ライフサイエンスコーパス: central

1 g various sorts of memory are therefore also central.

2 The central 0.1 parsecs of the Milky Way host a supermassive

3 rly involvement of the N-terminal (1-11) and central (12-19) fragments in interactions during the lag

4 dy highlight that modulating the size of the central acene ring is a highly effective molecular desig

5 Central activation in response to emotion and cognitive

6 Central adjudication by a CEC in the SHIFT study confirm

7 ntation challenges, including the nations of Central Africa, where efforts may necessitate establishi

8 Furthermore, central alpha-klotho inhibition via an anti-alpha-klotho

9 o polluted conditions-wet and dry seasons in central Amazonia and Southeastern U.S. summer.

10 BAergic neurons activated by GA in the mouse central amygdala (CeA(GA) neurons).

11 asing factor (CRF)-expressing neurons in the central amygdala (CeA) antagonize the extinction memory

12 o the bed nucleus stria terminalis (BNST) or central amygdala (CEA) generates an aversive memory.

13 e brain [i.e., neurons that project from the central amygdala (CeA) to the lateral hypothalamus (LH)]

14 revealed by chemogenetic manipulation of the central amygdala, a stress-sensitive nucleus that forms

15 the presence of a chiral catalyst, both the central and axial chirality of the product can be contro

16 closely resembles Micoquian assemblages from central and eastern Europe, including the northern Cauca

17 Furthermore, genes involved in central and energy metabolism and ribosome biogenesis we

18 ples from migratory waterfowl throughout the Central and Mississippi Migratory Flyways in the United

19 asively assess acidosis associated with both central and peripheral innate immune activation.

20 ations that affect multiple organs, with the central and peripheral nervous system often affected.

21 We observed widespread gene expression in, central and peripheral nervous system, liver, kidney and

22 nnels that regulate synaptic activity in the central and peripheral nervous system, presynaptically a

23 th cones to their proper targets in both the central and peripheral nervous systems.

24 ulted in significant gadolinium retention in central and peripheral nervous tissues (1.8-333.2 nmol G

25 in Neolithic vessels from Britain, Anatolia, central and western Europe, and Saharan Africa.

26 uried within the structural core are network-central, and those on the surface are not.

27 niridia 15%, 10%, and 0% (P = .001), shallow central anterior chamber in 22.5%, 22.5%, and 7.5% (P =

28 or Medical Sphygmocor XCEL) (n = 5) revealed central aortic systolic pulse (CASP) and central augment

29 Training decreased systolic and diastolic central (aortic) blood pressure by 4 mm Hg (95% CI: 2.8

30 Central area thickness decreased more with ranibizumab (

31 We, the WHO HIVResNet working group, defined central areas of future investigations to guide further

32 ring various structural modifications at the central aromatic core are presented.

33 y continue to increase in eastern Europe and central Asia, particularly among people who inject drugs

34 is whether the structure and function of the central auditory and visual systems follow similar traje

35 led central aortic systolic pulse (CASP) and central augmentation index (cAIx) estimates with precisi

36 irus type 1 (HTLV-1) subtype c is endemic to central Australia.

37 n the inner wall surface implode towards the central axis.

38 a series of fluorene oligomers containing a central benzothiadiazole(10) unit to demonstrate that th

39 the variable regions of the antibodies and a central bi-directional promoter.

40 We find that proton transport from the central binding site to the lumen has a microsecond time

41 n about homeostatic mechanisms in the intact central brain in vivo.

42 tivity of visually responsive neurons in the central brain was blocked by transient dFB activation, c

43 sphate stereoisomers that naturally occur as central building blocks in the biosynthesis of distinct

44 L compounds but the bonding situation of the central C(2) in this motif differs remarkably from that

45 ATP binding cassette (ABC) transporters, and central carbon metabolic proteins) were positively corre

46 ndence, G311 sensitivity, stoichiometry, and central cavity accessibility.

