ライフサイエンスコーパス: cellular reprogramming

1 gene expression, embryonic development, and cellular reprogramming.

2 t the Hippo pathway constitutes a barrier to cellular reprogramming.

3 ize their importance in ESC pluripotency and cellular reprogramming.

4 and sequence of molecular events inherent to cellular reprogramming.

5 constraints overcomes molecular barriers to cellular reprogramming.

6 he absence of complex soluble chemistries or cellular reprogramming.

7 t undergoes dynamic DNA demethylation during cellular reprogramming.

8 and describe how pioneer factors may enable cellular reprogramming.

9 NA methylation and hydroxymethylation during cellular reprogramming.

10 ific chromatin factor provides a barrier for cellular reprogramming.

11 eful tool to study the mechanisms underlying cellular reprogramming.

12 properties of stem cells and the process of cellular reprogramming.

13 properties of stem cells and the process of cellular reprogramming.

14 esponse to pathogen attack involves dramatic cellular reprogramming.

15 nto S phase, followed by rapid divisions and cellular reprogramming.

16 aintenance in breast cancer cells and during cellular reprogramming.

17 d animals implicating cell-cycle dynamics in cellular reprogramming.

18 tion, regulated by OCT4 phase separation, in cellular reprogramming.

19 stoids can be generated from adult cells via cellular reprogramming.

20 mplifies transcriptional noise to facilitate cellular reprogramming.

21 iptional networks throughout development and cellular reprogramming.

22 that the PpCSP genes function redundantly in cellular reprogramming.

23 eash cellular plasticity and favor oncogenic cellular reprogramming.

24 nd RBMXL1, that impede gene induction during cellular reprogramming.

25 source of insulin(+) cells after undergoing cellular reprogramming.

26 dicates DNA methylation changes induced upon cellular reprogramming.

27 types and 134 tissues, defining an atlas of cellular reprogramming.

28 new insights into the mechanisms underlying cellular reprogramming.

29 quences of inactivating Rb in the context of cellular reprogramming.

30 sive environment for cell fate change during cellular reprogramming.

31 nsect cells will be the method of choice for cellular reprogramming.

32 expression of OCT4 and FGF4 and accelerated cellular reprogramming.

33 e therefore unavailable for purification and cellular reprogramming.

34 s provide a global view of barriers to human cellular reprogramming.

35 ons, cardiomyocytes or beta-cells, and after cellular reprogramming.

36 Emerging evidence increasingly points to cellular reprogramming, a process during which fully dif

37 lethal gene interactions and oncogene-driven cellular reprogramming ('addiction'), giving rise to new

38 4 additionally mediates immune responses and cellular reprogramming, although the full extent of its

39 s shared mechanisms in stress adaptation and cellular reprogramming and address the therapeutic impli

40 duced during differentiation and reversed in cellular reprogramming and cancer.

41 a general use of 3D bioprinting for studying cellular reprogramming and cell cycle reentry toward tis

42 Recent innovations in cellular reprogramming and differentiation techniques ha

43 ture patient-derived neurons in a dish using cellular reprogramming and differentiation techniques.

44 " which is pronounced "dither"), potentiates cellular reprogramming and differentiation.

45 te transitions for diverse processes such as cellular reprogramming and differentiation.

46 lects how these target sites are used during cellular reprogramming and early mouse development.

47 lls overcomes an early epigenetic barrier in cellular reprogramming and facilitates the generation of

48 foundation for elucidating the mechanisms of cellular reprogramming and for studying the safety and e

49 including, synthetic and structural biology, cellular reprogramming and functional pharmaceutical scr

50 Lin28, a key factor for cellular reprogramming and generation of induced pluripo

51 We use cellular reprogramming and genome engineering to functio

52 that make Muller glia attractive targets for cellular reprogramming and highlighted the potential for

53 ction and provide an unexpected link between cellular reprogramming and host-pathogen interaction.

54 ce, which highlight innovative approaches to cellular reprogramming and how this revolutionary techni

55 emphasis on understanding the mechanisms of cellular reprogramming and its potential applications in

56 n to consider classical observations such as cellular reprogramming and multilineage locus priming.

57 In parallel, cellular reprogramming and organoid engineering are expa

58 ues, providing insight into hormone-mediated cellular reprogramming and proliferation during sex-type

59 , a previously unrecognized role of Jmjd3 in cellular reprogramming and provide molecular insight int

60 genous CX45 expression significantly blocked cellular reprogramming and reduced the efficiency.

61 ve become a valuable model for investigating cellular reprogramming and retinal regeneration.

62 r supports the crucial role played by p53 in cellular reprogramming and suggests an alternative metho

63 ocking potential applications in biosensing, cellular reprogramming and sustainability.

