ライフサイエンスコーパス: chemical chaperone

1 nts are useful for developing an aS-specific chemical chaperone.

2 ns lacking polyphosphate, a newly recognized chemical chaperone.

3 eticulum stress inhibitor, ammonia sink, and chemical chaperone.

4 t-containing nAChRs, possibly by acting as a chemical chaperone.

5 n and markers of ER stress are reversed by a chemical chaperone.

6 inase and could be inhibited by an exogenous chemical chaperone.

7 rinated nondetergent surfactants that act as chemical chaperones.

8 for therapeutic purposes with orally active chemical chaperones.

9 l and targetable to the plasma membrane with chemical chaperones.

10 gical correction of the processing defect by chemical chaperones.

11 egradation by using proteasome inhibitors or chemical chaperones.

12 mplications for the biological roles of such chemical chaperones.

13 s restored by eliminating ER stress with the chemical chaperone 4-phenyl butyric acid (4-PBA).

14 We discovered that chemical chaperone 4-phenyl butyric acid and antioxidant

15 We have previously shown that the chemical chaperone 4-phenylbutyrate (4-PBA) promotes the

16 asma membrane localization for rescue by the chemical chaperone 4-phenylbutyrate (4-PBA).

17 Finally, we showed that administration of chemical chaperone 4-phenylbutyrate or genetic inhibitio

18 of Tat- or GFAP-induced UPR/ER stress by the chemical chaperone 4-phenylbutyrate significantly allevi

19 of miR-708 was blocked by treatment with the chemical chaperone 4-phenylbutyrate, uncovering the invo

20 Treatment of db/db mouse islets with the chemical chaperone 4-phenylbutyric acid partially restor

21 MCC was preserved in mice given the chemical chaperone 4-phenylbutyric acid, but was disrupt

22 Pretreatment with the chemical chaperone 4-phenylbutyric acid, the JNK inhibit

23 ment of MHV-A59-infected astrocytes with the chemical chaperone 4-sodium phenylbutyrate increased ERp

24 t the patient's fibroblasts treated with the chemical chaperones 4-phenylbutiric acid or curcumin inc

25 Administration of a chemical chaperone, 4-phenolbutyrate, was protective aga

26 were observed with a structurally unrelated chemical chaperone, 4-phenylbutyric acid (100 mg.kg(-)(1

27 e pathobiology of these lesions, we employed chemical chaperone, 4-phenylbutyric acid (4-PBA) which a

28 Remarkably, the chemical chaperone, 4-phenylbutyric acid, and small mole

29 Two chemical chaperones, 4PBA and TUDCA, were used to amelio

30 We suggest that the chemical chaperones act to stabilize the alpha-helical c

31 estrin2 reconstitution, mTORC1 inhibition or chemical chaperone administration.

32 lead to pain behavior that is reversed by a chemical chaperone and an inhibitor of sEH.

33 macromolecular complexes, it is considered a chemical chaperone and has found numerous practical appl

34 nt was reversed using an ER stress-relieving chemical chaperone and via macrophage-specific knockdown

35 Chemical chaperones and low temperature, which help prop

36 They also serve as chemical chaperones and maintain the functionality of ma

37 organic osmolytes, solutes that function as chemical chaperones and restore osmotic homeostasis.

38 Solution pH, ionic strength, cofactors, chemical chaperones, and osmolytes perturb the chemical

39 Chemical chaperones are small molecules that prevent pro

40 athogenicity of D1080N substitution and that chemical chaperones are therapeutic candidates for the m

41 asizing the translational potential of small chemical chaperones as stress effectors.

42 These nAChR accessories include protein and chemical chaperones as well as auxiliary subunits.

43 ethylsulfoxide (DMSO), which we refer to as 'chemical chaperones' because of their influence on prote

44 eins are misfolded, but functional, and that chemical chaperones both correct the trafficking and fol

45 are small-molecule compounds that can act as chemical chaperones by altering the environment in a cel

46 tic underpinnings of concentration-dependent chemical chaperoning by ATP against prion-like transmiss

47 The presence of chemical chaperones can sometimes alleviate or even rest

48 Our results show that sulfonylureas, as chemical chaperones, can dictate manifestation of the tw

49 In vitro, chemical chaperones caused a dramatic, rapid change in H

50 of ER stress by genetic deletion of CHOP or chemical chaperone conferred a resistance to the LPS-ind

51 escue provides a specific mechanism by which chemical chaperones could be developed for the correctio

52 CB4(S320F) and ABCB4(A953D), suggesting that chemical chaperones could be exploited for therapeutic b

53 We propose that these chemical chaperones could be used as alternative therape

54 portantly, treatment of patient cells with a chemical chaperone decreased intracellular COL4A2 levels

55 Although the chemical chaperones did not appear to affect the existin

56 ilizing the active conformation of MKP3, the chemical chaperone dimethyl sulfoxide was able to mimic

57 e use of 4-phenylbutyric acid (4-PBA), an ER chemical chaperone, diminished ER stress markers and abo

58 Treatment with tauroursodeoxycholic acid, a chemical chaperone drug that functions as an endoplasmic

59 n aggregation is an important determinant of chemical chaperone efficiency under endogenous expressio

60 Our results demonstrate that chemical chaperones enhance the adaptive capacity of the

61 We propose that 6AHA and proline can act as chemical chaperones for apo(a).

62 ve shown previously to act as small molecule chemical chaperones for K(ATP) channels.

