ライフサイエンスコーパス: channeling

1 es) and particle interactions (which reduces channeling).

2 mental confirmation of this structure or the channeling.

3 tatic-mediated and proximity-based substrate channeling.

4 leased into the bulk medium, i.e., substrate channeling.

5 ux control analysis provides no evidence for channeling.

6 eriments, additional evidences for substrate channeling.

7 This stepwise process is termed substrate channeling.

8 eviated by co-incubation with oleate via TAG channeling.

9 ferase (GatDE) function sequentially without channeling.

10 OXPHOS supercomplexes and promotes metabolic channeling.

11 he role of the supercomplexes extends beyond channeling.

12 catalysis and in the regulation of substrate channeling.

13 atics plays an essential role in the APS(2-) channeling.

14 E1a region is essential for the intermediate channeling.

15 g suggestions of steric shielding and oxygen channeling.

16 ations are discussed with respect to ammonia channeling.

17 ear evidence against dihydrofolate substrate channeling.

18 sites to exogenous APS all argue against APS channeling.

19 d the controversial phenomena of direct NADH channeling.

20 tiple distinct catalytic sites via substrate channeling.

21 osed to regulate electron flux via substrate channeling.

22 imits complex (C)I turnover, arguing against channeling.

23 metabolic enzymes communicate via substrate channeling.

24 lusive form of PutA that exhibits suboptimal channeling.

25 interdomain tunnel associated with substrate channeling.

26 nce of the glucosyltransferase for metabolic channeling.

27 lies a selection pressure favoring substrate channeling.

28 Channeling a good catalyst: Highly porous palladium nano

29 This strategy entails a selective condition "channeling" a karyotypically divergent population into o

30 lding the same efficiency benefits as direct channeling, a well-known mechanism in which enzymes are

31 ne of two released intermediates or through "channeling" (activation without the release of an interm

32 ertheless, CfPutA exhibited normal substrate-channeling activity, indicating that it isomerizes into

33 the leucine substitution directing substrate channeling along different reaction channels in a simila

34 dynamics simulations in studies of substrate channeling, also provides new insights into the molecula

35 tion of ammonia and ring formation in IGP by channeling ammonia from one remote active site to the ot

36 lution, raising the possibility of substrate channeling among the active sites in these two proteins.

37 in the DmpF protomer may be correlated with channeling and activity at the DmpG protomer.

38 ticated catalytic concepts such as substrate channeling and allosteric communication existed already

39 osteric interactions that regulate substrate channeling and catalysis in the tryptophan synthase bien

40 mbrane supercomplexes that promote substrate channeling and catalytic efficiency.

41 n upward drag force increased locally by gas channeling and downward contact forces, and thus the phy

42 of reactions involving amino acid substrate channeling and enzymatic multimodule skipping and iterat

43 thout a lag phase, consistent with substrate channeling and implying that the observed tunnel is func

44 o understand coclustering-mediated metabolic channeling and its application to both efficiency improv

45 hysically associated to facilitate substrate channeling and overcome diffusive barriers.

46 ng and kinetic characterization of substrate channeling and quinone reduction.

47 ein interactions that would enable substrate channeling and regulation of the metabolic flux.

48 hat antigen processing is based on substrate channeling and review recent studies from the antigen pr

49 ther approaches provided strong evidence for channeling and transient complex formation between A. ae

50 te brines might be the cause of the observed channeling and weathering in the surface.

51 mphipathic nature of GGPP suggest metabolite channeling and/or competition for GGPP among enzymes tha

52 BchJ may play an important role in substrate channeling and/or regulation of Chl biosynthesis but sho

53 basis for exploring mechanisms of catalysis, channeling, and allosteric communication in the tryptoph

54 ortant information regarding the processing, channeling, and functions of plant siRNAs.

55 development of a porous altered layer, flow channeling, and increasingly limited calcite dissolution

56 9 in the context of light harvesting, energy channeling, and photoprotection within photosystem II.

