ライフサイエンスコーパス: chemerin

1 t cell tryptase are all potent activators of chemerin.

2 mistry for detection of leptin, visfatin and chemerin.

3 tor chemR23, which binds the chemoattractant chemerin.

4 altered hepatic expression of lipocalin2 or chemerin.

5 , macrophage inflammatory protein 3alpha and chemerin.

6 ctivated endothelial cells specifically bind chemerin.

7 1) but failed to observe any response at the chemerin(1) receptor.

8 in was used as agonist and complete when the chemerin(149-157) nonapeptide was used as agonist.

9 zation and a much higher potency against the chemerin(149-157) nonapeptide-induced response.

10 ating this chemoattractant by generating the chemerin 156F and 158S isoforms.

11 tions for the most critical ligand residues: Chemerin-9 residue F(8) binds to a hydrophobic pocket in

12 Based on active CMKLR1/chemerin-9 structures and the inactive AlphaFold model,

13 Here, we identify the binding mode of chemerin-9, the C-terminus of chemerin, at the receptor

14 ompound 16 showed a slightly lower effect on chemerin-9-mediated arrestin recruitment and internaliza

15 tion of a ubiquitous plasma chemoattractant, chemerin, a ligand for the G-protein-coupled receptor CM

16 In addition, chemerin, a natural ligand for CMKLR1, was up-regulated

17 Chemerin, a novel chemoattractant protein, is closely as

18 a major serum agonist activity for CMKLR1 as chemerin, a proteolytically activated attractant and the

19 sequence of the human host defense protein, chemerin, a seven-residue amphipathic stretch located in

20 pression datasets we found that the gene for chemerin, a widely expressed endogenous chemoattractant

21 ter analysis demonstrated that both RvE1 and chemerin activate the CD55 promoter.

22 To define the pathophysiologic triggers of chemerin activity, we evaluated the ability of serum- an

23 Chemerin acts as a chemoattractant for monocytes and mac

24 Chemerin also increased expression of the cytoskeletal p

25 Intratumoral injection of chemerin also inhibited tumor growth, suggesting the pot

26 Chemerin, an inflammatory chemokine, with a known role i

27 edite the development of long acting, stable chemerin analogs as candidate therapeutics, we used memb

28 ke 2 (CCRL2) binds leukocyte chemoattractant chemerin and can regulate local levels of the attractant

29 time, tissue-specific expression patterns of Chemerin and ChemR23 in mouse tooth development.

30 CONCLUSIONAnalysis of chemerin and Gal-3BP levels in mid-gestation amniotic fl

31 d 92.9%-92.6% negative predictive value (for chemerin and Gal-3BP, respectively).

32 The levels of other biochemical parameters, chemerin and IL-1beta, were significantly decreased comp

33 GCF chemerin and IL-6 levels decreased following therapy in

34 Greater values for GCF chemerin and IL-6 levels were found in CP groups than in

35 nked immunosorbent assay was used to measure chemerin and IL-6 levels.

36 P = 0.02), and MMP-13 (r = 0.781, P = 0.01); chemerin and IL-8 (r = 0.913, P <0.01), MMP-8 (r = 0.770

37 raction of macrophages to inflamed tissue by chemerin and in the initiation of resolution of inflamma

38 (t2DM); 2) analyze the relationship between chemerin and interleukin (IL)-6 in periodontally healthy

39 ceptor (GPCR) that responds to the adipokine chemerin and is highly expressed in innate immune cells,

40 augmenting the expression of IFN-alpha/beta, chemerin and its receptor ChemR23, p-cofilin, LIMK2 and

41 Serum chemerin and omentin concentrations were significantly d

42 Chemerin and omentin depletion in COVID-19 patients sugg

43 blast cell line OCCM-30 after treatment with chemerin and siChemR23 was examined by qRT-PCR and Weste

44 inflammation-associated proteases to cleave chemerin and stimulate CMKLR1-mediated chemotaxis.

45 hat is triggered by two ligands, the peptide chemerin and the eicosapentaenoic acid-derived lipid med

46 proteins retinoic acid receptor responder 2 (chemerin) and galectin-3-binding protein (Gal-3BP) - wer

47 Increased immunoreactivity for leptin and chemerin, and decreased immunoreaction for visfatin were

48 the bioactivity of leukocyte chemoattractant chemerin, and further extend the molecular link between

49 Here, we show that the C15 precursor, chemerin, and its receptor, ChemR23, are both upregulate

50 titis and t2DM induced aberrant secretion of chemerin, and non-surgical periodontal therapy influence

51 Recently, coagulation-activated osteopontin, chemerin, and protease-activated receptor signaling, as

52 eceptor 1), the chemoattractant receptor for chemerin, and was abrogated by NK cell depletion.

