ライフサイエンスコーパス: checkpoint kinase 2

1 horylation-deficient mutant (T68A mutant) of checkpoint kinase 2.

2 ylation by the tumor-suppressor kinase Chk2 (checkpoint kinase 2) and that this regulation is require

3 nction variants in the tumor suppressor gene checkpoint kinase 2 (CHEK2) are at an increased risk for

4 Checkpoint kinase 2 (CHEK2) deficiency prevents eliminat

5 The screen reveals checkpoint kinase 2 (Chek2) to be the most important kin

6 Checkpoint kinase 2 (CHK-2) is a key component of the DN

7 Here, we report that checkpoint kinase 2 (Chk2 or Chek2), is essential for cu

8 ication at Ser1981 and by phosphorylation of checkpoint kinase 2 (CHK2) and chromatin/transcription r

9 ectasia mutated, checkpoint kinase 1 (CHK1), checkpoint kinase 2 (CHK2) and poly(ADP-ribose) polymera

10 ules ataxia-telangiectasia mutated (ATM) and checkpoint kinase 2 (CHK2) are inhibited by rLOX-PP expr

11 ia telangiectasia and Rad3-related (ATR) and checkpoint kinase 2 (Chk2) checkpoint kinases, blocking

12 ation of H(2)A.X at Ser139 and activation of checkpoint kinase 2 (Chk2) in all the three cell lines.

13 sustained by the DNA damage response kinase Checkpoint kinase 2 (Chk2) in mitosis.

14 thermore, FoxM1 protein is phosphorylated by checkpoint kinase 2 (Chk2) in response to DNA damage.

15 all interfering RNA to assess the effects of checkpoint kinase 2 (Chk2) inhibition on G(1)-S progress

16 Checkpoint kinase 2 (CHK2) inhibitor rather than GNF2 pr

17 We have previously demonstrated that checkpoint kinase 2 (CHK2) is a critical negative regula

18 Checkpoint kinase 2 (Chk2) is a DNA damage-activated pro

19 Here, we show that the DNA damage-activated Checkpoint kinase 2 (Chk2) is a novel tau kinase and enh

20 In response to ionizing radiation, checkpoint kinase 2 (Chk2) is activated in an ataxia tel

21 Checkpoint kinase 2 (CHK2) is an important serine/threon

22 Checkpoint kinase 2 (Chk2) is known to mediate diverse c

23 Through its interactions with the checkpoint kinase 2 (Chk2) kinase and Rad51, BRCA1 promo

24 Checkpoint kinase 2 (CHK2) kinase is a key mediator in m

25 cancer cell growth led to our discovery that checkpoint kinase 2 (CHK2) knockdown dramatically increa

26 ently reported that the DNA damage-activated Checkpoint kinase 2 (Chk2) phosphorylates tau at Ser262

27 assays and gammahistone 2AX (gammaH2AX) and checkpoint kinase 2 (CHK2) phosphorylation.

28 The human checkpoint kinase 2 (Chk2) plays a central role in regul

29 Here we show that checkpoint kinase 2 (CHK2), a central effector of DDR, r

30 -telangiectasia mutated (ATM) and cell cycle checkpoint kinase 2 (CHK2), a DNA damage response (DDR)

31 asia mutated) DNA damage response kinase and checkpoint kinase 2 (CHK2), a known ATM substrate.

32 s independent of p53, and requires activated checkpoint kinase 2 (Chk2), a putative tumor suppressor.

33 orylated p53, gamma-H2AX, and phosphorylated checkpoint kinase 2 (Chk2), although E235 does not appea

34 axia-telangiectasia mutated kinase (ATM) and checkpoint kinase 2 (Chk2), two protein kinases that reg

35 The mnk (also known as loki) gene encodes Checkpoint kinase 2 (Chk2), which functions in DNA-damag

36 ent with SFN was the result of activation of checkpoint kinase 2 (Chk2), which was associated with Se

37 of the DNA damage response signaling enzyme checkpoint kinase 2 (CHK2).

38 blocked at the level of the effector kinase, checkpoint kinase 2 (Chk2).

39 show that PRD-4 is an ortholog of mammalian checkpoint kinase 2 (Chk2).

40 been reported to be physiological targets of checkpoint kinase 2 (Chk2).

41 3 and Schizosaccharomyces pombe Cds1, called checkpoint kinase 2 (chk2).

42 show that tumour-intrinsic PDL1 promotes the checkpoint kinase-2 (Chk2)-mediated DNA damage response.

43 Cellular stress by DNA damage induces checkpoint kinase-2 (CHK2)-mediated phosphorylation and

44 h patterning defects that result from Chk-2 (checkpoint kinase-2) DNA damage checkpoint activation.

45 The lack of a role of checkpoint kinase 2 in diallyl trisulfide-induced phosph

46 The protein kinase Chk2 (checkpoint kinase 2) is a major effector of the replicat

47 by expression of very low baseline levels of checkpoint kinase 2 mRNA and protein.

48 R abundance after HS, and (3) the HuR kinase checkpoint kinase 2 protected against the loss of HuR by

49 On the other hand, depletion of checkpoint kinase 2 protein did not have any appreciable

50 oreover, NPY-Y5R activation dephosphorylates checkpoint kinase 2 to promote clonogenicity and prolife

51 A null mutation in the Drosophila checkpoint kinase 2 tumor suppressor homolog (DmChk2) bl

52 caused activation of checkpoint kinase 1 and checkpoint kinase 2, which are intermediaries of DNA dam