57 nal SK in catalyzing the kinase reaction and channeling APS is illustrated by the strict requirements

58 Potential underlying causes of activation of channeling are discussed.

59 is and find that the conclusion of substrate channeling arises from the particular behavior of a sing

60 TS calls into question surface electrostatic channeling as the universal means of dihydrofolate trans

61 A channeling assay that optically detects solution-phase A

62 iChS by chemical modifications favors anion channeling at the expense of substrate transport, sugges

63 hominis TS-DHFR kinetic mechanism, substrate channeling behavior, and domain-domain communication.

64 spiratory chain function by allowing quinone channeling between complexes I and III.

65 Our results provide evidence for substrate channeling between hBCATm and BCKD complex and formation

66 plex structure appears to rule out substrate channeling between the active sites of TreS and Pep2.

67 between conformation and control of ammonia channeling between the enzyme's active sites, and explai

68 effort to probe the possibility of substrate channeling between the TS and DHFR active sites and to i

69 te of reduction (19 min (-1)), suggesting no channeling between the two active sites.

70 Notably, substrate "channeling" between the enzymes in supercomplexes has be

71 s observed with anti-TNF therapy may reflect channeling bias, whereby patients with the highest risk

72 To decrease potential "channeling" bias, the study included only new episodes o

73 netics of the bisynthase, not only by steric channeling but also by preferential escape of the produc

74 One solution is metabolic channeling by forming a transitory HpaB-HpaC complex.

75 LDH) through the control of NAD(+) substrate channeling by specifically shifting NAD(+) between the t

76 We show that, in general, proximity channeling can enhance reaction velocity in the presence

77 as a lid that covers the internal substrate channeling cavity, thus preventing escape of the catalyt

78 ntiation checkpoints or branching points for channeling cells to more than one lineages.

79 nteraction between CypD and the IP3R1 Ca(2+) channeling complex increased concomitantly with mitochon

80 s showed that LDH and GAPDH can form a leaky channeling complex only at the limiting NADH concentrati

81 protein-protein interaction of the substrate channeling complex with the pleiotropic protein kinase,

82 was built for a proposed PRODH-P5CDH enzyme channeling complex.

83 mate uptake assays, we identified a chloride-channeling conformer, iChS, transiently accessible as EA

84 Shortcomings in study design, including channeling, confounding bias, and study heterogeneity, m

85 h resolution X-ray diffraction, and electron channeling contrast imaging.

86 This channeling determines the nature of the subsequent repai

87 AH1-encoded phosphatidate phosphatase and by channeling diacylglycerol to phosphatidylcholine via the

88 Moreover, RMH-1 also has a major role in channeling DSBs into an NCO HR outcome near the centers

89 and discusses the notion that the substrate channeling during DNA polymerase-mediated nucleotide ins

90 substrate-level phosphorylation), substrate channeling (e.g., of oxaloacetate from malate dehydrogen

91 lower but significant electrostatic-mediated channeling efficiency (?15-25%) at physiological pH (7.0

92 nd TS active sites significantly reduces the channeling efficiency of P. falciparum DHFR-TS.

93 t organisms capable of forming a biofilm and channeling electrons from substrates to the anode at hig

94 intermediates for biosynthetic pathways and channeling electrons to the respiratory chain complexes.

95 e high affinity for substrates combined with channeling ensures the efficient transfer of carbamoyl p

96 c tissues as well as cellular mechanisms for channeling excess fatty acid to particular metabolic fat

97 Channeling fatty acid substrates into TG resulted in dec

98 that each isoform has distinct functions in channeling fatty acids into different metabolic pathways

99 f THF-activated one-carbon unit synthesis by channeling folate cofactors to other folate-dependent en

100 engineering protocols can exploit substrate channeling for metabolic flux control by fine-tuning sub

101 The pol beta ACF was capable of substrate channeling for steps in vitro BER and was proficient in

102 We analyzed the mechanism of NADH-channeling from D-glyceraldehyde-3-phosphate dehydrogena

103 rapidly hydrolyzed, possibly via "substrate channeling" from the channel to the phosphodiesterase PD

104 V termination, Pol IV-RDR2 coupling, and RNA channeling, from template DNA transcription to siRNA str

105 tures and cell spreading and reveal a signal-channeling function for a MEK1/ERK scaffold in orchestra

106 NPP1 (Enpp1(-/-)), or defective in the PP(i) channeling function of ANK (ank/ank), have decreased lev

107 lar dynamic simulations that investigate the channeling function of hisF.

