ライフサイエンスコーパス: channel activity

1 ograms (neuronal, Wnt signaling, calcium/ion channel activity).

2 n between pore size, lipid accommodation and channel activity.

3 ement (GIRK2) or suppression (GIRK3) of GIRK channel activity.

4 e secretory pathway are independent of E ion channel activity.

5 c regulatory site to differentially modulate channel activity.

6 ) manifested no suppressive effects on Kv4.3 channel activity.

7 genetic or pharmacological blockade of TRPV4 channel activity.

8 changes between layers and command receptor channel activity.

9 order of 100~300 Pa, and is modulated by ion channel activity.

10 act with the KATP channel complex to inhibit channel activity.

11 d vesicles using a fluorescence assay for gA channel activity.

12 lasmic reticulum to regulate hERG levels and channel activity.

13 gating, thereby establishing authentic CRAC channel activity.

14 accessory proteins, or CaMKII that modulate channel activity.

15 with Na(+) for binding, but does not support channel activity.

16 le mechanism by which glibenclamide inhibits channel activity.

17 egulator (CFTR) that compromise its chloride channel activity.

18 y protein kinase A (PKA) is required for its channel activity.

19 otential drug target to interfere with TRPC6 channel activity.

20 signaling, gene expression, and membrane ion channel activity.

21 t the nucleotide-binding domain and inhibits channel activity.

22 iable DHB tension, which could be related to channel activity.

23 a synthetic peptide of the NSP4 VPD has ion channel activity.

24 e essential for enhancement or inhibition of channel activity.

25 uses Liddle syndrome by increasing intrinsic channel activity.

26 rat hippocampal neurons resulted in enhanced channel activity.

27 te for the ERK-dependent modulation of TRPV3 channel activity.

28 eillance and cytokine release require THIK-1 channel activity.

29 effect when co-produced with wild-type ITPR1 channel activity.

30 g link between metabolic regulation and TRPV channel activity.

31 he C-terminus resulted in constitutive anion channel activity.

32 vanilloids in their binding site, prolonging channel activity.

33 ther important regulatory events to modulate channel activity.

34 base proton transfer and strongly inhibited channel activity.

35 s could have completely different effects on channel activity.

36 stimulation, suggesting a reduction in RyR1 channel activity.

37 es is, in part, due to METH regulation of BK channel activity.

38 impairing the ability of CIPK23 to regulate channel activity.

39 e-cell electrophysiology was used to monitor channel activity.

40 g stomatal opening, CO2 assimilation and ion channel activity.

41 CSD- and the NMDA-triggered increase in Kir channel activity.

42 he TQ mutant explaining the dramatic loss of channel activity.

43 rge-conductance Ca(2+)-activated K(+) (BKCa) channel activity.

44 rgely on the opposite side of S6, suppressed channel activity.

45 oreceptor synaptic output by altering Ca(2+) channel activity.

46 alters the effects of intracellular MTSET on channel activity.

47 o stabilizes TRPC3 proteins to enhance TRPC3 channel activity.

48 unctional channels, or resulted in a reduced channel activity.

49 ionylation and a concomitant loss in calcium channel activity.

50 counted for by their ability to modulate ion channel activity.

51 g the channel and MgATP and MgADP increasing channel activity.

52 , mitochondrial Ca(2+) uptake regulates CRAC channel activity.

53 synaptic transmissions or by changes in ion channel activity.

54 hanges in mitochondria resulting from sodium channel activity.

55 3 upregulation translated to increased Kv1.3 channel activity.

56 esults identify heme as a regulator of hERG3 channel activity.

57 IP(2) affinity have corresponding effects on channel activity.

58 complex disables matrix Ca(2+) regulation of channel activity.

59 mation of DAG and negatively regulates TRPV1 channel activity.

60 phorylation on its N terminus increases this channel activity.

61 ents, we identified that heme inhibits hERG3 channel activity.

62 o Kv1.3 and posttranslationally modified its channel activity.

63 nt of therapeutic agents targeting aquaporin channel activity.

64 to bear a key structural role in support of channel activity.

65 hich are well known to modulate vascular ion channel activity.

66 tations to determine their effects on IP(3)R channel activity.

