ライフサイエンスコーパス: central region

1 the northwest and 457 of 6082 (7.5%) in the central region.

2 ative diagnostic MR criterion of FCD2 in the central region.

3 istal ends, and a maximum loss of 39% in the central region.

4 r flexible and tightly anchored to the rigid central region.

5 n the far periphery and decreased toward the central region.

6 grow from the edge of the droplet toward the central region.

7 uth Central region to 100% in the West North Central region.

8 as the disorder and flexibility in the ING4 central region.

9 cular depressions, often with pores in their central region.

10 th deletions of conserved amino acids in the central region.

11 e, with minimal effect on the N-terminus and central region.

12 r relative order are highly conserved in the central region.

13 g any clear directional signals outside this central region.

14 eposition from on-axis association to the SC central region.

15 lving several unexpected triples formed at a central region.

16 se of recombination complexes to/from the SC central region.

17 uenced by the bubble passage compared to the central region.

18 oA-I while the other five mAbs recognize the central region.

19 nd 96 (1.5%) for disease of 6581 in the East Central region.

20 ly foci form along synaptonemal complex (SC) central regions.

21 ssures in the South, Mediterranean, and some central regions.

22 ns a disproportionate share of topologically central regions.

23 peared to gain dominance across northern and central regions.

24 uter parts, indicating ongoing growth of the central regions.

25 gion (2.18, 1.44-3.28) and 41% higher in the central region (1.41, 0.99-2.01) than in the eastern reg

26 ) with automated static perimetry within the central regions (+/-15 degrees ) examined with SD OCT.

27 Here we show that the central region (213 residues) of chicken INCENP is not a

28 Deletion of the central region ((676)I-W(760)) of AgAPN2tb eliminated it

29 tibodies was highest against the PvMSP3alpha central region (77.6%).

30 a combination of three attributes of the SC central region: a CO-promoting activity that functions l

31 is weakly associated with the membrane and a central region acting as a sensor of the lipid propertie

32 ransfer of stem cells between the border and central regions, all Lgr5(+) cells are endowed with long

33 ross-links with Raptor were clustered in the central region (amino acid residues 56-72) we call RCR (

34 B pathway by forming a stable complex with a central region (amino acids 150-272) of the inhibitor of

35 ings) with histologically proven FCD2 of the central region and 44 control subjects on the basis of a

36 facilities in the Federal Capital Territory, central region and in Kano, northwest Nigeria.

37 oboration for cooperative assembly of the SC central region and indicates that SYP-1 preferentially a

38 ctional, with more growth contributed by the central region and less growth at either end.

39 hered state, whereas the largely hydrophobic central region and part of the carboxy (C)-terminal hydr

40 ward (soft substrate/low friction) or in the central region and propagate outward (stiff substrate/hi

41 at contain residues 17-23 (LVFFAED) from the central region and residues 30-36 (AIIGLMV) from the C-t

42 vestigation of two key regions of Abeta: the central region and the C-terminal region.

43 tutions induce structural instability in the central region and the overlapping ends of Tm, respectiv

44 metrics clearly indicates low cell stress in central regions and high cell stress at the periphery of

45 cture comprising both highly inter-connected central regions and sparsely connected peripheral region

46 dynamically coupled hydration changes of the central region, and conformational changes of Glu(in) an

47 ded by multiple genes that share a conserved central region, and epitope mapping revealed T-cell epit

48 e Aalpha and Bbeta chains extending from the central region, and the short gamma chain "tail" extendi

49 tern region of China than in the eastern and central regions, and injury was a main cause of death in

50 r N-terminal conserved domain and the 4E-BP1 central region are closely located, we found that peptid

51 Several different deletions spanning the central region as well as three disease-associated point

52 and bottom interfaces of the films while the central regions behave similarly to the bulk with a clea

53 pate in pore formation, the role of the YopD central region between amino acids 150-227 remains unkno

54 The protein is localized by a central region between the N-terminal COBL domain and th

55 nd its regulators INCENP and TD60, whereas a central region binds MCAK, Kif2a, and microtubules, sugg

56 owever, preferentially be found today in the central regions ('bulges') of galaxies, because they for

57 abolish the barrier to transcription in the central region by decreasing the local wrapping rate.

