ライフサイエンスコーパス: ceruloplasmin

1 protein carriers (albumin, transcuprein, and ceruloplasmin).

2 of hepatopathy with very low values of serum ceruloplasmin.

3 where it delivers copper to the ferroxidase ceruloplasmin.

4 dentity to the serum multicopper ferroxidase ceruloplasmin.

5 potentials of C. cinereus laccase and human ceruloplasmin.

6 th the determination of the concentration of ceruloplasmin.

7 .007) between expression levels of c-jun and ceruloplasmin.

8 cted with cDNAs encoding wild-type or mutant ceruloplasmin.

9 ltammetric peak increased in the presence of ceruloplasmin.

10 te protease inhibitor, apolipoprotein E, and ceruloplasmin.

11 apoTF] and catalytic oxidation of 6-OHDA by ceruloplasmin.

12 parenchyma in association with absent serum ceruloplasmin.

13 f multinuclear copper oxidases that includes ceruloplasmin.

14 ed band revealed identity to the ferroxidase ceruloplasmin.

15 activities of paraoxonase, arylesterase, and ceruloplasmin.

16 cedure) and peroxide-oxidized forms of human ceruloplasmin.

17 east, homologous to the human plasma protein ceruloplasmin.

18 d hypercholesterolemia, as well as low serum ceruloplasmin.

19 e plasma levels of ferritin, transferrin and ceruloplasmin.

20 ge of other proteins, including human plasma ceruloplasmin.

21 vity could not be fully explained by Heph or ceruloplasmin.

22 Ceruloplasmin, a Cu-containing ferroxidase, is found at

23 f metal ions is not known; however, purified ceruloplasmin, a plasma protein containing 7 coppers, ox

24 Nitrated ceruloplasmin, a significant biomarker for cardiovascula

25 number of key differences relative to human ceruloplasmin: a lower copper content and a lack of a ty

26 As further evidence for a role of ceruloplasmin, activation of U937 cells with zymosan ind

27 as liver (67)Cu retention, serum copper, and ceruloplasmin activity increase.

28 Ceruloplasmin activity, benzylamine oxidase, and superox

29 Plasma copper, ceruloplasmin activity, ceruloplasmin concentration, and

30 Plasma copper, ceruloplasmin activity, ceruloplasmin protein, plasma ma

31 luding age of onset, clinical manifestation, ceruloplasmin activity, hepatic copper levels, and the p

32 oxide levels, paraoxonase, arylesterase, and ceruloplasmin activity, prolidase level, and total sulfh

33 Apart from the ferroxidase ceruloplasmin, all are involved in myelin homeostasis; 1

34 An increase in serum ceruloplasmin, an estrogen-responsive liver protein, was

35 on's disease was ruled out with normal serum ceruloplasmin and 24-urine copper.

36 a distinct group of patients with low serum ceruloplasmin and basal ganglia symptoms identified a se

37 liver, is required for copper metallation of ceruloplasmin and biliary copper excretion.

38 was a significant correlation between plasma ceruloplasmin and disease severity (Pearson product mome

39 aracteristics of those found in domain II of ceruloplasmin and fungal laccase.

40 The mammalian ferroxidases ceruloplasmin and hephaestin are homologs of Fet3p.

41 Its functional homologs, e.g. ceruloplasmin and hephaestin, could play a similar role

42 Fet3p is a ferroxidase that, like ceruloplasmin and hephaestin, couples the oxidation of 4

43 tive, and quantitative detection of nitrated ceruloplasmin and hold a great promise for point-of-care

44 EPA+GLA had a significant reduction in BALF ceruloplasmin and IL-8 during the study as compared with

45 motif, which is repeated six times in human ceruloplasmin and is conserved in the homologous protein

46 nal iron overload resulting from knockout of ceruloplasmin and its homologue hephaestin exhibit retin

47 ase domain and compare it with that of human ceruloplasmin and other multicopper oxidases that are de

48 network for biosynthetic incorporation into ceruloplasmin and sequesters excess copper to endocytic

49 es are oxidized in peroxide-oxidized chicken ceruloplasmin and that none of the type 1 copper sites d

50 e channels was examined by cotransfection of ceruloplasmin and the chloride channel.

