ライフサイエンスコーパス: chemical group

1 sum regressions applied to mixtures for each chemical group.

2 ique challenge for introducing electrophilic chemical groups.

3 ve chemical bonds or protonated/deprotonated chemical groups.

4 antiviral activity is influenced by specific chemical groups.

5 chemicals might possess adaptations to other chemical groups.

6 ces and phthalate esters were the less toxic chemical groups.

7 erial as well as properties of its ionizable chemical groups.

8 istically preferred positions of interacting chemical groups.

9 receptor antagonists containing a variety of chemical groups.

10 ches of transparent conductors in unexpected chemical groups.

11 bles facile functionalization with different chemical groups.

12 s that have been modified by the addition of chemical groups.

13 anup steps make it selective toward targeted chemical groups.

14 ions with isovalent elements from different chemical groups.

15 when binding sites are composed of specific chemical groups.

16 ories: 74 chemical groups and nine "end-use" chemical groups.

17 ed for the spatially controlled transport of chemical groups across gels.

18 d to align NMR peaks that represent the same chemical groups across multiple 2D NMR spectra.

19 However, the role of individual chemical groups, active site metal, amino acid compositi

20 In natural living systems, the chemical groups added following translation are often cr

21 y or cytokeratin 18 (CK-18) levels with each chemical group among the 45 EDCs measured in maternal bl

22 ver, similar results were obtained regarding chemical group and cavity positions.

23 H, and delta(15)N of four analytes from each chemical group and developed a solid-phase extraction (S

24 f any arbitrary combination of tip material, chemical group and substrate.

25 al of 38% of the subjects were exposed to 52 chemical groups and 257 specific chemicals.

26 ion of a series of interactions with various chemical groups and alpha-helical structure presented by

27 iments concerning the oxidation of different chemical groups and could be of interest, in the wide ar

28 rve as universal donors and acceptors of key chemical groups and electrons.

29 to a priori-defined exposure categories: 74 chemical groups and nine "end-use" chemical groups.

30 These fluorophores target chemical groups and reveal their distribution on the spe

31 erein, we report the orientation of selected chemical groups and secondary structure elements in alig

32 onfers resistance to herbicides of different chemical groups and sites of action and can extend to ne

33 the chemical bonding network, including the chemical groups and their connections.

34 t to probe the influence of compound charge, chemical groups, and structural features.

35 ested revealed that odorants within the same chemical group are widely dispersed while odorants from

36 Bioorthogonal (click) chemical groups are powerful tools for the specific dete

37 interactions or proximity and orientation of chemical groups, are evident in the equilibrium-averaged

38 umbers of components, chemicals from diverse chemical groups, assays with different in vitro endpoint

39 Our results have revealed that chemical group at the gamma-carbon of the phosphonate ri

40 rants precipitated through hydrolysis of key chemical groups at extremely acidic (pH 1) and lose red

41 as a hydrophobic region(s) to interact with chemical groups at the 3- and/or 4-positions of 4-CmC.

42 ctional group that is different from the six chemical groups attached to the aromatic rings.

43 ctionalisation of intact virus particles via chemical groups attached to the DNA.

44 satraplatin, and picoplatin contain bulkier chemical groups attached to the platinum core compared w

45 ls representing 73 parent compounds) in nine chemical groups: bactericides, benzophenones, bisphenols

46 Unlike conventional LC-MS, it analyzes chemical-group-based submetabolomes and uses the combine

47 ectron donor or electron acceptor power of a chemical group bonded to an aromatic ring.

48 Targeting individual chemical groups by selective excitation in a 1D experime

49 Alternatively, random combinations of chemical groups can be used to generate diverse molecule

50 Chemical groups capable of connecting molecules physical

51 They include reactive chemical groups capable of covalently binding to their t

52 nslational modifications (PTMs) are covalent chemical groups capable of modeling chromatin accessibil

53 olomes can be profiled and thus knowledge of chemical group classification is important in guiding su

54 D window to correlate patterns of functional/chemical group conservation in the query protein with th

55 Chemical group contributions to the energetics of bindin

56 tensities of the most significantly affected chemical groups demonstrated a strong correlation betwee

57 These substances belong to five chemical groups: derivatives of (i) N-(tosyl)carbamate,

58 The pyrophosphate moiety, a highly conserved chemical group different from the L-Lys-D-Ala-D-Ala dock

59 other nucleotide analogs for the analysis of chemical groups essential to a variety of RNA and DNA ac

60 ated biphenyls were generally the most toxic chemical group, followed by polybrominated diphenyl ethe

61 ved that the potency changes induced by most chemical groups follows a nearly normal distribution cen

62 urface of microfluidic channels provide free chemical groups for further surface modification.

