ライフサイエンスコーパス: chemical compound

1 s, demonstrating a wide-range effect of this chemical compound.

2 that is interfered with by a cell-permeable chemical compound.

3 and significantly alters the reactivity of a chemical compound.

4 g/g ranged from 52% to 98%, depending on the chemical compound.

5 Results: Analysis with GC-MS identified 377 chemical compounds.

6 ility to many current antimalarial drugs and chemical compounds.

7 and in silico tools that can be used to test chemical compounds.

8 , to capture the functional role of approved chemical compounds.

9 enerally occurs via the physical exchange of chemical compounds.

10 ed as production hosts for a wide variety of chemical compounds.

11 ity to rapidly separate and characterize the chemical compounds.

12 n response to exposure to a small library of chemical compounds.

13 ary of molecular entities focused on 'small' chemical compounds.

14 elevant concentrations of a diverse range of chemical compounds.

15 ods to convert carbohydrates to a variety of chemical compounds.

16 assessing the relative cell permeability of chemical compounds.

17 e mixtures of tens to hundreds of individual chemical compounds.

18 ansition in the presence of NCp7 and various chemical compounds.

19 r a virtual screening of a large database of chemical compounds.

20 ral odorants are complex mixtures of diverse chemical compounds.

21 velopment of insecticide resistance to these chemical compounds.

22 delivery devices require precise release of chemical compounds.

23 g targets and in deconvolving the effects of chemical compounds.

24 sitive tool for detecting proteins and other chemical compounds.

25 nding assay for high-throughput screening of chemical compounds.

26 ies on nucleic acids, and a variety of small chemical compounds.

27 We identified over 100 different chemical compounds.

28 thorough evaluation of the human response to chemical compounds.

29 nce of aromatic or electronically conjugated chemical compounds.

30 on, distribution, metabolism and toxicity of chemical compounds.

31 charides as part of the 'active' cocktail of chemical compounds.

32 mediated selective advantage across diverse chemical compounds.

33 combination with specific growth factors and chemical compounds.

34 mpounds and identified 3 chromatin-modifying chemical compounds (3C) consisting of sodium butyrate (a

35 oach was utilized for the production of four chemical compounds, a peptide antibiotic, and carbohydra

36 ded for locating biodegradative pathways for chemical compounds according to a given set of constrain

37 -genetic interaction screen of nearly 14,000 chemical compounds across seven diverse compound collect

38 taste is stimulated when nutrients or other chemical compounds activate specialized receptor cells w

39 disruptive contaminants (metals and organic chemical compounds) affect plasma TH levels in free-rang

40 -cell patch clamping experiments than either chemical compound alone in HEK293 cells.

41 f coupled graphene oxide (GO) with sensitive chemical compounds along with gold nanostars (Au NS) tha

42 le half-reaction that can produce a valuable chemical compound and operate at a lower potential.

43 acid (AA) is a highly water-soluble organic chemical compound and plays a significant role in human

44 There are >550 chemical compounds and >100 phytocannabinoids isolated f

45 The chemical compounds and biosynthetic genes behind floral

46 The spatial distribution of chemical compounds and concentration of reactive mercury

47 al interactions between reporter enzymes and chemical compounds and emphasize the importance of imple

48 MetaCyc also describes reactions, chemical compounds and genes.

49 e expansion of public databases dealing with chemical compounds and metabolic reactions facilitates t

50 as the presence of hydrating water, specific chemical compounds and microscopic structures, such as t

51 A number of chemical compounds and mixtures were surveyed for the ab

52 g, paving the foundation for new boron-based chemical compounds and nanomaterials.

53 works called ReSimNet that take as input two chemical compounds and predicts the CMap score of the tw

54 t can analyse bonding arrangements, identify chemical compounds and probe many other important proper

55 fied by its use of a shared set of component chemical compounds and reactions, providing a detailed m

56 access to patent data, including abstracts, chemical compounds and sequences.