108 or glucokinase activator, which resulted in channeling glucose/G6P toward glycolysis and lipid synth

109 n suggest two potential physiological roles: channeling GS-hydroquinones back to hydroquinones and re

110 -type and mutant GSAT for binding to GTR and channeling GSA from GTR to GSAT.

111 Metabolic channeling has been proposed to occur at the entry point

112 Substrate channeling has previously been shown for bifunctional Pu

113 , discovering a process we termed "substrate channeling." Here, we investigate the protein-protein in

114 ur findings do not support the electrostatic channeling hypothesis.

115 e, we report the first evidence of substrate channeling in a PRODH-P5CDH two-enzyme pair.

116 sient kinetics approaches developed to study channeling in bienzyme complexes to an archaeal protein

117 sed on the well-known mechanism of substrate channeling in enzyme complexes, SA-induced H2O2 accumula

118 Allosteric interactions regulate substrate channeling in Salmonella typhimurium tryptophan synthase

119 ian respiratory chain that depend on whether channeling in supercomplexes is kinetically important, a

120 findings demonstrating a role for magnesium channeling in T-cell responses to EBV.

121 enesis to test the hypothesis that substrate channeling in the bifunctional thymidylate synthase-dihy

122 s the first structural evidence of substrate channeling in the Krebs cycle metabolon.

123 site coupling suggests a role for substrate channeling in the PDE-dependent dissociation and hydroly

124 direct "channeling." Our results reveal cAMP channeling in the PDE8-RIalpha complex and a molecular d

125 re, we reveal the reactions that account for channeling in the small interfering RNA (siRNA) biogenes

126 Disrupting gas channeling in the soil improved mass transport of O3 to

127 des structural evidence for direct substrate channeling in the supercomplex assembly with short diffu

128 Substrate channeling in the tryptophan synthase bienzyme complex f

129 Substrate channeling in the tryptophan synthase bienzyme complex i

130 There was no channeling in the usage of selective COX-2 inhibitors to

131 to the electrostatically mediated substrate channeling in vitro, in situ, and in vivo.

132 work also highlighted the need for substrate channeling (in human) and ATP hydrolysis (in yeast) for

133 These complexes may enable substrate channeling, in which a substrate bearing, for example, N

134 icating that the mutants disrupt PRODH-P5CDH channeling interactions.

135 acts to maintain homolog bias by preventing channeling into sister interactions.

136 a chaperone protein that mediates substrate channeling into the pathway.

137 ing this process is essential to prevent its channeling into toxic structures threatening cell viabil

138 Metabolite channeling is a common feature of multifunctional enzyme

139 e ferritin core, we propose that ferric iron channeling is a conserved feature of iron homeostasis in

140 Substrate channeling is a mechanism for the internal transfer of h

141 riodic feedwater switching, and preferential channeling is observed in the latter.

142 The channeling is observed only in assays that mimic cytosol

143 ging strategy to promote efficient substrate channeling is to spatially organize pathway enzymes in a

144 of Sgs1 in meiotic recombination, including channeling JMs into physiological crossover and noncross

145 -enzyme interactions and direct intermediate channeling, leading to a decrease in the overall reactio

146 This gas channeling mechanism also generates other gravitational

147 This channeling mechanism could facilitate the consecutive re

148 monofunctional enzymes utilize an analogous channeling mechanism has not been examined.

149 membranous forms of DbetaM, if an efficient channeling mechanism is operative in vivo, soluble Dbeta

150 understanding the molecular basis of such a channeling mechanism remains a major challenge.

151 thermophilus are consistent with a substrate channeling mechanism, as the approach to steady-state fo

152 Kinetic data for SmPutA indicate a substrate-channeling mechanism, in agreement with previous studies

153 rmin or phenformin) initiating the substrate channeling mechanism, the catalytic subunit of CK2 (CK2a

154 Ftr1p for permeation by a classic metabolite channeling mechanism.

155 ake with a kinetic pattern consistent with a channeling mechanism.