53 rin levels and its bioactivity, and enhances chemerin- and CMKLR1-dependent lymphocyte/EC adhesion in

54 ddition, administration of neutralizing anti-chemerin antibody before zymosan challenge resulted in a

55 Plasma levels of total chemerin are elevated in CCRL2(-/-) mice and are signifi

56 We further identify chemerin as a natural nonsignaling protein ligand for bo

57 ecific mechanism for the local enrichment of chemerin at inflammatory sites, regulating the recruitme

58 inding mode of chemerin-9, the C-terminus of chemerin, at the receptor by combining complementary mut

59 t" or professional chemokine interreceptors, chemerin binding does not trigger ligand internalization

60 In vitro, chemerin binding to CCRL2 on endothelial cells triggers

61 ed for cleavage at Lys(158) or regulation of chemerin bioactivity.

62 to evaluate changes in leptin, visfatin and chemerin biosynthesis in the liver of men with different

63 ctivation to a similar extent as proteolyzed chemerin, but exhibited reduced activity as a MPhi chemo

64 8(+) T cells, while forced overexpression of chemerin by mouse prostate cancer cells leads to an accu

65 Activation of chemerin by the serine protease cascades that trigger ra

66 ransmembrane domain receptor ligands such as chemerin can regulate pDC migration.

67 eased number of responders, and orchestrated chemerin, CCL17 and CCL22 release.

68 nerate the likely physiologic form of active chemerin, chem157S, and suggested a possible role in mal

69 of plasma, levels of the most potent form of chemerin, chem157S, as well as inactive chem155A, increa

70 er immune cells expressing its receptor, the chemerin chemokine receptor 1 (CMKLR1), to sites of tumo

71 domain-containing protein 2, rs3135500; and chemerin chemokine-like receptor 1, rs1878022) were geno

72 Several studies have linked chemerin/chemokine-like receptor 1 (CMKLR1) to inflammat

73 Chemerin/ChemR23 induced TNF-alpha and IL-6 expression d

74 We aimed to explore possible roles of the chemerin/ChemR23 interaction in cementoblast function an

75 signaling, are phosphorylated in response to Chemerin/ChemR23 signaling in vitro and are expressed in

76 tein S6 (rS6) and Akt, downstream targets of Chemerin/ChemR23 signaling, are phosphorylated in respon

77 onstitute new tools to study the role of the chemerin/ChemR23 system in physiological and pathologica

78 Together, these results suggest roles for Chemerin/ChemR23-mediated DE-DM cell signaling during to

79 pathways as signaling pathways downstream of chemerin/ChemR23.

80 Chemerin circulates as an inactive precursor (chem163S),

81 Chemerin circulates as an inactive precursor in blood wh

82 The results identify a role for chemerin:CMKLR1 in defining a specialized NK-like CD8 T

83 duals, deregulation of a specific adipokine, chemerin, contributes to innate initiation of metaflamma

84 Chemerin-deficient (Chem(-/-) ) mice were compared to wi

85 d NK-like CD8 T cell, and suggest the use of chemerin-dependent modalities to target effector CMKLR1-

86 more, alpha4 integrin blockade abrogated the chemerin-dependent recruitment of CD8(+) T effector memo

87 rane and promoted in a more efficient manner chemerin-dependent transmigration of dendritic cells.

88 l activity present in human skin exudates is chemerin-dependent, just how chemerin shapes skin defens

89 Collectively, these results show that chemerin-derived peptides may represent a novel therapeu

90 Furthermore, because recent data shows that chemerin-derived peptides possess antiinflammatory prope

91 portant endogenous antiinflammatory role for chemerin-derived species.

92 merin, providing a unique mechanism by which chemerin enhances inflammation.

93 an experimental prostate tumor mouse model, chemerin expression is downregulated in the tumor microe

94 Moreover, chemerin expression was positively correlated with TNF-a

95 chemotaxis to several chemoattractants like chemerin, fMLF, and MCP-1; and doubled the phagocytic ac

96 d lymphatic murine endothelial cells produce chemerin following retinoic acid stimulation.

97 (FXIa) cleaved chem163S, generating a novel chemerin form, chem162R, as an intermediate product, and

98 can be further processed to the most active chemerin form, providing a molecular link between coagul

99 l proteolytic cleavages resulting in diverse chemerin forms with different levels of activity.