47 Eligibility was highest in the East South Central Census Division (14.8 per 1000).

48 The central challenge in curing HBV is eradication of the st

49 In this review, we posit that SPs are central chromatin regulators of gene silencing that esta

50 and Sequential Organ Failure Assessment, and central circadian rhythm by melatonin profile.

51 xymelatonin is not a reliable measure of the central circadian rhythm in critically ill patients.

52 lobal scaling have been observed only within central circuits, and on the postsynaptic side.

53 While the central common feature of the neurodegenerative diseases

54 n between tinnitus and an incomplete form of central compensation to hearing loss, rather than excess

55 cokinin-immunoreactive neurons in the locust central complex and associated brain areas.

56 neurons innervating all substructures of the central complex exhibit orcokinin immunoreactivity.

57 Clustering commonly constitutes a central component in analyzing this type of data.

58 The nP is a central component of all electrosensory feedback pathway

59 Resource sharing has always been a central component of human sociality.

60 re not exclusively pets or pests, but both a central component of human societies and an important, o

61 Glucocorticoids (GCs) are a central component of therapy for patients with T cell ac

62 Enzymes are central components of most physiological processes, and

63 e and amount of sorbent were optimized using central composite design (CCD) methodology.

64 heic flow using 20 recirculating flumes in a central composite face factorial design.

65 discussed.SIGNIFICANCE STATEMENT Agency is a central concept in philosophy and psychology.

66 Antibodies targeting the RSV G central conserved domain are protective in both prophyla

67 l wash antibodies, especially binding to the central conserved domain.

68 structures(10-14), but the structure of the central core module is unknown.

69 assay, we localized regulatory activity to a central core region that depends on the motif sequences

70 eld together by two stacked G:C pairs at the central core that rotate with respect to each other in a

71 The central corneal thickness (CCT) and biometry of all subj

72 y aimed to determine the influence of age on central corneal thickness and corneal endothelial morpho

73 Mean central corneal thickness was 573.0 +/- 39.0 mum.

74 Other factors associated with greater mean central corneal thickness were younger age, female gende

75 UCC1 forms a central CS nanodomain in comparison with other CS-locate

76 The hotspots for MSMs were central DC and non-MSM in south DC.

77 These findings suggest that turgor is a central driver of the forest carbon sink and should be c

78 gands impose strong magnetic axiality on the central Dy(III) ion.

79 IL4RA was among the top 3 central dysregulated genes.

80 bronchial epithelial cells and constitutes a central element of the defense of the airways against ba

81 the oxidation of 5-methylcytosine (5mC), the central epigenetic regulator of mammalian DNA.

82 nal diet modified the expression profiles of central epigenetic regulators of DNA methylation, histon

83 This complex spanned most of central Europe and exhibits demographic and cultural ass

84 w death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of

85 rvations implicate T-cell dysregulation as a central event in the pathogenesis of rheumatoid arthriti

86 The central FA pathway protein, FANCD2, locates to stalled r

87 e Japanese group engaging in greater eye and central face looking.

88 distributed information and presents it in a central, feature-rich portal.

89 pite carbon-carbon (C-C) bonds providing the central framework for organic molecules, development of

90 HY5, the phytochromes and the PIFs exerts a central function in coupling these growth responses and

91 e imaged by scanning laser ophthalmoscopy in central gaze and at 35 degrees abduction and adduction.

92 cells inside the nucleus pulposus (NP), the central gelatinous region of the intervertebral disc (IV

93 nation in most demersal species in the north central GoM declined in the first few years following DW

94 at the tubulin mutation severely impairs the central hearing pathway most probably by progressive cen

95 teosarcoma Study Group database with primary central high-grade osteosarcoma of the extremities, trea

96 he special topology of reaction spaces, with central hub molecules involved in multiple reactions, re

97 The central idea of this joint effort is to highlight key pa

98 une regulator (Aire), a critical mediator of central immune tolerance.

