ライフサイエンスコーパス: cementum

1 rade III CEPs appeared completely covered by cementum.

2 (PP(i)) and a severe deficiency in acellular cementum.

3 ing alveolar bone, periodontal ligament, and cementum.

4 LSCs) giving rise to PDL, alveolar bone, and cementum.

5 (PM2) mesial roots including removal of root cementum.

6 in Hyp mouse molars, focusing on dentin and cementum.

7 t between the periodontal ligament (PDL) and cementum.

8 determine whether this material was bone or cementum.

9 ritical in preventing abnormal resorption of cementum.

10 predictably stimulate formation of acellular cementum.

11 maged calcified tissue confirmed that it was cementum.

12 is a 14 kDa polypeptide sequestered in tooth cementum.

13 surfaces were planed in order to remove root cementum.

14 mandibular molar to move up by building more cementum.

15 h mineralized tissues, particularly bone and cementum.

16 ansition from acellular cementum to cellular cementum.

17 erostin can similarly increase the amount of cementum.

18 f 3 mineralized tissues: enamel, dentin, and cementum.

19 P < 0.01), and a sharp reduction in cellular cementum.

20 e root, differentiate and secrete dentin and cementum.

21 ar bone (0.7 +/- 0.1 to 0.9 +/- 0.2 GPa) and cementum (0.6 +/- 0.1 to 0.8 +/- 0.3 GPa) was observed u

22 n = 66; dentin, 0.9 +/- 9.2 mV, n = 59; and cementum, -0.8 +/- 8.2 mV, n = 42, with a positive sing

23 ), including new bone (2.33 mm vs. 0.23 mm), cementum (1.74 mm vs. 0.23 mm), and associated periodont

24 n = 46; dentin, -8.1 +/- 7.4 mV, n = 45; and cementum, -14.3 +/- 8.0 mV, n = 34.

25 Cellular cementum, a mineralized tissue covering apical tooth roo

26 Cementum, a mineralized tissue lining the tooth root sur

27 Proper formation of cementum, a mineralized tissue lining the tooth root sur

28 Cementum, a specialized bony layer covering an entire mo

29 Cementum, alveolar bone, and the PDL of periostin-null m

30 Differences in cementum and AB regeneration in response to reduced PP(i

31 Ank, Enpp1, and both factors concurrently on cementum and AB regeneration, mandibular fenestration de

32 ntal complex includes 2 mineralized tissues, cementum and alveolar bone (AB), both essential for toot

33 However, hardness of cementum and alveolar bone at any given age were signifi

34 re we investigated the histologic changes of cementum and alveolar bone in a pycnodysostosis patient,

35 he histologic and ultrastructural changes of cementum and alveolar bone might be affected by CTSK mut

36 sed localization of DMP1 in vivo in cellular cementum and alveolar bone of mice treated with a single

37 specialised connective tissue that connects cementum and alveolar bone to maintain and support teeth

38 tion, loss of attachment, and destruction of cementum and alveolar bone.

39 eruption rate is due to a lack of acellular cementum and associated defective periodontal attachment

40 nt contained dentin with overlying acellular cementum and associated periodontal ligament tissue.

41 delivery significantly increased regenerated cementum and bone in WT mice.

42 Cementum and bone mineralization is regulated by factors

43 uter layer of adjoining mineralized tissues (cementum and bone).

44 the specialized matrices of enamel, dentin, cementum and bone.

45 ination of the primary teeth revealed normal cementum and dentin structure.

46 f plaque, calculus, and perhaps contaminated cementum and dentin.

47 sence of a narrow pouch-like opening between cementum and enamel in 15 of 16 teeth (93.8%).

48 n associated with the formation of acellular cementum and it has been found to stimulate periodontal

49 There is little potential for new cementum and new bone formation.

50 unction of BSP in the formation of acellular cementum and periodontal attachment are well documented,

51 in the formation of gingival pockets between cementum and periodontal epithelium, a hallmark of perio

52 Wnt/beta-catenin stimuli to regenerate bone, cementum and periodontal ligament fibres in a murine per

53 lity of EGR to induce formation of acellular cementum and promote significant anaplasis of the suppor

54 mage to tooth structure (enamel, dentin, and cementum), and alteration in tooth sensitivity.

