction, cellular localization, and functional domains of these t

101 een exogenous cysteine, cellular metabolism, cellular localization, and Hg(II) coordination in aerobi

102 ittle is known about the expression profile, cellular localization, and physiological contribution of

103 y-based probes enable noninvasive detection, cellular localization, and proteomic identification of p

104 hich are essential for its activity, correct cellular localization, and regulation for protein glycos

105 n length, the chain length distribution, the cellular localization, and the cation composition.

106 ntermediates to regulate the protein levels, cellular localizations, and/or DNA binding of BRI1-EMS s

107 Cellular localization assay carried out by making a Musa

108 Cellular localization assay performed using transiently

109 rdingly, as revealed by in vitro binding and cellular localization assays, ANX A13a variants that fav

110 as been shown to indicate the possibility of cellular localization-based role diversity, which may ha

111 Cellular localization, biochemistry, protein interaction

112 ore generally, network architecture reflects cellular localization, biological process, and molecular

113 nd NOD2 share striking similarities in their cellular localization, both localize to membrane ruffles

114 d into a stable protein that displays normal cellular localization but is unable to hydrolyze cyclic

115 ved a change in CSE1L staining intensity and cellular localization by immunohistochemistry.

116 nt Seurat, a computational strategy to infer cellular localization by integrating single-cell RNA-seq

117 with a fluorescent protein and examined its cellular localization by live-cell microscopy.

118 Here, we report a dual regulation of p27 cellular localization by Ral downstream pathways, based

119 PKA and ERK1&2 kinase activities in the same cellular localization by using FRET biosensors.

120 lls and to distinguish their extra- vs intra-cellular localizations by real-time spectroscopy in ense

121 gastric cancer cells by affecting E-cadherin cellular localization, cis-dimer formation, molecular as

122 o degradation and also showed changes in sub-cellular localization compared to wild-type SIK1.

123 these subtypes), and often displays altered cellular localization compared with healthy tissue.

124 is initiated by exogenous signal gradients, cellular localization cues, and an intricate hierarchy o

125 ng tissue-specific gene expression data, sub-cellular localization data, co-clustering of interacting

126 ing a unique combination of experimental sub-cellular localization datasets, tissue expression, predi

127 anscriptional regulation, suggesting its sub-cellular localization-dependent function.

128 ellular processes including innate immunity, cellular localization, development and differentiation,

129 n the specific conditions, interactions, and cellular localization, different conformations may be st

130 UBP27 demonstrates similar sub-cellular localization, domain structure, membrane topolo

131 ansferase 1 (CARM1) and prevents its correct cellular localization during mitosis.

132 ttranslational modifications, and nuclear or cellular localization, during the course of virus infect

133 s and epithelial cells, as well as different cellular localization dynamics in infected cells.

134 with Smad2, Smad3, and Smad7 expression and cellular localization examined by Western blotting.

135 We performed site-directed mutagenesis, cellular localization experiments, and molecular dynamic

136 usal mutations in this cohort was studied by cellular localization experiments.

137 l nucleus as expected based on the known sub-cellular localization for Dyrk1a, we found that the GFPN

138 ge is abundant in the VTA, but alpha6*-nAChR cellular localization, function, pharmacology, and roles

139 rofile kernel SVM) to predict the native sub-cellular localization in 18 classes for eukaryotes, in s

140 ntrolled by regulating protein stability and cellular localization in cells.

141 Xs was investigated: first by expression and cellular localization in mouse and human pancreatic isle

142 efforts to understand how TDP-43 alters its cellular localization in response to proteotoxic stress,

143 ces were found for DAT kinetic parameters or cellular localization in the vehicle controls.

144 on of these transcription factors and their "cellular localization" in bronchoscopic airway biopsies

145 signaling pathways from PPIs that leverages cellular localization information about proteins.