58 ranscriptional activation domain of ZLD to a central region characterized by low complexity.

59 end of lower endothelial cell density in the central region compared with the peripheral region.

60 ividually required for SC stability, or a SC central region component causes functional redeployment

61 Here, we identify a novel role for a central region component of the SC, SYP-4, in negatively

62 We find that SYP-2, a SC central region component, is a potential target for MPK-

63 e X similarly to paired chromosomes, but the central region component, SYP-1, is not loaded on the X

64 Abs to juxtamembrane and central region constructs were both DR4 associated.

65 single-stranded DNA oligomers composed of a central region containing (SNS)6 or (ANi)5 covalently at

66 (Pol) I and RNA Pol II in yeast through its central region containing conserved NusG N-terminal homo

67 The central region contains five domains and is important fo

68 At all ages we observed SEPs over central regions contralateral to the stimulated hand.

69 nsory afferent traffic as well as input from central regions controlling sympathetic nerve activity,

70 pectedly, the increased proliferation in the central region corresponded to a trend of lower endothel

71 ism is cardiac muscle troponin T (cTnT), the central region (CR) and the T2 region of which differ si

72 The conserved central region (CR) of PrP(C) has been hypothesized to s

73 cifically the hydrophobic domain (HD) or the central region (CR).

74 emonstrate that Rictor contains two distinct central regions critical for mTORC2 function.

75 rminal domain favoring alpha(t), whereas the central region demonstrated a preference for Palphabeta.

76 d and coastal subpopulations, separated by a central region dominated by A. coluzzii.

77 model, where the numerator originates from a central region driving the neuron and the denominator or

78 YP-1, a major structural component of the SC central region, during meiosis in Caenorhabditis elegans

79 in the N-terminal leader and throughout the central region encoding the AIP signal.

80 receptive field structure: an OFF-dominated central region flanked by ON-dominated subfields.

81 DAXX's central region folds with the H3.3/H4 dimer, providing a

82 als that the D-loop is ordered and acts as a central region for hydrophobic and electrostatic interac

83 The central region forms a flexible domain with two antipara

84 euronal projections within a collagen-filled central region, generating 3D neural networks with struc

85 The central region (harboring nucleoporin-binding sites) reg

86 r compensates for mismatches, pairing to the central region has been known to function only at rare s

87 We find that a dilated central region has the strongest impact in thick cell wa

88 quitin ligase activity that is mediated by a central region homologous to mammalian U-box domains.

89 ese AuNPs can be (i) solely located within a central region, (ii) uniformly distributed throughout th

90 broadly expressed in several peripheral and central regions important for pain processing and mood r

91 outh-Central region to 607 in the East North-Central region in 2002 (93.2% higher; P < .001).

92 We identified a conserved central region in the SidE proteins that was sufficient

93 osing gradients are matched, cells home to a central region in which the signals from multiple chemok

94 apy (ART) clinics in the southwest and north central regions in Nigeria.

95 persistent activation in medial frontal and central regions in patients.

96 Region A, the central region including the foveal center, had normal O

97 uted across the retina, being present in the central region (including in the fovea), but absent from

98 Our data indicate that the INCENP central region increases Dsn1 phosphorylation by enrichi

99 the bridge stage, and then directly mediates central region installation during SC nucleation.