100 we established that a 9-amino acid-tethered chemerin fragment (amino acids 149-157) activates both m

101 Hepatic expression of leptin, visfatin and chemerin genes was determined by qRT-PCR method.

102 including the resistin, angiotensinogen, and chemerin genes, in addition to induction of brown-specif

103 To study the role of chemerin in adipocyte metabolism, we examined the functi

104 cyte metabolism, we examined the function of chemerin in brown adipose tissue.

105 stoma (GBM), we examined the significance of chemerin in GBM biology.

106 sure to DEP plus HDM, elevated the levels of chemerin in the bronchoalveolar lavage fluid of WT mice.

107 d weaker immunoreaction against visfatin and chemerin in the liver, compared to individuals with norm

108 The role of chemerin in the maintenance of skin homeostasis has rece

109 that the expression of leptin, visfatin and chemerin in the male liver is altered in overweight indi

110 The main enzymes responsible for processing chemerin in the skin, however, remain elusive.

111 The total level of cleaved and noncleaved chemerins in cerebrospinal fluids was approximately 10%

112 igh levels of RARRES2 protein (also known as chemerin) in PTH-expressing cells, which could indicate

113 enhancement of efficacy as an antagonist of chemerin induced intracellular calcium mobilization and

114 nobody behaves as an efficient antagonist of chemerin-induced chemotaxis of human primary cells.

115 that the nanobodies were able to antagonize chemerin-induced intracellular calcium increase.

116 ansplantable mouse melanoma, tumor-expressed chemerin inhibited in vivo tumor growth without altering

117 ) was mimicked by 2 weeks of ICV infusion of chemerin into rats.

118 Chemerin is a chemoattractant and adipokine that circula

119 Chemerin is a chemoattractant involved in immunity that

120 Chemerin is a chemoattractant involved in innate and ada

121 Chemerin is a chemotactic protein that binds to the G pr

122 f class I myosin in susceptible Fusarium sp. Chemerin is a leukocyte attractant, adipokine, and antim

123 Chemerin is a multifunctional protein that requires limi

124 mine whether gingival crevicular fluid (GCF) chemerin is a novel predictive marker for patients with

125 Chemerin is a potent chemoattractant for cells expressin

126 Chemerin is a proinflammatory plasma protein that binds

127 le known ligand for CMKLR1, and we show that chemerin is activated during blood coagulation and attra

128 from its role in inflammation and immunity, chemerin is also involved in white adipocyte biology.

129 Chemerin is expressed during brown adipocyte differentia

130 These results revealed that chemerin is expressed during brown adipocyte differentia

131 We show that Chemerin is expressed in cultured DE progenitor cells, w

132 The bioactivity of chemerin is post-translationally regulated; the attracta

133 Chem158K was the dominant chemerin isoform, and it was not generated by ex vivo pr

134 logy for production of different recombinant chemerin isoforms (chem163S, chem157S, and chem155A) whi

135 To identify and quantify the in vivo chemerin isoforms in biological specimens, we developed

136 eptides from the C terminus of the different chemerin isoforms.

137 ion-dependent fashion, regulates circulating chemerin levels and its bioactivity, and enhances chemer

138 Elevated serum chemerin levels correlate with increased severity of pol

139 ontal therapy influenced the decrease of GCF chemerin levels in patients with CP with and without t2D

140 Furthermore, it suggests GCF chemerin levels may be considered a potential proinflamm

141 t of non-surgical periodontal therapy on GCF chemerin levels.

142 e regulation, where the inflammatory signal, chemerin, links TH and RA signaling to hypothalamic remo

143 igenesis and suggest that down-regulation of chemerin may be an important mechanism of tumor immune e

144 eptides possess antiinflammatory properties, chemerin may be involved in both the initiation and reso

145 We conclude that CMKLR1 expression and chemerin-mediated chemotaxis distinguish circulating pDC

146 Moreover, high chemerin messenger RNA expression in tumors correlated w

147 adipocyte differentiation and knock down of chemerin mRNA results in decreased brown adipocyte diffe

148 In silico analysis showed chemerin mRNA was significantly increased in tissue from

149 Serum chemerin, omentin and vaspin concentrations were measure

150 The aim was to assess concentrations of chemerin, omentin, and vaspin among COVID-19 patients wi

151 By contrast, acute ICV bolus injection of chemerin on a 12 h:12 h photoperiod inhibited food intak

152 ingly, activated endothelial cells expressed chemerin on the plasma membrane and promoted in a more e