51 Conventional WD testing utilizing serum ceruloplasmin and/or serum copper levels are less sensit

52 and VCAM), parietal epithelial cells (e.g., ceruloplasmin), and podocytes (e.g., nephrin and prepron

53 platelet-activating factor acetylhydrolase, ceruloplasmin, and apoJ in HDL occur during acute influe

54 Plasma copper, ceruloplasmin, and cholesterol are relatively insensitiv

55 ve and significant decline in plasma copper, ceruloplasmin, and Cu/Zn superoxide dismutase activity i

56 of the iron-regulating proteins transferrin, ceruloplasmin, and ferritin are present in glaucoma.

57 ed increased mRNA expression of transferrin, ceruloplasmin, and ferritin heavy and light chains.

58 the iron, had high levels of ferroportin 1, ceruloplasmin, and hephaestin mRNA.

59 he mRNAs in question encode 15-lipoxygenase, ceruloplasmin, and histones.

60 Serum copper, ceruloplasmin, and manganese levels were normal, but her

61 beta-hydroxylase, amyloid precursor protein, ceruloplasmin, and other proteins required for normal br

62 on, the ratio of enzymatic to immunoreactive ceruloplasmin, and plasma copper, independently of chrom

63 uid (BALF) for measurement of total protein, ceruloplasmin, and transferrin, total neutrophil count,

64 transferrin receptor, increased ferritin and ceruloplasmin, and unchanged ferroportin were observed i

65 Ceruloplasmin antioxidant function is mainly related to

66 increased in heart failure (HF), can affect ceruloplasmin antioxidant function through amino acid mo

67 Consistently, the ceruloplasmin AP-1 site was specifically recognized by c

68 Copper in milk ceruloplasmin appears to be particularly available for a

69 onship between the two-domain MCOs and human ceruloplasmin appears to extend not only to the 3D struc

70 nding consistent with early work identifying ceruloplasmin as a ferroxidase and with recent findings

71 corporated into both secreted and GPI-linked ceruloplasmin as a late event in the secretory pathway.

72 Additionally, peripheral infusion of ceruloplasmin attenuated neurodegeneration and nigral ir

73 , FeOxII, ceruloplasmin, nitrotyrosine-bound ceruloplasmin, B-type natriuretic peptide, norepinephrin

74 Ceruloplasmin, B-type natriuretic peptide, norepinephrin

75 ores than plasma concentrations of copper or ceruloplasmin because the enzyme activities are sensitiv

76 intracellular copper and reduces plasma non-ceruloplasmin-bound copper (NCC) by forming tripartite c

77 tabolism, evidenced by low plasma copper and ceruloplasmin, but lack evidence of copper toxicity in t

78 s with IFN-gamma increased the production of ceruloplasmin by at least 20-fold.

79 t to previous cell-free experiments in which ceruloplasmin by itself (in PBS) oxidizes LDL, under the

80 odel postulates repression of translation of ceruloplasmin by mRNA binding proteins.

81 studies revealed synthesis and secretion of ceruloplasmin by these cells.

82 Thus, one of the additional Type 1 sites in ceruloplasmin cannot be catalytically relevant in the fo

83 ipase A2 group VI, fatty acid 2-hydroxylase, ceruloplasmin, chromosome 19 open reading frame 12 and A

84 ase response proteins: alpha2-macroglobulin, ceruloplasmin, complement components, lipocalin-2, metal

85 Plasma copper, ceruloplasmin concentration and activity, and urinary co

86 Plasma copper, ceruloplasmin activity, ceruloplasmin concentration, and erythrocyte superoxide

87 Plasma copper, ceruloplasmin concentration, and urinary copper increase

88 with Wilson's disease, such as reduced serum ceruloplasmin concentrations.

