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1 e when its endogenous FAS was inhibited with cerulenin.
2 e superfamily, and the site of alkylation by cerulenin.
3 LDs, a phenomenon not exhibited by 2-FPA and cerulenin.
4  (2-BP), 2-fluoro palmitic acid (2-FPA), and cerulenin.
5 s on viral replication compared to 2-FPA and cerulenin.
6 esence of the fatty acid synthesis inhibitor cerulenin.
7 and fasted wild-type mice, were treated with cerulenin.
8 ity of elongation reactions to inhibition by cerulenin.
9 he addition of the FA biosynthesis inhibitor cerulenin.
10 o natural products, thiolactomycin (TLM) and cerulenin.
11 ed condensation reaction, was insensitive to cerulenin (100 microM) and cross-reacted with spinach KA
12 e have demonstrated that the natural product cerulenin ([2R,3S]-2,3-epoxy-4-oxo-7,10-trans,trans-dode
13     We examined the effects of the mycotoxin cerulenin (a covalent FAS inactivator), and the novel sm
14                                              Cerulenin, a FAS inhibitor, causes a similar biphasic ch
15  and carcinoma lines are growth inhibited by cerulenin, a noncompetitive inhibitor of fatty acid synt
16 yond C10 following treatment with 10 microns cerulenin, a potent inhibitor of KAS I.
17                    The inhibition of FASN by cerulenin, a small molecule antibiotic, blocked cellular
18                           We also found that cerulenin, a specific inhibitor of DIF-1 biosynthesis, a
19 FASN as the inhibitor of its activity, named cerulenin, abolished the growth response to both ligands
20 methods to unravel the covalent mechanism of cerulenin against type II fatty acid ketosynthases.
21 ith the beta-ketoacyl-ACP synthase inhibitor cerulenin also blocked acylation.
22                               Injection with cerulenin also decreased Fos immunoreactivity in the gra
23 stration of a fatty acid synthase inhibitor, cerulenin, also alleviated the pathology of psoriasis.
24          A fadR strain was hypersensitive to cerulenin, an antibiotic that at low concentrations spec
25 tures are also smaller in cells treated with cerulenin, an inhibitor of de novo fatty acid synthesis
26                           In the presence of cerulenin, an inhibitor of de novo fatty acid synthesis,
27  medium containing dextrose, oleic acid, and cerulenin, an inhibitor of fatty acid synthesis.
28 te elongation was 85% inhibited by 50 microm cerulenin, an inhibitor of ketoacyl-acyl carrier protein
29    Expression of each marker is inhibited by cerulenin, an inhibitor of polyketide synthesis, and can
30                                              Cerulenin, an inhibitor of the key fatty acid elongation
31 side other palmitoylation inhibitors such as cerulenin and 2-fluoro palmitic acid (2-FPA), as well as
32                                        While cerulenin and 2-FPA exhibited moderate inhibition of vir
33 s it effectively counteracted the effects of cerulenin and 2-FPA.
34 As or the fatty acid biosynthesis inhibitors cerulenin and 5-(tetradecyloxy)-2-furoic acid.
35 ed growth in YPD medium containing 25 microM cerulenin and 500 microM fatty acid (myristate (C14:0),
36                                              Cerulenin and a related compound, C75, have recently bee
37 e with fatty acid synthase (FAS) inhibitors (cerulenin and a synthetic compound C75) led to inhibitio
38                                 In addition, cerulenin and C75 dramatically attenuate IE and early ly
39               Pharmacological FAS inhibitors cerulenin and C75 were found to suppress p185(HER2) onco
40                    Antiestrogenic effects of cerulenin and C75 were observed by dose-dependent inhibi
41                 Two specific FAS inhibitors, cerulenin and C75, prevent R activation of IE (Z) and ea
42                                 In contrast, cerulenin and diazoborine, specific inhibitors of fatty
43      The subtle differences between the FabB-cerulenin and FabF-cerulenin structures explain the diff
44 tment with the fatty acid synthase inhibitor cerulenin and is rescued by addition of exogenous unsatu
45 e catabolic effects associated with feeding, cerulenin and leptin.
46 ds and the labeling of ACP were inhibited by cerulenin and required ATP and Mg2+.
47 ynthase (FAS), including the natural product cerulenin and the novel compound c75, are selectively cy
48 ynthase (FAS), including the natural product cerulenin and the novel synthetic compound c75, are sele
49 75 based on the known mechanism of action of cerulenin and the theoretical reaction intermediates of
50 oth enzymes were sensitive to KAS inhibitors cerulenin and thiolactomycin.
51 growth of fat1Delta cells in the presence of cerulenin and under hypoxic conditions.
52 gar metabolism (2-DG), fatty acid synthesis (cerulenin), and N-linked glycosylation (tunicamycin) com
53 antly by dimethyl itaconate, C75, haloxyfop, cerulenin, and 1,2-cyclohexanedione.
54                          To rule out non-FAS cerulenin- and C75-related effects, we finally monitored
55                                              Cerulenin, another drug that inhibits palmitoylation, al
56  the mycothiol S-conjugate of the antibiotic cerulenin as a substrate for Mca.
57 nder seed extracts was strongly inhibited by cerulenin at concentrations as low as 10 microM.
58 al rearrangement upon covalent inhibition of cerulenin at the active cysteine residue in E. coli type
59 solution structures of the FabB-TLM and FabB-cerulenin binary complexes were determined.
60                                              Cerulenin binding mimics the condensation transition sta
61 mportance of the two His residues in TLM and cerulenin binding.