55 including formation of periodontal ligament, cementum, and alveolar bone.

56 g apparatus, including periodontal ligament, cementum, and alveolar bone.

57 failed to rescue the defects in the dentin, cementum, and alveolar bones in the Dmp1-KO mice.

58 ssues--including periodontal ligament (PDL), cementum, and bone--are a major cause of tooth loss in a

59 vivo with ultrastructure of dentin, enamel, cementum, and bone.

60 l regeneration, i.e., formation of new bone, cementum, and connective tissue attachment.

61 The permselectivity of human enamel, cementum, and dentin sections was examined, in a microwe

62 xtracellular matrix protein present in bone, cementum, and dentin.

63 n, detailed through histology with new bone, cementum, and inserting fibers.

64 Instead of generating new bone, cementum, and inserting periodontal ligament fibers, CTG

65 the formation and mineralization of dentin, cementum, and jaw bones.

66 ed stimulation of osteogenesis, regenerative cementum, and new attachment formation.

67 alveolar bone, the periodontal ligament, the cementum, and oral mucosa.

68 ar roots with thin dentin, lack of acellular cementum, and osteoid accumulation in alveolar bone.

69 ERS cells are attached to the surface of the cementum, and others separate to become the epithelial r

70 econstruct periodontal tissues such as bone, cementum, and periodontal ligament cells (PDL).

71 After 5 mos, analysis showed alveolar bone, cementum, and periodontal ligament formation in all trea

72 New alveolar bone, cementum, and periodontal ligament were consistently obs

73 In this model, regeneration (new bone, cementum, and periodontal ligament) of 71% of the origin

74 enhancing the regeneration of alveolar bone, cementum, and periodontal ligament.

75 red by formation of tissues resembling bone, cementum, and possibly dentin.

76 s denuded of its periodontal ligament (PDL), cementum, and superficial dentin through a bony window c

77 te functional periodontal tissues (including cementum) are largely unsuccessful due to a lack of full

78 Hyp molars exhibiting 28% increased cellular cementum area versus 22% in WT mice at 21 dpp.

79 Cellular cementum area was significantly increased in Hyp versus

80 tory mechanisms of root resorption repair by cementum at the proteomic and transcriptomic levels.

81 pecific markers, cementum protein 1 (CEMP1), cementum attachment protein (CAP), and recently reported

82 ic force microscopy analysis showed that the cementum became significantly thickened, softened, and f

83 mentocytes in perilacunar mineralization and cementum biology.

84 nt of periodontal regeneration including new cementum, bone and connective tissue, and area measureme

85 h and graft, and no histological evidence of cementum, bone, or periodontal ligament (PDL) and, there

86 ens analyzed histologically demonstrated new cementum, bone, periodontal ligament, and connective tis

87 canning microscopy showed increased cellular cementum by 21 dpp.

88 Additionally, we challenged the cementum by taking out the opposing tooth to cause the f

89 Cellular cementum (CC) includes cementocytes, cells suspected to

90 MPf only developed significantly greater new cementum compared with controls.

91 oth is made of an enamel-covered crown and a cementum-covered root.

92 Cementum-covered roots of 20 extracted human premolars w

93 cted teeth and evaluated for the presence of cementum covering these areas by stereomicroscopy, light

94 t their absence is associated with increased cementum defects in amelogenin-knockout (KO) mice.

95 180 and LRAP mRNA expression correlated with cementum defects observed in the amelogenin-null mice.

96 The cementum defects were characterized by an increased pres

97 imbalance as the etiology of HPP-associated cementum defects.

98 notype, including dentin, alveolar bone, and cementum defects.

99 ickness ( P = 0.00007) and a 23% increase in cementum density ( P = 0.009) compared to age-matched he

100 oth growth along the enamel/dentine and then cementum/dentine boundaries.

101 (-/-) mouse molar and incisor roots, and the cementum deposited appeared hypomineralized.

