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1 atic chemical approach to exploring biology (chemical genetics).
2  leads and tools to dissect function through chemical genetics.
3 unction through small-molecule evolution and chemical genetics.
4 ncluding zebrafish, a model for genetics and chemical genetics.
5 proaches to modulate neuronal activity using chemical genetics.
6  yet present challenging targets for reverse chemical genetics.
7 activity towards MEK1 by in vitro assays and chemical genetics.
8 nce, we dissect their activation pathways by chemical genetics.
9 lk1-depleted cells, is readily revealed with chemical genetics.
10 all molecules has been a technical hurdle of chemical genetics.
11 small molecules in conjunction with genetics-chemical genetics.
12 ay with genetic screens, targeted LC-MS, and chemical genetics.
13 chanisms of cellular events-a process termed chemical genetics.(1) Unfortunately, the majority of cur
14                   Here we demonstrate, using chemical genetics, a mutually agonistic interaction betw
15                                    Thus, our chemical genetics analysis demonstrates the utility of t
16  Our studies exemplify the combined power of chemical genetics and biochemical analyses for discoveri
17                                    Utilizing chemical genetics and chemoproteomics, we validate that
18 loped screen takes advantage of the power of chemical genetics and combines it with the known substra
19 n (BET) proteins in DLBCL, using integrative chemical genetics and functional epigenomics.
20                      Therefore, by combining chemical genetics and homologous gene replacement in som
21                          We further employed chemical genetics and identified NDR1/2 substrates in th
22                                  Here we use chemical genetics and optogenetic techniques to dissect
23   Our results illustrate the combined use of chemical genetics and proteomics in biological discovery
24                                 Here, we use chemical genetics and report the generation of an analog
25 ctivity in RPE1 human epithelial cells using chemical genetics and verifying results in additional li
26 erichia coli against 15 different AMPs using chemical-genetics and compare to the cross-resistance sp
27                                        Using chemical-genetics and mass spectrometry, we identified s
28 nge of novel applications in drug discovery, chemical genetics, and proteomics research.
29 nt modifiers of diverse protein families for chemical genetics applications.
30                    Here, we have initiated a chemical genetics approach and isolated compounds that i
31 ns in Phytophthora infestans, we initiated a chemical genetics approach by screening for a stage-spec
32      Our analysis illustrates the power of a chemical genetics approach for the analysis of signal tr
33                    Therefore, our cell-based chemical genetics approach for the discovery of apoptosi
34  bulky N(6)-substituted ATP analogs, using a chemical genetics approach initially pioneered with v-Sr
35                                            A chemical genetics approach revealed pronounced species d
36                           Here we describe a chemical genetics approach that overcomes this limitatio
37                             We report here a chemical genetics approach to identify host cellular fac
38                                    We used a chemical genetics approach to identify SIR1, a regulator
39                        In summary, we used a chemical genetics approach to reveal STAT3 as a novel ne
40                                Here we use a chemical genetics approach using knock-in mice in which
41                  To overcome this barrier, a chemical genetics approach was employed in which 43,783
42                                      Using a chemical genetics approach, the Saccharomyces cerevisiae
43                                      Using a chemical genetics approach, the small molecule [5-(3,4-d
44             This was achieved by utilizing a chemical genetics approach, where ectopically expressed
45                                      Using a chemical genetics approach, which combined a pH-homeosta
46 t might be encountered upon adopting a given chemical genetics approach.
47 iosynthesis in Arabidopsis thaliana, using a chemical genetics approach.
48                                   Using this chemical-genetics approach, we assign particular amino a
49         Combining chemical manipulations and chemical genetics at the photoautotrophic transition che
50 imed at promoting the development and use of chemical genetics by scientists worldwide.