67 nnels, we hypothesized that PMP22 alters ion channel activity.

68 s and dimers, but not monomers, gave rise to channel activity.

69 riods likely to have increased T-type Ca(2+) channel activity.

70 fects are cell autonomous and depend on Para channel activity.

71 ily have either lipid scramblase or chloride channel activity.

72 )1.3(42A) isoform showed patterns of the low channel activity.

73 The extent to which sodium channel activity after injury contributes to synaptic tr

74 gonist-, and antagonist-binding sites affect channel activity allosterically.

75 cted with VPD unexpected alterations in K(+) channel activities and changes in stomatal conductance o

76 made it possible to investigate directly ion channel activities and characteristics in isolated endol

77 ETX001 increased the Ca(2+)-activated Cl(-) channel activity and anion secretion in human bronchial

78 Noradrenaline also evoked TRPC1 channel activity and associations between TRPC1, STIM1,

79 Here, we report ryanodine receptor (RyR) channel activity and Ca(2+) release both are increased,

80 ted the relationship between bioelectric ion channel activity and calcium, finding that cell hyperpol

81 ere with the CaM binding, thereby inhibiting channel activity and CDI.

82 revealed links between modifications of ion channel activity and changes in neuronal excitability, s

83 vating mutations, and Rac1 induces TRPC5 ion channel activity and cytoskeletal remodeling in podocyte

84 at anionic gold nanoparticles (AuNPs) reduce channel activity and extend channel lifetimes without di

85 ly restored BEST1 calcium-activated chloride channel activity and improved rhodopsin degradation in a

86 Ca(2+)](ER) is a major regulator of InsP(3)R channel activity and InsP(3)R-mediated [Ca(2+)](i) signa

87 uanosine monophosphate (cGMP) analog on KATP channel activity and insulin secretion point to particip

88 To define the nuances of TRPM3 channel activity and its modulators, we succeeded in inc

89 s sEV release by regulating lysosomal TRPML1 channel activity and lysosome-MVB interaction, which imp

90 metic mutants of ALMT4 S382 showed increased channel activity and Mal(2-) efflux.

91 ivation process enables fine tuning of PANX1 channel activity and may be a generalized regulatory mec

92 athway supported the increase in L-type Ca2+ channel activity and myogenic tone in two animal models

93 , and pharmacological modulators alter TREK1 channel activity and overlaps with positions found to mo

94 synaptic terminals, thereby altering Ca(2+) channel activity and photoreceptor output.

95 proximal C-terminus leads to the boosting of channel activity and promotes calcium-dependent inactiva

96 ned whether urinary MUC1 also enhances TRPV5 channel activity and protects against nephrolithiasis.

97 protein required for the nutrient-permeable channel activity and protein export at the PVM.

98 on of ATP release and volume-regulated anion channel activity and provide critical links among cellul

99 lso causes ligand-independent changes in ion channel activity and second-messenger signaling.

100 co-incubation greatly increased F508del-CFTR channel activity and temporal stability in most, but not

101 NHERF proteins are direct regulators of ion channel activity and that DAG sensitivity is a distincti

102 nctional, cytoplasmic machine modulating the channel activity and the domain organization of CatSper.

103 helix that faces the U motif, enhanced basal channel activity and the sensitivity to Ca(2+) or caffei

104 nt regulator of voltage-gated hERG potassium channel activity and therefore cardiac repolarization an

105 al hypertension indicated basal constitutive channel activity and thus a different gain-of-function m

106 5 in PKA-dependent modulation of L-type Ca2+ channel activity and vascular reactivity during acute hy

107 ignaling module that regulates L-type Ca(2+) channel activity and vascular reactivity upon elevated g

108 le nitric oxide attenuated endothelial TRPV4 channel activity and vasodilation in obese animals.

109 te-dependent impairment of endothelial TRPV4 channel activity and vasodilation was also observed in t

110 recording and Ca(2+) imaging to examine the channel activity, and (4) gene manipulations and other m

111 harmacologically active agents influence the channel activity, and a similar mechanism may be operati

112 including, chemo- and optogenetic control of channel activity, and blocking channels either on the ba

113 howed reduced interaction, reduced Ca(V) 1.3 channel activity, and changes in surface expression.