99 Thus, it is now a real possibility, and of central importance at this time, to assess the potential

100 uantum information over long distances is of central importance in quantum science and engineering(1)

101 aternal immune activation (MIA) disrupts the central innate immune system during a critical neurodeve

102 e-rich and fibronectin domains reside at the central intersection.

103 Central involvement is present in one third of eyes at t

104 We examined the contribution of central K(ATP) channels to glucose effectiveness.

105 uantification will take place in specialized central laboratories simply connected by regular, paper-

106 cross-sectional study, in partnership with a central laboratory that receives samples from approximat

107 in contrast to previous applications of the central limit theorem to protein energetics.

108 ts or spheroids) with a single, fluid-filled central lumen when grown in 3D matrices.

109 A connectome from central macaque retina was generated by serial blockface

110 Early RFI volatility with a central macular RFI increase by >=5 points from week 4 t

111 OCT images were graded for central macular thickness (CMT) and the presence of flui

112 BCVA and either the spherical equivalent or central macular thickness after 6 months, with p-values

113 Thus, p38beta MAPK is a central mediator and therapeutic target of cancer-induce

114 ATM is a central mediator of response for cellular DNA double-str

115 EM147, respectively, suggest routes into the central membrane cavity.

116 latory T-cell variation and over 50% of CD8+ central memory variation.

117 pe differentiation of T-PLL with predominant central-memory stages and frequent noncanonical patterns

118 d survival of S. aureus mutants deficient in central metabolic pathways, including glycolysis, glucon

119 t study establishes that another key step in central metabolism is poisoned by molecular oxygen itsel

120 The acyl-enzyme intermediate is a central milestone in the hydrolysis reaction catalyzed b

121 P90A-TCL1A-AKT pathway ignited by NANOG is a central molecular axis and a potential target for immune

122 SAP3 as being important for the formation of central MT pairs, proper orientation of basal bodies, an

123 network of transcription factors including a central MYB-basic helix-loop-helix-WD40 complex containi

124 ntibodies generally elicited by RTS,S to the central NANP repeat region of CSP.

125 evaluate the risks/benefits of prophylactic central neck dissection (pCND) in patients with clinical

126 t the distribution of KMD is limited between central Nepal on the east and north-east Afghanistan on

127 to limit virus dissemination throughout the central nervous system (CNS) following many neurotropic

128 Inflammation in the central nervous system (CNS) has been linked to demyelin

129 ow that the AIM2 inflammasome contributes to central nervous system (CNS) homeostasis specifically th

130 Central nervous system (CNS) infections cause substantia

131 However, the transcriptomic landscape of central nervous system (CNS) innate immune cells contrib

132 lae following clinical radiotherapy (RT) for central nervous system (CNS) malignancies are often long

133 n barrier is a major impediment for targeted central nervous system (CNS) therapeutics, especially wi

134 ehavior in metazoans, but how they enter the central nervous system (CNS) through the blood-brain bar

135 l fluid (CSF) flow dynamics in children with central nervous system (CNS) tumors before intraventricu

136 cytes are the most abundant cell type in the central nervous system (CNS), performing complex functio

137 n microglia, the resident macrophages of the central nervous system (CNS).

138 r injury and during axon regeneration in the central nervous system (CNS).

139 those occurring in the persistently inflamed central nervous system (CNS).

140 gent of a fatal demyelinating disease of the central nervous system (CNS).

141 sensory nerve pathway between the colon and central nervous system (spinal cord and brain) that unde

142 myelitis, 0.5 to 0.9 per 100 000 persons for central nervous system abscesses, and 24.4 to 32.9 per 1

143 nisms by which the immune system affects the central nervous system after surgical trauma.

144 e most effective interventions for adult non-central nervous system cancer patients to manage cancer-

145 ts following cranial radiotherapy to control central nervous system cancers.

146 rotein isoforms that are highly expressed in central nervous system cells.