64 wn that pioneer factors are also crucial for cellular reprogramming and that they are implicated in t

65 adult stem cells and pluripotent stem cells, cellular reprogramming and tissue engineering are in pro

66 tylation in other cell states such as during cellular reprogramming and to quantify non-histone prote

67 he potential oncogenicity that may arise via cellular reprogramming, and could represent a valuable i

68 linking Sox proteins with stem cell biology, cellular reprogramming, and disease with an emphasis on

69 pluripotent stem cells (iPSCs) generated by cellular reprogramming, and further discuss manipulation

70 ation of autophagy, generation of hiPSCs via cellular reprogramming, and neuronal differentiation.

71 in embryonic development, are essential for cellular reprogramming, and rewire gene networks in canc

72 ractions at silent genes during development, cellular reprogramming, and steroid hormone induction.

73 processes, such as cellular differentiation, cellular reprogramming, and the emergence of drug resist

74 c manipulations, senescent cell ablation and cellular reprogramming-and discuss their mechanisms of a

75 using a recently demonstrated microRNA-based cellular reprogramming approach, human fibroblasts from

76 Transcriptional mechanisms underlying this cellular reprogramming are still poorly understood.

77 Metabolic rewiring and cellular reprogramming are trademarks of neoplastic init

78 ggest a fundamentally different function for cellular reprogramming as a means of 'chromosome therapy

79 e model for tissue regeneration, implicating cellular reprogramming as an essential element.

80 transient loss of cell polarity to the total cellular reprogramming, as found by transcriptional anal

81 It is now clear that the extensive cellular reprogramming associated with defence will redu

82 To analyze cellular reprogramming at the single-cell level, mass cy

83 ng the use of transcription factors (TFs) in cellular reprogramming, based on a device commonly used

84 he characteristics and mechanisms of partial cellular reprogramming by chemicals remain unclear.

85 s process, we systematically dissected human cellular reprogramming by combining a genome-wide RNAi s

86 1.The ubiquitin-proteasome system regulates cellular reprogramming by degradation of key pluripotenc

87 Cellular reprogramming by only small molecules holds eno

88 ings indicate that culture conditions during cellular reprogramming can strongly influence the epigen

89 Applied to lineage-traced cellular reprogramming data, predicted fate probabilitie

90 indings that establish the essential role of cellular reprogramming during neoplastic transformation

91 Although cellular reprogramming enables the generation of new cel

92 y which GATA3 functions as a pioneer TF in a cellular reprogramming event relevant to breast cancer,

93 WIND1 served as a key cellular reprogramming factor, initiating differentiatio

94 en require genetic modifications and complex cellular reprogramming for effective metastatic dissemin

95 gan, the intestine is a promising source for cellular reprogramming for replacing lost pancreatic bet

96 Application of the principles of cellular reprogramming for the treatment of cancer, howe

97 trate for the first time that HMGA1 enhances cellular reprogramming from a somatic cell to a fully pl

98 Cellular reprogramming from somatic cells to induced plu

99 e diverse functions in embryonic stem cells, cellular reprogramming, growth, and oncogenesis.

100 Cellular reprogramming has been recently intensively stu

101 iscuss how progress in stem cell biology and cellular reprogramming has enabled exciting new strategi

102 d more restricted cell fates, recent work in cellular reprogramming has proven that one cellular iden

103 The remarkable advances in cellular reprogramming have made it possible to generate

104 Cellular reprogramming highlights the epigenetic plastic

105 d phenotypes by epigenetic remodeling during cellular reprogramming highlights the role of epigenetic

106 Repression of cellular reprogramming in germ cells is critical to main

107 high affinities, opens up opportunities for cellular reprogramming in tissue regeneration.

108 uncover a sequential, two-step mechanism of cellular reprogramming in which repression of pre-existi

109 during cold response, there is a proteolytic cellular reprogramming in which the proteasome acquires

110 Efferocytosis triggers cellular reprogramming, including the induction of mRNA

111 During cellular reprogramming induced by the pioneer factor GAT

112 the catalytic endonuclease activity enhances cellular reprogramming, Integrator recruits RNA polymera

113 ll-type-specific E-P interactions to promote cellular reprogramming into pluripotent or two-cell-like

114 ls to pluripotency, a "second generation" of cellular reprogramming involves lineage-restricted trans

115 Somatic cellular reprogramming is a fast-paced and evolving fiel

116 Cellular reprogramming is a new and rapidly emerging fie

117 Our data suggest that human cellular reprogramming is a transcription factor-driven

118 The theory and utility of RNA use for cellular reprogramming is explored in this review.

119 One potential mediator of long-term cellular reprogramming is heritable (epigenetic) regulat

120 Transcription factor-dependent cellular reprogramming is integral to normal development

121 ganization of the cell during the process of cellular reprogramming is valuable for stem cell researc

122 Cellular reprogramming leading to induction of Muller gl

123 combination of regulatory genomic data sets: cellular reprogramming, liver dedifferentiation, and for

124 ggest that immunoediting of tumor results in cellular reprogramming may be accompanied by alterations

125 This cellular reprogramming may be indicative of a stress res

126 For example, therapeutic cloning and cellular reprogramming may one day provide a potentially

127 n remodeling provides the foundation for the cellular reprogramming necessary to drive metastasis.