114 (R204A) reduces apparent PIP2 sensitivity of channel activity, and here we show that Ala or Cys subst

115 phenotypes, ion transporter expression, ROMK channel activity, and localization under normal and high

116 , transepithelial voltage, epithelial sodium channel activity, and pendrin abundance and subcellular

117 r its formation of multimeric complexes, ion channel activity, and, ultimately, release of infectious

118 ns within the same gene suggests that unique channel activities are influenced by each class of mutat

119 ks") and corresponding Ca(2+)-activated K(+) channel activity are critically important for balancing

120 Our data indicate that SOCE and KATP channel activity are regulated by STIM1.

121 His-OsPIP1;3 in liposomes demonstrated water channel activity, as revealed by stopped-flow light scat

122 By analyzing single-channel activities at limiting calcium concentrations, w

123 in-induced translocation system enhances the channel activity at physiological membrane potentials, s

124 ltage relationship, suggesting loss of KCNQ2 channel activity at subthreshold membrane potentials is

125 EXP1 is critical for the nutrient-permeable channel activity at the PVM.

126 ce (IC50 of 14 muM), with no effect on water channel activity (at up to 200 muM).

127 addition, we observed notable differences in channel activity between C6 glioma cells and tsA201 cell

128 reas phosphorylation serves only to maintain channel activity beyond termination of the PKA signal.

129 a misfolded CFTR protein, which has residual channel activity but is prematurely degraded.

130 ic changes were independent of l-type Ca(2+) channel activity but were contingent on the crucial AIS

131 ne residues by palmitoylation, which enhance channel activity by altering interactions of the channel

132 e not SLO2 pore blockers, but rather inhibit channel activity by an allosteric modification of channe

133 Release of Rad-mediated inhibition of Ca(2+) channel activity by beta-adrenergic agonists/PKA also re

134 Regulation of channel activity by Ca(2+) , nucleotides, phosphorylatio

135 Ca(V)3.2 channels and suggest that increased channel activity by Cdk5-mediated phosphorylation after

136 at low levels of RyR2 oxidation increase the channel activity by decreasing the threshold for SOICR,

137 function, the Galpha(q)-PLC pathway inhibits channel activity by depleting PI(4,5)P(2).

138 st several disease-related mutations enhance channel activity by disrupting interfacial interactions.

139 r results indicate that D207E increases KATP channel activity by increasing intrinsic stability of th

140 oxia has a direct effect in suppressing BKCa channel activity by increasing oxidative stress.

141 Specifically, increasing channel activity by introducing the mutation K1250A or p

142 verely impaired lipid scrambling, but robust channel activity by L302A.

143 The modulation of ion channel activity by lipids is increasingly recognized as

144 confirming functional downregulation of KCa2 channel activity by mGlu5 receptors.

145 ts indicate that such mutations can increase channel activity by multiple molecular mechanisms.

146 that H2 S may act in a novel manner to alter channel activity by potentiating the zinc sensitivity/af

147 Mechanistically, O(2) suppresses TRPA1 channel activity by protein internalization via O(2)-dep

148 Deletion of Trpm7 and inhibition of TRPM7 channel activity by the FDA-approved drug FTY720 increas

149 +) entry exerts a feedback control on T-type channel activity, by modulating the channel availability

150 utations which cause small changes in sodium channel activity can have devastating consequences for t

151 irect pharmacological modulation of VSMC Kv7 channel activity can influence blood vessel contractilit

152 y rescues the defective processing and anion channel activity conferred by the major cystic fibrosis-

153 the ability of Klotho to down-regulate TRPC6 channel activity confirm the importance of these residue

154 TRPM7 channel activity contributes to the maintenance of store

155 sitivity to cocaine, whereas increasing GIRK channel activity decreased behavioral sensitivity to coc

156 ed chloride absorption and epithelial sodium channel activity, despite principal cell mineralocortico

157 A Kir6.2 mutation (C166S) that increases channel activity did not affect nucleotide binding, but

158 induces Ca(2+) imbalance by depressing RyR2 channel activity during excitation-contraction coupling,

159 LCS are triggered by both L-type Ca(2+) channel activity during the action potential plateau, as

160 In addition, the L273D mutation depressed channel activity equally regardless of which Orai1 subun

161 ls, WT dimers displayed the high-conductance channel activity expected for the mitochondrial megachan

162 nder stress result from perturbations in ion channel activity, expression or localization.