62                    More than 30 analogues of cerulenin, both aromatic and aliphatic, with various cha
63 lished ascites tumor; and (e) treatment with cerulenin causes reduction in ascites incidence, delay i
64 etworks and differential network analyses on cerulenin, chlorpromazine, ethionamide, ofloxacin, thiol
65         The present studies demonstrate that cerulenin cytotoxicity is mediated by fatty acid pathway
66 e, the major product of FAS, indicating that cerulenin cytotoxicity is mediated through fatty acid st
67              However, in contrast to leptin, cerulenin did not prevent effects of fasting on plasma c
68  about 30% (P<0.05), further suggesting that cerulenin does not non-specifically activate wide variet
69 rescues DNA synthesis/S phase progression in cerulenin-exposed cells.
70                  In contrast, injection with cerulenin had no grossly observable effects on cortical
71 ts selective and potent inhibitory activity, cerulenin has found significant utility in multidiscipli
72                                   Therefore, cerulenin has no deleterious effect on the L-type Ca(2+)
73       In the presence of the KAS I inhibitor cerulenin, however, transgenic seed extracts extended 6:
74 sensitive to thiolactomycin and resistant to cerulenin in an in vitro assay.
75 administration of the FAS inhibitors C75 and cerulenin in rats.
76 y acid synthase was inhibited with 45 microm cerulenin in the presence of 100 microm oleate (C(18:1))
77                                      C75 and cerulenin increased phosphorylation of S6K1 and S6, and
78              The protein acylation inhibitor cerulenin inhibited both phases of glucose-stimulated in
79 f pea H protein was inhibited by addition of cerulenin into the assay medium.
80                               The antibiotic cerulenin is a fungal natural product identified as a co
81 ns or when the fatty-acid synthase inhibitor cerulenin is included in the growth media.
82 The mechanism of DNA synthesis inhibition by cerulenin is indirect, because expression of certain vir
83 t studies have shown that the FAS inhibitor, cerulenin, is selectively cytotoxic to cell lines derive
84                                         (3)H-cerulenin labeling of the various Act KS mutant proteins
85                               Injection with cerulenin, like feeding and leptin, also increased Fos i
86  the specific fatty acid synthase inhibitor, cerulenin, markedly reduces tumor cell fatty acid biosyn
87                                      C75 and cerulenin modulate AMPK phosphorylation and activity.
88  Conjugates of mycothiol with the antibiotic cerulenin, N-ethylmaleimide, 3-(N-maleimidopropionyl)-bi
89  contrast, the fatty-acid synthase inhibitor cerulenin nearly completely blocked sphingoid base produ
90 age was taken of this to study the effect of cerulenin on the K(ATP) channel-independent pathway of g
91                               Fas inhibitors cerulenin or C75 inhibited 2-ME-induced caspase activati
92 entiated apoptosis induced by FAS inhibitors cerulenin or C75 only in cells with constitutively activ
93   Furthermore, inhibition of FAS activity by cerulenin or C75 resulted in downregulation of phospho-A
94 harmacological inhibition of FAS activity by cerulenin or the novel compound C75.
95 -altering inhibitor of fatty acid synthesis (cerulenin), or an inhibitor of intracellular membrane tr
96 s a correlation between growth on fatty acid/cerulenin plates, the levels of fatty acid accumulation,
97        In the presence of KCl and diazoxide, cerulenin powerfully inhibited the augmentation of insul
98  increased metabolic rate in ob/ob mice, and cerulenin produced the same effects in wild-type mice, w
99                  These data demonstrate that cerulenin produces metabolic effects similar to effects
100                                 Like leptin, cerulenin reduced body weight and food intake and increa
101                      These results implicate cerulenin-resistant condensing activity in production of
102 ilis resting cells whereas a strain having a cerulenin-resistant FabF mutant produced more biotin.
103 alent inhibition profile has been confirmed, cerulenin's mechanism has not been fully determined at a
104 nsitive to the fatty acid synthase inhibitor cerulenin, showed aberrant expression of fatty acid bios
105 esis with 5-(tetradecyloxy)-2-furoic acid or cerulenin significantly attenuates the enhancement of HC
106 ferences between the FabB-cerulenin and FabF-cerulenin structures explain the differences in the sens
107 Tsc13p-GFP into NV junctions is perturbed by cerulenin, suggesting that its binding to Nvj1p depends
108 eatment with the chemical inhibitors C75 and cerulenin suppressed NLRP3-mediated caspase-1 activation
109           In contrast to two agents, C75 and cerulenin, that are widely used as inhibitors of mammali
110 on of the fatty acid biosynthesis inhibitor, cerulenin, that possesses an alkyl chain length in the r
111  inhibit fatty acid oxidation is affected by cerulenin, these data suggest that protein acylation is
112 lic acid fully restored biotin production in cerulenin-treated cells.
113                         Here, we report that cerulenin treatment of human breast cancer cells inhibit
114 tty acid biosynthesis (FAB), since following cerulenin treatment, wild-type and relA strains expresse
115                 Also, in contrast to leptin, cerulenin was highly effective to reduce body weight in
116 for growth under hypoxic conditions and when cerulenin was included in the culture media in the prese
117 ected with the fatty acid synthase inhibitor cerulenin were examined for Fos (a marker for neuronal a
118           The pharmacological agents H89 and cerulenin, which are inhibitors of endoplasmic reticulum
119 d mass/cell) but retain their sensitivity to cerulenin, which is reversed by 3-fold excess oleate sup
120  medium show a dose-dependent sensitivity to cerulenin, which is reversed by palmitate, the major pro
121 inishes, and the cells become insensitive to cerulenin while acquiring a differentiated, macrophage-l

 
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