57 also used this method to screen a library of chemical compounds and showed that it can be used to rap

58 technique is therefore widely used to apply chemical compounds and to study the properties of molecu

59 ics, proteomics, genetic variants, pathways, chemical compounds, and diseases, and that adheres to th

60 modelled as graphs in which nodes represent chemical compounds, and edges represent chemical reactio

61 calization and distribution of biomolecules, chemical compounds, and other molecules on different sur

62 (e.g. genes/proteins, diseases, enzymes and chemical compounds) appearing in the documents retrieved

63 ME) is a popular sampling technique in which chemical compounds are collected with a sorbent-coated f

64 Naturally derived chemical compounds are the foundation of much of our pha

65 irment of antiviral signaling and a panel of chemical compounds arresting the cell cycle at different

66 Together, our results identified chemical compounds as novel modulators of GR and reveale

67 odulating Hri-eIF2alphaP-Atf4 signaling with chemical compounds as pharmaceutical therapies for beta-

68 could be exploited for chiral resolution of chemical compounds as well as controlled assembly of chi

69 rmediates for the synthesis of a plethora of chemical compounds at industrial scale.

70 nt such a device with repeatable delivery of chemical compounds at multiple locations on a chip surfa

71 Bisphenol A (BPA), a high volume production chemical compound attracts growing attention as a health

72 er pressure, unexpected and counterintuitive chemical compounds become stable.

73 Characterizing how chemical compounds bind to human serum albumin (HSA) is

74 Different interactions may be related to chemical compound, but this has not been systematically

75 Identification of chemical compounds by gas chromatography-mass spectrosco

76 Similarity searching and clustering of chemical compounds by structural similarities are import

77 to predict the physicochemical properties of chemical compounds can be applied to predict the toxicit

78 organisms and thermal degradation of certain chemical compounds can be either described by the Arrhen

79 We have previously shown that a variety of chemical compounds can inactivate the whole virus by att

80 We demonstrate here that several different chemical compounds can inhibit the metabolism of FICZ, t

81 ere steep gradients of antibiotics and other chemical compounds can occur.

82 oughput screens have demonstrated that small chemical compounds can selectively inhibit some enzymes

83 PubChem BioAssays and associated chemical compounds can then be queried and manipulated i

84 g a dual-color splicing reporter to identify chemical compounds capable of regulating G-quadruplex-de

85 Odorant binding proteins (OBPs) are chemical compound carriers, involved in diverse physiolo

86 We had previously identified a chemical compound class termed Inhibitor of Wnt Producti

87 decomposing complex metabolite networks into chemical compound classes and molecular annotations rema

88 gnificantly expand the possible detection of chemical compounds compared to previous biomarker-focuse

89 A small chemical compound (compound 5) designed to disrupt inter

90 f methods that combine protein structure and chemical compound databases.

91 Curcumin, a chemical compound derived from the curry spice tumeric,

92 Chemical compounds derived from the biotransformation of

93 differentiation of these cells with various chemical compounds did not induce C1qRP expression.

94 energies, where XAFS signals of the involved chemical compounds differ significantly, can also be use

95 hile the majority of microbial and with that chemical compound diversity remains inaccessible for cul

96 hat are present in cloud water because these chemical compounds drive the oxidant capacity of the clo

97 arvae require the use of either highly toxic chemical compounds (e.g. 1-phenyl-2-thiourea, PTU) or pi

98 as validated using the z and E(a) of various chemical compounds, enzymes, and vegetative cells and sp

99 of, and biodegradation pathways for, organic chemical compounds, especially those produced by man.

100 space refers to the vast set of all possible chemical compounds, estimated to contain 10(60) molecule

101 ental factors (e.g., UV), certain drugs, and chemical compounds, etc.

102 opulation reports using cannabidiol (CBD), a chemical compound extracted from cannabis that does not

103 o cover whole-genome RNAi collections and/or chemical compound files, and often collect measurements

104 rages, and pharmaceuticals, is the most used chemical compound for mental alertness.