128 Cellular reprogramming occurred under homeostatic condit

129 at oncogene expression was associated with a cellular reprogramming of adult interfollicular cells in

130 acid-sensing pathways to be essential in the cellular reprogramming of chemoresistance, and chemother

131 (Ambystoma mexicanum) that is indicative of cellular reprogramming of differentiated cells to a germ

132 ect link between the observed plasticity and cellular reprogramming of differentiating cells in adult

133 l-based regenerative therapies hold promise, cellular reprogramming of endogenous cardiac fibroblasts

134 133, 208, and 499 capable of inducing direct cellular reprogramming of fibroblasts to cardiomyocyte-l

135 Cellular reprogramming of mammalian glia to an induced n

136 chnologies such as multiomics approaches and cellular reprogramming of microbes that can enable signi

137 In this study, we investigated whether cellular reprogramming of neural stem cells with interle

138 We also discovered that HMGA1 enhances cellular reprogramming of somatic cells to iPSCs togethe

139 Cellular reprogramming of somatic cells to patient-speci

140 ed by PGE2 and suggest a process of adaptive cellular reprogramming of the intestinal epithelium that

141 During cellular reprogramming, only a small fraction of cells b

142 n well documented as an effective method for cellular reprogramming or directed differentiation.

143 gical problems of the new century, including cellular reprogramming, organogenesis, regeneration, gen

144 o offer a strategy to study the variances in cellular reprogramming outcomes due to different in vitr

145 Here we report a unique cellular reprogramming phenomenon, called stimulus-trigg

146 ors across developmental stages reveals that cellular reprogramming precedes the induction of neurona

147 g the diverse molecular actors implicated in cellular reprogramming presents a major challenge for fu

148 This cellular reprogramming process overcomes various barrier

149 This process, which we term adaptive cellular reprogramming, promotes regeneration in one of

150 Direct cellular reprogramming provides a powerful platform to s

151 actor 4 (Klf4), one of the factors directing cellular reprogramming, recognizes the CpG dinucleotide

152 on nanotransfection-driven (i.e., nonviral) cellular reprogramming represent a promising strategy fo

153 a somatic cell to a pluripotent state during cellular reprogramming requires DNA methylation to silen

154 exploration include cardiac cell therapy and cellular reprogramming targeting cell death and regenera

155 tifying the top TF candidates for a specific cellular reprogramming task.

156 Here, we present an overview of cellular reprogramming techniques used in regenerative m

157 Significant advances in cellular reprogramming technologies and hematopoietic di

158 Cellular reprogramming technologies represent an alterna

159 to leverage genomic data from patients using cellular reprogramming technologies to recapitulate comp

160 Cellular reprogramming technology has created new opport

161 blueprint of the intercellular crosstalk and cellular reprogramming that balances the metabolic and p

162 al-mesenchymal transition and other modes of cellular reprogramming that influence the tumor microenv

163 ell signaling, and ultimately coordinate the cellular reprogramming that leads to PTI.

164 During cellular reprogramming, the mesenchymal-to-epithelial tr

165 ogether our findings demonstrate that during cellular reprogramming, the metabolome of fibroblasts is

166 During cellular reprogramming, the pioneer transcription factor

167 l role for ubiquitin-specific protease 26 in cellular reprogramming through polycomb-repressive compl

168 Cellular reprogramming through targeting microRNAs (miRN

169 ion is driven by advances in genome editing, cellular reprogramming, tissue engineering, and informat

170 RNA or a dominant-negative construct blocks cellular reprogramming to a pluripotent state.

171 d cells, while highly infected cells undergo cellular reprogramming to an embryonic-like transcriptio

172 een of 70 transcription factors using direct cellular reprogramming to identify regulators that speci

173 Human cellular reprogramming to induced pluripotency is still

174 es in the maintenance of pluripotency during cellular reprogramming to induced pluripotent stem cells

175 o transcriptional and epigenetic remodeling, cellular reprogramming to pluripotency is also accompani

176 In vitro studies have demonstrated that cellular reprogramming to pluripotency reverses cellular

177 Here we show that, by applying cellular reprogramming to primary CML cells, aberrant DN

178 tivity, leading to an Src/Akt/NF-kB-mediated cellular reprogramming toward an inflammatory phenotype

179 Cellular reprogramming using chemically defined conditio

180 This study provides an example of cellular reprogramming using defined factors in an adult

181 We now report the use of in vivo cellular reprogramming, using ATOH1, to drive MCC develo

182 This cellular reprogramming was demonstrated through increase

183 To investigate the cell cycle during cellular reprogramming, we developed a comprehensive set

184 gnaling pathways and illustrates one case of cellular reprogramming where the identity of the cell of

185 une surveillance; 2) stem cell therapies and cellular reprogramming, which seek to regenerate the dep

186 Here, we review the progress in direct cellular reprogramming, with a focus on the paradigm of

187 sis that environmental perturbations trigger cellular reprogramming, with downstream effects on cellu