63 -conjugated bile acids (TBA) facilitates TBA chemical chaperone function and alleviates endoplasmic r

64 The chemical chaperone glycerol produced a redistribution of

65 The chemical chaperone glycerol was found to improve the exp

66 After growth of cells for 48 h in the chemical chaperone glycerol, AQP2 mutants T126M and A147

67 degradation is blunted by treatment with the chemical chaperone glycerol, which retains SM N100-GFP i

68 correctable, cells were incubated with the "chemical chaperone" glycerol for 48 h.

69 In this study we show that the chemical chaperone, glycerol, and the transcriptional re

70 Reduced growth temperature and the chemical chaperone, glycerol, were found to correct the

71 Treatment with chemical chaperones, growth at permissive temperature, o

72 Chemical chaperones have been shown to stabilize various

73 ew study highlights a critical role for this chemical chaperone in energy-independent maintenance of

74 tance, detailed studies on the role of these chemical chaperones in modulating structure and dimensio

75 stration of sodium 4-phenylbutyrate (PBA), a chemical chaperone, increased protein stability, enzymat

76 roblasts at a permissive temperature or with chemical chaperones increases cellular Hex activity by i

77 In contrast, chemical chaperones inhibited conversion.

78 ization of the dissociated PTS1 subunit with chemical chaperones inhibited toxin export to the cytoso

79 We hypothesized that chemical chaperones known to suppress ER stress signalin

80 g the efficiency of tyrosinase folding using chemical chaperones led to a reduction in the level of s

81 cells initially accumulate both protein and chemical chaperones, like Hsp104 and trehalose, respecti

82 Attenuating ER stress with clinically used chemical chaperones may be a novel therapeutic strategy

83 propriate specificity and affinity acting as chemical chaperones may find application for increasing

84 ailure in Wolfram syndrome and indicate that chemical chaperones might have therapeutic relevance und

85 Unlike many known chemical chaperones, myo-inositol's primary target was n

86 Neither chemical chaperones nor CHOP gene deficiency reduced dia

87 ogical manipulation of this pathway by using chemical chaperones offers a therapeutic option for trea

88 J, indicated a rather indirect effect of the chemical chaperones on folding of CBS mutants.

89 have thoroughly characterized the effects of chemical chaperones on Hmg2p.

90 Reduction of ER stress by treatment with chemical chaperones or overexpression of ER chaperone pr

91 Chemical chaperones or the antioxidant N-acetylcysteine

92 C) inhibitors, but not other antipsychotics, chemical chaperones, or VPA structural analogues.

93 l taurine, an amino acid that functions as a chemical chaperone/osmolyte and enhances cellular antiox

94 Treatment of the mice with a chemical chaperone partially corrected stability, enzyma

95 in-1 expression, while administration of the chemical chaperone PBA to ob/ob mice led to amelioration

96 from protein misfolding, as treatment with a chemical chaperone permits it to exit the endoplasmic re

97 ral treatment of Col4a1 mutant mice with the chemical chaperone phenyl butyric acid (PBA), which redu

98 Reduction of ER stress with a chemical chaperone, phenylbutyric acid (PBA), prevented

99 Pretreatment with a chemical chaperone, phenylbutyric acid, or adenoviral tr

100 In conclusion, the chemical chaperones present in the expression medium wer

101 d the degradation mechanisms, we tested some chemical chaperones previously used for treating CFTR F5

102 ar basis for the ability of TMAO to act as a chemical chaperone remains unknown.

103 h a US Food and Drug Administration-approved chemical chaperone resulted in a decreased collagen intr

104 we show that mitigation of ER stress with a chemical chaperone results in marked protection against

105 Conversely, reduction of ER stress with a chemical chaperone significantly protected against both

106 Modulating ER stress using chemical chaperones significantly reduced the induction

107 ro studies reported a positive effect of the chemical chaperone sodium 4-phenylbutyrate (4-PBA) on mu

108 Treatment of those cells with the chemical chaperone sodium 4-phenylbutyrate could partial

109 The chemical chaperones sodium 4-phenylbutyrate and taurours

110 f hyperostosis that can be suppressed with a chemical chaperone, sodium 4-phenobutyrate (4-PBA).

111 of mice carrying the I4895T mutation with a chemical chaperone, sodium 4-phenylbutyrate (4PBA), redu

112 telet aggregation, while clinically approved chemical chaperone, sodium 4-phenylbutyrate reduced the

113 by co-treatment with either of two different chemical chaperones, sodium 4-phenylbutyrate and taurour

114 ess protectants, but also serve as effective chemical chaperones stabilizing protein functionality.