153 dditionally, we modeled IRR in wild-type and chemerin-overexpressing mice and injected transgenic mic

154 In vivo, chemerin overexpression worsened IRR.

155 r, cytochrome c These results suggest that a chemerin p4-based defense strategy combats bacterial cha

156 strate that p4, a potent antimicrobial human chemerin peptide derivative, displays killing activity a

157 r, TAFIa) enhanced the bioactivity of 10-mer chemerin peptide NH(2)-YFPGQFAFSK-COOH by removing the c

158 ptor 1 (BLT1) antagonist U-75302, but not by chemerin peptide, a ligand specific for another RvE1 rec

159 PMN exposure to RvE1 or chemerin (peptide agonist of ChemR23) reduced transepith

160 Adipokines such as leptin, visfatin and chemerin play a pivotal role not only in the pathogenesi

161 We demonstrate that murine chemerin possesses potent antiinflammatory properties th

162 ilence KLK14, we demonstrate that KLK14 is a chemerin-processing enzyme in the skin, rapidly and stab

163 Visfatin, chemerin, progranulin, interleukin (IL)-1beta, IL-8, MMP

164 Active chemerin promotes chemotaxis of CMKLR1-expressing CD8 ef

165 addition, we discovered that platelets store chemerin protein and release it upon stimulation.

166 een identified as an additional receptor for chemerin, providing a unique mechanism by which chemerin

167 Gene expression of chemerin (Rarres2) and its receptors were localised with

168 The goal of this study was to investigate Chemerin (Rarres2)/ChemR23(Cmklr1) signaling in DE-DM ce

169 The chemerin receptor (CMKLR1) is a G protein-coupled recept

170 o known as chemerin receptor 23 (ChemR23) or chemerin receptor 1, is a chemoattractant G protein-coup

171 kine-like receptor 1 (CMKLR1), also known as chemerin receptor 23 (ChemR23) or chemerin receptor 1, i

172 We previously reported that chemerin receptor chemokine-like receptor 1 (CMKLR1) is

173 ) effector memory RA phenotypes, express the chemerin receptor CMKLR1 and bind chemerin via the recep

174 sion and inflammation via the cell-signaling chemerin receptor CMKLR1.

175 U-87 MG cells, a human GBM line, express the chemerin receptors, chemokine-like receptor 1 and chemok

176 action between CMKLR1 and its protein-ligand chemerin remains uncharacterized, and no drugs targeting

177 lipid and peptide agonists, resolvin E1 and chemerin, respectively.

178 tandem repeat of the 7-mer, "KVLGRLV" human chemerin segment.

179 only those identical to specific C-terminal chemerin sequences exerted antiinflammatory effects at p

180 Here, using recombinant inactive chemerin, several isolated KLKs, and human primary kerat

181 kin exudates is chemerin-dependent, just how chemerin shapes skin defenses remains obscure.

182 rentiated into adipocytes in the presence of Chemerin siRNA.

183 When tested in vivo, a chemerin SMAL decreased allergic airway inflammation and

184 Finally, chemerin stimulation of myeloid dendritic cells induced

185 Chemerin suppressed cementoblast differentiation and min

186 This interaction might be regulated by chemerin, TGF-beta, and interleukin-1, which would stimu

187 ed receptors of the protumorigenic adipokine chemerin that is involved in ccRCC lipid metabolism.

188 Chemerin, the ChemR23 ligand, was detected by immunohist

189 mmon binding site that overlaps with that of chemerin, the natural ligand of ChemR23.

190 olayers through the endogenous production of chemerin, the upregulation of CCRL2, and the activation

191 d increase local concentrations of bioactive chemerin, thus providing a link between CCRL2 expression

192 nsignaling receptor able to bind and present chemerin to ChemR23(+) dendritic cells.

193 tudy provides the first direct evidence that chemerin undergoes extensive proteolytic processing in v

194 xpress the chemerin receptor CMKLR1 and bind chemerin via the receptor.

195 Expression of leptin and chemerin was enhanced in the liver of overweight individ

196 The inhibition was partial when chemerin was used as agonist and complete when the cheme

197 On the other hand, the fraction of cleaved chemerins was much higher in synovial fluid and cerebros

198 expressing M1 macrophages are chemotactic to chemerin, whereas M2 macrophages not expressing ChemR23

199 These results show that chemerin, whether expressed by tumor cells or within the

200 hemerin9, a nanopeptide agonist derived from chemerin, which induced complex phenotypic changes of ma

201 stically significant positive correlation of chemerin with IL-6, glycated hemoglobin, sampled-site cl