163 mentation, but showed normalization of BEST1 channel activity following CRISPR-Cas9 editing of the mu

164 with Vx809, which can significantly restore channel activity for multiple CFTR variants.

165 um, allowing further fine-tuning of Ca(V)1.3 channel activity for particular cellular needs.

166 hat is mediated by neurotransmitters and ion channel activity.Functions of the embryonic brain prior

167 ce of 3 mM free Mg(2+) and 1 mM ATP, whereas channel activity further decreased to ~20% of control wh

168 GLR3.3 and GLR3.6 displayed Ca(2+)-permeable channel activities gated by both glutamate and extracell

169 Whereas anion channel activity has been extensively investigated, phos

170 details of drug and nucleotide regulation of channel activity has been illuminated by cryo-electron m

171 ling with K(+) nutrition and guard cell K(+) channel activities have not been fully explored in Arabi

172 r Ca(2+) signaling pathways through multiple channel activities: hemichannels, endoplasmic reticulum

173 MICU2 are EF-hand proteins that regulate the channel activity in a Ca(2+)-dependent manner.

174 ty of ASOs in correcting CFTR expression and channel activity in a manner expected to be therapeutic

175 ration of 6 mmol/L and decreased KATP single-channel activity in beta-cells of control mice but not o

176 orated by experimental results on gramicidin channel activity in bilayers of different thickness.

177 diminished spontaneous Ca(2+) sparks and BK channel activity in bladder and urethra SMCs.

178 emerging role for heme as a regulator of ion channel activity in cells.

179 approach to bidirectionally manipulate GIRK channel activity in DA neurons of the VTA.

180 cule, AC1903, that specifically blocks TRPC5 channel activity in glomeruli of proteinuric rats.

181 of WT vessels, suggesting that basal K(ATP) channel activity in LSM is not an essential component of

182 gomyelinase C (SMase) inhibits CFTR chloride channel activity in multiple cell systems, an effect tha

183 These data suggest that enhancement of HCN2 channel activity in NAc ChIs is a feasible approach for

184 hich the bi-lobe motion in ATD regulates the channel activity in NMDA receptors.

185 hether noradrenaline can down-regulate TRPV1 channel activity in nociceptors and reduce their synapti

186 n H441 monolayers and of alphabetagamma-ENaC channel activity in oocytes.

187 r findings suggest that attenuation of TRPC6 channel activity in pathologic VSMCs could be a rational

188 s transmembrane conductance regulator (CFTR) channel activity in patient-derived airway epithelia.

189 TR variants, restoring cell surface chloride channel activity in primary human bronchial epithelial c

190 cancer cells to noninvasively monitor cation channel activity in real time by the appearance of lithi

191 powerful Ca(2+)-feedback mechanism to adjust channel activity in response to Ca(2+) influx.

192 kout (dKO) mice to genetically upregulate BK channel activity in the absence of FMRP and determine it

193 pression in part by regulating Kir4.1/Kir5.1 channel activity in the DCT is unknown.

194 ced ATP sensitivity and a marked increase of channel activity in the intact cell irrespective of the

195 Our results suggest a role for GluA3 channel activity in the regulation of sleep behavior in

196 hannel beta1 subunit and inhibiting the BKCa channel activity in uterine arteries of pregnant sheep.

197 ect effect of hypoxia in inhibiting the BKCa channel activity in uterine arteries via increased oxida

198 targeted to Golgi membranes, and has cation channel activity in vitro The E protein from avian infec

199 ment of PLCdelta4 in the regulation of TRPM8 channel activity in vivo.