105 (Urd) was found in a screen of a library of chemical compounds for ability to inhibit bacterial tran

106 r cell lines (the NCI-60) to screen >100,000 chemical compounds for anticancer activity.

107 enotype was used to screen a library of 1040 chemical compounds for drugs that ameliorate the defect,

108 We screened a library of 309,989 chemical compounds for growth inhibition of Ewing sarcom

109 ments for testing the functionality of these chemical compounds for humans.

110 ccess this diversity of structurally complex chemical compounds for industrial and biomedical applica

111 Although initially a variety of known chemical compounds-for other purposes-proved disappointi

112 on among the elemental segregation, types of chemical compounds formed, and possible mechanisms of th

113 age in lung cancers and aristolochic acid, a chemical compound found in certain herbal medicines, in

114 actors were retrieved and related to typical chemical compounds found in red wine.

115 ine, in combination with nontoxic doses of a chemical compound from the endoperoxide class that decom

116 reasing or decreasing the extraction of some chemical compounds from coffee grounds.

117 have a significant impact on the release of chemical compounds from complex sample matrices, the dif

118 raph mass spectrometry (GC-MS) analysis, the chemical compounds from essential oil and oleoresin from

119 igm of SERS sensing to detect trace level of chemical compounds from minimum volume of analyte using

120 y of the ion source by detecting organic and chemical compounds from pure reference standards, biolog

121 Male orchid bees acquire chemical compounds from their environment to concoct spe

122 Moreover, the ramanomes upon six chemical compounds from three categories, including anti

123 Various chemical compounds function as central messengers within

124 olic pathways, enzymatic reactions, enzymes, chemical compounds, genes and review-level comments.

125 cell-derived cardiomyocytes and identified 4 chemical compound groups: inhibitors of glycogen synthas

126 stant elemental composition but with varying chemical compounds has been developed.

127 expression profiles of cellular responses to chemical compounds have also recently became available.

128 he chemosensitivity profiles of thousands of chemical compounds have been determined.

129 A variety of unexpected chemical compounds have been identified, including NaCl,

130 he carbon-rich star IRC+10216, >50 different chemical compounds have been identified, including such

131 Studies on biological effects of chemical compounds have increased in scale and accessibi

132 can also be activated by a variety of small chemical compounds identified in a high throughput scree

133 Fungal secondary metabolites are chemical compounds important for development, environmen

134 ReSimNet learns the embedding vector of a chemical compound in a transcriptional response space.

135 l product (including bioactive ingredient or chemical compound in food) is going to enlarge the curre

136 eparating isotopes by centrifuging dissolved chemical compounds in a liquid is introduced.

137 These devices separate chemical compounds in a mixture and provide information

138 our phases: (1) high-throughput screening of chemical compounds in cell cultures of tobacco (Nicotian

139 A longstanding limitation for using chemical compounds in complex tissues has been the inabi

140 patent system treats DNA sequences as large chemical compounds in determining their patentability.

141 Concentrations of chemical compounds in e-cig aerosols are generally lower

142 The identification of chemical compounds in exhaled human breath is promising

143 Concern exists for the use of chemical compounds in gas wells due to the risk of groun

144 This approach was also used to detect trace chemical compounds in illicit drugs and explosives, in w

145 dicate that the composition and diversity of chemical compounds in litter are potentially important f

146 ed assay designed to evaluate the effects of chemical compounds in living small-animal models.

147 ng identification as well as localisation of chemical compounds in non-homogenous samples.

148 The detection and discrimination of chemical compounds in potential foods are essential sens

149 A device that releases chemical compounds in small volumes and at multiple, wel

150 Rapid characterization of thermally stable chemical compounds in solid or liquid states is achieved

151 s oxidized mercury (GOM) and identifying the chemical compounds in the atmosphere are important for d

152 ative ions are produced from a wide range of chemical compounds in the pure stateand as mixtures in t

153 ored the possibility of the formation of new chemical compounds in the system Al-O.