89 y, we have determined that peroxide-oxidized ceruloplasmin contains one permanently reduced Type 1 si

90 presence of chloride and hydrogen peroxide, ceruloplasmin converted myeloperoxidase to Compound II a

91 ysteine by thiol/disulfide exchange, whereas ceruloplasmin converts cysteine to cystine by copper-dep

92 ytic cleavage or removal of one of the seven ceruloplasmin copper atoms inhibited activity.

93 ein product in the retina and the liver, and ceruloplasmin could be identified in the retina by immun

94 To determine whether the ferroxidase ceruloplasmin (Cp) and its homolog hephaestin (Heph) are

95 ntified in mice deficient in the ferroxidase ceruloplasmin (Cp) and its homologue hephaestin (Heph) (

96 QTLs) from the same BC population identified ceruloplasmin (Cp) as a positional eQTL in macrophages b

97 We selected the ferroxidase Ceruloplasmin (CP) as an exemplary gene to dissect PAX8

98 Ceruloplasmin (Cp) decreases nitric oxide bioavailabilit

99 Individuals with hereditary ceruloplasmin (Cp) deficiency have profound iron accumul

100 us work has shown that hephaestin (Heph) and ceruloplasmin (Cp) double knockout (KO) mice induced iro

101 Ceruloplasmin (Cp) expression is increased locally as a

102 lex by RNA affinity chromatography using the ceruloplasmin (Cp) GAIT element as ligand.

103 aceruloplasminemia by disrupting the murine ceruloplasmin (Cp) gene.

104 A role of the copper protein ceruloplasmin (Cp) in iron metabolism is suggested by it

105 Fet3p is functionally homologous to ceruloplasmin (Cp) in that both are ferroxidases.

106 A role for ceruloplasmin (Cp) in vertebrate iron metabolism is sugg

107 Ceruloplasmin (Cp) is a copper-containing ferroxidase th

108 Ceruloplasmin (Cp) is a Cu-containing plasma protein tho

109 Ceruloplasmin (Cp) is a glycoprotein secreted by the liv

110 Human ceruloplasmin (CP) is a multicopper oxidase essential fo

111 Ceruloplasmin (CP) is also induced by hypoxia and inflam

112 Ceruloplasmin (Cp) is an acute-phase protein with ferrox

113 Unraveling the mechanism of ceruloplasmin (Cp) is fundamentally important toward und

114 Activated Inhibitor of Translation (GAIT) of ceruloplasmin (Cp) mRNA by a genetic screen for Cp 3'-UT

115 . those derived from CCL22, CXCL13, CCR4 and ceruloplasmin (Cp) mRNAs) have substantially different a

116 per ferroxidase, that is, hephaestin (Heph), ceruloplasmin (Cp) or both.

117 We used Hephaestin (Heph) and Ceruloplasmin (Cp) single or double (Heph/Cp) knockout (

118 cing of gamma interferon (IFN-gamma)-induced ceruloplasmin (Cp) synthesis in monocytes.

119 s the liver-derived, multicopper ferroxidase ceruloplasmin (Cp) that is important for iron release fr

120 escence; we show that hBMVEC express soluble ceruloplasmin (Cp) transcript as well.

121 Ceruloplasmin (Cp) was measured by both oxidase activity

122 rophage iron efflux, focusing on the role of ceruloplasmin (Cp), a copper protein with a potent ferro

123 Ceruloplasmin (Cp), a ferroxidase present in the cerebro

124 in GAIT complex that silences translation of ceruloplasmin (Cp), a protein linked to the inflammatory

125 We have shown previously that human ceruloplasmin (Cp), a serum protein containing seven Cu

126 We here show that ceruloplasmin (Cp), an acute phase reactant with importa

127 issues express either Heph or its homologue, ceruloplasmin (Cp), but the retina expresses both.

128 In the case of ceruloplasmin (Cp), induced synthesis of the protein by

129 -acid glycoprotein (AAG), transferrin (TF), ceruloplasmin (CP), neutrophil gelatinase-associated lip

130 utside the cell, a multi-copper ferroxidase, ceruloplasmin (Cp), oxidizes ferrous to ferric ion.