102 ralization were unaffected, whereas cellular cementum deposition increased although it displayed dela

103 of erupted molars and incisors but excessive cementum deposition with increased numbers of Ibsp- and

104 Cementum-derived attachment protein (CAP) is a collageno

105 Cementum-derived growth factor (CGF) is a 14 kDa polypep

106 HERS cells also participate in the cementum development and may differentiate into cementoc

107 gene of the Hyp mouse resulted in defective cementum development.

108 Nonsignificant changes in acellular cementum did not appear to affect periodontal attachment

109 ded thinner BSP-positive staining within the cementum, discontinuous mineralization, and a globular a

110 s are involved in the formation of acellular cementum during development of the periodontal attachmen

111 to be involved in the formation of acellular cementum during tooth development, suggesting that these

112 oglycans were identified at PDL-bone and PDL-cementum entheses using alcian blue stain.

113 New cementum formation (CF) presented better results for SRP

114 defect fill (DF) in G1 and higher BD and new cementum formation (NCF) in both groups.

115 DF), newly formed bone density (BD), and new cementum formation (NCF) were histometrically assessed.

116 in designing methods for enhancing bone and cementum formation adjacent to root surfaces.

117 al tissues, and thus events and modifiers of cementum formation and mineralization need to be determi

118 In Phospho1(-/-) mice, acellular cementum formation and mineralization were unaffected, w

119 y defects, impairing new bone formation, new cementum formation and new attachment.

120 hat differentially induced genes may mediate cementum formation and resorption.

121 , this bound peptide significantly increased cementum formation compared with that attained in contro

122 intramembranous bone formation and enhanced cementum formation during periodontal wound healing.

123 Mean new cementum formation experimental sites 1.36 mm (71% of in

124 ges of development, was reduced during rapid cementum formation from P28 to P56.

125 acellular phosphate concentration may affect cementum formation have not been elucidated.

126 hogenetic protein-2 (BMP-2)-induced bone and cementum formation in a previously established rat model

127 he effect of sustained PDGF gene transfer on cementum formation in an ex vivo ectopic biomineralizati

128 n was not critical for acellular or cellular cementum formation in Ibsp(KAE/KAE) mice.

129 Cementum formation is deemed to be instrumental for the

130 r cementum, further revealing that acellular cementum formation is not substantially regulated by PHO

131 evealed a significant reduction in acellular cementum formation on Bsp (-/-) mouse molar and incisor

132 of ankylosis; however, a marked increase in cementum formation on the root surfaces of fully develop

133 No significant new cementum formation or ankylosis was noted.

134 lial rest cells contribute to the control of cementum formation via epithelial-mesenchymal interactio

135 New cementum formation was greatest in the BMP acid conditio

136 Minimal new bone and cementum formation was observed.

137 tachment, new epithelial attachment, and new cementum formation).

138 helium and connective tissue attachment, new cementum formation, and new bone formation were evaluate

139 niofacial region including reduced acellular cementum formation, detachment of the periodontal ligame

140 BSP plays a non-redundant role in acellular cementum formation, likely involved in initiating minera

141 ENPP1 (reducing PP(i)) resulted in increased cementum formation, suggesting PP(i) metabolism may be a

142 MP-2/ACS supported significantly greater new cementum formation.

143 or identification of new bone, ankylosis and cementum formation.

144 ion of maxillary molars, promoting rapid new cementum formation.

145 cementocyte activity in association with new cementum formation.

146 steoblasts and cementoblasts during cellular cementum formation.

147 The amount of new cementum formed for the rhPDGF-BB/equine group (4.8 +/-

148 tribute not only to odontoblasts but also to cementum-forming cementoblasts of the elongating root, w

149 on patterns of Axin2 and beta-catenin within cementum-forming periodontal ligament (PDL) cells are ne

150 mineralization of alveolar bone and cellular cementum, further revealing that acellular cementum form

151 dontium, where similar tissues like bone and cementum grow at different rates.

152 ress this issue, we first identified a rapid cementum growth window from the ages of postnatal day 28

153 ntribute to postnatal acellular and cellular cementum growth.

154 cells) resulted in a reduction of postnatal cementum growth.

155 ial cells, significantly contribute to rapid cementum growth.

156 ar and cellular cementoblast cell number and cementum growth.