156 molecular pathways that limit exhaustion by channeling metabolic processes essential for the rapid r

157 portant for the accumulation of ChlH and for channeling metabolites into the chlorophyll biosynthetic

158 ArgRS, exactly as would be predicted by the channeling model for mammalian translation.

159 Given this evidence, we propose a substrate channeling model for the efficient conversion of dimethy

160 Channeling morphogenic signaling gradients intrinsic to

161 ficantly to global biogeochemical budgets by channeling nutrients through alternate trophic pathways.

162 These findings are consistent with channeling of 10:0 into TAG through the combined activit

163 f enzymatic reactions may enhance the direct channeling of a variety of substrates.

164 ddition of l-carnitine enabled the metabolic channeling of acyl-CoA through carnitine palmitoyltransf

165 alpha)(8) in the closed state may assist the channeling of ammonia at the interface of the two functi

166 ant were consistent with the model where the channeling of ammonia has been disrupted due to the leak

167 The direct channeling of an intermediate between enzymes that catal

168 results provide definitive evidence for the channeling of beta-aspartyl phosphate between aspartokin

169 intermodular "linker pairs" in the selective channeling of biosynthetic intermediates between adjacen

170 se of BCKDC, forming a metabolon that allows channeling of branched-chain alpha-keto acids from BCATm

171 ole for LCB Delta8 unsaturation in selective channeling of ceramides for the synthesis of complex sph

172 nd IV is about 6 nm, which supports proposed channeling of cytochrome c between the individual comple

173 objective of understanding the electrostatic channeling of dihydrofolate generated at the TS active s

174 oil of the PDAT overexpressors is due to the channeling of fatty acids from phosphatidylcholine into

175 Such cellular events include excessive channeling of glucose intermediaries into various metabo

176 sm through stimulation of glucose uptake and channeling of glucose intermediates into the hexosamine

177 al benefit of this form of metabolism is the channeling of glucose into biosynthetic pathways.

178 3 plant, low temperature also influences the channeling of glycerolipids from the ER to chloroplast.

179 physical and functional complex that allows channeling of GSA between the enzymes.

180 on is thought to represent reduced metabolic channeling of HCO3- to the intracellular HCO3- binding s

181 riments reveal an entropic trap that ensures channeling of highly mobile protons along the membrane i

182 abolic network with multiple IAN sources and channeling of IAOx-derived IAN into camalexin biosynthes

183 ar concentration of active Ste5 enhanced the channeling of inappropriate stimuli to Fus3.

184 The channeling of indole between the alpha- and beta-sites v

185 r mechanisms of attention and how it affects channeling of information in different neuronal circuits

186 dent sequential enzyme activities, including channeling of intermediate and conformational change.

187 exes, or metabolons, to facilitate efficient channeling of intermediates and to prevent undesired met

188 ompelling evidence in favor of the so-called channeling of intermediates between enzyme active sites

189 loroplast stroma to facilitate the efficient channeling of intermediates through the pathway.

190 be constructed, providing for the efficient channeling of intermediates to final products, and if th

191 c models, most interestingly, voltage-driven channeling of ions through a pair of activation-energy b

192 yase (ASL) is required for the synthesis and channeling of L-arginine to nitric oxide synthase (NOS)

193 s vacuolation and clustering, leading to the channeling of large PI(3)P-positive membranes to CCVs fo

194 de a mechanism for the sorting and selective channeling of lipid precursors between the galactolipid

195 creased its specific activity and stimulated channeling of long-chain base precursors into sphingolip

196 sulates riboflavin synthase (BsRS), enabling channeling of lumazine from the site of its generation t

197 A selective channeling of LVST inputs through segmentally and dorsov

198 mbering (sn)-1 position from PC and likely a channeling of lysophosphatidic acid, derived from PC, in

199 titive, and non-competitive) mechanisms, the channeling of metabolic flow through isozymes, the chann

200 ling of metabolic flow through isozymes, the channeling of metabolic flow via transamination reaction

201 Channeling of metabolic intermediates via enzyme complex

202 ylcarnitine and ketone bodies, and (iii) the channeling of mitochondrial acetyl-CoA from pyruvate deh

203 ffects E1a-E2o assembly, leading to impaired channeling of OADHc intermediates.