146 This signaling, related to the cellular localization inside the bone marrow niche and/o

147 HHIPL1 cellular localization, interaction with sonic hedgehog (

148 (MBNL1) is a splicing factor whose improper cellular localization is a central component of myotonic

149 verexpressed gene (TOG) domain array, proper cellular localization is a requisite for full activity a

150 The prediction of protein sub-cellular localization is an important step toward elucid

151 Furthermore, we found that cellular localization is critical for the proper functio

152 onal components of cells, knowledge of their cellular localization is crucial to gaining an understan

153 Its cellular localization is dependent not only on signal tr

154 the polar chemosensory cluster and that its cellular localization is dependent on the presence of Ch

155 ed by the addition Ca(2+) ionophore and that cellular localization is dependent upon the presence of

156 Cellular localization is determined by the length of the

157 e demonstrate that FOXO1 phosphorylation and cellular localization is regulated by insulin signaling

158 a(2+) sensor, is unclear with respect to its cellular localization, its Ca(2+)-dependent mobilization

159 s, inflammasomes, or cGAS, each with its own cellular localization, ligand specificity, and signal re

160 , fluorescent affinity (RFA) tag that allows cellular localization, manipulation of cellular levels,

161 6, we performed experiments to determine the cellular localization of ABCC6 in its physiological envi

162 Chamber-specificity and cellular localization of adrenergic remodeling were comp

163 Cellular localization of AGR2 is emerging as a key compo

164 Here, we first report the cellular localization of alternatively spliced human MOC

165 d C-terminal hydrophobic motif necessary for cellular localization of ALTO.

166 etabolism remains poorly understood, but the cellular localization of APP and its interaction with va

167 eported that copper promotes a change in the cellular localization of APP.

168 The polar, cellular localization of Arabidopsis PIN-FORMED (PIN) pr

169 Our findings reveal that the cellular localization of beta-TrCP1 is altered in gliobl

170 By contrast, Fe availability affects the cellular localization of bHLH121 protein in roots.

171 uding several rab GTPases, known to modulate cellular localization of cadherins.

172 rformed to detect mRNA expression and define cellular localization of calcitonin receptor-like recept

173 We therefore thoroughly examined the cellular localization of CB2R in the vervet monkey (Chlo

174 as therefore to explore the distribution and cellular localization of CEACAM6 using immunohistochemis

175 Together, our results show that cellular localization of Clusterin leads to divergent ef

176 Cellular localization of connexin 50 (Cx50) and connexin

177 rther analysis of the chemical structure and cellular localization of DAG in skeletal muscle revealed

178 ortance of taking the chemical structure and cellular localization of DAG into account when evaluatin

179 We investigated the spatial and cellular localization of DPP4 to evaluate an association

180 investigation characterized the function and cellular localization of EmaA glycosylation.

181 Here we define the cellular localization of endogenous FMNL3, the dynamics

182 nction, relatively little is known about the cellular localization of endogenous GRKs.

183 plore these questions, we first examined the cellular localization of endogenous myomaker.

184 Cellular localization of estrogen receptor (ER) was eval

185 Cellular localization of FAM13A protein and mRNA levels

186 Moreover, NPM1c alters the cellular localization of FLT3-TKD from the cell surface

187 s demonstrate that SadB kinases regulate the cellular localization of gamma-tubulin and thereby contr

188 In this study, we report on the cellular localization of GbpC.

189 Our results define a crucial role of the cellular localization of HDAC4 in the events leading to

190 ion of SOX-9 and FGFR-3, as well as aberrant cellular localization of heparan sulfate proteoglycans,

191 In this study, we have characterized the cellular localization of human phospholipid scramblase 4

192 Expression and sub-cellular localization of IFT43 in the retina and transie

193 or cell proliferation and survival, controls cellular localization of KDM4A and consequently its asso

194 SUMOylation did not affect the cellular localization of LEDGF proteins and was not nece

195 Downstream, the cellular localization of MAP kinase signaling is determi

196 Furthermore, cellular localization of miR-218-5p in human and murine

197 un proteomics has substantially resolved the cellular localization of morphine biosynthesis in opium

198 on studies on genetically modified mice, the cellular localization of mPGES-1 in the mouse brain has

199 Here, we investigated the expression and cellular localization of MSI1 and MSI2 in the brains tis

200 Our data suggest that cellular localization of Mtbhsp60 upon interaction with

201 scribe our efforts to fully characterize the cellular localization of MUCL1, investigate its regulati

202 erization of these mutations showed aberrant cellular localization of mutant and endogenous ETV6, dec

203 The observed divergence in cellular localization of mutants in MDCKII cells versus

204 s-of-function mutant demonstrates how proper cellular localization of MyD88 to the Myddosome is a fea

205 te precursor cells as well as expression and cellular localization of myelin basic protein.