115 munoglobulin protein (BiP) or treatment with chemical chaperones strengthens the oscillation amplitud

116 s a novel target to ameliorate OI phenotype; chemical chaperones such as 4PBA may be, alone or in com

117 ght CBS mutants expressed in the presence of chemical chaperones such as ethanol, dimethyl sulfoxide,

118 y shown that Hmg2p is strongly stabilized by chemical chaperones such as glycerol, which stabilize mi

119 The above in vitro results offer the use of chemical chaperones such as TMAO as an approach to mitig

120 Chemical chaperones such as TUDCA and PBA alleviate diff

121 ns, protecting against ER stress using small chemical chaperones, such as 4-phenylbutyrate and taurou

122 Treatment with chemical chaperones, such as sodium 4-phenylbutyrate (PB

123 Chemical chaperones, such as trimethylamine N-oxide (TMA

124 Experiments with chemical chaperones suggested that this likely occurs th

125 cation in mice that have been treated with a chemical chaperone, supporting the connection between im

126 In addition, these chemical chaperones suppressed proliferation and induced

127 ent of cells expressing C321R-LAMB2 with the chemical chaperone taurodeoxycholic acid (TUDCA), which

128 The chemical chaperones tauroursodeoxycholate (TUDCA) and 4-

129 ced chaperone response and the orally active chemical chaperones tauroursodeoxycholate (TUDCA) and 4-

130 1RjK) heterozygous pregnant females with the chemical chaperone tauroursodeoxycholic acid alleviated

131 Small chemical chaperone tauroursodeoxycholic acid treatment o

132 Restoration of protein folding by the chemical chaperone tauroursodeoxycholic acid, a hydrophi

133 proapoptotic UPR, whereas application of the chemical chaperones tauroursodeoxycholic acid or 4-pheny

134 is study is to examine the efficacy of an ER chemical chaperone, tauroursodeoxycholic acid (TUDCA), i

135 Administration of the chemical chaperone, tauroursodeoxycholic acid, to Eif2s1

136 wild-type phenotype with the addition of the chemical chaperone, tauroursodexycholic acid (TUDCA).

137 Among various chemical chaperones tested in cell culture, betaine subs

138 Of four chemical chaperones tested, 4-phenylbutyric acid (4-PBA)

139 Among various chemical chaperones tested, arginine was the most effect

140 hermore, following treatment with a panel of chemical chaperones (thapsigargin, glycerol or sodium 4-

141 Tauroursodeoxycholic acid (TUDCA), a chemical chaperone that alleviates ER stress, was used t

142 We propose that polyphosphate acts as a chemical chaperone that helps refold MetA and/or may sti

143 reatment with 4-phenylbutyrate, a well-known chemical chaperone that improves trafficking of several

144 ministration of tauroursodeoxycholic acid, a chemical chaperone that inhibits ER stress, significantl

145 Pretreatment of cells with glycerol, a chemical chaperone that reduces the extent of stress-ind

146 he defects are not reversed with glycerol, a chemical chaperone that rescues channel function in some

147 Most importantly, we found that chemical chaperones that alleviate ER and oxidative stre

148 f these conditions has led to the search for chemical chaperones that can slow, arrest or revert dise

149 UDCA), a bile acid derivative that acts as a chemical chaperone to enhance protein folding and amelio

150 Thus, the use of a CA inhibitor as a chemical chaperone to reduce ER stress may delay or prev

151 ian cells and degraded but can be rescued by chemical chaperones to function as plasma membrane water

152 The ability of chemical chaperones to overcome the dominant negative ef

153 re, we assessed the therapeutic potential of chemical chaperones to relieve plectinopathies.

154 Here we demonstrate the potential for chemical chaperones to rescue cell-surface expression of

155 ort here that sulfonylureas also function as chemical chaperones to rescue K(ATP) channel trafficking

156 cancer: from the structure-guided design of chemical chaperones to restore the function of conformat

157 utic approaches to age-related cataracts use chemical chaperones to solubilize HMW aggregates, while

158 Development of chemical chaperones to solubilize membrane protein compl

159 is and demonstrates the possibility of using chemical chaperones to treat cystinosin(7Delta).

160 Strikingly, chemical chaperone treatment can reduce the lumenal cyst

161 Finally, chemical chaperone treatment protects cells from ER stre

162 onse involves a dramatic accumulation of the chemical chaperone trehalose and induction of trehalose-

163 The chemical chaperone trehalose has been used effectively t

164 Treatment of S. cerevisiae with the chemical chaperone trimethylamine-N-oxide resulted in ne

165 A chemical chaperone, trimethylamine oxide, administered f

166 le to demonstrate that administration of the chemical chaperone TUDCA helped to maintain lymphocyte h

167 R stress in vitro using dexamethasone or the chemical chaperones TUDCA and 4PBA attenuated MMP9 expre

168 ent with 4-phenylbutyric acid, a nonspecific chemical chaperone used in other protein-folding disorde

169 s in the living cell, the in vitro action of chemical chaperones was highly specific for Hmg2p and co

170 that changes similar to those observed with chemical chaperones were brought about by alteration of

171 In this study, we show that several "chemical chaperones," which have been shown to reverse t