154 pharmacologically significant quantities of chemical compounds in tobacco smoke.

155 dynamic processes, such as the diffusion of chemical compounds, in tissues.

156 oRNAs along with activity reports for 20,503 chemical compounds including 102 drugs approved by the U

157 luorescence quenching was observed for other chemical compounds including common nitro-aromatic explo

158 parameters (weight, colour, texture and pH), chemical compounds including nutrients (proteins, sugars

159 Molecular ON-switches in which a chemical compound induces protein-protein interactions c

160 f starch and interactions among minerals and chemical compounds influenced the cooking profiles than

161 s present, we hypothesize that this class of chemical compounds inhibit DNMTs by interacting with the

162 cid dissociation reacts with the halochromic chemical compounds inside the droplets, leading to the c

163 ed from pharmaceutical chemistry - designing chemical compounds intended to disrupt a crucial pathway

164 ery, it is critical to identify how multiple chemical compounds interact to perturb biological system

165 n, and cell migration, suggesting that these chemical compounds interfere with the invasion step of t

166 he Hg and Se relationship should incorporate chemical compound into the evaluation.

167 or bioconversion into biofuels and commodity chemical compounds is limited primarily by the availabil

168 Accurate and reliable identification of chemical compounds is the ultimate goal of mass spectrom

169 Pifithrin alpha (PFTalpha) is a chemical compound isolated for its ability to suppress p

170 Importantly, a chemical compound, K201, can block RyR2-Ser2808 phosphor

171 , and the ability to reverse the arrest with chemical compounds known as methylxanthines.

172 , and inhibition of fascin function by small chemical compounds leads to a block of tumor metastasis.

173 for filtering, clustering and networking of chemical compound libraries facilitating both drug disco

174 ed processes and particularly the screens of chemical compound libraries for the identification of le

175 rate the utility of the assay by screening a chemical compound library, resulting in the identificati

176 ased virtual screening of a large commercial chemical compounds library identified 306 virtual best h

177 A chemical compound like 7DW8-5 that is easy to administer

178 atural products constitute a wide variety of chemical compounds, many which can have antibiotic, anti

179 e to suggest that combinatorial screening of chemical compounds may uncover possible additive/synergi

180 first example to our knowledge of a defined chemical compound mediating efficient cell immortalizati

181 g to Hsp90 enabled identification of several chemical compounds modulating the effect of Aha1 on Hsp9

182 ensor platform for nondestructive and online chemical compound monitoring.

183 s, we assessed the risk of 110 non-mutagenic chemical compounds, most of which are known as inhibitor

184 Chemical compounds networks appear more modular than mat

185 Several chemical compounds not known to interact with tumor necr

186 The chemical compound NSC23766 was identified by a structure

187 Application of a Rac-specific inhibitor, the chemical compound NSC23766, to schwannoma cells restored

188 Along with these chemical compounds occur endogenous metabolites that are

189 ing the identification and quantification of chemical compounds occurring in A. dioicus shoots harves

190 ew avenues for real-time sensing of volatile chemical compounds, odors, and flavors.

191 Exemplarily, chemical compounds of 43 beer samples were analyzed.

192 process allowed to separate all investigated chemical compounds of selenium: seleno-l-methionine, met

193 The chemical compounds of the oils were examined by GC/MS.

194 issues in vivo, but assessing the effects of chemical compounds on cells in specific regions of 3D cu

195 review investigated the impact of different chemical compounds on conformations of gluten and its su

196 learner accurately learned the effects of 48 chemical compounds on the subcellular localization of 48

197 containing tens of thousands to millions of chemical compounds, one problem is assessing the sensiti

198 finding relevant documents for a particular chemical compound or family.