63 the existence of preferred and nonpreferred chemical groups for lead optimization.

64 Substitution of different chemical groups for the 1-hydroxyl of 4-CmC resulted in

65 open wide perspectives, together with other chemical groups, for the implementation of such features

66 (380-420 nm), we successfully modify two key chemical groups (formyl and alpha-amino) with high effic

67 In Pennsylvania, two organic chemicals/groups had reduced odds of detection with incr

68 ic interactions occur between aminoglycoside chemical groups important for antibiotic activity and co

69 ochemical method that rapidly identifies the chemical groups important for RNA function.

70 ely matches the overall shape and pattern of chemical groups in D-fructose.

71 rules governing the location of a variety of chemical groups in membranes by comparison of the result

72 enables the precise encoding of non-natural chemical groups in proteins.

73 dentification of the specific roles of these chemical groups in substrate recognition.

74 dular, permitting incorporation of different chemical groups in the backbone without causing adverse

75 etic derivatives, we have identified the key chemical groups in the benzoselenadiazole scaffold respo

76 Spectroscopy was used to identify the major chemical groups in the extracted dye.

77 well we can experimentally analyze the major chemical groups in two representative samples (i.e., hum

78 ions of 64 organic and inorganic UOG-related chemicals/groups in residential groundwater from 255 hom

79 Those chemical groups included petroleum derivatives for anenc

80 to image and three-dimensionally reconstruct chemical groups inside a protein complex.

81 tly reduced by its adsorption on the surface chemical groups instead of directly on the SWNT array it

82 ild non-covalent interactions with selective chemical groups into precisely designed configurations b

83 In biomaterials, incorporating non-natural chemical groups into protein-based polymers facilitates

84 s twist residues, forming the lariat to join chemical groups involved in branching.

85 othioate substitutions, we identify specific chemical groups involved in substrate binding.

86 a new set of monomers each time a different chemical group is introduced in the backbone.

87 Here we show that mechanically sensitive chemical groups make it possible to harness the mechanic

88 ide modified with larger (di-tBu) or smaller chemical groups (Me).

89 Of 11 chemical groups, metals/metalloids were most frequently

90 Here the effects of these chemical group modifications on the conformational prope

91 The materials did not show changes in chemical groups nor thermal properties.

92 tion of the parent molecular system with the chemical group of known pai-electron-donating or -accept

93 The chemical groups of deoxystreptamine presented to the RNA

94 e using various GDP analogues and identified chemical groups of GDP as essential for the substrate ac

95 (NMR) were employed to identify the specific chemical groups of PSO, MD, and GA in the PSO-GA/MD comp

96 talytic center with conserved characteristic chemical groups of the beta-lactam substrates.

97 robial strains capable of detecting specific chemicals, groups of chemicals or global biological effe

98 el system, we showed that the sugar ring C2' chemical groups on cytarabine and gemcitabine snugly fit

99 acid aptamer can control access to specific chemical groups on its target, which suggests that aptam

100 t-translational access to such reactions and chemical groups on proteins could be useful in both reve

101 In total, the chemical groups on the adenine base at the branch site a

102 The chemical groups on the adenine base were varied systemat

103 chol derivatives, we identified the specific chemical groups on the agonist responsible for the rapid

104 We tailored cell surfaces with bioorthogonal chemical groups on the basis of a liposome-fusion and -d

105 We also grafted the chemical groups on the nanoparticle surface to investiga

106 s governed by molecular interactions between chemical groups on the nanoparticle surfaces and the ami

107 icular they allow substitution of individual chemical groups or atoms in a protein of interest.

108 ruler to determine the positions of specific chemical groups or atoms within proteins under condition

109 rality can be induced by inclusion of chiral chemical groups or dopants; these bias molecular twist t

110 a provide the first evidence that a reactive chemical group plays an essential role in the conformati

111 ay show different sensitivities to different chemical groups present in the environment.

112 The determined orientation of chemical groups provides strong constraints for modeling

113 Chemical groups related to aging, such as proteins, wate

114 logues was designed and tested to define the chemical groups relevant for activity and selectivity.