200 versely proportional to the strength of GIRK channel activity in VTA DA neurons and suggest that dire

201 We found that decreasing GIRK channel activity in VTA DA neurons increased behavioral

202 dy was to determine how the strength of GIRK channel activity in VTA DA neurons influences sensitivit

203 Here we define a regulatory mechanism of MCU-channel activity in which cytoplasmic Ca(2+) regulation

204 Here, we show that inhibition of Orai1 channel activity increases average cell velocities by re

205 tablished to identify modulators of NBD1/CL1 channel activity independent of F508del CFTR and pharmac

206 activated potassium (BK) channels inhibiting channel activity independently of effects on channel sur

207 ertheless, CfPutA exhibited normal substrate-channeling activity, indicating that it isomerizes into

208 Modulation of Ca(V) 1/Ca(V) 2 channel activity is a powerful mechanism to regulate phy

209 Thus, unbalanced calcium channel activity is a presynaptic mechanism to consider

210 ontaining a GluN2A subunit is that their ion channel activity is allosterically inhibited by a nano-m

211 Accordingly, channel activity is almost entirely abolished by elimina

212 KCNQ2/3 channel activity is augmented in vivo by phosphatidylino

213 utrition and a robust guard cell K(+) inward channel activity is considered critical for plants' adap

214 TRPC6 channel activity is controlled by protein expression and

215 LMT4 can mediate Mal(2-) efflux and that the channel activity is dependent on a phosphorylatable C-te

216 Voltage-dependent Ca(2+) channel activity is dependent on orchestrated fluctuatio

217 Ca(2+) channel activity is dynamically modulated under basal co

218 These findings show that K(Na)1 channel activity is essential for normal cochlear functi

219 We also found that P2X7 channel activity is facilitated by phosphatidylglycerol

220 Anion channel activity is known to depend on phosphorylation b

221 Up-regulation of EAG channel activity is linked to cancer and neurological di

222 ient for channel activation, whereas TRPC4/5 channel activity is potentiated by phosphatidylinositol

223 expression system to shed light on how CFTR channel activity is reduced by SMase.

224 athway coupling blue light perception to ion channel activity is relatively well understood [3], we k

225 However, the physiologic regulation of Kv7 channel activity is still poorly understood.

226 We propose a model wherein APOL1 channel activity is the upstream event causing cell deat

227 is shifted towards trans, while steady-state channel activity is unaffected.

228 abolic syndrome and diabetes mellitus change channel activity leading to changes in insulin secretion

229 creased KCa3.1 histidine phosphorylation and channel activity, leading to increased calcium flux and

230 Closure of residual K(ATP) channel activity leads to membrane depolarization and an

231 We provide evidence that augmented BK channel activity manifests as increased intrinsic excita

232 the positive modulators in potentiating SK2 channel activity may be attributed primarily to specific

233 irming the long-standing hypothesis that the channel activity measured at the PVM is required for par

234 ings of macroscopic and single hERG1a and 1b channel activity, mutagenesis, and the recent cryoEM str

235 studies thus suggest that upregulation of BK channel activity normalizes multi-level deficits caused

236 ation of the regulatory mechanisms mediating channel activities of an ALMT from the grass Brachypodiu

237 , were analyzed for effects on water and ion channel activities of human AQP1 channels expressed in X

238 d bilayer experiments were used to study the channel activities of the viral protein.

239 Here we report light-induced chloride channel activity of a purified ACR protein reconstituted

240 is thought to be critical for the regulated channel activity of CFTR.

241 t the structure, stability and intercellular channel activity of gap junctions; however, the molecula

242 ntraburst gating, we investigated the single-channel activity of human CFTR at different intracellula

243 cultured cortical neurons in which both the channel activity of NMDARs and the glycine receptors are

244 ls regulate the subcellular localization and channel activity of the polycystin complex through its i

245 cantly amplified, which, in turn, affect the channel activity of the portal protein, GP10, embedded i

246 of EXP1 affected only the nutrient-permeable channel activity of the PVM but not protein export.

247 6 and report induced expression and enhanced channel activity of TRPC6 in association with glomerular

248 y inhibit the ion channel, but not the water channel, activity of AQP1.

249 nd assess the consequences of altered K(ATP) channel activity on lymphatic pump function.

250 represent a record of past ocean levels and channel activity on Mars.