131 Ceruloplasmin (CP), the major plasma anti-oxidant and co

132 are modulators of copper incorporation into ceruloplasmin (CP).

133 disease due to mutations in the ferroxidase ceruloplasmin (Cp).

134 n of central nervous system tissue utilizing ceruloplasmin cRNA probes reveals abundant ceruloplasmin

135 ge significantly during copper depletion but ceruloplasmin decreased during copper repletion.

136 Our results demonstrate that ceruloplasmin decreases the bioavailability of iron in u

137 hese tissues was equivalent in wild-type and ceruloplasmin-deficient mice.

138 Plasma copper and ceruloplasmin did not change significantly during copper

139 ng examination for Kayser-Fleischer rings or ceruloplasmin, did not improve these estimates because o

140 loss of the copper-containing plasma enzyme ceruloplasmin disrupt mammalian iron homeostasis.

141 ite reductase domain 2, laccase domain 3 and ceruloplasmin domains 2, 4 and 6.

142 e chain reaction demonstrated high levels of ceruloplasmin expression in retina and liver, but minima

143 In situ hybridization identified ceruloplasmin expression in the inner nuclear and gangli

144 e results demonstrate abundant cell-specific ceruloplasmin expression within the central nervous syst

145 In Fet3p, as in ceruloplasmin, Fe(II) is oxidized to Fe(III) at the type

146 We found a approximately 80% loss of ceruloplasmin ferroxidase activity in the substantia nig

147 Val, Leu or Phe in the axial position) as in ceruloplasmin, Fet3p, fungal laccases and some plantacya

148 steine oxidation, and immunoprecipitation of ceruloplasmin from human plasma did not inhibit the capa

149 the expression of the ATP7B target protein, ceruloplasmin, from PN to Bergmann glia, where ATP7A (Me

150 Despite the need for copper in ceruloplasmin function, this protein plays no essential

151 n of systemic tissues revealed cell-specific ceruloplasmin gene expression in hepatocytes, the spleni

152 g ceruloplasmin cRNA probes reveals abundant ceruloplasmin gene expression in specific populations of

153 , these data reveal that glial cell-specific ceruloplasmin gene expression is essential for iron home

154 In the central nervous system, abundant ceruloplasmin gene expression was detected in specific p

155 A locus on the ceruloplasmin gene on chromosome 3 was significantly ass

156 cessive disorder caused by a mutation in the ceruloplasmin gene, which is clinically manifested by da

157 in phlebotomized mice with a deletion of the ceruloplasmin gene.

158 inherited loss-of-function mutations in the ceruloplasmin gene.

159 condary to loss-of-function mutations in the ceruloplasmin gene.

160 h patients reveal inherited mutations in the ceruloplasmin gene.

161 ted with specific inherited mutations in the ceruloplasmin gene.

162 toms identified a series of mutations in the ceruloplasmin gene.

163 Chicken ceruloplasmin has been previously reported to display a

164 ome chemical or spectroscopic differences in ceruloplasmin have been reported depending on the method

165 Saccharomyces cerevisiae Fet3p and human ceruloplasmin (hCp) are members of this family that exhi

166 mologous human plasma copper-binding protein ceruloplasmin (hCp) has been solved, and the A domains o

167 ce-associated macrophage protein 1 (Nramp1), ceruloplasmin, hephaestin, and glyceraldehyde 3-phosphat

168 pcidin-resistant Fpn; hepcidin knockout; and ceruloplasmin/hephaestin double knockout).

169 Ceruloplasmin/Hephaestin double-knockout (DKO) mice with

170 l gene, Heph, encoding a transmembrane-bound ceruloplasmin homologue that is mutant in the sla mouse

171 n the ferroxidase reaction catalyzed by this ceruloplasmin homologue.