204 xperiments appear high enough to abolish any channeling of oxaloacetate.

205 lakoid membrane, possibly to allow metabolic channeling of potentially phototoxic Chl breakdown inter

206 racting transferases that may facilitate the channeling of PUFA from PC to TAG in flax and possibly a

207 The channeling of recombination from reciprocal exchange to

208 e findings identify a unique pathway for the channeling of small lymph-borne antigens and chemoattrac

209 ial reactions is often envisaged to occur by channeling of substrate between enzyme active sites with

210 organization, called a metabolon, results in channeling of substrates between enzymes.

211 nor to these key enzymes, therefore enabling channeling of sulfur substrate in the cell as well as gr

212 this macromolecular machine by promoting the channeling of the intermediates of catalysis between the

213 transfer from ArsD to ArsA, consistent with channeling of the metalloid from one protein to the othe

214 A ligase I in a coupled reaction governs the channeling of the pol beta insertion products.

215 This results from the channeling of the propionyl moiety of heptanoate into an

216 It is characterized by the channeling of the reaction intermediate indole and the m

217 entity of the mismatch affects the substrate channeling of the repair pathway and the mechanism under

218 dietary long chain fatty acids is related to channeling of these lipids to distinct cellular metaboli

219 fursome and thus enables a global long-range channeling of tRNA(Cys) between SepRS and SepCysS distan

220 nd facilitate activation, which involves the channeling of two nickel ions into the active site.

221 ecognition, deubiquitylation, unfolding, and channeling of ubiquitylated substrates to the 20S protea

222 in efficiency by restricted diffusion (i.e., channeling) of an intermediate APS(2-) between active si

223 emerged that there is no effect of proximity channeling on the reaction velocity of the popular GOx-H

224 o explore the question of whether there is a channeling or "hand-off" of the repair intermediates dur

225 the hydrolysis site on PDE8 through direct "channeling." Our results reveal cAMP channeling in the P

226 ed in processes associated with the sorting, channeling, packaging, and transport of synaptic materia

227 acids rescue palmitate-induced apoptosis by channeling palmitate into triglyceride pools and away fr

228 A structure-based, substrate channeling pathway from the ECH active site to the HAD a

229 The structural model predicts that the core channeling pathway of bifunctional PutA enzymes is conse

230 be caused by the slow leakage of DA from the channeling pathway to the ghost interior.

231 Nevertheless, the functional consequences of channeling peripheral taste signals through inappropriat

232 ted protein kinases (MAPKs), responsible for channeling physiological and environmental signals to th

233 These data suggest that interstitial fluid channeling precedes and may even direct lymphangiogenesi

234 This article describes modeling of the whole channeling process by numerical solution of the Smolucho

235 rse-grained Brownian dynamics, the substrate channeling process has been studied with reactions in mu

236 rafficking pathway as would be expected in a channeling process.

237 (Dlg1) specifies TCR-dependent functions by channeling proximal signals toward the activation of p38

238 e simple equations to estimate the effect of channeling quantitatively and demonstrate that proximity

239 studies revealed that CRABP-II functions by "channeling" RA to RAR, thereby enhancing the transcripti

240 ) and Rutherford backscattering spectrometry channeling (RBS-C) spectra show that the range of radiat

241 hrough the capillary network and dynamically channeling red blood cells toward the initiating signal.

242 of the readily releasable pool of SVs and in channeling retrieved SVs toward direct recycling rather

243 fasciculation of the POC, consistent with a ;channeling' role for these repellent molecules.

244 nization of HIV-1 particles and suggest that channeling serine into lipid biosynthesis may not be a c

245 ceptors, precluding G protein activation and channeling signaling to alternative pathways.

246 ns produced changes consistent with impaired channeling, so our findings do not support the electrost

247 increased significantly in K562/IMA-1 cells, channeling sphingoid bases to the sphingosine kinase pat

248 ts suggest that EcPutA achieves an activated channeling state during the approach to steady state and

249 Instead, a combination of oxygen channeling, steric shielding, and selective radical trap

250 Substrate channeling studies have frequently failed to provide con

251 ing a alphabetabetaalpha complex with indole channeling taking place.