51                We have used a combination of chemical genetics, chromatin proteomics, and imaging to
52                                              Chemical genetics employs diverse small-molecule compoun
53                                  Our forward chemical genetics followed by biophysical analyses eluci
54 d compounds, we applied phage-based, reverse chemical genetics for the discovery of caveolin-1 ligand
55                                        Using chemical genetics, here, we report the identification of
56                  To study neurobiology using chemical genetics, high-throughput cell and organismal a
57  Cancer Institute created the Initiative for Chemical Genetics (ICG), to enable public research using
58                           Here, we have used chemical genetics in a human cell line to address these
59 al changes that promote cytokinesis, we used chemical genetics in Dictyostelium to identify genetic s
60                       Specific inhibition by chemical genetics in MEFs confirmed the involvement of J
61 ng approaches followed by drug optimization, chemical genetics in plant systems tends to be fueled by
62 ovide an overview of the current progress in chemical genetics in plants, with a focus on the discove
63                                For instance, chemical genetics involves the discovery of small-molecu
64                                              Chemical genetics is a biochemical approach to develop s
65 pound affecting plant immunity indicate that chemical genetics is a powerful tool to study whole-orga
66                                              Chemical genetics is an emerging technology for revealin
67  The National Cancer Institute Initiative in Chemical Genetics is designed to encourage the developme
68 ful screening campaigns in drug discovery or chemical genetics is the availability of structurally an
69                                              Chemical genetics, or the specific modulation of cellula
70      Here we developed a CRISPR interference chemical-genetics platform to titrate the expression of
71 ation of deep metric learning to large-scale chemical genetics projects highlights the utility of thi
72                             Here, we combine chemical genetics, proximity labeling, and proteome-wide
73 in this issue of Cell in which a new type of chemical genetics revealed the function of a new outer m
74                                      Here, a chemical genetics screen of kinase inhibitors revealed p
75 ll infection, we performed a high-throughput chemical genetics screen of known inhibitors and agonist
76                    Therefore, results from a chemical genetics screen suggest that intersections of t
77                                Here we use a chemical genetics screen to identify direct substrates o
78 ated immunity, we designed and carried out a chemical genetics screen to search for small molecules t
79                                         In a chemical genetics screen we identified the small-molecul
80                                      Using a chemical genetics screen, in this study we report the id
81 ing insulin activity, we performed a forward chemical-genetics screen based on translocation of a glu
82                   Here, we have used forward chemical genetics screening to identify DFPM-insensitive
83      In contrast to RID(WT) and RID(D1114G), chemical genetics shows that the interaction of RID(Delt
84                                      Using a chemical genetics strategy wherein Bur1 kinase was engin
85  conserved cysteines and data from different chemical genetics studies, we suggest that CYSTM protein
86                                        Using chemical genetics, super resolution microscopy, and live
87 uman Aurora A kinase (as-AurA) engineered by chemical genetics techniques.
88                                        Using chemical genetics, the systematic screening of chemical
89 ryonic tissues with genetic manipulation and chemical genetics thus provides a powerful approach to u
90                                      We used chemical genetics to control the activity of budding yea
91 so demonstrate the feasibility of exploiting chemical genetics to define the pathways that govern ver
92                           We previously used chemical genetics to dissect auxin-signaling mechanisms
93 e exploited Mycobacterium tuberculosis (Mtb) chemical genetics to identify pathways influencing antib
94                                      We used chemical genetics to interrogate human DDK with maximum
95                                        Using chemical genetics to reversibly inhibit Cdk1, we find th
96                        In this study, we use chemical genetics to show that the protein kinase Mps1 r
97 have applications in medicinal chemistry and chemical genetics too.
98                We implemented cortistatin A, chemical genetics, transcriptomics, and other methods to
99                                              Chemical genetics uncovered requirements for the metazoa
100 mimicked the effects of BRD0476, and reverse chemical genetics using a known inhibitor of USP9X block
101                                        Using chemical genetics, we discovered thirteen candidate MST3
102                                        Using chemical genetics, we show that kinase inhibitors bypass
103                                        Using chemical genetics, we show that kinase-active Plk4 is in
104 ic synthesis offers the promise of advancing chemical genetics, where small molecules are used to exp
105 pike-induced syncytium formation, we combine chemical genetics with 4D confocal imaging to establish
106                                    Combining chemical genetics with comparative genomics of Mtb clini
107                                 By combining chemical genetics with multimodal imaging, we have ident

 
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