147 NA-binding protein of 43 kDa (TDP-43) in the central nervous system characterizes frontotemporal deme

148 DHA is a key central nervous system constituent and the precursor of

149 The central nervous system hosts parenchymal macrophages, kn

150 aled that these receptors' expression in the central nervous system is crucial for T cell recruitment

151 cohort to provide a detailed description of central nervous system lesions in Leigh syndrome and the

152 iled distribution of Pax6 cells in the adult central nervous system of lungfishes, the closest living

153 ntial to become drug candidates for distinct central nervous system pathologies and possessing accent

154 Cyclophosphamide, systemic cytarabine, and central nervous system radiotherapy were not used.

155 altered phenotype in key compartments of the central nervous system responsible for regulating feedin

156 astrocytic processes are an integral part of central nervous system synapses(1,2); however, the molec

157 tures within the extracellular matrix of the central nervous system that have generated an explosion

158 er to liver, heart, skeletal muscle, and the central nervous system, its use in adipose tissue has be

159 d Capn15 expression throughout the brain and central nervous system, strongest during early developme

160 The internalization of the central nervous system, termed neurulation in vertebrate

161 l PET imaging ligand for mGluR2 in different central nervous system-related conditions.

162 signing and executing experiments within the central nervous system.

163 channel THIK-1 is strongly expressed in the central nervous system.

164 tly needed, given their critical role in the central nervous system.

165 for people with severe symptoms and include central neuromodulators, intestinal secretagogues, drugs

166 The central node of this network is G3BP1, which functions a

167 PFC, the insula and the vmPFC appeared to be central 'nodes' or hubs of the fatigue network.

168 Given the role of the central nucleus of the amygdala (CeA) in the expression

169 vitro electrophysiological recordings in the central nucleus of the amygdala (CeA), we found that rat

170 The central nucleus of the amygdala plays a significant role

171 Mutations that are not aligned with this central oncogenic driver activate divergent pathways and

172 n of the RNA-binding protein HuR/ELAVL1 as a central oncogenic driver for malignant peripheral nerve

173 suggesting that male mosquitoes possess the central or peripheral neural circuits required to host-s

174 With recurring attacks, central oval stromal opacities accumulated.

175 yer thickness and both El Nino amplitude and central Pacific variability.

176 Oxidative stress is a central part of innate immune-induced neurodegeneration.

177 loss of insulin-producing beta-cells is the central pathological event in type 1 and 2 diabetes, whi

178 Fibrosis was staged by a central pathology committee using the Ishak fibrosis sco

179 Atrial-tissue fibrosis is a central pathophysiological feature of atrial fibrillatio

180 ides (412) were redox switched, representing central pathways of mitochondrial energy metabolism, inc

181 the cervical and lumbar spinal enlargements, central pattern generator (CPG) circuitry produces the r

182 d in the spinal cord, known as the locomotor central pattern generator (CPG).

183 rs have other neurological manifestations of central/peripheral hyperexcitabability including seizure

184 Phosphatidic acid (PA) is both a central phospholipid biosynthetic intermediate and a mul

185 Through our study, DOT1L is emerging as a central player in physiology of CD8(+) T cells, acting a

186 and Trithorax Group (TrxG) proteins are the central players in this cell type-specific chromatin org

187 6) revealed that it forms a ring with a wide central pore and radially arrayed helix-turn-helix domai

188 nction by threading macromolecules through a central pore of a disc-shaped hexamer.

189 y rate (FDR) of spectral identification is a central problem in mass spectrometry-based proteomics.

190 s in taste weaken satiation by impairing the central processing of sensory signals.

191 nto interneurons as well as species-specific central projection patterns.

192 ale signals and female preferences remains a central question in the study of animal communication.

193 A central question is how direct photochemical electron de

194 uld affect the rate of star formation in the central regions of the Galaxy.