206 pletion of either Scrib or Lgl1 disrupts the cellular localization of myosin II.

207 alyses of replisomes, to investigate the sub-cellular localization of nascent DNA and replisomes.

208 protein, suggesting that Lgl1 regulates the cellular localization of NMII-A.

209 In contrast, the cellular localization of NT-PCG-1alpha results in a long

210 Different cellular localization of OPN is associated with its dist

211 revealed a strict correspondence between sub-cellular localization of origin domains and their conden

212 cur, or indirectly, i.e., by determining the cellular localization of p53/MDM2-interacting factors.

213 Here we show that residues 1-180 mediate the cellular localization of PakB.

214 s, relatively few studies have addressed the cellular localization of pathways for synthesis of funga

215 hat repeats 9-14, which are required for the cellular localization of PelA with PelB are also essenti

216 The tissue and cellular localization of PHs was determined during fruit

217 Furthermore, cellular localization of PLZF was not altered in the abs

218 interactions, altering the stability and sub-cellular localization of Polbeta and providing mechanist

219 SUMOylation does not affect the stability or cellular localization of PR8 NS1.

220 Polar cellular localization of proteins is often associated wi

221 rane-bound Rac1 but dramatically changes the cellular localization of Rac1, causing polarization, whi

222 D-1 localizes to the cell periphery and that cellular localization of RCD-1 was correlated with conse

223 differentially, regulate the activities and cellular localization of RECQL5 and WRN, suggesting that

224 We sought to resolve the cellular localization of REEP1 and further elucidate the

225 iochemical approaches was used to refine the cellular localization of REEP1.

226 antibodies was used for data validation, and cellular localization of selected proteins was determine

227 ontrast, Vmax for [(3)H]serotonin uptake and cellular localization of SERT in mPFC and OFC were not d

228 strains lacking plrS, the production and/or cellular localization of several immune-recognized prote

229 On the other hand, cellular localization of slow myofiber-type genes reveal

230 unohistochemical methods to characterize the cellular localization of SR and D-serine in the mouse an

231 AS up-regulated SSTR1; neither drug affected cellular localization of SSTRs.

232 of the glycosylation consensus sequence, and cellular localization of target proteins.

233 ing, assembly of the telomerase complex, the cellular localization of telomerase and its recruitment

234 opy, biochemistry and molecular biology, the cellular localization of the ALC, its effect on carboxys

235 The cellular localization of the alpha(2)delta(3) subunit in

236 Expression and cellular localization of the brain water channel aquapor

237 living organelle, since the composition and cellular localization of the different constitutive cell

238 The cellular localization of the Far complex has yet to be f

239 se two mutations determine the stability and cellular localization of the FRI protein.

240 Ras signaling activity requires correct cellular localization of the GTPase.

241 These findings support a model in which the cellular localization of the miRISC regulates the fate o

242 Proper expression and cellular localization of the mutated DbpA proteins were

243 Cellular localization of the MybA::Gfp fusion and immuno

244 However, the cellular localization of the NIF system and the involvem

245 the mouse Pramel1 gene, and to determine the cellular localization of the PRAMEL1 protein during the

246 Cellular localization of the resulting Bsep mutants was

247 The cellular localization of the resulting green fluorescent

248 e of familial ALS, profoundly alters the sub-cellular localization of the SMN protein, preventing the

249 une RNA structure-targeting compounds to the cellular localization of the target.