172 cular genetic examination of the CP gene for ceruloplasmin identified a new variant c.1664G > A (p.Gl

173 lpha1-antichymotrypsin, alpha-fetal protein, ceruloplasmin, IGF binding protein 1, transferrin, apoli

174 ependent on the logarithmic concentration of ceruloplasmin in blood.

175 her, these data reveal no essential role for ceruloplasmin in copper metabolism and suggest a previou

176 To elucidate the role of ceruloplasmin in copper metabolism, the kinetics of copp

177 ion as an essential ferroxidase, the role of ceruloplasmin in copper transport and metabolism remains

178 r revealed a critical physiological role for ceruloplasmin in determining the rate of iron efflux fro

179 ngs reveal an essential physiologic role for ceruloplasmin in determining the rate of iron efflux fro

180 The possible role of ceruloplasmin in inhibiting reaction oxygen species in t

181 To elucidate the role of ceruloplasmin in iron homeostasis, we created an animal

182 al role for astrocyte-specific expression of ceruloplasmin in iron metabolism and neuronal survival i

183 The concentrations of copper and ceruloplasmin in milk vary with lactational stage.

184 We have studied the copper sites of chicken ceruloplasmin in order to probe the origin of these diff

185 Consistent with a role for ceruloplasmin in PD etiopathogenesis, ceruloplasmin knoc

186 This may indicate that the resting form of ceruloplasmin in plasma under aerobic conditions is a fo

187 n-related proteins ferritin, hephaestin, and ceruloplasmin in relation to oxidative damage in the bra

188 antibodies was the presence of a fragment of ceruloplasmin in serum, which was eliminated in purified

189 the upregulation of alpha2-macroglobulin and ceruloplasmin in the diabetic retina, but not in the cer

190 n protein delivers copper to the ferroxidase ceruloplasmin in the liver, it is likely that the Wilson

191 yloid A, LPS-binding protein, fibrinogen, or ceruloplasmin; in contrast, C3H/HeJ mice, which carry a

192 hese animals, hepatocyte copper intended for ceruloplasmin incorporation is trafficked into a compart

193 mparison of the structures of fVIII, fV, and ceruloplasmin indicates that the location of bound metal

194 Ceruloplasmin induction in monocytic cells was agonist s

195 highly specific polyclonal antibody to human ceruloplasmin inhibits LDL oxidation by at least 65%.

196 Collectively, our results indicate that ceruloplasmin inhibits myeloperoxidase by reducing Compo

197 uncated Asn355-glycans positioned in the MPO-ceruloplasmin interface are critical for uninterrupted i

198 Ceruloplasmin is a 132-kDa glycoprotein abundant in huma

199 Ceruloplasmin is a multicopper oxidase essential for nor

200 Ceruloplasmin is a serum ferroxidase that contains great

201 Ceruloplasmin is an abundant serum glycoprotein containi

202 Ceruloplasmin is an iron-export ferroxidase that is abun

203 Ceruloplasmin is present in these fluids and may also be

204 Although ceruloplasmin is synthesized primarily by the liver in a

205 Ceruloplasmin is unique among the multicopper oxidases i

206 oxidized 75% of the ascorbate in plasma from ceruloplasmin knock-out mice, but there was no significa

207 le for ceruloplasmin in PD etiopathogenesis, ceruloplasmin knockout mice developed parkinsonism that

208 onal studies done in sla, Heph-knockout, and ceruloplasmin-knockout mice proved that cytosolic FOX ac

209 isease severity (r =.30; p =.012) and plasma ceruloplasmin levels (r =.48; p =.00067).

210 s confirmed lower serum transferrin (Tf) and ceruloplasmin levels in ACLF and ACLF-MOF, compared to p

211 ApoJ and ceruloplasmin levels in HDL peaked 3 days after infectio

212 d neurologic deficits should have copper and ceruloplasmin levels measured as part of their diagnosti

213 Paired ceruloplasmin levels were available in six patients and

214 Zn superoxide dismutase, cytochrome oxidase, ceruloplasmin, lysyl oxidase, and dopamine beta-hydroxyl

215 son and/or Menkes proteins provide copper to ceruloplasmin made in the RPE.