100 Neurodegeneration within central regions involved in odour perception may contrib

101 imarily at dendritic tips but also from more central regions, involves adhesion to the keratinocyte,

102 tional change in ghrelin that structures its central region, involving the formation of a well-define

103 Previous studies have shown that its central region is essential for function even though its

104 By contrast, cell proliferation in the central region is minimally affected by MAPK1 deletion.

105 ghly extended, we show that flexibility in a central region is required for GCC185's ability to funct

106 We also found that the central region is required for the SAC beyond its role i

107 P required to promote DNA2 is located in the central region lacking in lower eukaryotes and is fully

108 the present pattern of a seismically active central region linked to more aseismic areas in the nort

109 ORNs) are optogenetically activated within a central region making this region attractive to the flie

110 In addition, the central region mediated binding to phosphatidylinositol

111 ults further highlight the importance of the central region near binding site S(2) in the selectivity

112 First, the central region of (CAG)(8) is more solvent-exposed than

113 tial feature of UL36 is the existence in its central region of a stalk capable of connecting capsid a

114 inhibited by specific antibodies against the central region of Abeta and by naturally occurring p3 pe

115 containing residues 17-23 (LVFFAED) from the central region of Abeta and residues 30-36 (AIIGLMV) fro

116 ot previously observed for the amyloidogenic central region of Abeta.

117 We identified the central region of Abeta42 as the most critical region fo

118 rafts are identified histochemically in the central region of adhered platelets where fibrin and myo

119 In contrast, point mutations in the central region of alpha-synuclein, referred to as nonamy

120 ion and map two LC8-binding sites within the central region of Ana2, Ana2M (residues 156-251).

121 Thus, cytotoxic immune synapses include a central region of bidirectional vesicular traffic, which

122 The central region of both Las17 and WASP is rich in proline

123 Chandler from the central region of Chile were evaluated.

124 also analyzed the replication dynamics of a central region of chromosome 1 in procyclic forms.

125 ure of the proton transport mechanism in the central region of ClC-ec1 at a molecular level.

126 e used to study proton transport through the central region of ClC-ec1, a widely studied ClC transpor

127 Simultaneously, a central region of complete outer-fluid displacement grow

128 ich disordered regions, and a large 1,700-aa central region of continuous alpha-helical domains.

129 opy on several constructs, one including the central region of CSP, which is rich in NANP amino acid

130 The central region of dorsocentral telencephalon (DC(core) )

131 ial pouches in which epithelial cells in the central region of each pouch undergo resorption, leaving

132 duced Smo signaling, whereas deletion of the central region of EC2 renders Smo fully active, suggesti

133 we show that 14-3-3 proteins interact with a central region of Exo1 and negatively regulate Exo1 dama

134 The sirtuin proteins contain a central region of high sequence conservation that is req

135 A segment of the central region of Hsl1 (residues 611-950), composed of t

136 The central region of INCENP has been proposed to comprise a

137 The central region of ING5, which contains the nuclear local

138 afferent response to stretch by AChRs in the central region of intrafusal fibres possibly fine-tuning

139 ted with the source or a location within the central region of its host galaxy.

140 Rab6 binding occurred through the central region of LidA and followed a stoichiometry for

141 ulates a second-site interaction between the central region of MDM2 and MDMX, and thus increases MDMX

142 nuclear Mpp6 exosome bound to RNA shows the central region of Mpp6 bound to the exosome core, positi

143 Antibodies to the polymorphic central region of MSPDBL2 were associated with reduced r

144 We present genetic data implicating the central region of mu1 in altering the cell attachment pr

145 nt Wnt pathway, may guide motor axons to the central region of muscle fibers for synapse formation in

146 sing site was mapped to aspartate-135 in the central region of MyD88.

147 as well as on the serine- and arginine-rich central region of N, which binds nsp3.

148 omain to the reported consensus motif in the central region of ORF45.

149 ition, we determined a critical role for the central region of Pan1 in endocytosis and viability.