195 In central regions of vestibular semicircular canal epithel

196 e searched the MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials from January 1, 19

197 We searched Cochrane Central Register of Controlled Trials, MEDLINE, and Emba

198 Target of rapamycin complex 1 (TORC1) is a central regulator of cell growth.

199 A central regulator of leukocyte recruitment is Rac1.

200 AMPK is a central regulator of metabolism and autophagy.

201 Our results establish BIN2 as a central regulator of platelet activation in thrombosis a

202 critical role in cell growth control as the central regulator of RNA polymerase (Pol) III activity.

203 ochondrial and cytosolic proteostasis are of central relevance for cellular stress resistance and org

204 y mapping visual pigment kinetics across the central retina, high fidelity IRD provides a unique insi

205 The disease is confined mainly to a central retinal region called the MacTel zone.

206 Mean reductions in central retinal thickness from baseline were 126.1, 127.

207 Central retinal thickness normalizes faster after surger

208 s included visual acuity, microperimetry and central retinal thickness.

209 Central retinal vein occlusion is a variable disease pat

210 ent allocation until the blinded independent central review (BICR) showed progressive disease for the

211 n-free survival (PFS) by blinded independent central review (BICR); additional assessments included o

212 Our data establish a central role for genes that were previously identified a

213 Our structure also indicates a central role for the ArpC3 subunit in stabilizing the ac

214 Here, we identify a central role for the human DEDD deadenylase TOE1 in dist

215 Synaptic dysfunction plays a central role in Alzheimer's disease (AD), since it drive

216 Despite this central role in development and evolution, the LPM remai

217 lic dysfunction, including fibrosis, plays a central role in DM pathogenesis.

218 Immune cells play a central role in early pregnancy establishment in cattle.

219 Polymer brush patterns have a central role in established and emerging research discip

220 ories, such reversed processing also plays a central role in later stages of perception.

221 or hematopoietic differentiation and plays a central role in malignant disease.

222 Living polymerizations currently play a central role in polymer chemistry.

223 cus on ROS at physiological levels and their central role in redox signalling via different post-tran

224 lent ytterbium ions (Yb(3+) ), have played a central role in the first demonstrations and subsequent

225 Results show the capsid protein plays a central role in the flavivirus assembly process.

226 s of the beta-amyloid peptide, Abeta, play a central role in the pathogenesis and progression of Alzh

227 Inflammation plays a central role in the pathogenesis of acute lung injury (A

228 arget of high biological interest due to its central role in various cancers.

229 Scholars have long argued for the central role of agency-the size of one's choice set-in t

230 However, the central role of alpha-klotho in metabolism remains large

231 In particular, the central role of B cells in the disease has been demonstr

232 oscopy and genetics were used to confirm the central role of GLR3.3 in the amino acid-elicited cytoso

233 Although the central role of NAD in plant metabolism and its regulato

234 With the central role of nucleic acids there is a need for develo

235 Given the central role of ovBNST in mediating maladaptive behavior

236 Together, these data reveal the central role of secreted polysaccharides in the intricat

237 wild organisms, particularly because of the central role that light regimes play in determining the

238 ts of a series of stator units surrounding a central rotor made up of two ring complexes, the MS-ring

239 9 stands (47 burned, 32 unburned) throughout central Saskatchewan to characterize above- and belowgro

240 Flight feathers are composed of a central shaft made up of a hollow calamus (quill), which

241 ld wet treeline (3250 m asl) in California's central Sierra Nevada.

242 Activation of the central SNAREpins associated with Synaptotagmin-1 by Ca(

243 al connections in the Circle of Willis are a central source of collateral blood flow and play an impo

244 interaction of changes in dust-Fe sources in Central South America with the circumpolar westerly wind

245 Here, we show impacts of the central South-to-North Water Diversion on GW storage rec

246 to hospital in the north region than in the central-south, with similar proportions between the vari

247 hese results indicate that the diversity and central specificity of pSNs and MNs are regulated by a c

248 centromeres in mitosis and subsequently the central spindle in anaphase.