157 ) cells are negatively associated with rapid cementum growth.

158 ial or mesenchymal cells) essential for root cementum growth.

159 feature of Gli1(+) PDL progenitor cells and cementum growth: a negative relationship between Gli1(+)

160 of B-catenin in Gli1(Lin) cells) revealed a cementum hyperplasia.

161 DTA-ablation of Gli1(Lin) cells led to a cementum hypoplasia, including a significant reduction o

162 2(CreERT2/+); R26R(DTA/+) mice led to severe cementum hypoplasia, whereas constitutive activation of

163 etails of the enamel (i.e., hypoplasias) and cementum (i.e., incremental lines), as well as of the cr

164 Removal of the detached cementum in combination with bone grafting using a minim

165 hether the cementocyte is a dynamic actor in cementum in comparable fashion with the osteocyte in the

166 logy revealed dramatically expanded cervical cementum in GACI teeth, including cementocyte-like cells

167 s, including bone, periodontal ligament, and cementum in human interproximal intrabony defects and mo

168 a pouch-like opening between the enamel and cementum in mandibular molars with Grade III CEPs.

169 nge, we found no difference in the amount of cementum in mice lacking sclerostin compared with normal

170 iograph showed an apparent separation of the cementum in the area of the pocket.

171 and furcation defects, but the length of new cementum in the interproximal intrabony defects was grea

172 tal ligament stem cells (PDLSCs) and forming cementum in vivo.

173 steocytes (bone), and cementocytes (cellular cementum) in wild-type (WT) mice.

174 nitor cells in contribution to both types of cementum, in which canonical Wnt/B-catenin signaling pos

175 Hyp versus WT long bone, alveolar bone, and cementum, including osteocyte/cementocyte marker dentin

176 Through its importance to cementum integrity, BSP is essential for periodontal fun

177 Cementum is a critical mineralized tissue; however, cont

178 ructurally/functionally competent tooth root cementum is a critical step for the successful restorati

179 Cementum is a key component of a functional periodontal

180 dontal support including bone, ligament, and cementum is a major goal of therapy.

181 Cementum is a mineralized tissue covering the tooth root

182 canalicular system of both alveolar bone and cementum is abnormal, with irregular lacunar walls and f

183 The cementum is also defective, as characterized by irregula

184 Restoration of functional cementum is considered a criterion for successful regene

185 Further, the presence of healthy cementum is considered to be an important criterion for

186 However, regenerating lost cementum is difficult and often incomplete.

187 Therefore, we conclude here that cementum is less sensitive to the absence of sclerostin

188 humans and mice reveal that the formation of cementum is sensitive to intra- and extracellular phosph

189 Cementum is the thin layer that covers the surface of th

190 st when the outermost layer of the tusk, the cementum, is used.

191 l tissue breakdown, with a lack of acellular cementum leading to periodontal ligament detachment, ext

192 flammation and may have produced cementum or cementum-like matrix on the titanium surface adjacent to

193 root lineage and led to formation of ectopic cementum-like structures.

194 he callus region; and 5) newly formed dental cementum-like tissue (NFC).

195 necting the adjacent bone to a thin layer of cementum-like tissue observed on the root surface.

196 Furthermore, HERS cells were able to form cementum-like tissue when transplanted into immunocompro

197 for periodontal ligament attachment and bone/cementum marker localization.

198 Immunohistochemistry (IHC) for cementum markers revealed intense dentin matrix protein-

199 We propose that defective alveolar bone and cementum may account for the periodontal breakdown and i

200 docrine signals and actively directing local cementum metabolism.

201 urition and menopause are recorded in dental cementum microstructure.

202 NB), density of newly formed bone (DNB), new cementum (NC), and extension of remaining defect (ERD) w

203 ea (NBA), area of bone trabeculae (ABT), new cementum (NC), and extension of remaining defect were hi

204 ed parameters (mm): total defect length; new cementum (NC); new bone (NB); gingival margin position;

205 n addition to the histologic findings of new cementum, new bone, a new periodontal ligament, and a ne

206 s notch showed evidence of regeneration (new cementum, new bone, and new periodontal ligament) in 3 s

207 o analyze the surface features of enamel and cementum of feline teeth affected with advanced FORL.