150 PDLP5 was found to localize at the central region of PD channels and associate with PD pit

151 Although flexibility is decreased in the central region of phospho-PAGE4, the polypeptide chain r

152 The central region of Pirh2 harbors a RING finger domain tha

153 ent with these results, the integrity of the central region of pny pnf SAMs can be partially restored

154 s have unacceptable eradication rates in the central region of Portugal and cannot be used, according

155 ated with failure of these treatments in the central region of Portugal.

156 alysis and site-directed mutations, that the central region of PP1c beta confers the isoform-specific

157 The central region of PrgI forms an alpha-helical hairpin, w

158 Mutations within the central region of prion protein (PrP) have been shown to

159 pendent on residues in the largely invariant central region of Pro1.

160 HEG1 binds to a central region of Rasip1 and deletion of this domain eli

161 ystal structure of Sus1 and Cdc31 bound to a central region of Sac3 (the CID domain) that is crucial

162 r as P. larvatus, likely introduced from the central region of southern Africa, with no genetic evide

163 rometry, methionine residues in the Met-rich central region of SspB were shown to be oxidized by H(2)

164 (71-98), were synthesized with Ala-d3 in the central region of the alpha-helix.

165 The central region of the alphaSyn sequence contains the non

166 + MACR concentrations are reported over the central region of the Amazon basin during the wet season

167 ructure of mammal species cooccurring in the central region of the Atlantic Forest.

168 The longer peptide is disordered through the central region of the cavity and has its C terminus boun

169 a(2+) signals did not fully propagate to the central region of the cell.

170 x treated and control cells showed up in the central region of the cells and were related to lipid pe

171 ter (low bond length alternation) around the central region of the chain.

172 FBF-2 suggested sequence specificity in the central region of the compact element.

173 The central region of the cornea, an important area for visu

174 late around epithelial tubes residing in the central region of the developing pancreas (associated wi

175 found visual motion-sensitive responses in a central region of the dorsal (AD) and intermediate (AI)

176 s and C terminus of gB and especially in the central region of the ectodomain reduced cell fusion act

177 nt between genotype A and D was found in the central region of the endemic areas, where three SFTSV g

178 B strains, and is typically confined to the central region of the enlarged capsule.

179 hed by the N-acetylglucosamine moiety in the central region of the enzyme binding cleft.

180 oss of chondrocytes and growth arrest in the central region of the epiphyses.

181 Thus, protein interactions with the central region of the fatty acyl chain optimize GCAP1 bi

182 utations are localized in the N-terminal and central region of the gene, leading to nonsense-mediated

183 oma galaxy clusters, which together form the central region of the Great Wall--the largest local stru

184 ons of up to 7 nt in its target opposite the central region of the guide.

185 In solution, the central region of the H3 segment is positioned close to

186 ize to peripheral arms but do not occupy the central region of the hexamers.

187 The central region of the human retina, the fovea, provides

188 ith Abs to an epitope located in the 831-862 central region of the IA-2 tyrosine phosphatase domain.

189 (HWD2), only the second borehole through the central region of the ice shelf, following J9 in 1977.

190 The central region of the LacI N-subdomain monomer-monomer i

191 f magnitude more weakly than that across the central region of the layers.

192 ole in controlling cell proliferation in the central region of the lens epithelium.

193 trategy for the key cyclization to forge the central region of the molecule, ring C.

194 nned residues 282 to 291 (GLSSKSPYSS) in the central region of the molecule.

195 The central region of the Nterm domain adopted alpha-helical

196 In murine polyomavirus, the central region of the origin contains four copies (P1 to

197 observed between MCV OBDs when bound to the central region of the origin.

198 HLA-B*35:08(LPEP) similarly, straddling the central region of the peptide but making limited contact

199 no acid substitutions, pinpointed to a small central region of the protein that is required to trigge

200 tary structural techniques, we show that the central region of the protein, encompassing amino acids

201 on of HCPro involved in this function in the central region of the protein.