249 hey had to associate tastants sampled from a central spout with different actions (i.e., licking eith

250 ugh the F(o) motor generates rotation of the central stalk, inducing conformational changes in the F(

251 stenosis or occlusion, arterial disease, and central stenosis.

252 fined based on different cut-offs for VA and central sub-field thickness (CST).

253 -nitrosothiol (SNO) Regulated 1 (SRG1), is a central target of NO bioactivity during plant immunity.

254 idual category members (exemplars) or by the central tendency abstracted from individual members (pro

255 We test two central tenets of the biotic interactions hypothesis: th

256 tions in the laboratory and clinic challenge central tenets of the current paradigm and demonstrate t

257 ubsequent fitness benefits and are therefore central to a species' ecology.

258 ation in the CO(2) vent population for genes central to calcification, including genes for calcium ma

259 ofilm formation and dispersal are considered central to disease transmission.

260 smission of cGAMP via LRRC8/VRAC channels is central to effective anti-viral immunity.

261 can endure large and complex deformations is central to emerging wearable electronics.

262 ty to decide whether, when and how to try is central to human learning.

263 The hippocampal complex (HC) is central to long-term memory storage and retrieval as wel

264 Therefore birth-death models are central to macroevolutionary as well as phylodynamic ana

265 The regulation of gene expression is central to many biological processes.

266 that this actin-based impaired relaxation is central to NEM6 pathology.

267 coupled two-dimensional heterostructures are central to next-generation optical, electronic, and quan

268 R signaling cascade is tightly regulated and central to normal neuronal development and survival.

269 ent of an SNP cut-off for transmission) were central to our analyses, both of which will inform the f

270 iation in the traits of their host plants is central to our understanding of the nutritional ecology

271 Abnormal neurotransmission is central to schizophrenia (SZ).

272 Holdase chaperones are known to be central to suppressing aggregation, but how they affect

273 Central to the adaptation-enhancing principle we identif

274 in 5xFAD mice and suggest that microglia is central to the association between PD and AD.

275 emporal processing deficits may develop more central to the auditory nerve, possibly due to a reduced

276 nd diastereoselectivities, both of which are central to the burgeoning domain of stereodivergent cata

277 Radiography remains central to the detection and characterisation of bone tu

278 Impaired microvascular perfusion is central to the development of coma and lactic acidosis i

279 Amyloid fibril formation is central to the etiology of a wide range of serious human

280 hat two or all three of these processes were central to the etiology of mania.

281 Central to this debate is whether wings are a novel stru

282 Central to this mechanism is the direct effect of IL-33-

283 E3 ligase recruiters remain central to this process yet relatively few have been ide

284 Analyzing genomic data across populations is central to understanding the role of genetic factors in

285 veal distinct positions of enrichment at the central transcription factor (TF) binding regions and at

286 the Rnf40-containing E3 ligase by Egr2, the central transcriptional regulator of peripheral myelinat

287 triangle of three [2]-rotaxanes bound to the central triangle while the [3]-rotaxane 4 contains only

288 contains only two [2]-rotaxanes bound to the central triangle.

289 tum) plantings at eight locations across the central USA for 3 yr and conducted quantitative trait lo

290 and acute liver cell necrosis, together with central vein thrombosis.

291 Central venous access devices (CVAD) are used to deliver

292 No patient had central venous catheter-related deep vein thrombosis.

293 ionnaire measuring 7 unidimesnional domains: central vision, color vision, contrast sensitivity, scot

294 foveated: we can see fine spatial details in central vision, whereas resolution is poor in our periph

295 Even with good central visual acuity, patients with glaucomatous macula

296 evealed additional undetected defects in the central visual field.

297 DRVD specifically indicates the glaucomatous central visual loss.

298 may provide an efficient means of optimizing central visual processing and perception across behavior

299 hearing pathway most probably by progressive central white matter degeneration.

300 itional knockout mice, formation of striolar/central zones is compromised, such that they resemble ex