251 rified human TRPA1 showed substantial single-channel activity only in the presence of protoporphyrin

252 We found that BKCa channel activity opposes pressure-induced constriction i

253 Moreover, inhibition of VDAC-1 channel activity or reducing protein expression blocked

254 tions, these three opioids can increase ASIC channel activity, possibly giving rise to opioid-induced

255 Rather, sparse channel activity preserves intracellular current, which

256 that Ca(2+)-CaM-dependent regulation of CNGC channel activity provides an auto-regulatory feedback me

257 Thus, alterations in M-channel activity rapidly trigger unique AIS plasticity t

258 fedtschenkoi, we found that guard cell anion channel activity, recorded under voltage clamp, follows

259 that phosphorylation-dependent reductions in channel activity require an intact Bateman domain dimer

260 Restoring authentic CRAC channel activity required both the presence of STIM1 and

261 g pathway leads to enhanced L-type Ca(V) 1.2 channel activity, resulting in increased Ca(2+) influx i

262 We propose a model in which prolonged channel activity results in calcium accumulation, trigge

263 tant variant of ALMT9 that exhibits enhanced channel activity showed higher Cl(-) and Na(+) accumulat

264 to form Ca(2+)-activated, large conductance channel activity similar to that of mitochondrial megach

265 odel exhibit proexcitatory alterations in Na channel activity, some of which were not seen in hippoca

266 e achieved by genetic downregulation of KATP channel activity specifically in VSM, and by chronic adm

267 n protein has a major role in regulating ion-channel activity, specifically the SK channels, in hyper

268 rm, AtMCU1, gives rise to a Ca(2+)-permeable channel activity that can be observed even in the absenc

269 hannel rundown, which is the gradual loss of channel activity that follows prolonged CaCC activation

270 and CaMKII could generate a facilitation of channel activity that outlasts a depolarizing stimulus.

271 aling a strong functional coupling to CaV1.3 channel activity that was accentuated by densin and CaMK

272 e studies of AKAP79/150 in regulation of ion channel activity, the major questions to be posed centre

273 r data demonstrate that independent of TRPC6 channel activity, the physical interaction between TRPC6

274 rkably, PI(4,5)P(2) directly enhances Flower channel activity, thereby establishing a positive feedba

275 potassium channels helps fine-tune long-term channel activity through conformational changes at the s

276 -coupled receptor stimulation inhibits TRPM3 channel activity through direct binding of the Gbetagamm

277 horylate human TRPC6 at serine 14 to control channel activity through increased membrane expression.

278 scues the channel phenotype and restores ion channel activity to levels seen in normal neurons.

279 r that of VX-770 alone, normalizing CFTR1281 channel activity to that of wild type CFTR.

280 f yeast mitochondria and identified four new channel activities: two anion-preferring channels and tw

281 the Ca(V)1.2 I-II loop interact to regulate channel activity under basal conditions, during beta-adr

282 ic Ca(2+) , are important regulators of CRAC channel activity under physiological conditions of weak

283 bilayers preincubated with gA, which reduced channel activity up to 10-fold.

284 a strategy for normalizing endothelial TRPV4 channel activity, vasodilation, and blood pressure in ob

285 Genetic upregulation of BK channel activity via deletion of BKbeta4 normalized acti

286 Genetic upregulation of BK channel activity via deletion of BKbeta4 was sufficient

287 asmic domain, unique to BASIC, that controls channel activity via membrane interaction.

288 polarization, the effect of TSPAN-7 on Ca(V) channel activity was examined.

289 Store-operated TRPC1 channel activity was inhibited by TRPC1 and STIM1 antibo

290 Channel activity was insensitive to inhibitors of the ad

291 In these experiments, sustained channel activity was observed long after fusion had been

292 PD was selective for cations over anions and channel activity was observed to have both well-defined

293 TRPV4(EC) channel activity was similar in MAs and PAs.

294 Furthermore, K(+) -uptake-channel activities were reduced in cpk3/5/6/11/23 quintu

295 if on the lower, D2 lobe of the LBD prolongs channel activity when auxiliary subunits are present.

296 planar bilayers, which produced much higher channel activity when the gA-containing vesicles were ad

297 primary sensory neurons, we detected single-channel activity with biophysical and pharmacological pr

298 nfantile epilepsy result in increased sodium channel activity with gain-of-function, characterized by

299 ation of MCU Cys-97 exhibited persistent MCU channel activity with higher [Ca(2+)]m uptake rate, elev

300 rent channels that conveys crosstalk between channel activities within single microdomains in tuning