216 Monocytic cell-derived ceruloplasmin may contribute to defense responses via it

217 indings show, in principle, that intravenous ceruloplasmin may have therapeutic potential in PD.

218 mal stability, polypeptide accessibility and ceruloplasmin-mediated inhibition potential relative to

219 studies to show that human albumin, but not ceruloplasmin, mediates the conversion of homocysteine t

220 ss in which copper bound to albumin, but not ceruloplasmin, mediates the reaction.

221 Parallel changes occur in ceruloplasmin messenger RNA expression in the mammary gl

222 e functional role of each copper site within ceruloplasmin, metabolic studies indicate that achieving

223 The maximal response was at 100-300 microg ceruloplasmin/ml, a level at or below the unevoked physi

224 The mechanism by which ceruloplasmin mobilizes iron from cell stores has been c

225 cultures confirmed that astrocytes expressed ceruloplasmin mRNA and biosynthetic studies revealed syn

226 This complex binds the 3'UTR of ceruloplasmin mRNA and blocks its translation.

227 ctivation of U937 cells with zymosan induces ceruloplasmin mRNA and ceruloplasmin protein synthesis a

228 eotides targeted to different regions of the ceruloplasmin mRNA block LDL oxidation by up to 95%.

229 rotein binds to and shuts off translation of ceruloplasmin mRNA.

230 IFN-gamma also increased ceruloplasmin mRNA.

231 Ferritin and ceruloplasmin mRNAs were significantly increased in the

232 d activity of serum FeOxI is associated with ceruloplasmin nitration and reduced survival in patients

233 atched controls (n=35), serum FeOxI, FeOxII, ceruloplasmin, nitrotyrosine-bound ceruloplasmin, B-type

234 Meta-analyses show that nonbound ceruloplasmin (non-Cp) copper (also known as free or lab

235 We assessed levels of copper, ceruloplasmin, non-Cp copper, iron, transferrin, ferriti

236 Neither ceruloplasmin nor O2. alone increased LDL oxidation, but

237 he current experiments (in RPMI 1640 medium) ceruloplasmin only oxidizes LDL in the presence of cells

238 n of ClC-4 doubled copper incorporation into ceruloplasmin (P = 0.011), whereas identical overexpress

239 nemia, the biosynthesis of a missense mutant ceruloplasmin (P177R) occurring in an affected patient w

240 stent with a mechanism in which cell-derived ceruloplasmin participates in oxidation of LDL by U937 m

241 The synthesis of holoceruloplasmin but not ceruloplasmin peptide was markedly diminished in CuR 41.

242 Ceruloplasmin plays a role in this second phase.

243 so show that cellular factors in addition to ceruloplasmin, possibly active oxygen species and/or lip

244 el that stimulates copper incorporation into ceruloplasmin, probably by improving the efficiency of t

245 Together, these results suggest that the ceruloplasmin promoter activity is significantly enhance

246 Ceruloplasmin promoter activity was significantly activa

247 oplasmin promoter to be critical for optimal ceruloplasmin promoter activity.

248 nude mice carrying SKOV3.ip1 xenografts, the ceruloplasmin promoter demonstrated significantly higher

249 We found that the ceruloplasmin promoter drove up to 30-fold higher lucife

250 ed an activator protein-1 (AP-1) site in the ceruloplasmin promoter to be critical for optimal cerulo

251 Total ceruloplasmin protein is related to copper status but re

252 with zymosan induces ceruloplasmin mRNA and ceruloplasmin protein synthesis after a 5-6 h lag that i

253 Plasma copper, ceruloplasmin activity, ceruloplasmin protein, plasma malondialdehyde, benzylami

254 and inversely related to nitrotyrosine-bound ceruloplasmin (r, -0.305; P=0.003).