115 Several of the chemical groups required to achieve a functioning hairpi

116 strands incorporating mechanically sensitive chemical groups-so-called mechanophores-that the directi

117 than for a single chemical only or multiple chemicals grouped solely by mechanism of action.

118 tion-metal molecular sandwich nanowires with chemical groups such as -F, -Cl, -CN, -NO(2), horizontal

119 nt advances in catalysis have allowed native chemical groups such as carboxylic acids, ketones and am

120 We found that hydrophilic chemical groups such as hydroxides were created on the s

121 o high pressures in the presence of specific chemical groups such as hydroxyl groups or hydrogens.The

122 t step of signal transduction that transfers chemical groups such as phosphate, acetyl and glycosyl g

123 , their effects are buffered by a cascade of chemical groups such as the NH3/NH4(+) group, leading to

124 l because vibrational frequencies of certain chemical groups, such as nitriles, are linearly sensitiv

125 ctivity was ensured against drugs from other chemical groups than fluoroquinolones.

126 ng plots indicated that fatty acids were one chemical group that discriminated between responses by A

127 This arm is typically a prosthetic chemical group that is covalently attached to the enzyme

128 e oxygens of A1492 and A1493 in 16S rRNA are chemical groups that are essential for a high-affinity R

129 ce dramatic rate enhancements using only the chemical groups that are supplied by their constituent a

130 edge of individual transfer free energies of chemical groups that become newly exposed on protein den

131 tionships between molecules and the putative chemical groups that differentiate them (e.g., H2, CH2,

132 ved in the photo-migration mechanism and the chemical groups that facilitate it.

133 easurements of molecular forces and specific chemical groups that govern silica scaling during bracki

134 sion that are inherently related to terminal chemical groups that limit molecular network connectivit

135 hree protein-coding genes and the five major chemical groups that were detected in the hierarchical c

136 erence between HA and FA was found for major chemical groups, that is, carbohydrates, phenols, benzen

137 Once Cys-430 is modified with a large chemical group, the channel is prevented from relaxing b

138 oparticle surface and ligands with different chemical groups, the types of bonding, the final dispers

139 lly contain an abundance of easily ionizable chemical groups, there is a gap in understanding of whet

140 , a PTM involving the covalent addition of a chemical group to a specific protein sequence, profoundl

141 udied LLBs presenting an additional reactive chemical group to allow their coupling to biological vec

142 the possibility of attaching a wide range of chemical groups to gaseous peptides and proteins and als

143 ecently, the attachment of cysteine-reactive chemical groups to pre-existing small molecule inhibitor

144 difying enzymes posttranscriptionally attach chemical groups to specific nucleotides, which not only

145 les for certain functions by identifying the chemical group upon which the residue acts.

146 e of 23 volatile organic compounds from four chemical groups was incomplete though the improvement in

147 s resolution we could not observe individual chemical groups, we could unambiguously define the posit

148 Studies of multiple chemical groups were also common (8%).

149 nd a range of compounds belonging to diverse chemical groups were assessed as potential substrates fo

150 The most prominent chemical groups were esters, ketones and alcohols.

151 The latter chemical groups were more heterogeneous for marine than

152 Using a sandwich hybridization approach, chemical groups were systematically introduced into a su

153 latile compounds (AVCs), categorised into 17 chemical groups, were identified in the beverages by hea

154 160 volatile compounds, distributed over 12 chemical groups, were identified in the wines by an adva

155 I complexes had different sizes, shapes, and chemical groups when interacting with the same hydrophob

156 ool to aid in the identification of probable chemical groups when interpreting optical and photochemi

157 ch of modulation/replacement of bioisosteric chemical groups, which allowed us to identify a combinat

158 ese reactions allow for the incorporation of chemical groups with highly selective reactivity into sm

159 es of carbon-hydrogen and/or oxygen-hydrogen chemical groups, with little contribution of nitrogen-hy

160 ochemical methods are needed to identify the chemical groups within an RNA that are essential to its

161 ation-interference assay, we have identified chemical groups within Escherichia coli 16S ribosomal RN

162 sing similarity to PF-46396 to determine the chemical groups within PF-46396 that contribute to antiv

163 he two bound substrates, the presentation of chemical groups within the active site of each complex i

164 e-dimensional structure formed by the target chemical groups within the protein complex using simple