199 Inhibition of autophagy by chemical compounds or knocking down the expression of ke

200 Four highly predictive chemical compounds positively correlated to cup score we

201 FT-ICR MS) technique to characterise in situ chemical compounds produced during natural ageing (from

202 iation-induced markers, as well as different chemical compounds produced from the lipidic fraction of

203 data from public datasets relating to drugs, chemical compounds, protein targets, diseases, side effe

204 lgae are emerging as a source of sustainable chemical compounds, proteins and metabolites, including

205 acteria to sense and respond to gradients of chemical compounds released by plant roots.

206 Chemical compounds released during bidirectional host-pa

207 d Snq2:Pdr5) in the presence of 1,246 unique chemical compounds revealed a positive correlation betwe

208 An unbiased chemical compound screen leveraging this model revealed

209 By contrast, certain small chemical compounds selected by high-throughput screening

210 LC plate passed through the ELDI source, the chemical compounds separated on the plate would be desor

211 d to those for ERalpha LBD bound to the same chemical compounds serve as an indication that ERbeta LB

212 int of view, these can be addressed by small chemical compounds, so-called biologicals (eg, mAbs and

213 We tested a novel class of antioxidant chemical compounds (SOD mimics: AEOL10113 and AEOL10150)

214 Chemical compound space (CCS), the set of all theoretica

215 ronic structure, interatomic potentials, and chemical compound space in chronological order.

216 Chemical compound space refers to the vast set of all po

217 Chemical compounds studied in this article: Tyramine (Pu

218 methods significantly promote changes on the chemical compounds studied, and the intensity of these v

219 This pigment may correspond to various chemical compounds such as PbCrO(4) and PbCr(1-x)S(x)O(4

220 hannels, is activated by mild cooling and by chemical compounds such as the supercooling agent, icili

221 Chemical compound surrogates of the intracellular antibo

222 Furthermore, a chemical compound targeting PrxII inhibits the expansion

223 stretching experiments can be used to screen chemical compounds targeting NC proteins and to further

224 1-associated MPNST to identify a novel small chemical compound that inhibits tumor cell growth.

225 thermore, treatment with salubrinal, a small chemical compound that specifically inhibits protein pho

226 (PCBs) are toxic, persistent, and lipophilic chemical compounds that accumulate to high levels in har

227 vestigation, functional IR complexes and the chemical compounds that activate them have not been iden

228 cell-based assays can be used to screen for chemical compounds that affect aggregation and may provi

229 the quantitative detection of mutations and chemical compounds that alter neurite morphology in vitr

230 ave been able to identify specific groups of chemical compounds that are more cytotoxic toward the re

231 showed that ReSimNet successfully identifies chemical compounds that are relevant to a prototype drug

232 The objective of this study was to identify chemical compounds that are synthetically lethal with VH

233 d design and deep learning, we show that the chemical compounds that can bind several different recep

234 proach for high-throughput identification of chemical compounds that can modulate precise genome edit

235 rocarbon material rich in O and N containing chemical compounds that could act as initiators of prebi

236 ious azomycin-containing synthons to produce chemical compounds that could chelate radioactive metals

237 Discovery of molecular mechanisms and chemical compounds that enhance neuronal regeneration ca

238 Chemical compounds that exist in multiple crystalline fo

239 ating myogenesis across species and identify chemical compounds that expand mouse satellite cells and

240 We have here also identified small chemical compounds that function as chemical or pharmaco

241 Dioxins are a family of chemical compounds that has received considerable attent

242 cintillation proximity assay to identify two chemical compounds that inhibit binding of human IL-5 to

243 The seed oils of CT, CTA, and CFA possess chemical compounds that make them useful in health-orien

244 The chemical compounds that make up gaseous oxidized mercury

245 s significantly enhanced our knowledge about chemical compounds that mediate the regulation of reprod

246 complexes in human cells, and to screen for chemical compounds that modulate the activities of the h

247 Chemical compounds that mostly contribute to the flavour

248 A screening approach identified chemical compounds that promote the differentiation and

249 tion for these diseases has been to identify chemical compounds that reduce the size or number of inc

250 gh-content imaging platform, we screened for chemical compounds that reverse transforming growth fact