208 dy, we characterized the dentin, enamel, and cementum of Sox2-Cre-mediated Fam20C KO mice.

209 ent and gingival collagen fibers to both the cementum of the root surface and alveolar bone.

210 L) is the connective tissue that anchors the cementum of the teeth to the alveolar bone.

211 tors and free nerve endings that connect the cementum of the tooth root to alveolar bone and are vita

212 ly high concentration of endogenous DNA, the cementum of tooth roots is often targeted for ancient DN

213 ing, but destructive sampling methods of the cementum often result in the loss of at least one entire

214 BSP and OCN genes, confirming its nature as cementum or bone.

215 lt in any inflammation and may have produced cementum or cementum-like matrix on the titanium surface

216 oronally advanced flap with EMD revealed new cementum, organizing PDL fibers and islands of condensin

217 the tissues necessary for regeneration: new cementum, organizing PDL fibers, and islands of condensi

218 ce with regard to the presence or absence of cementum over the enamel projection within the furcation

219 beta-TCP showed evidence of regeneration of cementum, PDL with inserting connective tissue fibers, a

220 iodontal attachment apparatus, including new cementum, PDL, and bone coronal to the root notch in fou

221 Structural defects in cementum-PDL interfaces in Bsp (-/-) mice caused PDL det

222 ts, PDLSCs showed the capacity to generate a cementum/PDL-like structure and contribute to periodonta

223 em cells that have the potential to generate cementum/PDL-like tissue in vivo.

224 aratus, including the acellular and cellular cementum, periodontal ligament (PDL), and alveolar bone,

225 ) has been shown to promote formation of new cementum, periodontal ligament (PDL), and bone and to si

226 gival recession defects in restoring missing cementum, periodontal ligament (PDL), and supporting alv

227 nce of the periodontal attachment apparatus (cementum, periodontal ligament [PDL], and bone).

228 The results revealed new cementum, periodontal ligament with Sharpey's fibers, an

229 Qualitatively, new cementum, periodontal ligament with Sharpey's fibers, an

230 dontal regeneration (e.g., formation of root cementum, periodontal ligament, and alveolar bone).

231 s to evaluate regeneration of alveolar bone, cementum, periodontal ligament, and associated root reso

232 anisms by which it promotes the formation of cementum, periodontal ligament, and bone are not well un

233 in order for the host cells to stimulate new cementum, periodontal ligament, and bone.

234 ted in intense 3H-MISO retention in cellular cementum, periodontal ligament, osteocytes, and, occasio

235 papilla, odontoblasts, dentine matrix, pulp, cementum, periodontal ligaments, chondrocytes in Meckel'

236 generation, multipotential differentiation, cementum/periodontal-ligament-like tissue regeneration,

237 In support of our hypothesis, a cementum phenotype was detected using a combination of i

238 al phosphate levels; thus, we hypothesized a cementum phenotype, likely of decreased formation, would

239 nhibited mineralization of tissue-engineered cementum possibly due to the observed downregulation of

240 The clinical significance of these cementum pouches has yet to be determined but bacterial

241 ethod for extracting ancient DNA from dental cementum present on the surface of tooth roots.

242 ne morphogenetic protein-2, osteocalcin, and cementum protein (CEMP)-1 expression at mRNA and protein

243 also included cementoblast-specific markers, cementum protein 1 (CEMP1), cementum attachment protein

244 Synthetic cementum protein 1-derived peptide regulates mineralizat

245 tigate the functions of a synthetic peptide, cementum protein 1-peptide1 (CEMP-1-p1), both in vitro a

246 Novel insights into cellular cementum provide evidence for a role for cementocytes in

247 ration 0.8+/-0.6 and 1.5+/-0.8 mm, and total cementum regeneration 2.0+/-1.3 and 1.6+/-1.7 mm for GTR

248 entoblasts, the key cells involved in dental cementum regeneration and the attachment of the tooth to

249 ion of Ank, Enpp1, or both factors increased cementum regeneration compared to controls at postoperat

250 evaluate space provision, alveolar bone, and cementum regeneration following use of a bioabsorbable,

251 Limited cementum regeneration was observed for PGA-TMC/rhBMP-2 a

252 d 2) limited and similar amounts of bone and cementum regeneration were observed for both the GTR+DBM

253 lation as a potential and novel approach for cementum regeneration, particularly targeting ENPP1 and/

254 There was limited, if any, appreciable cementum regeneration.

255 or cellular lacunae or featured evidence of cementum remodeling.