202 unexpected features, including a disordered central region of the PulG helical stem, and highly flex

203 suspension which were accumulated within the central region of the resulting mycelial pellets and tra

204 , the region of highest visual acuity in the central region of the retina.

205 slocation to become more concentrated in the central region of the RPE cells.

206 ilizing the SC in pachytene by switching the central region of the SC from a more dynamic to a less d

207 span a gap between cohesin complexes and the central region of the SC, consistent with their essentia

208 how these SYP proteins are organized in the central region of the SC.

209 Here, we show that the conserved central region of the second variable loop (V2) of gp120

210 oluene or single base pair mismatches in the central region of the sense strand (9-12 nt), significan

211 ogram hot water drill borehole melted in the central region of the shelf in December 2017 (HWD2), onl

212 modulate the toxic activity displayed by the central region of the SidE protein.

213 y inducing conformational changes within the central region of the stalk, which, in turn, promote fus

214 elial cell entry, on a prominent loop in the central region of the structure.

215 Here we report that the central region of the supernova remnant SNR 0509-67.5 (t

216 ulates the redistribution of CARD11 from the central region of the synapse to a distal region.

217 3, and SYP-4) have been proposed to form the central region of the synaptonemal complex (SC) thereby

218 In early pachytene Vilya localizes along the central region of the synaptonemal complex and to discre

219 d formation has effects extending toward the central region of the tropomyosin molecule, which alter

220 12 that synergistically form a switch in the central region of the two helices that governs whether a

221 hosphates and glutathione) indicate that the central region of these cell culture models experiences

222 were involved in these interactions, but the central region of this protein, which contains a repetit

223 show that the structural instability in the central region of Tm modifies cardiac contractile functi

224 hesis that the structural instability in the central region of Tm modulates the function of the overl

225 The S229E-induced instability in the central region of Tm(DM) altered the overlapping ends of

226 the cryo-electron microscopy structure of a central region of TPX2 bound to the MT surface.

227 ta3 at the C terminus and alphaVbeta5 at the central region of tropoelastin.

228 ventional and organic farming in the eastern-central region of Tunisia.

229 Here, we characterize a central region of UBN1 (UBN1 middle domain) that is evol

230 ed trial, we included primary schools in the central region of Uganda that taught year-5 children (ag

231 re of the skyrmion core, identifying a 25 nm central region of uniform magnetization followed by a la

232 These phenotypes require the central region of USP8, containing three extended Arg-X-

233 The central region of vIRF4 is required for its interaction

234 i (STEC) sampled from 104 dairy units in the central region of Zambia and compared these with isolate

235 dium and commercial-sized dairy farms in the central region of Zambia and its relationship to antibio

236 HF), a potentially deadly disease endemic to central regions of Argentina.

237 The central regions of blue counter-rotators show younger st

238 s a larger involvement of the N-terminal and central regions of CaM in this interaction.

239 ryon deficiency is typically observed in the central regions of clusters ( approximately 0.5 the viri

240 ejecting large amounts of cold gas from the central regions of galaxies, thereby strongly affecting

241 Conversely, in central regions of GC light zones, Tfh cells are much mo

242 dary ossification centers do not form in the central regions of Has2 mutant growth plates owing to a

243 Well-defined RNA structures in the central regions of HCV genomes appear to facilitate pers

244 Spinal and central regions of interest (ROI) included the bilateral

245 cetylcholine receptors are aggregated in the central regions of intrafusal muscle fibres.

246 d during senescence, preferentially from the central regions of lamina-associated domains (LADs), whi

247 n of the centered site type help explain why central regions of many miRNAs are evolutionarily conser

248 e different velocities of myosin V motors in central regions of S2 cells, suggesting regional control

249 region of origin (northern, northeastern or central regions of Thailand).

250 taples are located in the flattened, stacked central regions of the cisternae, the soluble aggregates

251 uld affect the rate of star formation in the central regions of the Galaxy.