251 Nonsteroidal anti-inflammatory drugs are chemical compounds that selectively inhibit the synthesi

252 s screening assays for the identification of chemical compounds that show beneficial effects against

253 o present and discuss examples of the latest chemical compounds that show promising inhibitory potent

254 The identification of chemical compounds that specifically and rapidly block C

255 study provides a new strategy for generating chemical compounds that specifically inhibit TGF-beta-SM

256 sion analysis and for the discovery of novel chemical compounds that specifically modulate the expres

257 CA provides clues for the development of new chemical compounds that target alternative binding sites

258 The cellular consequences of chemical compounds that target epigenetic regulators (ep

259 velop a biophysical method for investigating chemical compounds that target the nucleic acid chaperon

260 oceed without definite identification of the chemical compounds that they contain.

261 oncentration as well as by a subset of small chemical compounds that were previously identified as ac

262 yeast Saccharomyces cerevisiae to screen for chemical compounds that will inhibit fatty acid uptake.

263 The objective was to identify the chemical compounds that would typify each category.

264 itrenium D-cyclic triazanes E-are intriguing chemical compounds, the chemistry of which is completely

265 perties of an ubiquitin-binding protein by a chemical compound, thereby shedding light on a novel dru

266 significantly reduce the number of possible chemical compounds to be investigated.

267 High-throughput screening (HTS) of chemical compounds to identify modulators of molecular t

268 Our study opens a new avenue using chemical compounds to reprogram reactive glial cells int

269 ed that GPX4 can be directly activated using chemical compounds to suppress ferroptosis and inflammat

270 uld be used to determine the contribution of chemical compounds to the composition of EVOO produced i

271 Other chemical compounds traditionally used as inhibitors of g

272 profiles derived from human cell lines after chemical compound treatment to train our models combined

273 We can monitor effects of siRNA, ligand, and chemical compound treatments on their target pathways al

274 ibition of G9a H3K9 methyltransferase by the chemical compound UNC0638 activates fetal and represses

275 The large majority of chemical compounds underwent at least one catalytic step

276 e examined the mechanisms of action of these chemical compounds using biochemical, molecular biologic

277 e examination of radioprotective activity of chemical compounds using rat thymocytes.

278 Fungi can produce a wide range of chemical compounds via secondary metabolism.

279 ransistors conjugated with novel interfacing chemical compounds, was integrated into the microfluidic

280 -wide target profile as the fingerprint of a chemical compound, we predicted that seven FDA-approved

281 A total of 523 statistically significant chemical compounds were discovered.

282 16 chemical compounds were identified in the RPHE, includin

283 neybee pathogen, is kept in check by various chemical compounds which may enter the human diet throug

284 Alkylating agents comprise one group of chemical compounds which modify DNA by reacting with oxy

285 Ionic liquids are remarkable chemical compounds, which find applications in many area

286 Diisocyanates are highly reactive chemical compounds widely used in the manufacture of pol

287 ptors depending only on the structure of the chemical compound will be of big help for LC-MS/MS-based

288 eens are a valuable tool for identifying new chemical compounds with antimalarial activity.

289 Alkenes constitute a significant class of chemical compounds with applications in the bulk, pharma

290 in the absence and presence of a variety of chemical compounds with different binding modes and phar

291 hat the essential oil of L. grandis contains chemical compounds with good potential for the treatment

292 We have previously developed a series of chemical compounds with high affinity for the sigma-2 re

293 model predicts the biological activities of chemical compounds with higher specificity and sensitivi

294 Identification of chemical compounds with specific biological activities i

295 To identify chemical compounds with the ability to overcome the inhi

296 s for model organisms exposed to hundreds of chemical compounds with varying carcinogenicity and geno

297 atial organization of biological entities or chemical compounds within hydrogel microstructures.

298 Chemical compounds within individual nanoliter droplets

299 Information on the spatial distribution of chemical compounds within internally mixed individual pa

300 ntrolled by the composition and diversity of chemical compounds within plant litter mixtures, rather