256 mentocyte-like cells and unusual patterns of cementum resorption and repair.

257 control lesions with 2.78 and 2.57 mm of new cementum respectively.

258 toblasts on the surface of alveolar bone and cementum, respectively.

259 , the major mechanically responsive cells in cementum, respond to compressive stress to activate and

260 Twenty dentin/cementum root slabs were prepared for each thickness of

261 Alveolar bone and cementum share many biological and developmental similar

262 In many cases, dramatic amounts of new cementum, Sharpey's fibers, periodontal ligament, and bo

263 In many cases, dramatic amounts of new cementum, Sharpey's fibers, periodontal ligament, and bo

264 g formation of the apically located cellular cementum, some cementoblasts become embedded in the ceme

265 many resorptive lesions were noted along the cementum surface, with evidence of isolated cemental rep

266 evere enamel defects, very thin dentin, less cementum than normal, and overall hypomineralization in

267 In general, more cells attached to cementum than to calculus.

268 ray tomographic imaging of incremental tooth cementum, that they had maximum lifespans considerably l

269 BSP is present in cementum, the hard tissue covering the tooth root that a

270 subjects revealed 4-fold increased cervical cementum thickness ( P = 0.00007) and a 23% increase in

271 e molars revealed 4-fold increased acellular cementum thickness ( P = 0.002) and 5-fold increased cem

272 bone volume (20% and 37%, respectively) and cementum thickness (3- and 42-fold) in Ibsp(-/-) mice, w

273 Furthermore, dKO mice featured increased cementum thickness compared to single KOs at POD15 and A

274 function mouse models suggest that increased cementum thickness may be caused by decreased extracellu

275 ted a more profound improvement in acellular cementum thickness.

276 ty was correlated significantly with incisor cementum thickness.

277 entogenesis plus a transition from acellular cementum to cellular cementum.

278 th and to eliminate periodontal ligament and cementum to expose the tooth dentin.

279 Despite the significance of cementum to general oral health, the mechanisms controll

280 etermine if it does, we selected sperm whale cementum to provide large anisotropic substrates resembl

281 The sensitivity of cementum to reduced PPi levels in both human and mouse t

282 ggesting a targeted therapeutic approach for cementum turnover during periodontal regeneration.

283 thickness ( P = 0.002) and 5-fold increased cementum volume ( P = 0.002), with no changes in enamel

284 dentin volume and thickness and root dentin/cementum volume, whereas FGF23Ab effects were limited to

285 No new cementum was formed along the root surface in the above

286 No new cementum was found in furcations.

287 revious studies, we found that the amount of cementum was not different in mice without sclerostin co

288 Acellular cementum was thin and showed periodontal ligament detach

289 interpreted to be root planing marks on the cementum, we were able to demonstrate that complete peri

290 y significant increases in the amount of new cementum were observed in groups BG and BO/BG when compa

291 Bone, periodontal ligament, and cementum were removed as completely as possible with han

292 ars, and both periodontal ligament (PDL) and cementum were removed.

293 d significant increases in the amount of new cementum when compared to open flap debridement in a can

294 P1) is highly expressed in alveolar bone and cementum, which are important components of the periodon

295 mentoblast function and the formation of new cementum, which is critical for new attachment.

296 Additionally, in the smaller lesions, new cementum width at the level of the notch was twice as gr

297 The cementum width was slightly greater in the wider (4 and

298 cell infiltration and junctional epithelium, cementum with alveolar bone crest destruction, but anima

299 mbined 1 and 2 mm defects, the height of new cementum with EMD plus graft was 3.88 mm versus 2.03 mm

300 mbined 1 and 2 mm defects, the height of new cementum with enamel matrix protein treatment was 45% gr