252 nificant mid-gap states and different charge-channeling tendencies.

253 ues important for ferritin substrate-product channeling that, when identified, will outline the entir

254 rotects alginate from degradation by AlgL by channeling the alginate polymer through the proposed alg

255 ation products derived from omega-6 PUFAs by channeling the free radical pathway away from the F2-Iso

256 arget protein by SPR for confirmation before channeling the hits into Nuclear Magnetic Resonance (NMR

257 n alternative mechanism for potentiating and channeling the immune response.

258 ive antagonism from two allosteric sites, by channeling the inhibition towards the active site cavity

259 Therefore, elucidating the mechanism of channeling the intracellular effect of RTK stimulation t

260 components from P. aeruginosa and could help channeling the NO (directly from the site of formation t

261 he increased production of bioactive lipids, channeling the observed metabolic alterations into a key

262 prise nine enzymes that act synergistically, channeling the pathway intermediates to synthesize purin

263 omplex chemical synthesis can be achieved by channeling the reactivity of highly unsaturated molecule

264 se that sFRPs can act as a molecular switch, channeling the signal input for different non-canonical

265 receptors, blocking G protein activation and channeling the signaling to G protein-independent pathwa

266 Because of this channeling, the labeling of acetylcarnitine and ketone b

267 that are believed to contribute to acyl-CoA channeling, the metabolic consequences of loss of these

268 anglion away from nonsensory epithelia, thus channeling them into the sensory domains at E5-E8.

269 part by regulating intracellular fatty acid channeling, Them2 functions in brown adipose tissue to s

270 he relationship between our findings and the channeling theory of translational efficiency is discuss

271 presence of (*)OH and Mn(IV)-oxo species by channeling these oxidants toward the synthesis of a func

272 NA exosome complex, we explore how substrate channeling through the complex is affected by mutation.

273 been achieved due to the prominent electron channeling through the pores of polymeric nano-crystalli

274 ulses are applied only when microbubbles are channeling through the thrombus.

275 nd, thus, the potential for selective signal channeling to segments of the transcriptional network.

276 del of TAG synthesis suggests that substrate channeling to select enzymes and spatial separation of d

277 lation of cognate tRNAs and their subsequent channeling to the ribosome.

278 Our results indicated that dihydroflavonol channeling toward anthocyanin production was boosted dur

279 bstrate binding loop and seals the substrate-channeling tunnel via tertiary structural interactions t

280 y-state formation of NADH does not fit a non-channeling two-enzyme model.

281 hich helps to control the damage response by channeling ubiquitin from the proteosomal degradation pa

282 4-epimerase gene, UGE4, which is involved in channeling UDP-D-galactose (UDP-D-Gal) into cell wall po

283 thus alleviates PSII excitation pressure by channeling up to 30% of PSII-originated electrons.

284 e analysis showed formation of electrostatic channeling upon protein-protein association, which is th

285 The mutants were assessed for impaired channeling using two criteria: a lag in product formatio

286 Channeling was not detected in two of the three types of

287 Kinetic evidence for substrate channeling was sought by measuring the time courses for

288 tas comprising a large interlinked waterway, channeling water and animals into and across the Sahara,

289 r SGLT1 in either pumping water or passively channeling water contrast with its reported water transp

290 cinnamate 4-hydroxylase (C4H), to facilitate channeling, we generated transgenic tobacco (Nicotiana t

291 uct suggests a remarkable form of metabolite channeling where the next enzyme in the biosynthetic pat

292 )) and via the same reaction pathway (50-60% channeling, with the rest via the meizothrombin intermed

293 lar dynamics and metadynamics to investigate channeling within DmpFG in both the presence and absence

294 -GAPDH complex can be an extension of NAD(H)-channeling within each tetramer.

295 o membrane, our findings support hydrophobic channeling within membranes as a means of cellular and t

296 model of allosteric regulation and substrate channeling within protein complexes.

297 dhE filamentation is essential for substrate channeling within the filament and for the regulation of

298 scuss these data in the context of substrate channeling within the Golgi.

299 NAD(H)-channeling within the LDH-GAPDH complex can be an extens

300 We found that substrate channeling within this enzyme is energetically feasible