250 ed to cell-specific defects that matched the cellular localization of these receptors in the WT retin

251 brane upon expression of activated Galpha13, cellular localization of these RhoGEFs has been proposed

252 f canonical NF-kappaB, and exhibited altered cellular localization of this protein.

253 Here we examined the anatomical and cellular localization of TIP39 signaling that contribute

254 We report a distinct cellular localization of total STAT3 protein in Rex1(-/-

255 nantly by posttranslational modification and cellular localization of transcriptional activators.

256 nd DELM-2 does not disrupt the expression or cellular localization of TRPA-1, a TRP channel needed in

257 Accordingly, we investigated the cellular localization of US9-driven cargo in neurons and

258 KCNE4 alters the biophysical properties and cellular localization of voltage-gated potassium channel

259 While the sub-cellular localization of Wdr68 has been shown to be depe

260 We sought to characterize the cellular localization of wild type beta-arrestin-1 and a

261 The expression, regulation and cellular localization of ZmHyPRP, a gene marker of embry

262 However, while viral architecture and cellular localization often dictate the suitability of a

263 ty of PrP(Sc) to proteolysis, or altered the cellular localization or expression level of PrP(C).

264 himpanzee and orangutan displayed an altered cellular localization pattern with predominant cell surf

265 RNAs have highly complex and dynamic cellular localization patterns.

266 signing unique Soj conformations to distinct cellular localization patterns.

267 est, the N-terminal SteC domain alters Cdc24 cellular localization, preventing its nuclear accumulati

268 eceptor dysfunction despite retaining normal cellular localization, protein folding, and an ability t

269 Dependent on their cellular localization, Protein Kinase D (PKD) enzymes re

270 gical activities such as mRNA stability, sub-cellular localization, protein translation, protein bind

271 The cellular localization results showed that extension of t

272 cess, depending on TLRs' expression pattern, cellular localization, signaling, and deployment of infl

273 f the encoded microproteins reveals distinct cellular localizations, specific protein binding partner

274 , which are fundamental for controlling AQP2 cellular localization, stability, and function.

275 unique among human KIR genes in expression, cellular localization, structure, and function, yet the

276 Sub-cellular localization studies clearly indicated the invo

277 More detailed cellular localization studies establish mitochondrial ta

278 f LSD1, we performed genome-wide mapping and cellular localization studies of LSD1 and its dimethylat

279 , we combined modeling, in vitro assays, and cellular localization studies to investigate the seconda

280 Cellular localization studies, however, showed a differe

281 nal sequence and bioinformatics analyses and cellular localization studies, we have clarified the dom

282 domain organization, expression pattern, and cellular localization suggest that the zebrafish will pr

283 cal mutant signal peptides were assessed for cellular localization, surface expression, and collagen

284 anges under force stimulation as well as its cellular localization that bridges the cytoskeleton with

285 igh affinity for PG and display a pattern of cellular localization that is not influenced by depletio

286 We show here that cyclin E1 regulates Kv2.1 cellular localization via inhibition of Cdk5 activity.

287 ette subfamily A member 1 (ABCA1), whose sub cellular localization was altered in both J774 and prima

288 Cellular localization was analyzed by immune electron mi

289 Cellular localization was determined by ImageStream flow

290 ntibiotics were added to bacteria, and their cellular localization was visualized by confocal fluores

291 Protein interactions and cellular localization were analyzed using proximity liga

292 CLM-1 and CLM-8 expression and cellular localization were assessed in murine bone marro

293 NOX5 positivity and cellular localization were studied via IHC and digital-i

294 s beyond different substrate preferences and cellular localization, where m6A demethylation by ALKBH5

295 M variant did not alter protein stability or cellular localization, whereas its transactivation activ

296 RM1 was examined for the interaction and the cellular localization with MOCS3.

297 el regulatory mechanisms that couple protein cellular localization with the checkpoint response and c

298 ighlighted a significant alteration of iASPP cellular localization, with consequent deregulation of i

299 Seurat will be applicable to mapping cellular localization within complex patterned tissues i

300 ntiation 2 (Neurod2) contributes to terminal cellular localization within the cortical plate.