ライフサイエンスコーパス: chair conformation

1 2.73 A) suggesting a tension stabilizing the chair conformation.

2 gen bonds force these molecules to adopt the chair conformation.

3 nked to Trp-276 in TSR1 has an unusual (1)C4 chair conformation.

4 uce a considerable stabilization of the boat-chair conformation.

5 ts a boat rather than the typically observed chair conformation.

6 gher than that of 4 constrained in the alpha-chair conformation.

7 from the chair to the boat-like or inverted chair conformation.

8 seven-membered ring of retCPr adopts a twist chair conformation.

9 w that the cyclohexasilane monomer prefers a chair conformation.

10 hat exo-[6.6.6.6]metacyclophane 6a assumes a chair conformation.

11 operates via a phenyl equatorial piperidine chair conformation.

12 icyclo[3.3.1]nonane bicyclic unit in a chair-chair conformation.

13 gles of the glucopyranose ring toward a half-chair conformation.

14 ions and negatively charged HPH core in the chair conformation.

15 ubsequently transitioning to the more stable chair-conformation.

16 in free energy than their respective (4)C(1)-chair conformations.

17 ecause of stabilization of the single A-ring chair conformations.

18 ese compounds were selected for their stable chair conformations.

19 )SO-skew boat, and less frequently, in (4)C1-chair conformations.

20 g is forced to adopt a highly strained 'half-chair' conformation.

21 , in contrast to this earlier study, an "all-chair" conformation (3B) is found to be the most stable

22 chain might be in a boat rather than in the chair conformation, a result supported by molecular dyna

23 rt that pyranose ring into the reactive half-chair conformation and that a hydrogen bond is formed be

24 luoromethyl)cyclohexane displays a flattened chair conformation and the electrostatic profile of this

25 The former stabilizes the steroid A-ring chair conformation and the latter locks the A-ring in th

26 states relative to the ground states of the chair conformations and destabilize pathways that occur

27 an ring assumes only one of the two possible chair conformations and that methylation of the nitrogen

28 iling a Michaelis (ES) complex in a (1)C(4) (chair) conformation and a covalent glycosyl-enzyme inter

29 ,7-dioxaspiro[5.5]undecane, both rings adopt chair conformations, and both oxygens are axially dispos

30 The pyranose rings retain their (4)C1 chair conformation, as shown by molecular modeling and N

31 For deuterium-labeled cyclohexanes held in a chair conformation at -80 degrees C or lower, all four p

32 nformational rigidity and ability to adopt a chair conformation correlate strongly with experimental

33 simulations that allowed us to identify the chair conformation corresponding to the best binding aff

34 which adopts either a chair-chair or a boat-chair conformation depending on the substituents in the

35 that macrocycles adopt a highly folded half-chair conformation due to the disruption of conjugation

36 ties, which we trace back to piperazine boat/chair conformation effects: the cis-fused disulfide C-Di

37 confirmed that (a) IdoA (1)C(4)- and (4)C(1)-chair conformations exchange on the microsecond time sca

38 oducts are consistent with cyclization via a chair conformation, Figure 1.

39 and black phosphorus display the more common chair conformation for their six-rings.

40 demonstrate that this ring assumes the beta-chair conformation in all cases, and the 1alpha-hydroxyl

41 25% of the energy necessary to form the half-chair conformation in glucose.

42 n reveals some distortion of the cyclohexane chair conformation in the solid state.

43 ated by the theoretical calculations and the chair conformation of H(2)O molecules.

44 The chair conformation of the cyclohexyl group is clearly re

45 doaxial alkoxy group in the most stable half-chair conformation of the enolates, as shown in Schemes

46 rocyclic ring system to stabilize the active chair conformation of the parent gamma-secretase inhibit

47 uatorial orientation, resulting in a perfect chair conformation of the protecting group.

48 roxylated WIN analogues possessing a boat or chair conformation of the tropane ring were prepared and

49 ctive, a fact that is attributed to the half-chair conformation of these substances which reduces the

50 from substrate inhibition by the most stable chair conformation of UDP-D-xylose.

51 tituents to occupy the axial position in the chair conformation of various heterocycles.

52 transition states stemming from the two half-chair conformations of their lithium chelate.

53 The crown (chair-chair) conformations of the transition state account for

54 xible-rigid organic moiety, from its Boat to Chair conformation requires an activation energy of 42 k

55 elds UDP-xylose adopting the relaxed (4)C(1) chair conformation (step 3).

56 e comprised of Sn3As3 puckered hexagons in a chair conformation that share all edges.

57 rable to an equatorial group of a piperidine chair conformation, this information provides very stron

58 hexaNAG substrate binds with all sugars in a chair conformation, unlike the family 18 chitinase which

59 ethyl substituent at N3 stabilizes the chair-chair conformation, whereas ethylacetate or 2-pyridylmet

60 lographic analysis of 5 established that the chair conformation which is adopted has all six C-O bond

61 nyl group at C4 carbon and presented a major chair conformation, which is prone to weaken the C4-O3 b

62 the neutral parent, mono- and dianions) to a chair conformation, which was proved to be fully reversi

63 The molecule adopts a classic chair conformation with alternate C-F bonds aligned tria

64 ly distorted and strained and exhibited half chair conformation with restricted n-conjugation and con

65 s a mixture of two conformers possessing the chair conformation with the equatorial NMe group and dif

66 to explaining unusually large populations of chair conformations with axial substituents, noted previ

67 The nonplanar aliphatic ring exhibits two chair conformations with partial occupancies, each recap

68 (R(p))-5 and (R(p))-6 have chair conformations with the nucleobase substituent equa

69 d to pyranosyl ring flattening ((4)H(5) half-chair conformation) with little or no nucleophilic invol