252 surprisingly well tolerated in the seed and central regions of the guide strand and increase the sil

253 .198 Hz were stronger in the peripheral than central regions of the malignant tumours; however, no su

254 re found to interact with the N-terminal and central regions of the monomeric protein although with d

255 rial myoctes and were detected more often in central regions of the non-junctional SR compared to nor

256 the nasal, temporal, inferior, superior, and central regions of the posterior pole in 83%, 75%, 67%,

257 ta (29-50 mug/kg), but comparable to bogs in central regions of the province and lower than bogs in s

258 al biophysical properties of residues within central regions of the putative TM helices.

259 Surprisingly, Muller glia in central regions of the retina express Pax2, and levels o

260 specifically localize to the peripheral and central regions of the SAM were examined in Arabidopsis

261 hair cell-calyx afferent synapses present in central regions of the turtle vestibular semicircular ca

262 Some auras propagated from peripheral to central regions of the visual field-these typically foll

263 In central regions of vestibular semicircular canal epithel

264 helial outgrowths of the dorsal otocyst, the central regions of which fuse and resorb to leave three

265 uth of the country versus 3.91% in the north central region [P < 0.01]).

266 were drawn on the T1WI image in the tumours' central regions, peripheral regions and neighbouring tis

267 artial depletion of the synaptonemal complex central region proteins attenuates crossover interferenc

268 domains: an N-terminal BTB/POZ domain and a central region recruiting CtBP and NuRD complexes.

269 P with a deletion of residues 105-125 in the central region (referred to as DeltaCR PrP) provide impo

270 al practices (73 in each of two arms) in the Central Region (Region Midtjylland) of Denmark.

271 lected sequence changes in the p55 domain, a central region required for binding of the toxin to host

272 We identified a central region (residues 85 to 221) in the Guanarito vir

273 of intermolecular disulfide bonds within the central region (residues 91-115) of the morbillivirus H-

274 Phosphorylation in the central region resulted in complete inhibition of fibril

275 ing several different point mutations in the central region that cause familial prion diseases in hum

276 ular interaction between the RING domain and central region that regulates MDMX nuclear import.

277 They contain a unique, 80-kDa central region that shares no homology with other protei

278 ermediate, the formation of structure in the central region that spreads progressively toward each te

279 of the FGFR/Klb system to date and highlight central regions that may be of critical importance to as

280 This central region therefore becomes more compact and more n

281 taroline ranged from 96.7% in the West South Central region to 100% in the West North Central region.

282 y region, ranging from 314 in the East South-Central region to 607 in the East North-Central region i

283 During baroreflex onset, the capacity of the central region to drive activation declined with a decre

284 elical coiled-coil regions, which bridge the central region to each distal region, were also well pro

285 Therefore, the ability of the YopD central region to facilitate optimal effector protein de

286 ucleus: this was heaviest laterally, and the central region was generally zebrin negative.

287 ly, SidJ did not suppress toxicity when this central region was produced in yeast.

288 When the orientation of the central region was reversed with respect to these flanki

289 Beta power in lateral central regions was attenuated when a change in the visu

290 iod, we found that beta power within lateral central regions was decreased when a change in visual co

291 In 1 region (Central Region) we surveyed the same 100 randomly select

292 lar specialist, and living in the East North Central region were associated with greater rates of pre

293 pecimen geometry so that stresses within the central region were concentrated and homogenous while mi

294 moderately cross-linked bundles, but in the central region, where tethering loses its effect, featur

295 on in the dense environment of the cluster's central regions, where second-generation stars form.

296 e (alpha(t)GTPgammaS) in comparison with the central region, whereas an opposite pattern was observed

297 st was climatically unstable relative to the central region, which served as a large climatic refugiu

298 h a preferential distribution of body fat in central regions, which does not, however, seem to influe

299 volume-spanning gels at low density, whereas central regions with higher average valence gel at highe

300 areas and by their competitive potential in central regions with more mesic conditions.