255 Ceruloplasmin rapidly reduced Compound I, the Fe(V) redo

256 ation of serum samples and isolated purified ceruloplasmin reduced FeOxI activity while increasing ce

257 In conclusion, ceruloplasmin-related indexes in kidney dialysis patient

258 The gene for ceruloplasmin-related iron transport protein hephaestin

259 ribution among copper sites in the different ceruloplasmins relative to other multicopper oxidases.

260 Ceruloplasmin remained elevated throughout the time cour

261 Ceruloplasmin secreted by IFN-gamma-stimulated U937 cell

262 and/or zinc-containing serum glycoproteins, ceruloplasmin, serum amyloid P-component, and amyloid pr

263 We propose that ceruloplasmin should provide a protective shield against

264 sis and RNAse protection studies demonstrate ceruloplasmin-specific transcripts in multiple regions o

265 nd, superoxide dismutase effectively blocked ceruloplasmin-stimulated oxidation by both cell types.

266 itical role for cellular superoxide (O2.) in ceruloplasmin-stimulated oxidation.

267 mpletely reconstituted the oxidation rate of ceruloplasmin-stimulated SMC.

268 These results are the first to show that ceruloplasmin stimulates EC- and SMC-mediated oxidation

269 Exogenous addition of purified human ceruloplasmin stimulates U937 cell oxidation of LDL to n

270 s has been verified by showing inhibition of ceruloplasmin synthesis and by the ability of exogenous

271 human brain, and biosynthetic studies reveal ceruloplasmin synthesis and secretion in these same regi

272 e show that IFN-gamma is a potent inducer of ceruloplasmin synthesis by monocytic cells.

273 l type specific, as IFN-gamma did not induce ceruloplasmin synthesis in endothelial or smooth muscle

274 In human ceruloplasmin the reduction potential is further increas

275 etry were taken as evidence that, similar to ceruloplasmin, the enzyme likely contains multiple type

276 In an homologous structure, ceruloplasmin, the residue equivalent to Arg593, is in a

277 in synthesis and by the ability of exogenous ceruloplasmin to overcome the inhibition.

278 , are essential and act synergistically with ceruloplasmin to oxidize LDL.

279 suggests a critical role for this region in ceruloplasmin trafficking and indicates that substitutio

280 provide copper for important enzymes such as ceruloplasmin, tyrosinase, and peptidylglycine monooxyge

281 estigated the relationship between FeOxI and ceruloplasmin tyrosine and cysteine modification and exp

282 Both ceruloplasmin tyrosine nitration and cysteine thiol oxid

283 smin reduced FeOxI activity while increasing ceruloplasmin tyrosine nitration and cysteine thiol oxid

284 n; flavonoid(-)-epicatechin, which prevented ceruloplasmin tyrosine nitration but not cysteine oxidat

285 times higher than (64)Cu-albumin and (64)Cu-ceruloplasmin uptake, respectively.

286 ge in expression restores copper delivery to ceruloplasmin via ATP7A.

287 In contrast, ceruloplasmin was a highly efficient catalyst for the ox

288 Ceruloplasmin was a potent inhibitor of purified myelope

289 Ceruloplasmin was an ineffective catalyst of homocystein

290 Ceruloplasmin was expressed in the retina, and was induc

291 Quantitative detection of nitrated ceruloplasmin was realized by recording the fluorescence

292 Ceruloplasmin was the predominant protein associated wit

293 ositol (GPI)-linked wild-type or P177R human ceruloplasmin were examined by pulse-chase metabolic lab

294 in this disease, cDNA clones encoding murine ceruloplasmin were isolated and characterized.

295 In addition, ferroportin and ceruloplasmin were markedly decreased within the epithel

296 Plasma copper and ceruloplasmin were not affected by diet.

297 case, T. ferrooxidans rusticyanin, and human ceruloplasmin), which lie in a reduction potential range

298 BeWo cells also synthesized a form of ceruloplasmin whose structure differed from that of the

299 sensor displays rapid responses for nitrated ceruloplasmin with the concentration as low as 1 ng/mL.

300 sminemia can result from retention of mutant ceruloplasmin within the early secretory pathway.